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Items: 39

1.

Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening.

Kurata R, Shimizu K, Cui X, Harada M, Isagawa T, Semba H, Ishihara J, Yamada K, Nagai J, Yoshida Y, Takeda N, Maemura K, Yonezawa T.

Mar Drugs. 2020 Jan 17;18(1). pii: E60. doi: 10.3390/md18010060.

2.

Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy.

Okamura K, Nakagama Y, Takeda N, Soma K, Sato T, Isagawa T, Kido Y, Sakamoto M, Manabe I, Hirata Y, Komuro I, Ono M.

J Pharmacol Sci. 2019 Sep;141(1):56-63. doi: 10.1016/j.jphs.2019.09.005. Epub 2019 Sep 28.

3.

Cell Cycle Perturbation Induces Collagen Production in Fibroblasts.

Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.

Int Heart J. 2019 Jul 27;60(4):958-963. doi: 10.1536/ihj.18-710. Epub 2019 Jul 12.

4.

Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.

Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.

Nat Commun. 2019 Jun 27;10(1):2824. doi: 10.1038/s41467-019-10859-w.

5.

Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins.

Kumagai A, Shimizu K, Kurata R, Cui X, Isagawa T, Harada M, Nagai J, Yoshida Y, Ozaki KI, Takeda N, Semba H, Yonezawa T.

Curr Pharm Biotechnol. 2019;20(1):47-55. doi: 10.2174/1389201020666190206203640.

PMID:
30727885
6.

EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis.

Tanaka M, Ishikawa S, Ushiku T, Morikawa T, Isagawa T, Yamagishi M, Yamamoto H, Katoh H, Takeshita K, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Fukayama M.

Oncotarget. 2017 Sep 1;8(59):99552-99566. doi: 10.18632/oncotarget.20601. eCollection 2017 Nov 21.

7.

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.

Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.

Nat Commun. 2017 Nov 17;8(1):1597. doi: 10.1038/s41467-017-01599-w.

8.

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription.

Oishi Y, Hayashi S, Isagawa T, Oshima M, Iwama A, Shimba S, Okamura H, Manabe I.

Sci Rep. 2017 Aug 1;7(1):7086. doi: 10.1038/s41598-017-07100-3.

9.

CASTIN: a system for comprehensive analysis of cancer-stromal interactome.

Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, Aburatani H, Ishikawa S.

BMC Genomics. 2016 Nov 9;17(1):899.

10.

Loss of YAP1 defines neuroendocrine differentiation of lung tumors.

Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y.

Cancer Sci. 2016 Oct;107(10):1527-1538. doi: 10.1111/cas.13013. Epub 2016 Sep 9.

11.

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.

Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.

Nat Commun. 2016 May 18;7:11635. doi: 10.1038/ncomms11635.

12.

The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model.

Kobayashi S, Hara A, Isagawa T, Manabe I, Takeda K, MaruYama T.

PLoS One. 2014 Oct 27;9(10):e110838. doi: 10.1371/journal.pone.0110838. eCollection 2014. Erratum in: PLoS One. 2015;10(2):e0118159.

13.

Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.

Hanihara-Tatsuzawa F, Miura H, Kobayashi S, Isagawa T, Okuma A, Manabe I, MaruYama T.

J Biol Chem. 2014 Nov 7;289(45):30925-36. doi: 10.1074/jbc.M114.553230. Epub 2014 Aug 14.

14.

Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells.

Yukawa M, Akiyama T, Franke V, Mise N, Isagawa T, Suzuki Y, Suzuki MG, Vlahovicek K, Abe K, Aburatani H, Aoki F.

PLoS One. 2014 Mar 21;9(3):e92689. doi: 10.1371/journal.pone.0092689. eCollection 2014.

15.

Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.

Goda S, Isagawa T, Chikaoka Y, Kawamura T, Aburatani H.

J Biol Chem. 2013 Dec 27;288(52):36948-56. doi: 10.1074/jbc.M113.492595. Epub 2013 Nov 8.

16.

RNA-methylation-dependent RNA processing controls the speed of the circadian clock.

Fustin JM, Doi M, Yamaguchi Y, Hida H, Nishimura S, Yoshida M, Isagawa T, Morioka MS, Kakeya H, Manabe I, Okamura H.

Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.

17.

EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.

Tanaka M, Suzuki HI, Shibahara J, Kunita A, Isagawa T, Yoshimi A, Kurokawa M, Miyazono K, Aburatani H, Ishikawa S, Fukayama M.

Oncogene. 2014 May 8;33(19):2454-63. doi: 10.1038/onc.2013.204. Epub 2013 Jun 10.

PMID:
23752186
18.

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer.

Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H.

Sci Rep. 2013;3:1911. doi: 10.1038/srep01911.

19.

VEGF-A induces its negative regulator, soluble form of VEGFR-1, by modulating its alternative splicing.

Saito T, Takeda N, Amiya E, Nakao T, Abe H, Semba H, Soma K, Koyama K, Hosoya Y, Imai Y, Isagawa T, Watanabe M, Manabe I, Komuro I, Nagai R, Maemura K.

FEBS Lett. 2013 Jul 11;587(14):2179-85. doi: 10.1016/j.febslet.2013.05.038. Epub 2013 May 24.

20.

Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.

Yamamoto S, Tateishi K, Kudo Y, Yamamoto K, Isagawa T, Nagae G, Nakatsuka T, Asaoka Y, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Aburatani H, Omata M, Koike K.

Carcinogenesis. 2013 Oct;34(10):2380-8. doi: 10.1093/carcin/bgt174. Epub 2013 May 22.

PMID:
23698634
21.

The role of NF-κB signaling in the maintenance of pluripotency of human induced pluripotent stem cells.

Takase O, Yoshikawa M, Idei M, Hirahashi J, Fujita T, Takato T, Isagawa T, Nagae G, Suemori H, Aburatani H, Hishikawa K.

PLoS One. 2013;8(2):e56399. doi: 10.1371/journal.pone.0056399. Epub 2013 Feb 20.

22.

Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.

Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H.

Genome Res. 2012 Feb;22(2):208-19. doi: 10.1101/gr.123109.111. Epub 2011 Dec 7.

23.

DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.

Isagawa T, Nagae G, Shiraki N, Fujita T, Sato N, Ishikawa S, Kume S, Aburatani H.

PLoS One. 2011;6(10):e26052. doi: 10.1371/journal.pone.0026052. Epub 2011 Oct 7.

24.

ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.

Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H.

Lung Cancer. 2012 Jan;75(1):119-25. doi: 10.1016/j.lungcan.2011.05.028. Epub 2011 Jul 6.

PMID:
21737174
25.

Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.

Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H.

Hum Mol Genet. 2011 Jul 15;20(14):2710-21. doi: 10.1093/hmg/ddr170. Epub 2011 Apr 19.

PMID:
21505077
26.

GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma.

Inowa T, Hishikawa K, Matsuzaki Y, Isagawa T, Takeuchi T, Aburatani H, Kitamura T, Fujita T.

Stem Cells Int. 2010 Mar 14;2010:782967. doi: 10.4061/2010/782967.

27.

Three DNA methylation epigenotypes in human colorectal cancer.

Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A.

Clin Cancer Res. 2010 Jan 1;16(1):21-33. doi: 10.1158/1078-0432.CCR-09-2006. Epub 2009 Dec 22.

28.

Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells.

Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Gotoh N.

Br J Cancer. 2010 Jan 5;102(1):206-12. doi: 10.1038/sj.bjc.6605468. Epub 2009 Dec 8.

29.

Stepwise development of hematopoietic stem cells from embryonic stem cells.

Matsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyazaki S, Miyazaki J, Aburatani H, Nakauchi H, Ema H.

PLoS One. 2009;4(3):e4820. doi: 10.1371/journal.pone.0004820. Epub 2009 Mar 16.

30.

Differentiation and characterization of embryonic stem cells into three germ layers.

Shiraki N, Higuchi Y, Harada S, Umeda K, Isagawa T, Aburatani H, Kume K, Kume S.

Biochem Biophys Res Commun. 2009 Apr 17;381(4):694-9. doi: 10.1016/j.bbrc.2009.02.120. Epub 2009 Feb 27.

PMID:
19250925
31.

Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells.

Mukai H, Isagawa T, Goyama E, Tanaka S, Bence NF, Tamura A, Ono Y, Kopito RR.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10887-92. Epub 2005 Jul 22.

32.

Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization.

Inamura K, Fujiwara T, Hoshida Y, Isagawa T, Jones MH, Virtanen C, Shimane M, Satoh Y, Okumura S, Nakagawa K, Tsuchiya E, Ishikawa S, Aburatani H, Nomura H, Ishikawa Y.

Oncogene. 2005 Oct 27;24(47):7105-13.

PMID:
16007138
33.

Involvement of protein kinase PKN1 in G2/M delay caused by arsenite.

Isagawa T, Takahashi M, Kato T Jr, Mukai H, Ono Y.

Mol Carcinog. 2005 May;43(1):1-12.

PMID:
15791647
34.

Protein kinase PKN1 associates with TRAF2 and is involved in TRAF2-NF-kappaB signaling pathway.

Gotoh Y, Oishi K, Shibata H, Yamagiwa A, Isagawa T, Nishimura T, Goyama E, Takahashi M, Mukai H, Ono Y.

Biochem Biophys Res Commun. 2004 Feb 13;314(3):688-94.

PMID:
14741690
35.

Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.

Takahashi M, Gotoh Y, Isagawa T, Nishimura T, Goyama E, Kim HS, Mukai H, Ono Y.

J Biochem. 2003 Feb;133(2):181-7.

36.

PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division.

Misaki K, Mukai H, Yoshinaga C, Oishi K, Isagawa T, Takahashi M, Ohsumi K, Kishimoto T, Ono Y.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):125-9.

37.

Phosphorylation of tau is regulated by PKN.

Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, Hashimoto T, Terashima A, Nakai M, Mori H, Ono Y, Tanaka C.

J Biol Chem. 2001 Mar 30;276(13):10025-31. Epub 2000 Dec 4. Erratum in: J Biol Chem 2001 Jun 22;276(25):23212.

38.

Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.

Takahashi M, Mukai H, Oishi K, Isagawa T, Ono Y.

J Biol Chem. 2000 Nov 3;275(44):34592-6.

39.

Dual effects of PKNalpha and protein kinase C on phosphorylation of tau protein by glycogen synthase kinase-3beta.

Isagawa T, Mukai H, Oishi K, Taniguchi T, Hasegawa H, Kawamata T, Tanaka C, Ono Y.

Biochem Biophys Res Commun. 2000 Jun 24;273(1):209-12.

PMID:
10873588

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