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High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.

Razavi P, Li BT, Brown DN, Jung B, Hubbell E, Shen R, Abida W, Juluru K, De Bruijn I, Hou C, Venn O, Lim R, Anand A, Maddala T, Gnerre S, Vijaya Satya R, Liu Q, Shen L, Eattock N, Yue J, Blocker AW, Lee M, Sehnert A, Xu H, Hall MP, Santiago-Zayas A, Novotny WF, Isbell JM, Rusch VW, Plitas G, Heerdt AS, Ladanyi M, Hyman DM, Jones DR, Morrow M, Riely GJ, Scher HI, Rudin CM, Robson ME, Diaz LA Jr, Solit DB, Aravanis AM, Reis-Filho JS.

Nat Med. 2019 Dec;25(12):1928-1937. doi: 10.1038/s41591-019-0652-7. Epub 2019 Nov 25.


Frequency and outcomes of brain metastases in patients with HER2-mutant lung cancers.

Offin M, Feldman D, Ni A, Myers ML, Lai WV, Pentsova E, Boire A, Daras M, Jordan EJ, Solit DB, Arcila ME, Jones DR, Isbell JM, Beal K, Young RJ, Rudin CM, Riely GJ, Drilon A, Tabar V, DeAngelis LM, Yu HA, Kris MG, Li BT.

Cancer. 2019 Dec 15;125(24):4380-4387. doi: 10.1002/cncr.32461. Epub 2019 Aug 30.


Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next-Generation Sequencing in Surgically Resected Lung Adenocarcinoma.

Zhou J, Sanchez-Vega F, Caso R, Tan KS, Brandt WS, Jones GD, Yan S, Adusumilli PS, Bott M, Huang J, Isbell JM, Sihag S, Molena D, Rusch VW, Chatila WK, Rekhtman N, Yang F, Ladanyi M, Solit DB, Berger MF, Schultz N, Jones DR.

Clin Cancer Res. 2019 Dec 15;25(24):7475-7484. doi: 10.1158/1078-0432.CCR-19-1651. Epub 2019 Aug 27.


Goal-directed resuscitation following cardiac surgery reduces acute kidney injury: A quality initiative pre-post analysis.

Johnston LE, Thiele RH, Hawkins RB, Downs EA, Jaeger JM, Brooks C, Ghanta RK, Ailawadi G, Kron IL, Isbell JM; Virginia Interdisciplinary Cardiothoracic Outcomes Research Center.

J Thorac Cardiovasc Surg. 2019 May 17. pii: S0022-5223(19)31029-3. doi: 10.1016/j.jtcvs.2019.03.135. [Epub ahead of print]


Perioperative blood transfusion has a dose-dependent relationship with disease recurrence and survival in patients with non-small cell lung cancer.

Latif MJ, Tan KS, Molena D, Huang J, Bott MJ, Park BJ, Adusumilli PS, Rusch VW, Bains MS, Downey RJ, Jones DR, Isbell JM.

J Thorac Cardiovasc Surg. 2019 Jun;157(6):2469-2477.e10. doi: 10.1016/j.jtcvs.2018.12.109. Epub 2019 Feb 12.


Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium.

Li BT, Janku F, Jung B, Hou C, Madwani K, Alden R, Razavi P, Reis-Filho JS, Shen R, Isbell JM, Blocker AW, Eattock N, Gnerre S, Satya RV, Xu H, Zhao C, Hall MP, Hu Y, Sehnert AJ, Brown D, Ladanyi M, Rudin CM, Hunkapiller N, Feeney N, Mills GB, Paweletz CP, Janne PA, Solit DB, Riely GJ, Aravanis A, Oxnard GR.

Ann Oncol. 2019 Apr 1;30(4):597-603. doi: 10.1093/annonc/mdz046.


Initial results of pulmonary resection after neoadjuvant nivolumab in patients with resectable non-small cell lung cancer.

Bott MJ, Yang SC, Park BJ, Adusumilli PS, Rusch VW, Isbell JM, Downey RJ, Brahmer JR, Battafarano R, Bush E, Chaft J, Forde PM, Jones DR, Broderick SR.

J Thorac Cardiovasc Surg. 2019 Jul;158(1):269-276. doi: 10.1016/j.jtcvs.2018.11.124. Epub 2018 Dec 13.


Dynamics of Tumor and Immune Responses during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer.

Anagnostou V, Forde PM, White JR, Niknafs N, Hruban C, Naidoo J, Marrone K, Sivakumar IKA, Bruhm DC, Rosner S, Phallen J, Leal A, Adleff V, Smith KN, Cottrell TR, Rhymee L, Palsgrove DN, Hann CL, Levy B, Feliciano J, Georgiades C, Verde F, Illei P, Li QK, Gabrielson E, Brock MV, Isbell JM, Sauter JL, Taube J, Scharpf RB, Karchin R, Pardoll DM, Chaft JE, Hellmann MD, Brahmer JR, Velculescu VE.

Cancer Res. 2019 Mar 15;79(6):1214-1225. doi: 10.1158/0008-5472.CAN-18-1127. Epub 2018 Dec 12.


A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers.

Sabari JK, Offin M, Stephens D, Ni A, Lee A, Pavlakis N, Clarke S, Diakos CI, Datta S, Tandon N, Martinez A, Myers ML, Makhnin A, Leger Y, Yu HA, Paik PK, Chaft JE, Kris MG, Jeon JO, Borsu LA, Ladanyi M, Arcila ME, Hernandez J, Henderson S, Shaffer T, Garg K, DiPasquo D, Raymond CK, Lim LP, Li M, Hellmann MD, Drilon A, Riely GJ, Rusch VW, Jones DR, Rimner A, Rudin CM, Isbell JM, Li BT.

J Natl Cancer Inst. 2018 Nov 28. doi: 10.1093/jnci/djy156. [Epub ahead of print]


Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC).

Cottrell TR, Thompson ED, Forde PM, Stein JE, Duffield AS, Anagnostou V, Rekhtman N, Anders RA, Cuda JD, Illei PB, Gabrielson E, Askin FB, Niknafs N, Smith KN, Velez MJ, Sauter JL, Isbell JM, Jones DR, Battafarano RJ, Yang SC, Danilova L, Wolchok JD, Topalian SL, Velculescu VE, Pardoll DM, Brahmer JR, Hellmann MD, Chaft JE, Cimino-Mathews A, Taube JM.

Ann Oncol. 2018 Aug 1;29(8):1853-1860. doi: 10.1093/annonc/mdy218.


Neutrophil to Lymphocyte Ratio as Predictor of Treatment Response in Esophageal Squamous Cell Cancer.

Barbetta A, Nobel TB, Sihag S, Hsu M, Tan KS, Bains MS, Isbell JM, Janjigian YY, Wu AJ, Bott MJ, Jones DR, Molena D.

Ann Thorac Surg. 2018 Sep;106(3):864-871. doi: 10.1016/j.athoracsur.2018.04.007. Epub 2018 May 5.


Preoperative anemia versus blood transfusion: Which is the culprit for worse outcomes in cardiac surgery?

LaPar DJ, Hawkins RB, McMurry TL, Isbell JM, Rich JB, Speir AM, Quader MA, Kron IL, Kern JA, Ailawadi G; Investigators for the Virginia Cardiac Services Quality Initiative.

J Thorac Cardiovasc Surg. 2018 Jul;156(1):66-74.e2. doi: 10.1016/j.jtcvs.2018.03.109. Epub 2018 Apr 4.


Minimally Invasive Lobectomy Is Associated With Lower Noncancer-specific Mortality in Elderly Patients: A Propensity Score Matched Competing Risks Analysis.

Hristov B, Eguchi T, Bains S, Dycoco J, Tan KS, Isbell JM, Park BJ, Jones DR, Adusumilli PS.

Ann Surg. 2019 Dec;270(6):1161-1169. doi: 10.1097/SLA.0000000000002772.


Predictors of Nodal Metastases for Clinical T2N0 Esophageal Adenocarcinoma.

Barbetta A, Schlottmann F, Nobel T, Sewell DB, Hsu M, Tan KS, Gerdes H, Shah P, Bains MS, Bott M, Isbell JM, Jones DR, Molena D.

Ann Thorac Surg. 2018 Jul;106(1):172-177. doi: 10.1016/j.athoracsur.2018.02.087. Epub 2018 Apr 5.


Circulating tumor DNA: A promising biomarker to guide postoperative treatment and surveillance of non-small cell lung cancer.

Isbell JM, Jones DR, Li BT.

J Thorac Cardiovasc Surg. 2018 Jun;155(6):2628-2631. doi: 10.1016/j.jtcvs.2017.12.157. Epub 2018 Mar 13. No abstract available. Erratum in: J Thorac Cardiovasc Surg. 2019 Aug 30;:.


Safety and Feasibility of Lung Resection After Immunotherapy for Metastatic or Unresectable Tumors.

Bott MJ, Cools-Lartigue J, Tan KS, Dycoco J, Bains MS, Downey RJ, Huang J, Isbell JM, Molena D, Park BJ, Rusch VW, Sihag S, Jones DR, Adusumilli PS.

Ann Thorac Surg. 2018 Jul;106(1):178-183. doi: 10.1016/j.athoracsur.2018.02.030. Epub 2018 Mar 14.


Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by surgery for stage II to III esophageal squamous cell carcinoma.

Barbetta A, Hsu M, Tan KS, Stefanova D, Herman K, Adusumilli PS, Bains MS, Bott MJ, Isbell JM, Janjigian YY, Ku GY, Park BJ, Wu AJ, Jones DR, Molena D.

J Thorac Cardiovasc Surg. 2018 Jun;155(6):2710-2721.e3. doi: 10.1016/j.jtcvs.2018.01.086. Epub 2018 Feb 15.


Implementing a Thoracic Enhanced Recovery Program: Lessons Learned in the First Year.

Martin LW, Sarosiek BM, Harrison MA, Hedrick T, Isbell JM, Krupnick AS, Lau CL, Mehaffey JH, Thiele RH, Walters DM, Blank RS.

Ann Thorac Surg. 2018 Jun;105(6):1597-1604. doi: 10.1016/j.athoracsur.2018.01.080. Epub 2018 Mar 3.


Quality of Endoscopy Reports for Esophageal Cancer Patients: Where Do We Stand?

Barbetta A, Faraz S, Shah P, Gerdes H, Hsu M, Tan KS, Nobel T, Bains MS, Bott M, Isbell JM, Sewell DB, Jones DR, Molena D.

J Gastrointest Surg. 2018 May;22(5):778-784. doi: 10.1007/s11605-018-3710-4. Epub 2018 Mar 5.


Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers.

Li BT, Stephens D, Chaft JE, Rudin CM, Jones DR, Rusch VW, Rimner A, Isbell JM.

Ann Transl Med. 2017 Dec;5(23):479. doi: 10.21037/atm.2017.09.02.


Factors associated with distant recurrence following R0 lobectomy for pN0 lung adenocarcinoma.

Brandt WS, Bouabdallah I, Tan KS, Park BJ, Adusumilli PS, Molena D, Bains MS, Huang J, Isbell JM, Bott MJ, Jones DR.

J Thorac Cardiovasc Surg. 2018 Mar;155(3):1212-1224.e3. doi: 10.1016/j.jtcvs.2017.09.151. Epub 2017 Nov 13.


Lung Cancer Screening in the Post-National Lung Screening Trial Era: Applying Screening in the Real World.

Turner SR, Isbell JM.

Semin Thorac Cardiovasc Surg. 2017 Nov 27. pii: S1043-0679(17)30298-8. doi: 10.1053/j.semtcvs.2017.11.008. [Epub ahead of print]


Assessment of Fluorodeoxyglucose F18-Labeled Positron Emission Tomography for Diagnosis of High-Risk Lung Nodules.

Maiga AW, Deppen SA, Mercaldo SF, Blume JD, Montgomery C, Vaszar LT, Williamson C, Isbell JM, Rickman OB, Pinkerman R, Lambright ES, Nesbitt JC, Grogan EL.

JAMA Surg. 2018 Apr 1;153(4):329-334. doi: 10.1001/jamasurg.2017.4495.


Defining quality in the surgical care of lung cancer patients.

Brandt WS, Isbell JM, Jones DR.

J Thorac Cardiovasc Surg. 2017 Oct;154(4):1397-1403. doi: 10.1016/j.jtcvs.2017.05.100. Epub 2017 Jun 9. No abstract available.


Prospective study of giant paraesophageal hernia repair with 1-year follow-up.

Stringham JR, Phillips JV, McMurry TL, Lambert DL, Jones DR, Isbell JM, Lau CL, Kozower BD.

J Thorac Cardiovasc Surg. 2017 Aug;154(2):743-751. doi: 10.1016/j.jtcvs.2017.03.138. Epub 2017 Apr 11.


Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism.

Charles EJ, Mehaffey JH, Sharma AK, Zhao Y, Stoler MH, Isbell JM, Lau CL, Tribble CG, Laubach VE, Kron IL.

J Thorac Cardiovasc Surg. 2017 Nov;154(5):1811-1820. doi: 10.1016/j.jtcvs.2017.02.072. Epub 2017 Apr 12.


Capturing Genomic Evolution of Lung Cancers through Liquid Biopsy for Circulating Tumor DNA.

Offin M, Chabon JJ, Razavi P, Isbell JM, Rudin CM, Diehn M, Li BT.

J Oncol. 2017;2017:4517834. doi: 10.1155/2017/4517834. Epub 2017 Mar 14. Review.


Obesity Increases Risk-Adjusted Morbidity, Mortality, and Cost Following Cardiac Surgery.

Ghanta RK, LaPar DJ, Zhang Q, Devarkonda V, Isbell JM, Yarboro LT, Kern JA, Kron IL, Speir AM, Fonner CE, Ailawadi G.

J Am Heart Assoc. 2017 Mar 8;6(3). pii: e003831. doi: 10.1161/JAHA.116.003831.


Impact of Increasing Age on Cause-Specific Mortality and Morbidity in Patients With Stage I Non-Small-Cell Lung Cancer: A Competing Risks Analysis.

Eguchi T, Bains S, Lee MC, Tan KS, Hristov B, Buitrago DH, Bains MS, Downey RJ, Huang J, Isbell JM, Park BJ, Rusch VW, Jones DR, Adusumilli PS.

J Clin Oncol. 2017 Jan 20;35(3):281-290. doi: 10.1200/JCO.2016.69.0834. Epub 2016 Oct 31.


Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion.

Charles EJ, Huerter ME, Wagner CE, Sharma AK, Zhao Y, Stoler MH, Mehaffey JH, Isbell JM, Lau CL, Tribble CG, Laubach VE, Kron IL.

Ann Thorac Surg. 2016 Dec;102(6):1845-1853. doi: 10.1016/j.athoracsur.2016.06.043. Epub 2016 Sep 7.


Postoperative Hypoglycemia Is Associated With Worse Outcomes After Cardiac Operations.

Johnston LE, Kirby JL, Downs EA, LaPar DJ, Ghanta RK, Ailawadi G, Kozower BD, Kron IL, McCall AL, Isbell JM; Virginia Interdisciplinary Cardiothoracic Outcomes Research (VICTOR) Center.

Ann Thorac Surg. 2017 Feb;103(2):526-532. doi: 10.1016/j.athoracsur.2016.05.121. Epub 2016 Aug 25.


Jejunal administration of glucose enhances acyl ghrelin suppression in obese humans.

Tamboli RA, Sidani RM, Garcia AE, Antoun J, Isbell JM, Albaugh VL, Abumrad NN.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E252-9. doi: 10.1152/ajpendo.00082.2016. Epub 2016 Jun 7.


Enteral Access is not Required for Esophageal Cancer Patients Undergoing Neoadjuvant Therapy.

Huerter ME, Charles EJ, Downs EA, Hu Y, Lau CL, Isbell JM, McMurry TL, Kozower BD.

Ann Thorac Surg. 2016 Sep;102(3):948-954. doi: 10.1016/j.athoracsur.2016.03.041. Epub 2016 May 19.


Preoperative Renal Function Predicts Hospital Costs and Length of Stay in Coronary Artery Bypass Grafting.

LaPar DJ, Rich JB, Isbell JM, Brooks CH, Crosby IK, Yarboro LT, Ghanta RK, Kern JA, Brown M, Quader MA, Speir AM, Ailawadi G.

Ann Thorac Surg. 2016 Feb;101(2):606-12; discussion 612. doi: 10.1016/j.athoracsur.2015.07.079. Epub 2015 Dec 8.


Bundled Payments in Cardiac Surgery: Is Risk Adjustment Sufficient to Make It Feasible?

Yount KW, Isbell JM, Lichtendahl C, Dietch Z, Ailawadi G, Kron IL, Kern JA, Lau CL.

Ann Thorac Surg. 2015 Nov;100(5):1646-52; discussion 1652. doi: 10.1016/j.athoracsur.2015.04.086. Epub 2015 Jul 21.


Risk Factors for Urinary Tract Infections in Cardiac Surgical Patients.

Gillen JR, Isbell JM, Michaels AD, Lau CL, Sawyer RG.

Surg Infect (Larchmt). 2015 Oct;16(5):504-8. doi: 10.1089/sur.2013.115. Epub 2015 Jun 26.


Extracorporeal life support for adult cardiopulmonary failure.

Schaheen BW, Thiele RH, Isbell JM.

Best Pract Res Clin Anaesthesiol. 2015 Jun;29(2):229-39. doi: 10.1016/j.bpa.2015.04.004. Epub 2015 Apr 23. Review.


Impact of hemodynamic monitoring on clinical outcomes.

Downs EA, Isbell JM.

Best Pract Res Clin Anaesthesiol. 2014 Dec;28(4):463-76. doi: 10.1016/j.bpa.2014.09.009. Epub 2014 Oct 7. Review.


AKI associated with cardiac surgery.

Thiele RH, Isbell JM, Rosner MH.

Clin J Am Soc Nephrol. 2015 Mar 6;10(3):500-14. doi: 10.2215/CJN.07830814. Epub 2014 Nov 6. Review.


Multicenter evaluation of high-risk mitral valve operations: implications for novel transcatheter valve therapies.

LaPar DJ, Isbell JM, Crosby IK, Kern J, Lim DS, Fonner E Jr, Speir AM, Rich JB, Kron IL, Ailawadi G.

Ann Thorac Surg. 2014 Dec;98(6):2032-7; dicussion 2037-8. doi: 10.1016/j.athoracsur.2014.06.060. Epub 2014 Oct 3.


Planned cardiac reexploration in the intensive care unit is a safe procedure.

LaPar DJ, Isbell JM, Mulloy DP, Stone ML, Kern JA, Ailawadi G, Kron IL.

Ann Thorac Surg. 2014 Nov;98(5):1645-51; discussion 1651-2. doi: 10.1016/j.athoracsur.2014.05.090. Epub 2014 Aug 28.


Predictors of early recurrence for node-negative t1 to t2b non-small cell lung cancer.

Kiankhooy A, Taylor MD, LaPar DJ, Isbell JM, Lau CL, Kozower BD, Jones DR.

Ann Thorac Surg. 2014 Oct;98(4):1175-83. doi: 10.1016/j.athoracsur.2014.05.061. Epub 2014 Aug 16.


Mitral valve repair rates correlate with surgeon and institutional experience.

LaPar DJ, Ailawadi G, Isbell JM, Crosby IK, Kern JA, Rich JB, Speir AM, Kron IL; Virginia Cardiac Surgery Quality Initiative.

J Thorac Cardiovasc Surg. 2014 Sep;148(3):995-1003; discussion 1003-4. doi: 10.1016/j.jtcvs.2014.06.039. Epub 2014 Jun 28.


Understanding mortality as a quality indicator after esophagectomy.

Walters DM, McMurry TL, Isbell JM, Stukenborg GJ, Kozower BD.

Ann Thorac Surg. 2014 Aug;98(2):506-11; discussion 511-2. doi: 10.1016/j.athoracsur.2014.03.041. Epub 2014 May 17.


Readmission after lung cancer resection is associated with a 6-fold increase in 90-day postoperative mortality.

Hu Y, McMurry TL, Isbell JM, Stukenborg GJ, Kozower BD.

J Thorac Cardiovasc Surg. 2014 Nov;148(5):2261-2267.e1. doi: 10.1016/j.jtcvs.2014.04.026. Epub 2014 Apr 18.


Postoperative mortality is an inadequate quality indicator for lung cancer resection.

Hu Y, McMurry TL, Wells KM, Isbell JM, Stukenborg GJ, Kozower BD.

Ann Thorac Surg. 2014 Mar;97(3):973-9; discussion 978-9. doi: 10.1016/j.athoracsur.2013.12.016. Epub 2014 Jan 28.


Surgical Care Improvement Project measure for postoperative glucose control should not be used as a measure of quality after cardiac surgery.

LaPar DJ, Isbell JM, Kern JA, Ailawadi G, Kron IL.

J Thorac Cardiovasc Surg. 2014 Mar;147(3):1041-8. doi: 10.1016/j.jtcvs.2013.11.028. Epub 2014 Jan 11.


Marginal pulmonary function should not preclude lobectomy in selected patients with non-small cell lung cancer.

Taylor MD, LaPar DJ, Isbell JM, Kozower BD, Lau CL, Jones DR.

J Thorac Cardiovasc Surg. 2014 Feb;147(2):738-44; Discussion 744-6. doi: 10.1016/j.jtcvs.2013.09.064. Epub 2013 Nov 16.


Leiomyoma presenting as a massive calcified circumferential esophageal mass.

Walters DM, Vaughn NH, Isbell JM, Jeffus SK, Atkins KA, Sauer BG, Jones DR.

Ann Thorac Surg. 2013 Nov;96(5):1851-4. doi: 10.1016/j.athoracsur.2013.01.097.


Induction chemoradiotherapy and surgery for esophageal cancer: survival benefit with downstaging.

Taylor MD, LaPar DJ, Davis JP, Isbell JM, Kozower BD, Lau CL, Jones DR.

Ann Thorac Surg. 2013 Jul;96(1):225-30: discussion 230-1. doi: 10.1016/j.athoracsur.2013.01.074. Epub 2013 Apr 22.


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