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Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation.

van Weverwijk A, Koundouros N, Iravani M, Ashenden M, Gao Q, Poulogiannis G, Jungwirth U, Isacke CM.

Nat Commun. 2019 Jun 20;10(1):2698. doi: 10.1038/s41467-019-10592-4.


Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.

Wagner S, Vlachogiannis G, De Haven Brandon A, Valenti M, Box G, Jenkins L, Mancusi C, Self A, Manodoro F, Assiotis I, Robinson P, Chauhan R, Rust AG, Matthews N, Eason K, Khan K, Starling N, Cunningham D, Sadanandam A, Isacke CM, Kirkin V, Valeri N, Whittaker SR.

Oncogene. 2019 Jul;38(28):5746. doi: 10.1038/s41388-019-0835-1.


Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain.

Kijewska M, Viski C, Turrell F, Fitzpatrick A, van Weverwijk A, Gao Q, Iravani M, Isacke CM.

Breast Cancer Res. 2019 Jan 14;21(1):4. doi: 10.1186/s13058-018-1093-9.


Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.

Wagner S, Vlachogiannis G, De Haven Brandon A, Valenti M, Box G, Jenkins L, Mancusi C, Self A, Manodoro F, Assiotis I, Robinson P, Chauhan R, Rust AG, Matthews N, Eason K, Khan K, Starling N, Cunningham D, Sadanandam A, Isacke CM, Kirkin V, Valeri N, Whittaker SR.

Oncogene. 2019 Mar;38(10):1717-1733. doi: 10.1038/s41388-018-0554-z. Epub 2018 Oct 23. Erratum in: Oncogene. 2019 May 30;:.


Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host.

Jungwirth U, van Weverwijk A, Melake MJ, Chambers AF, Gao Q, Fivaz M, Isacke CM.

Dis Model Mech. 2018 Jan 18;11(1). pii: dmm031740. doi: 10.1242/dmm.031740.


The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.

Soady KJ, Tornillo G, Kendrick H, Meniel V, Olijnyk-Dallis D, Morris JS, Stein T, Gusterson BA, Isacke CM, Smalley MJ.

Development. 2017 Oct 15;144(20):3777-3788. doi: 10.1242/dev.149120. Epub 2017 Sep 4.


An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer.

Ashenden M, van Weverwijk A, Murugaesu N, Fearns A, Campbell J, Gao Q, Iravani M, Isacke CM.

Mol Cancer Ther. 2017 Sep;16(9):1967-1978. doi: 10.1158/1535-7163.MCT-16-0731. Epub 2017 Jun 13.


Endosialin-Expressing Pericytes Promote Metastatic Dissemination.

Viski C, König C, Kijewska M, Mogler C, Isacke CM, Augustin HG.

Cancer Res. 2016 Sep 15;76(18):5313-25. doi: 10.1158/0008-5472.CAN-16-0932.


Targeting the receptor tyrosine kinase RET in combination with aromatase inhibitors in ER positive breast cancer xenografts.

Andreucci E, Francica P, Fearns A, Martin LA, Chiarugi P, Isacke CM, Morandi A.

Oncotarget. 2016 Dec 6;7(49):80543-80553. doi: 10.18632/oncotarget.11826.


Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells.

Thway K, Robertson D, Jones RL, Selfe J, Shipley J, Fisher C, Isacke CM.

Br J Cancer. 2016 Aug 9;115(4):473-9. doi: 10.1038/bjc.2016.214. Epub 2016 Jul 19.


Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration.

Locard-Paulet M, Lim L, Veluscek G, McMahon K, Sinclair J, van Weverwijk A, Worboys JD, Yuan Y, Isacke CM, Jørgensen C.

Sci Signal. 2016 Feb 9;9(414):ra15. doi: 10.1126/scisignal.aac5820.


miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors.

Bacci M, Giannoni E, Fearns A, Ribas R, Gao Q, Taddei ML, Pintus G, Dowsett M, Isacke CM, Martin LA, Chiarugi P, Morandi A.

Cancer Res. 2016 Mar 15;76(6):1615-26. doi: 10.1158/0008-5472.CAN-15-2038. Epub 2016 Jan 21.


Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.

Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, Hanby AM, Speirs V, Sahai E, Calvo F, Isacke CM.

Nat Commun. 2016 Jan 18;7:10305. doi: 10.1038/ncomms10305.


Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis.

Smith SW, Croft AP, Morris HL, Naylor AJ, Huso DL, Isacke CM, Savage CO, Buckley CD.

Nephron. 2015;131(4):265-77. doi: 10.1159/000438754. Epub 2015 Dec 4.


CD44 increases the efficiency of distant metastasis of breast cancer.

McFarlane S, Coulter JA, Tibbits P, O'Grady A, McFarlane C, Montgomery N, Hill A, McCarthy HO, Young LS, Kay EW, Isacke CM, Waugh DJ.

Oncotarget. 2015 May 10;6(13):11465-76.


Mouse mammary stem cells express prognostic markers for triple-negative breast cancer.

Soady KJ, Kendrick H, Gao Q, Tutt A, Zvelebil M, Ordonez LD, Quist J, Tan DW, Isacke CM, Grigoriadis A, Smalley MJ.

Breast Cancer Res. 2015 Mar 4;17:31. doi: 10.1186/s13058-015-0539-6.


Soil amendments that slow cancer growth.

Isacke CM, Barcellos-Hoff MH.

Cancer Discov. 2014 Jun;4(6):637-9. doi: 10.1158/2159-8290.CD-14-0416.


An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.

Murugaesu N, Iravani M, van Weverwijk A, Ivetic A, Johnson DA, Antonopoulos A, Fearns A, Jamal-Hanjani M, Sims D, Fenwick K, Mitsopoulos C, Gao Q, Orr N, Zvelebil M, Haslam SM, Dell A, Yarwood H, Lord CJ, Ashworth A, Isacke CM.

Cancer Discov. 2014 Mar;4(3):304-17. doi: 10.1158/2159-8290.CD-13-0287. Epub 2014 Feb 11.


Targeting RET-interleukin-6 crosstalk to impair metastatic dissemination in breast cancer.

Morandi A, Isacke CM.

Breast Cancer Res. 2014 Jan 28;16(1):301. doi: 10.1186/bcr3608.


DNA promoter hypermethylation profiles in breast duct fluid.

Twelves D, Nerurkar A, Osin P, Dexter T, Ward A, Gui GP, Isacke CM.

Breast Cancer Res Treat. 2013 Jun;139(2):341-50. doi: 10.1007/s10549-013-2544-8. Epub 2013 May 15.


GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.

Morandi A, Martin LA, Gao Q, Pancholi S, Mackay A, Robertson D, Zvelebil M, Dowsett M, Plaza-Menacho I, Isacke CM.

Cancer Res. 2013 Jun 15;73(12):3783-95. doi: 10.1158/0008-5472.CAN-12-4265. Epub 2013 May 6.


MicroRNA-200 family modulation in distinct breast cancer phenotypes.

Castilla MÁ, Díaz-Martín J, Sarrió D, Romero-Pérez L, López-García MÁ, Vieites B, Biscuola M, Ramiro-Fuentes S, Isacke CM, Palacios J.

PLoS One. 2012;7(10):e47709. doi: 10.1371/journal.pone.0047709. Epub 2012 Oct 24.


The feasibility of nipple aspiration and duct lavage to evaluate the breast duct epithelium of women with increased breast cancer risk.

Twelves D, Nerurkar A, Osin P, Ward A, Isacke CM, Gui GP.

Eur J Cancer. 2013 Jan;49(1):65-71. doi: 10.1016/j.ejca.2012.07.012. Epub 2012 Aug 21.


Pericytes promote selective vessel regression to regulate vascular patterning.

Simonavicius N, Ashenden M, van Weverwijk A, Lax S, Huso DL, Buckley CD, Huijbers IJ, Yarwood H, Isacke CM.

Blood. 2012 Aug 16;120(7):1516-27. doi: 10.1182/blood-2011-01-332338. Epub 2012 Jun 27. Erratum in: Blood. 2012 Nov 15;120(20):4274. Huijber, Ivo J [corrected to Huijbers, Ivo J].


Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor.

Iorns E, Ward TM, Dean S, Jegg A, Thomas D, Murugaesu N, Sims D, Mitsopoulos C, Fenwick K, Kozarewa I, Naceur-Lombarelli C, Zvelebil M, Isacke CM, Lord CJ, Ashworth A, Hnatyszyn HJ, Pegram M, Lippman M.

Breast Cancer Res Treat. 2012 Aug;135(1):79-91. doi: 10.1007/s10549-012-2068-7. Epub 2012 Apr 26.


Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection?

Sartelet A, Klingbeil P, Franklin CK, Fasquelle C, Géron S, Isacke CM, Georges M, Charlier C.

Anim Genet. 2012 Oct;43(5):604-7. doi: 10.1111/j.1365-2052.2011.02311.x. Epub 2012 Jan 4.


CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration.

Lax S, Ross EA, White A, Marshall JL, Jenkinson WE, Isacke CM, Huso DL, Cunningham AF, Anderson G, Buckley CD.

FEBS Open Bio. 2012 Jul 20;2:187-90. doi: 10.1016/j.fob.2012.07.003. Print 2012.


Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties.

Sarrio D, Franklin CK, Mackay A, Reis-Filho JS, Isacke CM.

Stem Cells. 2012 Feb;30(2):292-303. doi: 10.1002/stem.791.


Mannose receptor 2 attenuates renal fibrosis.

López-Guisa JM, Cai X, Collins SJ, Yamaguchi I, Okamura DM, Bugge TH, Isacke CM, Emson CL, Turner SM, Shankland SJ, Eddy AA.

J Am Soc Nephrol. 2012 Feb;23(2):236-51. doi: 10.1681/ASN.2011030310. Epub 2011 Nov 17.


High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing.

Sims D, Mendes-Pereira AM, Frankum J, Burgess D, Cerone MA, Lombardelli C, Mitsopoulos C, Hakas J, Murugaesu N, Isacke CM, Fenwick K, Assiotis I, Kozarewa I, Zvelebil M, Ashworth A, Lord CJ.

Genome Biol. 2011 Oct 21;12(10):R104. doi: 10.1186/gb-2011-12-10-r104.


The 'alternative' EMT switch.

Klingbeil P, Isacke CM.

Breast Cancer Res. 2011 Aug 16;13(4):313. doi: 10.1186/bcr2915. Review.


The anatomy of fluid-yielding ducts in breast cancer.

Twelves D, Nerurkar A, Osin P, Ward A, Isacke CM, Gui GP.

Breast Cancer Res Treat. 2012 Apr;132(2):555-64. doi: 10.1007/s10549-011-1623-y. Epub 2011 Jun 15.


Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients.

Westbury CB, Sahlberg KK, Borresen-Dale AL, Isacke CM, Yarnold JR.

Radiat Oncol. 2011 Apr 26;6:42. doi: 10.1186/1748-717X-6-42.


CD248+ stromal cells are associated with progressive chronic kidney disease.

Smith SW, Eardley KS, Croft AP, Nwosu J, Howie AJ, Cockwell P, Isacke CM, Buckley CD, Savage CO.

Kidney Int. 2011 Jul;80(2):199-207. doi: 10.1038/ki.2011.103. Epub 2011 Apr 13.


The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation.

Hardie DL, Baldwin MJ, Naylor A, Haworth OJ, Hou TZ, Lax S, Curnow SJ, Willcox N, MacFadyen J, Isacke CM, Buckley CD.

Immunology. 2011 Jul;133(3):288-95. doi: 10.1111/j.1365-2567.2011.03437.x. Epub 2011 Apr 6.


Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.

Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambacorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM.

J Biol Chem. 2011 May 13;286(19):17292-302. doi: 10.1074/jbc.M110.168500. Epub 2011 Mar 22.


Multiple immunofluorescence labeling of formalin-fixed paraffin-embedded tissue.

Robertson D, Isacke CM.

Methods Mol Biol. 2011;724:69-77. doi: 10.1007/978-1-61779-055-3_4.


RET in breast cancer: functional and therapeutic implications.

Morandi A, Plaza-Menacho I, Isacke CM.

Trends Mol Med. 2011 Mar;17(3):149-57. doi: 10.1016/j.molmed.2010.12.007. Epub 2011 Jan 19. Review.


Mammary ductoscopy in the current management of breast disease.

Tang SS, Twelves DJ, Isacke CM, Gui GP.

Surg Endosc. 2011 Jun;25(6):1712-22. doi: 10.1007/s00464-010-1465-4. Epub 2010 Dec 18. Review.


Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome.

Henry LA, Johnson DA, Sarrió D, Lee S, Quinlan PR, Crook T, Thompson AM, Reis-Filho JS, Isacke CM.

Oncogene. 2011 Mar 3;30(9):1046-58. doi: 10.1038/onc.2010.488. Epub 2010 Nov 1.


Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance.

Plaza-Menacho I, Morandi A, Robertson D, Pancholi S, Drury S, Dowsett M, Martin LA, Isacke CM.

Oncogene. 2010 Aug 19;29(33):4648-57. doi: 10.1038/onc.2010.209. Epub 2010 Jun 7.


The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion.

Lax S, Hardie DL, Wilson A, Douglas MR, Anderson G, Huso D, Isacke CM, Buckley CD.

Eur J Immunol. 2010 Jul;40(7):1884-9. doi: 10.1002/eji.200939877.


A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.

Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, Isacke CM.

PLoS One. 2010 Mar 22;5(3):e9808. doi: 10.1371/journal.pone.0009808.


Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180.

Messaritou G, East L, Roghi C, Isacke CM, Yarwood H.

J Cell Sci. 2009 Nov 15;122(Pt 22):4042-8. doi: 10.1242/jcs.044305. Epub 2009 Oct 27.


Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle.

Fasquelle C, Sartelet A, Li W, Dive M, Tamma N, Michaux C, Druet T, Huijbers IJ, Isacke CM, Coppieters W, Georges M, Charlier C.

PLoS Genet. 2009 Sep;5(9):e1000666. doi: 10.1371/journal.pgen.1000666. Epub 2009 Sep 25.


Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation.

Westbury CB, Reis-Filho JS, Dexter T, Mahler-Araujo B, Fenwick K, Iravani M, Grigoriadis A, Parry S, Robertson D, Mackay A, Ashworth A, Yarnold JR, Isacke CM.

J Pathol. 2009 Sep;219(1):131-40. doi: 10.1002/path.2581.


CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification.

Klingbeil P, Natrajan R, Everitt G, Vatcheva R, Marchio C, Palacios J, Buerger H, Reis-Filho JS, Isacke CM.

Breast Cancer Res Treat. 2010 Feb;120(1):95-109. doi: 10.1007/s10549-009-0380-7. Epub 2009 Apr 7.


A HaemAtlas: characterizing gene expression in differentiated human blood cells.

Watkins NA, Gusnanto A, de Bono B, De S, Miranda-Saavedra D, Hardie DL, Angenent WG, Attwood AP, Ellis PD, Erber W, Foad NS, Garner SF, Isacke CM, Jolley J, Koch K, Macaulay IC, Morley SL, Rendon A, Rice KM, Taylor N, Thijssen-Timmer DC, Tijssen MR, van der Schoot CE, Wernisch L, Winzer T, Dudbridge F, Buckley CD, Langford CF, Teichmann S, Göttgens B, Ouwehand WH; Bloodomics Consortium.

Blood. 2009 May 7;113(19):e1-9. doi: 10.1182/blood-2008-06-162958. Epub 2009 Feb 19.


Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue.

Robertson D, Savage K, Reis-Filho JS, Isacke CM.

BMC Cell Biol. 2008 Mar 19;9:13. doi: 10.1186/1471-2121-9-13.


Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma.

Simonavicius N, Robertson D, Bax DA, Jones C, Huijbers IJ, Isacke CM.

Mod Pathol. 2008 Mar;21(3):308-15. doi: 10.1038/modpathol.3801006. Epub 2008 Jan 11.

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