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Items: 1 to 50 of 99

1.

Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

Li J, Cechova S, Wang L, Isakson BE, Le TH, Shi W.

Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1141-F1150. doi: 10.1152/ajprenal.00567.2018. Epub 2019 Apr 3.

PMID:
30943068
2.

Heterocellular Contact Can Dictate Arterial Function.

Shu X, Ruddiman CA, Keller TCS 4th, Keller AS, Yang Y, Good ME, Best AK, Columbus L, Isakson BE.

Circ Res. 2019 May 10;124(10):1473-1481. doi: 10.1161/CIRCRESAHA.118.313926.

PMID:
30900949
3.

Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane.

DeLalio LJ, Billaud M, Ruddiman CA, Johnstone SR, Butcher JT, Wolpe AG, Jin X, Keller TCS 4th, Keller AS, Rivière T, Good ME, Best AK, Lohman AW, Swayne LA, Penuela S, Thompson RJ, Lampe PD, Yeager M, Isakson BE.

J Biol Chem. 2019 Apr 26;294(17):6940-6956. doi: 10.1074/jbc.RA118.006982. Epub 2019 Feb 27.

PMID:
30814251
4.

Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.

Novielli-Kuntz NM, Jelen M, Barr K, DeLalio LJ, Feng Q, Isakson BE, Gros R, Laird DW.

Biosci Rep. 2019 Feb 27;39(2). pii: BSR20182350. doi: 10.1042/BSR20182350. Print 2019 Feb 28.

5.

RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger.

Artamonov MV, Sonkusare SK, Good ME, Momotani K, Eto M, Isakson BE, Le TH, Cope EL, Derewenda ZS, Derewenda U, Somlyo AV.

Sci Signal. 2018 Oct 30;11(554). pii: eaar3924. doi: 10.1126/scisignal.aar3924.

6.

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension.

Brown IAM, Diederich L, Good ME, DeLalio LJ, Murphy SA, Cortese-Krott MM, Hall JL, Le TH, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):1969-1985. doi: 10.1161/ATVBAHA.118.311229.

PMID:
30354262
7.

Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility.

Lechauve C, Butcher JT, Freiwan A, Biwer LA, Keith JM, Good ME, Ackerman H, Tillman HS, Kiger L, Isakson BE, Weiss MJ.

J Clin Invest. 2018 Nov 1;128(11):5073-5082. doi: 10.1172/JCI99933. Epub 2018 Oct 8.

8.

"Yin and Yang" for Notch signaling in the mature vasculature.

Good ME, Isakson BE.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1789-H1790. doi: 10.1152/ajpheart.00626.2018. Epub 2018 Sep 28. No abstract available.

PMID:
30265155
9.

Induction of microvascular network growth in the mouse mesentery.

Suarez-Martinez AD, Peirce SM, Isakson BE, Nice M, Wang J, Lounsbury KM, Scallan JP, Murfee WL.

Microcirculation. 2018 Nov;25(8):e12502. doi: 10.1111/micc.12502. Epub 2018 Oct 10.

PMID:
30178505
10.

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.

DeLalio LJ, Keller AS, Chen J, Boyce AKJ, Artamonov MV, Askew-Page HR, Keller TCS 4th, Johnstone SR, Weaver RB, Good ME, Murphy SA, Best AK, Mintz EL, Penuela S, Greenwood IA, Machado RF, Somlyo AV, Swayne LA, Minshall RD, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078. doi: 10.1161/ATVBAHA.118.311290.

PMID:
30026274
11.

Replacement Therapies in Metabolic Disease.

Keller AS, Keller Iv TCS, DeLalio LJ, Shahab G, Yang Y, Murphy SA, Shu X, Isakson BE.

Curr Pharm Biotechnol. 2018;19(5):382-399. doi: 10.2174/1389201019666180619151413. Review.

PMID:
29921204
12.

Connexins and Pannexins in Vascular Function and Disease.

Molica F, Figueroa XF, Kwak BR, Isakson BE, Gibbins JM.

Int J Mol Sci. 2018 Jun 5;19(6). pii: E1663. doi: 10.3390/ijms19061663. Review.

13.

On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability.

Diederich L, Suvorava T, Sansone R, Keller TCS 4th, Barbarino F, Sutton TR, Kramer CM, Lückstädt W, Isakson BE, Gohlke H, Feelisch M, Kelm M, Cortese-Krott MM.

Front Physiol. 2018 May 11;9:332. doi: 10.3389/fphys.2018.00332. eCollection 2018.

14.

Epithelial and Endothelial Pannexin1 Channels Mediate AKI.

Jankowski J, Perry HM, Medina CB, Huang L, Yao J, Bajwa A, Lorenz UM, Rosin DL, Ravichandran KS, Isakson BE, Okusa MD.

J Am Soc Nephrol. 2018 Jul;29(7):1887-1899. doi: 10.1681/ASN.2017121306. Epub 2018 Jun 4.

PMID:
29866797
15.

Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone".

Good ME, Chiu YH, Poon IKH, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.

Circ Res. 2018 May 25;122(11):e88-e89. doi: 10.1161/CIRCRESAHA.118.313080. No abstract available.

16.

Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury.

Sharma AK, Charles EJ, Zhao Y, Narahari AK, Baderdinni PK, Good ME, Lorenz UM, Kron IL, Bayliss DA, Ravichandran KS, Isakson BE, Laubach VE.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L301-L312. doi: 10.1152/ajplung.00004.2018. Epub 2018 May 10.

PMID:
29745255
17.

Klf4 has an unexpected protective role in perivascular cells within the microvasculature.

Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H402-H414. doi: 10.1152/ajpheart.00084.2018. Epub 2018 Apr 6.

PMID:
29631369
18.

'Gaps' in targeted ischaemic injury therapies in ST-elevation myocardial infarction.

Johnstone SR, Isakson BE.

Heart. 2018 Oct;104(19):1557-1558. doi: 10.1136/heartjnl-2018-313084. Epub 2018 Mar 30. No abstract available.

PMID:
29602882
19.

Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone.

Good ME, Eucker SA, Li J, Bacon HM, Lang SM, Butcher JT, Johnson TJ, Gaykema RP, Patel MK, Zuo Z, Isakson BE.

JCI Insight. 2018 Mar 22;3(6). pii: 96272. doi: 10.1172/jci.insight.96272.

20.

TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction.

Hong K, Cope EL, DeLalio LJ, Marziano C, Isakson BE, Sonkusare SK.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):542-554. doi: 10.1161/ATVBAHA.117.310038. Epub 2018 Jan 4.

21.

Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries.

Marziano C, Hong K, Cope EL, Kotlikoff MI, Isakson BE, Sonkusare SK.

J Am Heart Assoc. 2017 Dec 23;6(12). pii: e007157. doi: 10.1161/JAHA.117.007157.

22.

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.

Good ME, Chiu YH, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.

Circ Res. 2018 Feb 16;122(4):606-615. doi: 10.1161/CIRCRESAHA.117.312380. Epub 2017 Dec 13.

23.

Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function.

Biwer LA, Good ME, Hong K, Patel RK, Agrawal N, Looft-Wilson R, Sonkusare SK, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):120-130. doi: 10.1161/ATVBAHA.117.309886. Epub 2017 Nov 9.

24.

Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.

Nyberg M, Piil P, Kiehn OT, Maagaard C, Jørgensen TS, Egelund J, Isakson BE, Nielsen MS, Gliemann L, Hellsten Y.

Hypertension. 2018 Jan;71(1):151-159. doi: 10.1161/HYPERTENSIONAHA.117.10251. Epub 2017 Oct 30.

25.

A Cell Culture Model of Resistance Arteries.

Biwer LA, Lechauve C, Vanhoose S, Weiss MJ, Isakson BE.

J Vis Exp. 2017 Sep 8;(127). doi: 10.3791/55992.

26.

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.

Keller AS, Diederich L, Panknin C, DeLalio LJ, Drake JC, Sherman R, Jackson EK, Yan Z, Kelm M, Cortese-Krott MM, Isakson BE.

Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C593-C603. doi: 10.1152/ajpcell.00178.2017. Epub 2017 Aug 30.

27.

ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design.

DeLalio LJ, Isakson BE.

Br J Pharmacol. 2017 Aug;174(15):2606-2607. doi: 10.1111/bph.13891. Epub 2017 Jul 9.

28.

The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature.

Keller AS, Isakson BE.

Antioxid Redox Signal. 2017 Jun 1;26(16):881-885. doi: 10.1089/ars.2017.7059. Epub 2017 Apr 14.

29.

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.

Durgin BG, Cherepanova OA, Gomez D, Karaoli T, Alencar GF, Butcher JT, Zhou YQ, Bendeck MP, Isakson BE, Owens GK, Connelly JJ.

Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H943-H958. doi: 10.1152/ajpheart.00029.2017. Epub 2017 Mar 10.

30.

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries.

Genet N, Billaud M, Rossignol R, Dubois M, Gillibert-Duplantier J, Isakson BE, Marthan R, Savineau JP, Guibert C.

Front Physiol. 2017 Feb 9;8:76. doi: 10.3389/fphys.2017.00076. eCollection 2017.

31.

Pannexin channel and connexin hemichannel expression in vascular function and inflammation.

Begandt D, Good ME, Keller AS, DeLalio LJ, Rowley C, Isakson BE, Figueroa XF.

BMC Cell Biol. 2017 Jan 17;18(Suppl 1):2. doi: 10.1186/s12860-016-0119-3. Review.

32.

Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.

Kuhn V, Diederich L, Keller TCS 4th, Kramer CM, Lückstädt W, Panknin C, Suvorava T, Isakson BE, Kelm M, Cortese-Krott MM.

Antioxid Redox Signal. 2017 May 1;26(13):718-742. doi: 10.1089/ars.2016.6954. Epub 2017 Jan 18. Review.

33.

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).

Keller TC 4th, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, Yeager M, Peirce SM, Hu S, Doctor A, Barrett E, Le TH, Columbus L, Isakson BE.

Hypertension. 2016 Dec;68(6):1494-1503. Epub 2016 Oct 31.

34.

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus.

Liu S, DeLalio LJ, Isakson BE, Wang TT.

Circ Res. 2016 Nov 11;119(11):1183-1189. doi: 10.1161/CIRCRESAHA.116.309866. Epub 2016 Sep 20.

35.

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet.

Naresh NK, Butcher JT, Lye RJ, Chen X, Isakson BE, Gan LM, Kramer CM, Annex BH, Epstein FH.

J Cardiovasc Magn Reson. 2016 Sep 9;18(1):53. doi: 10.1186/s12968-016-0273-y.

36.

Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone.

Kauffenstein G, Tamareille S, Prunier F, Roy C, Ayer A, Toutain B, Billaud M, Isakson BE, Grimaud L, Loufrani L, Rousseau P, Abraham P, Procaccio V, Monyer H, de Wit C, Boeynaems JM, Robaye B, Kwak BR, Henrion D.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1598-606. doi: 10.1161/ATVBAHA.116.307739. Epub 2016 Jun 2.

37.

Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells.

Good ME, Begandt D, DeLalio LJ, Johnstone SR, Isakson BE.

Methods Mol Biol. 2016;1437:71-82. doi: 10.1007/978-1-4939-3664-9_5.

PMID:
27207287
38.

Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.

Biwer LA, Taddeo EP, Kenwood BM, Hoehn KL, Straub AC, Isakson BE.

Biochim Biophys Acta. 2016 Jul;1861(7):671-9. doi: 10.1016/j.bbalip.2016.04.014. Epub 2016 Apr 19.

39.

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.

Ivanov S, Scallan JP, Kim KW, Werth K, Johnson MW, Saunders BT, Wang PL, Kuan EL, Straub AC, Ouhachi M, Weinstein EG, Williams JW, Briseño C, Colonna M, Isakson BE, Gautier EL, Förster R, Davis MJ, Zinselmeyer BH, Randolph GJ.

J Clin Invest. 2016 Apr 1;126(4):1581-91. doi: 10.1172/JCI84518. Epub 2016 Mar 21.

40.

Endoplasmic reticulum-mediated signalling in cellular microdomains.

Biwer LA, Isakson BE.

Acta Physiol (Oxf). 2017 Jan;219(1):162-175. doi: 10.1111/apha.12675. Epub 2016 Apr 5. Review.

41.

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes.

Adamson SE, Meher AK, Chiu YH, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, Peirce-Cottler SM, Isakson BE, McNamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N.

Mol Metab. 2015 Jul 3;4(9):610-8. doi: 10.1016/j.molmet.2015.06.009. eCollection 2015 Sep.

42.

Endothelial nitric oxide synthase in the microcirculation.

Shu X, Keller TC 4th, Begandt D, Butcher JT, Biwer L, Keller AS, Columbus L, Isakson BE.

Cell Mol Life Sci. 2015 Dec;72(23):4561-75. doi: 10.1007/s00018-015-2021-0. Epub 2015 Aug 25. Review.

43.

The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration.

Chen CH, Mayo JN, Gourdie RG, Johnstone SR, Isakson BE, Bearden SE.

Am J Physiol Cell Physiol. 2015 Nov 1;309(9):C600-7. doi: 10.1152/ajpcell.00155.2015. Epub 2015 Aug 19.

44.

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.

Lohman AW, Leskov IL, Butcher JT, Johnstone SR, Stokes TA, Begandt D, DeLalio LJ, Best AK, Penuela S, Leitinger N, Ravichandran KS, Stokes KY, Isakson BE.

Nat Commun. 2015 Aug 5;6:7965. doi: 10.1038/ncomms8965.

45.

Emerging concepts regarding pannexin 1 in the vasculature.

Good ME, Begandt D, DeLalio LJ, Keller AS, Billaud M, Isakson BE.

Biochem Soc Trans. 2015 Jun;43(3):495-501. doi: 10.1042/BST20150045. Review.

46.

A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.

Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE.

Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824.

47.

Recombinant PAI-1 therapy restores myoendothelial junctions and erectile function in PAI-1-deficient mice.

Kavoussi PK, Heberlein K, Straub AC, Lowe GJ, Oliver JL, Smith RP, Steers WD, Annex BH, Isakson BE, Lysiak JJ.

Andrologia. 2015 Dec;47(10):1147-52. doi: 10.1111/and.12395. Epub 2014 Dec 29.

48.

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.

Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2.

49.

The myoendothelial junction: connections that deliver the message.

Straub AC, Zeigler AC, Isakson BE.

Physiology (Bethesda). 2014 Jul;29(4):242-9. doi: 10.1152/physiol.00042.2013. Review.

50.

Hemoglobin α in the blood vessel wall.

Butcher JT, Johnson T, Beers J, Columbus L, Isakson BE.

Free Radic Biol Med. 2014 Aug;73:136-42. doi: 10.1016/j.freeradbiomed.2014.04.019. Epub 2014 May 14. Review.

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