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Items: 1 to 50 of 96

1.

Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs.

Church VA, Pressman S, Isaji M, Truscott M, Cizmecioglu NT, Buratowski S, Frolov MV, Carthew RW.

Cell Rep. 2017 Sep 26;20(13):3123-3134. doi: 10.1016/j.celrep.2017.09.010.

2.

Molecular Structures and Functions of Chlorophylls-a Esterified with Geranylgeranyl, Dihydrogeranylgeranyl, and Tetrahydrogeranylgeranyl Groups at the 17-Propionate Residue in a Diatom, Chaetoceros calcitrans.

Mizoguchi T, Isaji M, Yamano N, Harada J, Fujii R, Tamiaki H.

Biochemistry. 2017 Jul 18;56(28):3682-3688. doi: 10.1021/acs.biochem.7b00381. Epub 2017 Jul 5.

PMID:
28627163
3.

Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation.

Inoue T, Takemura M, Fushimi N, Fujimori Y, Onozato T, Kurooka T, Asari T, Takeda H, Kobayashi M, Nishibe H, Isaji M.

Eur J Pharmacol. 2017 Jul 5;806:25-31. doi: 10.1016/j.ejphar.2017.04.010. Epub 2017 Apr 11.

PMID:
28410751
4.

Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout.

Tatani K, Hiratochi M, Kikuchi N, Kuramochi Y, Watanabe S, Yamauchi Y, Itoh F, Isaji M, Shuto S.

J Med Chem. 2016 Apr 28;59(8):3719-31. doi: 10.1021/acs.jmedchem.5b01884. Epub 2016 Apr 11.

PMID:
27007871
5.

Remogliflozin Etabonate Improves Fatty Liver Disease in Diet-Induced Obese Male Mice.

Nakano S, Katsuno K, Isaji M, Nagasawa T, Buehrer B, Walker S, Wilkison WO, Cheatham B.

J Clin Exp Hepatol. 2015 Sep;5(3):190-8. doi: 10.1016/j.jceh.2015.02.005. Epub 2015 Apr 28.

6.

First records of tool-set use for ant-dipping by Eastern chimpanzees (Pan troglodytes schweinfurthii) in the Kalinzu Forest Reserve, Uganda.

Hashimoto C, Isaji M, Koops K, Furuichi T.

Primates. 2015 Oct;56(4):301-5. doi: 10.1007/s10329-015-0478-y. Epub 2015 Aug 5.

PMID:
26243503
7.

Cultural differences in ant-dipping tool length between neighbouring chimpanzee communities at Kalinzu, Uganda.

Koops K, Schöning C, Isaji M, Hashimoto C.

Sci Rep. 2015 Jul 22;5:12456. doi: 10.1038/srep12456.

8.

Role of thermal excitation in ultrafast energy transfer in chlorosomes revealed by two-dimensional electronic spectroscopy.

Jun S, Yang C, Kim TW, Isaji M, Tamiaki H, Ihee H, Kim J.

Phys Chem Chem Phys. 2015 Jul 21;17(27):17872-9. doi: 10.1039/c5cp01355k. Epub 2015 Jun 22.

PMID:
26095203
9.

Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors.

Tatani K, Hiratochi M, Nonaka Y, Isaji M, Shuto S.

ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. doi: 10.1021/ml500343r. eCollection 2015 Mar 12.

10.

The 17-propionate esterifying variants of bacteriochlorophyll-a and bacteriopheophytin-a in purple photosynthetic bacteria.

Mizoguchi T, Isaji M, Harada J, Tsukatani Y, Tamiaki H.

J Photochem Photobiol B. 2015 Jan;142:244-9. doi: 10.1016/j.jphotobiol.2014.12.013. Epub 2014 Dec 19.

PMID:
25559490
11.

Clinical manifestations of children with microbiologically confirmed pertussis infection and antimicrobial susceptibility of isolated strains in a regional hospital in Japan, 2008-2012.

Horiba K, Nishimura N, Gotoh K, Kawaguchi M, Takeuchi S, Hattori F, Isaji M, Okai Y, Hosono H, Takemoto K, Ozaki T.

Jpn J Infect Dis. 2014;67(5):345-8.

12.

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in langendorff-perfused guinea-pig hearts.

Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M.

Biol Pharm Bull. 2014;37(7):1168-76.

13.

Coherent Oscillations in Chlorosome Elucidated by Two-Dimensional Electronic Spectroscopy.

Jun S, Yang C, Isaji M, Tamiaki H, Kim J, Ihee H.

J Phys Chem Lett. 2014 Apr 17;5(8):1386-92. doi: 10.1021/jz500328w. Epub 2014 Apr 1.

PMID:
26269984
14.

Assessment of the loop-mediated isothermal amplification assay for rapid diagnosis of Mycoplasma pneumoniae in pediatric community-acquired pneumonia.

Gotoh K, Nishimura N, Takeuchi S, Hattori F, Horiba K, Isaji M, Okai Y, Ohshima Y, Hosono H, Takemoto K, Iwata Y, Nakane K, Funahashi K, Ozaki T.

Jpn J Infect Dis. 2013;66(6):539-42.

15.

Functionally diverse microRNA effector complexes are regulated by extracellular signaling.

Wu PH, Isaji M, Carthew RW.

Mol Cell. 2013 Oct 10;52(1):113-23. doi: 10.1016/j.molcel.2013.08.023. Epub 2013 Sep 19.

16.

[A study on the HA amount of HA influenza vaccination on efficacy and safety in infants].

Takahashi H, Yano T, Fukuta M, Yamauchi A, Okuma K, Ihara T, Nakano T, Matsuda T, Torigoe S, Nii R, Isaji M, Watanabe M, Ochiai H, Sakatoku H, Kato T, Maeda K, Okuno Y, Kamiya H.

Kansenshogaku Zasshi. 2013 Mar;87(2):195-206. Japanese.

PMID:
23713330
17.

Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).

Fushimi N, Teranishi H, Shimizu K, Yonekubo S, Ohno K, Miyagi T, Itoh F, Shibazaki T, Tomae M, Ishikawa-Takemura Y, Nakabayashi T, Kamada N, Yamauchi Y, Kobayashi S, Isaji M.

Bioorg Med Chem. 2013 Feb 1;21(3):748-65. doi: 10.1016/j.bmc.2012.11.041. Epub 2012 Dec 5.

PMID:
23273606
18.

Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.

Fushimi N, Fujikura H, Shiohara H, Teranishi H, Shimizu K, Yonekubo S, Ohno K, Miyagi T, Itoh F, Shibazaki T, Tomae M, Ishikawa-Takemura Y, Nakabayashi T, Kamada N, Ozawa T, Kobayashi S, Isaji M.

Bioorg Med Chem. 2012 Nov 15;20(22):6598-612. doi: 10.1016/j.bmc.2012.09.037. Epub 2012 Sep 24.

PMID:
23062824
19.

Structure-dependent demetalation kinetics of chlorophyll a analogs under acidic conditions.

Saga Y, Hirai Y, Sadaoka K, Isaji M, Tamiaki H.

Photochem Photobiol. 2013 Jan-Feb;89(1):68-73. doi: 10.1111/j.1751-1097.2012.01213.x. Epub 2012 Aug 30.

PMID:
22827616
20.

Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides.

Hiratochi M, Tatani K, Shimizu K, Kuramochi Y, Kikuchi N, Kamada N, Itoh F, Isaji M.

Eur J Pharmacol. 2012 Sep 5;690(1-3):183-91. doi: 10.1016/j.ejphar.2012.06.015. Epub 2012 Jun 16.

PMID:
22709993
21.

KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models.

Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji M.

J Pharmacol Exp Ther. 2012 Aug;342(2):288-96. doi: 10.1124/jpet.112.193045. Epub 2012 Apr 26.

PMID:
22537769
22.

Isolation and pigment composition of the reaction centers from purple photosynthetic bacterium Rhodopseudomonas palustris species.

Mizoguchi T, Isaji M, Harada J, Tamiaki H.

Biochim Biophys Acta. 2012 Mar;1817(3):395-400. doi: 10.1016/j.bbabio.2011.12.001. Epub 2011 Dec 13.

23.

Myosin VI regulates actin structure specialization through conserved cargo-binding domain sites.

Isaji M, Lenartowska M, Noguchi T, Frank DJ, Miller KG.

PLoS One. 2011;6(8):e22755. doi: 10.1371/journal.pone.0022755. Epub 2011 Aug 11.

24.

A pre-embedding immunogold approach reveals localization of myosin VI at the ultrastructural level in the actin cones that mediate Drosophila spermatid individualization.

Lenartowska M, Isaji M, Miller KG.

Protoplasma. 2012 Apr;249(2):337-46. doi: 10.1007/s00709-011-0284-3. Epub 2011 May 15.

PMID:
21573935
25.

SGLT2 inhibitors: molecular design and potential differences in effect.

Isaji M.

Kidney Int Suppl. 2011 Mar;(120):S14-9. doi: 10.1038/ki.2010.511. Review.

PMID:
21358697
26.

KTO-7924, a Beta3-adrenergic receptor agonist, reduces hyperglycemia, and protects beta-cells in the islets of langerhans of db/db mice.

Oana F, Takeda H, Matsuzawa A, Akahane S, Hayashi M, Tamura T, Uehara M, Isaji M, Akahane M.

Endocr Res. 2010;35(4):174-82. doi: 10.3109/07435800.2010.507733. Epub 2010 Aug 19.

PMID:
20722489
27.

Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice.

Katsuno K, Fujimori Y, Ishikawa-Takemura Y, Isaji M.

Eur J Pharmacol. 2009 Sep 15;618(1-3):98-104. doi: 10.1016/j.ejphar.2009.07.001. Epub 2009 Jul 15.

PMID:
19615995
28.

Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats.

Fujimori Y, Katsuno K, Ojima K, Nakashima I, Nakano S, Ishikawa-Takemura Y, Kusama H, Isaji M.

Eur J Pharmacol. 2009 May 1;609(1-3):148-54. doi: 10.1016/j.ejphar.2009.03.007. Epub 2009 Mar 10.

PMID:
19281809
29.

Crystal structures of the apo and holo form of rat catechol-O-methyltransferase.

Tsuji E, Okazaki K, Isaji M, Takeda K.

J Struct Biol. 2009 Mar;165(3):133-9. doi: 10.1016/j.jsb.2008.11.012. Epub 2008 Dec 10.

PMID:
19111934
30.

Structure-activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors.

Hirabayashi A, Mukaiyama H, Kobayashi H, Shiohara H, Nakayama S, Ozawa M, Miyazawa K, Misawa K, Ohnota H, Isaji M.

Bioorg Med Chem. 2009 Jan 1;17(1):284-94. doi: 10.1016/j.bmc.2008.10.070. Epub 2008 Nov 5.

PMID:
19010686
31.

Coiled-coil-mediated dimerization is not required for myosin VI to stabilize actin during spermatid individualization in Drosophila melanogaster.

Noguchi T, Frank DJ, Isaji M, Miller KG.

Mol Biol Cell. 2009 Jan;20(1):358-67. doi: 10.1091/mbc.E08-07-0776. Epub 2008 Nov 12.

32.

Structure-activity relationship studies of imidazo[1,2-c]pyrimidine derivatives as potent and orally effective Syk family kinases inhibitors.

Hirabayashi A, Mukaiyama H, Kobayashi H, Shiohara H, Nakayama S, Ozawa M, Tsuji E, Miyazawa K, Misawa K, Ohnota H, Isaji M.

Bioorg Med Chem. 2008 Oct 15;16(20):9247-60. doi: 10.1016/j.bmc.2008.09.015. Epub 2008 Sep 9.

PMID:
18823784
33.

A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives.

Hirabayashi A, Mukaiyama H, Kobayashi H, Shiohara H, Nakayama S, Ozawa M, Miyazawa K, Misawa K, Ohnota H, Isaji M.

Bioorg Med Chem. 2008 Aug 1;16(15):7347-57. doi: 10.1016/j.bmc.2008.06.017. Epub 2008 Jun 14.

PMID:
18585046
34.

Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models.

Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M.

J Pharmacol Exp Ther. 2008 Oct;327(1):268-76. doi: 10.1124/jpet.108.140210. Epub 2008 Jun 26.

PMID:
18583547
35.

Identification of 3,4-didehydrorhodopin as major carotenoid in Rhodopseudomonas species.

Mizoguchi T, Isaji M, Harada J, Tamiaki H.

Photochem Photobiol Sci. 2008 Apr;7(4):492-7. doi: 10.1039/b719272j. Epub 2008 Mar 13.

PMID:
18385894
36.

Composition and localization of bacteriochlorophyll a intermediates in the purple photosynthetic bacterium Rhodopseudomonas sp. Rits.

Harada J, Mizoguchi T, Yoshida S, Isaji M, Oh-Oka H, Tamiaki H.

Photosynth Res. 2008 Feb-Mar;95(2-3):213-21. Epub 2007 Oct 3.

PMID:
17912605
37.

Sodium-glucose cotransporter inhibitors for diabetes.

Isaji M.

Curr Opin Investig Drugs. 2007 Apr;8(4):285-92. Review.

PMID:
17458177
38.

Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level.

Katsuno K, Fujimori Y, Takemura Y, Hiratochi M, Itoh F, Komatsu Y, Fujikura H, Isaji M.

J Pharmacol Exp Ther. 2007 Jan;320(1):323-30. Epub 2006 Oct 18.

PMID:
17050778
39.

The localization of LAP2 beta during pronuclear formation in bovine oocytes after fertilization or activation.

Isaji M, Iwata H, Harayama H, Miyake M.

Zygote. 2006 May;14(2):157-67.

PMID:
16719951
40.

Aplasia cutis congenita and skull defects after exposure to methimazole in utero.

Nakamura S, Nishikawa T, Isaji M, Ishimori M, Shimizu N, Iwamura M, Nishikawa Y, Kubo M, Totani R.

Intern Med. 2005 Nov;44(11):1202-3. No abstract available.

41.

Familial occurrence of silent thyroiditis.

Nakamura S, Isaji M, Ishimori M.

Endocr J. 2005 Oct;52(5):617-21.

42.

Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas.

Tanahashi H, Mune T, Takahashi Y, Isaji M, Suwa T, Morita H, Yamakita N, Yasuda K, Deguchi T, White PC, Takeda J.

J Clin Endocrinol Metab. 2005 Nov;90(11):6226-31. Epub 2005 Aug 23.

PMID:
16118341
43.

Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin.

Oana F, Takeda H, Hayakawa K, Matsuzawa A, Akahane S, Isaji M, Akahane M.

Metabolism. 2005 Aug;54(8):995-1001.

PMID:
16092047
44.

DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924.

Oana F, Homma T, Takeda H, Matsuzawa A, Akahane S, Isaji M, Akahane M.

Pharmacol Res. 2005 Nov;52(5):395-400. Epub 2005 Jul 18.

PMID:
16027000
45.

Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist.

Oana F, Takeda H, Matsuzawa A, Akahane S, Isaji M, Akahane M.

Eur J Pharmacol. 2005 Jul 25;518(1):71-6.

PMID:
15979609
46.

Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2.

Isaji M, Mune T, Takada N, Yamamoto Y, Suwa T, Morita H, Takeda J, White PC.

J Hypertens. 2005 Jun;23(6):1149-57.

PMID:
15894890
47.

Rat model of the hypercalcaemia induced by parathyroid hormone-related protein: characteristics of three bisphosphonates.

Komatsu Y, Imai Y, Itoh F, Kojima M, Isaji M, Shibata N.

Eur J Pharmacol. 2005 Jan 10;507(1-3):317-24. Epub 2004 Dec 19.

PMID:
15659323
48.

SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.

Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M, Takemura Y, Maruyama H, Sugiyama T, Wakamatsu A, Isogai T, Isaji M.

Life Sci. 2005 Jan 14;76(9):1039-50. Erratum in: Life Sci. 2010 Oct 9;87(15-16):514.

PMID:
15607332
49.

Plasma adrenomedullin concentration patients with Graves' disease.

Nakamura S, Isaji M, Ishimori M.

Intern Med. 2004 Jul;43(7):628-9. No abstract available.

50.

The localization of LAP2beta in bovine oocytes after in vitro activation and fertilization.

Isaji M, Iwata H, Harayama H, Miyake M.

Zygote. 2004 Feb;12(1):81-93.

PMID:
15214585

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