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Items: 1 to 50 of 147


Conformational pathway provides unique sensitivity to a synaptic mGluR.

Habrian CH, Levitz J, Vyklicky V, Fu Z, Hoagland A, McCort-Tranchepain I, Acher F, Isacoff EY.

Nat Commun. 2019 Dec 5;10(1):5572. doi: 10.1038/s41467-019-13407-8.


Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.

Donthamsetti PC, Broichhagen J, Vyklicky V, Stanley C, Fu Z, Visel M, Levitz JL, Javitch JA, Trauner D, Isacoff EY.

J Am Chem Soc. 2019 Jul 24;141(29):11522-11530. doi: 10.1021/jacs.9b02895. Epub 2019 Jul 10.


Optical control of sphingosine-1-phosphate formation and function.

Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D.

Nat Chem Biol. 2019 Jun;15(6):623-631. doi: 10.1038/s41589-019-0269-7. Epub 2019 Apr 29.


Restoration of high-sensitivity and adapting vision with a cone opsin.

Berry MH, Holt A, Salari A, Veit J, Visel M, Levitz J, Aghi K, Gaub BM, Sivyer B, Flannery JG, Isacoff EY.

Nat Commun. 2019 Mar 15;10(1):1221. doi: 10.1038/s41467-019-09124-x.


Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system.

Xiao T, Ackerman CM, Carroll EC, Jia S, Hoagland A, Chan J, Thai B, Liu CS, Isacoff EY, Chang CJ.

Nat Chem Biol. 2018 Jul;14(7):655-663. doi: 10.1038/s41589-018-0062-z. Epub 2018 Jun 4.


Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.

Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff EY.

Nat Commun. 2018 Mar 13;9(1):1112. doi: 10.1038/s41467-018-03585-2.


Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.

Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff EY.

Nat Commun. 2017 Nov 30;8(1):1862. doi: 10.1038/s41467-017-01990-7. Erratum in: Nat Commun. 2018 Mar 13;9(1):1112.


Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin.

Gaub BM, Berry MH, Visel M, Holt A, Isacoff EY, Flannery JG.

Methods Mol Biol. 2018;1715:177-189. doi: 10.1007/978-1-4939-7522-8_12.


Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

Donthamsetti PC, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D.

J Am Chem Soc. 2017 Dec 27;139(51):18522-18535. doi: 10.1021/jacs.7b07659. Epub 2017 Dec 13.


Measuring Behavioral Individuality in the Acoustic Startle Behavior in Zebrafish.

Pantoja C, Hoagland A, Carroll E, Schoppik D, Isacoff EY.

Bio Protoc. 2017 Apr 5;7(7). pii: e2200. doi: 10.21769/BioProtoc.2200.


Precise modulation of neuronal activity with synthetic photoswitchable ligands.

Kienzler MA, Isacoff EY.

Curr Opin Neurobiol. 2017 Aug;45:202-209. doi: 10.1016/j.conb.2017.05.021. Epub 2017 Jul 6. Review. No abstract available.


Sequential Steps of CRAC Channel Activation.

Palty R, Fu Z, Isacoff EY.

Cell Rep. 2017 May 30;19(9):1929-1939. doi: 10.1016/j.celrep.2017.05.025.


Synapses in the spotlight with synthetic optogenetics.

Berlin S, Isacoff EY.

EMBO Rep. 2017 May;18(5):677-692. doi: 10.15252/embr.201744010. Epub 2017 Apr 10. Review.


Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.

Levitz J, Broichhagen J, Leippe P, Konrad D, Trauner D, Isacoff EY.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3546-E3554. doi: 10.1073/pnas.1619652114. Epub 2017 Apr 10.


A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.

Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA.

J Gen Physiol. 2017 May 1;149(5):577-593. doi: 10.1085/jgp.201611742. Epub 2017 Mar 30.


Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction.

Newman ZL, Hoagland A, Aghi K, Worden K, Levy SL, Son JH, Lee LP, Isacoff EY.

Neuron. 2017 Mar 22;93(6):1388-1404.e10. doi: 10.1016/j.neuron.2017.02.028. Epub 2017 Mar 9.


Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO).

Barber DM, Schönberger M, Burgstaller J, Levitz J, Weaver CD, Isacoff EY, Baier H, Trauner D.

Chem Sci. 2016;7(3):2347-2352. doi: 10.1039/C5SC04084A. Epub 2015 Nov 23.


Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.

Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff EY.

Neuron. 2016 Oct 5;92(1):143-159. doi: 10.1016/j.neuron.2016.08.036. Epub 2016 Sep 15.


Neuromodulatory Regulation of Behavioral Individuality in Zebrafish.

Pantoja C, Hoagland A, Carroll EC, Karalis V, Conner A, Isacoff EY.

Neuron. 2016 Aug 3;91(3):587-601. doi: 10.1016/j.neuron.2016.06.016. Epub 2016 Jul 7.


MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.

Chen Y, Bharill S, O'Hagan R, Isacoff EY, Chalfie M.

G3 (Bethesda). 2016 Apr 7;6(4):1121-30. doi: 10.1534/g3.115.023507.


Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand.

Broichhagen J, Damijonaitis A, Levitz J, Sokol KR, Leippe P, Konrad D, Isacoff EY, Trauner D.

ACS Cent Sci. 2015 Oct 28;1(7):383-93. doi: 10.1021/acscentsci.5b00260. Epub 2015 Oct 16.


Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.

Levitz J, Royal P, Comoglio Y, Wdziekonski B, Schaub S, Clemens DM, Isacoff EY, Sandoz G.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4194-9. doi: 10.1073/pnas.1522459113. Epub 2016 Mar 28.


Molecular basis for multimerization in the activation of the epidermal growth factor receptor.

Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J.

Elife. 2016 Mar 28;5. pii: e14107. doi: 10.7554/eLife.14107.


A phosphotyrosine switch regulates organic cation transporters.

Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JHM, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N.

Nat Commun. 2016 Mar 16;7:10880. doi: 10.1038/ncomms10880.


Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.

Chen Y, Bharill S, Altun Z, O'Hagan R, Coblitz B, Isacoff EY, Chalfie M.

Mol Biol Cell. 2016 Apr 15;27(8):1272-85. doi: 10.1091/mbc.E15-08-0561. Epub 2016 Mar 3.


A family of photoswitchable NMDA receptors.

Berlin S, Szobota S, Reiner A, Carroll EC, Kienzler MA, Guyon A, Xiao T, Trauner D, Isacoff EY.

Elife. 2016 Mar 1;5. pii: e12040. doi: 10.7554/eLife.12040.


Allosteric substrate switching in a voltage-sensing lipid phosphatase.

Grimm SS, Isacoff EY.

Nat Chem Biol. 2016 Apr;12(4):261-7. doi: 10.1038/nchembio.2022. Epub 2016 Feb 15.


A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors.

Levitz J, Popescu AT, Reiner A, Isacoff EY.

Front Mol Neurosci. 2016 Feb 2;9:2. doi: 10.3389/fnmol.2016.00002. eCollection 2016.


Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1).

Palty R, Isacoff EY.

J Biol Chem. 2016 Jan 1;291(1):334-41. doi: 10.1074/jbc.M115.685289. Epub 2015 Nov 6.


Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans.

Chen Y, Bharill S, Isacoff EY, Chalfie M.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11690-5. doi: 10.1073/pnas.1515968112. Epub 2015 Aug 31.


Conformational dynamics of a class C G-protein-coupled receptor.

Vafabakhsh R, Levitz J, Isacoff EY.

Nature. 2015 Aug 27;524(7566):497-501. doi: 10.1038/nature14679. Epub 2015 Aug 10.


Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging.

Berlin S, Carroll EC, Newman ZL, Okada HO, Quinn CM, Kallman B, Rockwell NC, Martin SS, Lagarias JC, Isacoff EY.

Nat Methods. 2015 Sep;12(9):852-8. doi: 10.1038/nmeth.3480. Epub 2015 Jul 13.


Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.

Palty R, Stanley C, Isacoff EY.

Cell Res. 2015 Aug;25(8):963-80. doi: 10.1038/cr.2015.80. Epub 2015 Jul 3.


Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.

Gaub BM, Berry MH, Holt AE, Isacoff EY, Flannery JG.

Mol Ther. 2015 Oct;23(10):1562-71. doi: 10.1038/mt.2015.121. Epub 2015 Jul 3.


A specialized molecular motion opens the Hv1 voltage-gated proton channel.

Mony L, Berger TK, Isacoff EY.

Nat Struct Mol Biol. 2015 Apr;22(4):283-290. doi: 10.1038/nsmb.2978. Epub 2015 Mar 2.


BMP signaling and microtubule organization regulate synaptic strength.

Ball RW, Peled ES, Guerrero G, Isacoff EY.

Neuroscience. 2015 Apr 16;291:155-66. doi: 10.1016/j.neuroscience.2015.01.069. Epub 2015 Feb 11.


Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics.

Carroll EC, Berlin S, Levitz J, Kienzler MA, Yuan Z, Madsen D, Larsen DS, Isacoff EY.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E776-85. doi: 10.1073/pnas.1416942112. Epub 2015 Feb 4.


Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential.

Reiner A, Levitz J, Isacoff EY.

Curr Opin Pharmacol. 2015 Feb;20:135-43. doi: 10.1016/j.coph.2014.12.008. Epub 2015 Jan 5. Review.


Fluorescent labeling for patch-clamp fluorometry (PCF) measurements of real-time protein motion in ion channels.

Berger TK, Isacoff EY.

Methods Mol Biol. 2015;1266:93-106. doi: 10.1007/978-1-4939-2272-7_6.


Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells.

Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5574-83. doi: 10.1073/pnas.1414162111. Epub 2014 Dec 8.


A spinal opsin controls early neural activity and drives a behavioral light response.

Friedmann D, Hoagland A, Berlin S, Isacoff EY.

Curr Biol. 2015 Jan 5;25(1):69-74. doi: 10.1016/j.cub.2014.10.055. Epub 2014 Dec 4.


Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative.

Rullo A, Reiner A, Reiter A, Trauner D, Isacoff EY, Woolley GA.

Chem Commun (Camb). 2014 Dec 4;50(93):14613-5. doi: 10.1039/c4cc06612j.


Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13547-52. doi: 10.1073/pnas.1407160111. Epub 2014 Sep 2.


APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses.

Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I.

Cell Rep. 2014 Jun 12;7(5):1560-1576. doi: 10.1016/j.celrep.2014.04.024. Epub 2014 May 15.


Stoichiometry and specific assembly of Best ion channels.

Bharill S, Fu Z, Palty R, Isacoff EY.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6491-6. doi: 10.1073/pnas.1400248111. Epub 2014 Apr 18.


Photoswitching of cell surface receptors using tethered ligands.

Reiner A, Isacoff EY.

Methods Mol Biol. 2014;1148:45-68. doi: 10.1007/978-1-4939-0470-9_4.


Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy.

Reiner A, Isacoff EY.

Nat Chem Biol. 2014 Apr;10(4):273-80. doi: 10.1038/nchembio.1458. Epub 2014 Feb 23.


Evoked and spontaneous transmission favored by distinct sets of synapses.

Peled ES, Newman ZL, Isacoff EY.

Curr Biol. 2014 Mar 3;24(5):484-93. doi: 10.1016/j.cub.2014.01.022. Epub 2014 Feb 20.


Conduits of life's spark: a perspective on ion channel research since the birth of neuron.

Isacoff EY, Jan LY, Minor DL Jr.

Neuron. 2013 Oct 30;80(3):658-74. doi: 10.1016/j.neuron.2013.10.040. Review.


A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor.

Kienzler MA, Reiner A, Trautman E, Yoo S, Trauner D, Isacoff EY.

J Am Chem Soc. 2013 Nov 27;135(47):17683-6. doi: 10.1021/ja408104w. Epub 2013 Nov 14.

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