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Items: 1 to 50 of 94

1.

Clinical features related to statin-associated muscle symptoms.

Ochs-Balcom HM, Nguyen LM, Ma C, Isackson PJ, Luzum JA, Kitzmiller JP, Tarnopolsky M, Weisman M, Christopher-Stine L, Peltier W, Wortmann RL, Vladutiu GD.

Muscle Nerve. 2019 May;59(5):537-543. doi: 10.1002/mus.26397. Epub 2019 Jan 11.

PMID:
30549046
2.

RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms.

Isackson PJ, Wang J, Zia M, Spurgeon P, Levesque A, Bard J, James S, Nowak N, Lee TK, Vladutiu GD.

Pharmacogenomics. 2018 Nov;19(16):1235-1249. doi: 10.2217/pgs-2018-0106. Epub 2018 Oct 16.

PMID:
30325262
3.

GATM polymorphism associated with the risk for statin-induced myopathy does not replicate in case-control analysis of 715 dyslipidemic individuals.

Luzum JA, Kitzmiller JP, Isackson PJ, Ma C, Medina MW, Dauki AM, Mikulik EB, Ochs-Balcom HM, Vladutiu GD.

Cell Metab. 2015 Apr 7;21(4):622-7. doi: 10.1016/j.cmet.2015.03.003.

4.

Ryanodine receptor type 1 gene variants in the malignant hyperthermia-susceptible population of the United States.

Brandom BW, Bina S, Wong CA, Wallace T, Visoiu M, Isackson PJ, Vladutiu GD, Sambuughin N, Muldoon SM.

Anesth Analg. 2013 May;116(5):1078-86. doi: 10.1213/ANE.0b013e31828a71ff. Epub 2013 Apr 4.

5.

Novel mutations in the gene encoding very long-chain acyl-CoA dehydrogenase identified in patients with partial carnitine palmitoyltransferase II deficiency.

Isackson PJ, Sutton KA, Hostetler KY, Vladutiu GD.

Muscle Nerve. 2013 Feb;47(2):224-9. doi: 10.1002/mus.23498. Epub 2012 Nov 21.

PMID:
23169530
6.

Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS.

Isackson PJ, Ochs-Balcom HM, Ma C, Harley JB, Peltier W, Tarnopolsky M, Sripathi N, Wortmann RL, Simmons Z, Wilson JD, Smith SA, Barboi A, Fine E, Baer A, Baker S, Kaufman K, Cobb B, Kilpatrick JR, Vladutiu GD.

Muscle Nerve. 2011 Oct;44(4):531-8. doi: 10.1002/mus.22115. Epub 2011 Aug 8.

7.

Genetic risk for malignant hyperthermia in non-anesthesia-induced myopathies.

Vladutiu GD, Isackson PJ, Kaufman K, Harley JB, Cobb B, Christopher-Stine L, Wortmann RL.

Mol Genet Metab. 2011 Sep-Oct;104(1-2):167-73. doi: 10.1016/j.ymgme.2011.07.001. Epub 2011 Jul 12.

8.

SLCO1B1 variants and statin-induced myopathy.

Vladutiu GD, Isackson PJ.

N Engl J Med. 2009 Jan 15;360(3):304. doi: 10.1056/NEJMc081975. No abstract available.

PMID:
19144951
9.

CPT2 gene mutations resulting in lethal neonatal or severe infantile carnitine palmitoyltransferase II deficiency.

Isackson PJ, Bennett MJ, Lichter-Konecki U, Willis M, Nyhan WL, Sutton VR, Tein I, Vladutiu GD.

Mol Genet Metab. 2008 Aug;94(4):422-7. doi: 10.1016/j.ymgme.2008.05.002. Epub 2008 Jun 11.

PMID:
18550408
10.

Metabolic myopathies discovered during investigations of statin myopathy.

Baker SK, Vladutiu GD, Peltier WL, Isackson PJ, Tarnopolsky MA.

Can J Neurol Sci. 2008 Mar;35(1):94-7. No abstract available.

PMID:
18380285
11.

Statin therapy depresses total body fat oxidation in the absence of genetic limitations to fat oxidation.

Fisher NM, Meksawan K, Limprasertkul A, Isackson PJ, Pendergast DR, Vladutiu GD.

J Inherit Metab Dis. 2007 Jun;30(3):388-99. Epub 2007 Apr 5.

PMID:
17410478
12.

Identification of 16 new disease-causing mutations in the CPT2 gene resulting in carnitine palmitoyltransferase II deficiency.

Isackson PJ, Bennett MJ, Vladutiu GD.

Mol Genet Metab. 2006 Dec;89(4):323-31. Epub 2006 Sep 22.

PMID:
16996287
13.

Genetic risk factors associated with lipid-lowering drug-induced myopathies.

Vladutiu GD, Simmons Z, Isackson PJ, Tarnopolsky M, Peltier WL, Barboi AC, Sripathi N, Wortmann RL, Phillips PS.

Muscle Nerve. 2006 Aug;34(2):153-62.

PMID:
16671104
14.

Myoadenylate deaminase deficiency caused by alternative splicing due to a novel intronic mutation in the AMPD1 gene.

Isackson PJ, Bujnicki H, Harding CO, Vladutiu GD.

Mol Genet Metab. 2005 Sep-Oct;86(1-2):250-6. Epub 2005 Jul 22.

PMID:
16040263
15.

A novel mutation in the PYGM gene in a family with pseudo-dominant transmission of McArdle disease.

Isackson PJ, Tarnopolsky M, Vladutiu GD.

Mol Genet Metab. 2005 Jul;85(3):239-42. Epub 2005 Apr 7.

PMID:
15979037
16.

Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease.

Christophi GP, Isackson PJ, Blaber S, Blaber M, Rodriguez M, Scarisbrick IA.

J Neurochem. 2004 Dec;91(6):1439-49.

18.

MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system.

Scarisbrick IA, Isackson PJ, Ciric B, Windebank AJ, Rodriguez M.

J Comp Neurol. 2001 Mar 12;431(3):347-61.

PMID:
11170010
19.

Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter.

Scarisbrick IA, Asakura K, Blaber S, Blaber M, Isackson PJ, Bieto T, Rodriguez M, Windebank AJ.

Glia. 2000 May;30(3):219-30.

PMID:
10756072
20.
22.

Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript.

Berchtold NC, Oliff HS, Isackson P, Cotman CW.

Brain Res Mol Brain Res. 1999 Jul 23;71(1):11-22.

PMID:
10407182
23.

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus.

Oliff HS, Berchtold NC, Isackson P, Cotman CW.

Brain Res Mol Brain Res. 1998 Oct 30;61(1-2):147-53.

PMID:
9795193
24.
25.

Transcript-specific effects of adrenalectomy on seizure-induced BDNF expression in rat hippocampus.

Lauterborn JC, Poulsen FR, Stinis CT, Isackson PJ, Gall CM.

Brain Res Mol Brain Res. 1998 Mar 30;55(1):81-91.

PMID:
9645963
26.

The messenger RNA encoding VGF, a neuronal peptide precursor, is rapidly regulated in the rat central nervous system by neuronal activity, seizure and lesion.

Snyder SE, Cheng HW, Murray KD, Isackson PJ, McNeill TH, Salton SR.

Neuroscience. 1998 Jan;82(1):7-19.

PMID:
9483499
27.
28.
29.

Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampus.

Garcia ML, Murray KD, Garcia VB, Strehler EE, Isackson PJ.

Brain Res Mol Brain Res. 1997 May;45(2):230-8.

PMID:
9149097
30.

Organization, sequence and functional analysis of a mouse BDNF promoter.

Hayes VY, Towner MD, Isackson PJ.

Brain Res Mol Brain Res. 1997 May;45(2):189-98.

PMID:
9149093
31.

Long-term alterations in growth factor mRNA expression following seizures.

Garcia ML, Garcia VB, Isackson PJ, Windebank AJ.

Neuroreport. 1997 Apr 14;8(6):1445-9.

PMID:
9172151
32.
34.

Glucocorticoids differentially increase nerve growth factor and basic fibroblast growth factor expression in the rat brain.

Mocchetti I, Spiga G, Hayes VY, Isackson PJ, Colangelo A.

J Neurosci. 1996 Mar 15;16(6):2141-8.

35.

Acidic fibroblast growth factor mRNA is expressed by basal forebrain and striatal cholinergic neurons.

Bizon JL, Lauterborn JC, Isackson PJ, Gall CM.

J Comp Neurol. 1996 Mar 11;366(3):379-89.

PMID:
8907353
36.

A metabotropic glutamate receptor agonist regulates neurotrophin messenger RNA in rat forebrain.

Murray KD, Wood PL, Rosasco C, Isackson PJ.

Neuroscience. 1996 Feb;70(3):617-30.

PMID:
9045076
37.
38.

Trophic factor response to neuronal stimuli or injury.

Isackson PJ.

Curr Opin Neurobiol. 1995 Jun;5(3):350-7. Review.

PMID:
7580158
39.
41.

Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs.

Seroogy KB, Lundgren KH, Tran TM, Guthrie KM, Isackson PJ, Gall CM.

J Comp Neurol. 1994 Apr 15;342(3):321-34.

PMID:
7912699
42.
43.

Seizures increase basic fibroblast growth factor mRNA in adult rat forebrain neurons and glia.

Gall CM, Berschauer R, Isackson PJ.

Brain Res Mol Brain Res. 1994 Feb;21(3-4):190-205.

PMID:
8170344
44.

Cellular localization of NGF and NT-3 mRNAs in postnatal rat forebrain.

Lauterborn JC, Isackson PJ, Gall CM.

Mol Cell Neurosci. 1994 Feb;5(1):46-62.

PMID:
8087414
45.
46.

Nerve growth factor mRNA is expressed by GABAergic neurons in rat hippocampus.

Lauterborn JC, Tran TM, Isackson PJ, Gall CM.

Neuroreport. 1993 Dec 13;5(3):273-6.

PMID:
8298089
47.

Identification of a polymorphism in the human neurotensin receptor gene.

Watson M, Isackson PJ, Makker M, Yamada MS, Yamada M, Cusack B, Richelson E.

Mayo Clin Proc. 1993 Nov;68(11):1043-8.

PMID:
8231267
48.

Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra.

Bolden-Watson C, Watson MA, Murray KD, Isackson PJ, Richelson E.

J Neurochem. 1993 Sep;61(3):1141-3.

PMID:
8395560
49.
50.

Synthetic chimeras of mouse growth factor-associated glandular kallikreins. I. Kinetic properties.

Blaber M, Isackson PJ, Burnier JP, Marsters JC Jr, Bradshaw RA.

Protein Sci. 1993 Aug;2(8):1210-9.

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