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Comment on: "Cost-Effectiveness of Niraparib Versus Routine Surveillance, Olaparib and Rucaparib for the Maintenance Treatment of Patients with Ovarian Cancer in the United States".

Wallace K, Goble S, Isaacson J, Maloney L, Cameron T, Bedel J.

Pharmacoeconomics. 2019 Jun 7. doi: 10.1007/s40273-019-00815-3. [Epub ahead of print] No abstract available.


Digest: How do nonnative frugivorous birds adapt to life in O'ahu?

Isaacson J.

Evolution. 2019 May 24. doi: 10.1111/evo.13764. [Epub ahead of print]


Using social media to disseminate education about Alzheimer's prevention & treatment: a pilot study on Alzheimer's universe (

Isaacson RS, Seifan A, Haddox CL, Mureb M, Rahman A, Scheyer O, Hackett K, Caesar E, Chen JL, Isaacson J, McInnis M, Mosconi L, Safdieh J.

J Commun Healthc. 2018;11(2):106-113. doi: 10.1080/17538068.2018.1467068. Epub 2018 May 5.


Evaluation of Drug-Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P-gp Substrates in Patients With an Advanced Solid Tumor.

Xiao JJ, Nowak D, Ramlau R, Tomaszewska-Kiecana M, Wysocki PJ, Isaacson J, Beltman J, Nash E, Kaczanowski R, Arold G, Watkins S.

Clin Transl Sci. 2019 Jan;12(1):58-65. doi: 10.1111/cts.12600. Epub 2018 Dec 20.


BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.

Lin KK, Harrell MI, Oza AM, Oaknin A, Ray-Coquard I, Tinker AV, Helman E, Radke MR, Say C, Vo LT, Mann E, Isaacson JD, Maloney L, O'Malley DM, Chambers SK, Kaufmann SH, Scott CL, Konecny GE, Coleman RL, Sun JX, Giordano H, Brenton JD, Harding TC, McNeish IA, Swisher EM.

Cancer Discov. 2019 Feb;9(2):210-219. doi: 10.1158/2159-8290.CD-18-0715. Epub 2018 Nov 13.


Impact of a brief faculty training to improve patient-centered communication while using electronic health records.

Lee WW, Alkureishi ML, Isaacson JH, Mayer M, Frankel RM, London DA, Wroblewski KE, Arora VM.

Patient Educ Couns. 2018 Dec;101(12):2156-2161. doi: 10.1016/j.pec.2018.06.020. Epub 2018 Jul 3.


Antenatal Vulvar Pain Management, Labour Management, and Postpartum Care of Women With Vulvodynia: A Survey of Physicians and Midwives.

Smith KB, Basson R, Sadownik LA, Isaacson J, Brotto LA.

J Obstet Gynaecol Can. 2018 May;40(5):579-587. doi: 10.1016/j.jogc.2017.09.014.


Silent Witnesses: Faculty Reluctance to Report Medical Students' Professionalism Lapses.

Ziring D, Frankel RM, Danoff D, Isaacson JH, Lochnan H.

Acad Med. 2018 Nov;93(11):1700-1706. doi: 10.1097/ACM.0000000000002188.


Fear Learning Regulates Cortical Sensory Representations by Suppressing Habituation.

Gillet SN, Kato HK, Justen MA, Lai M, Isaacson JS.

Front Neural Circuits. 2018 Jan 10;11:112. doi: 10.3389/fncir.2017.00112. eCollection 2017.


PSMA-targeted bispecific Fab conjugates that engage T cells.

Patterson JT, Isaacson J, Kerwin L, Atassi G, Duggal R, Bresson D, Zhu T, Zhou H, Fu Y, Kaufmann GF.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5490-5495. doi: 10.1016/j.bmcl.2017.09.065. Epub 2017 Oct 6.


Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.

Coleman RL, Oza AM, Lorusso D, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Clamp A, Scambia G, Leary A, Holloway RW, Gancedo MA, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Garcia-Donas J, Swisher EM, Floquet A, Konecny GE, McNeish IA, Scott CL, Cameron T, Maloney L, Isaacson J, Goble S, Grace C, Harding TC, Raponi M, Sun J, Lin KK, Giordano H, Ledermann JA; ARIEL3 investigators.

Lancet. 2017 Oct 28;390(10106):1949-1961. doi: 10.1016/S0140-6736(17)32440-6. Epub 2017 Sep 12. Erratum in: Lancet. 2017 Oct 28;390(10106):1948.


Digest: Premating barriers drive reproductive isolation between two damselfly species.

Isaacson J.

Evolution. 2017 Oct;71(10):2541-2542. doi: 10.1111/evo.13331. Epub 2017 Sep 13. No abstract available.


Digest: Does intralocus sexual conflict affect cricket nutrition?

Isaacson J.

Evolution. 2017 Sep;71(9):2271-2272. doi: 10.1111/evo.13319. Epub 2017 Aug 9. No abstract available.


Network-Level Control of Frequency Tuning in Auditory Cortex.

Kato HK, Asinof SK, Isaacson JS.

Neuron. 2017 Jul 19;95(2):412-423.e4. doi: 10.1016/j.neuron.2017.06.019. Epub 2017 Jul 6.


A Professionalism Curricular Model to Promote Transformative Learning Among Residents.

Foshee CM, Mehdi A, Bierer SB, Traboulsi EI, Isaacson JH, Spencer A, Calabrese C, Burkey BB.

J Grad Med Educ. 2017 Jun;9(3):351-356. doi: 10.4300/JGME-D-16-00421.1.


Training internal medicine residents to manage chronic pain and prescription opioid misuse.

Ruff AL, Alford DP, Butler R, Isaacson JH.

Subst Abus. 2017 Apr-Jun;38(2):200-204. doi: 10.1080/08897077.2017.1296526. Epub 2017 Apr 10.


A Phase I-II Study of the Oral PARP Inhibitor Rucaparib in Patients with Germline BRCA1/2-Mutated Ovarian Carcinoma or Other Solid Tumors.

Kristeleit R, Shapiro GI, Burris HA, Oza AM, LoRusso P, Patel MR, Domchek SM, BalmaƱa J, Drew Y, Chen LM, Safra T, Montes A, Giordano H, Maloney L, Goble S, Isaacson J, Xiao J, Borrow J, Rolfe L, Shapira-Frommer R.

Clin Cancer Res. 2017 Aug 1;23(15):4095-4106. doi: 10.1158/1078-0432.CCR-16-2796. Epub 2017 Mar 6.


Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA.

Lancet Oncol. 2017 Jan;18(1):75-87. doi: 10.1016/S1470-2045(16)30559-9. Epub 2016 Nov 29.


Clinicians' Perspectives and Experiences Regarding Maternity Care in Women With Vulvodynia.

Smith KB, Sadownik LA, Basson R, Isaacson J, Brotto LA.

J Obstet Gynaecol Can. 2016 Sep;38(9):811-819. doi: 10.1016/j.jogc.2016.04.008. Epub 2016 Jun 11.


Flexible Sensory Representations in Auditory Cortex Driven by Behavioral Relevance.

Kato HK, Gillet SN, Isaacson JS.

Neuron. 2015 Dec 2;88(5):1027-1039. doi: 10.1016/j.neuron.2015.10.024. Epub 2015 Nov 12.


A 79-year-old with acute portal vein thrombosis.

Zhu L, Gornik H, Isaacson JH.

Cleve Clin J Med. 2015 May;82(5):287-93. doi: 10.3949/ccjm.82a.14028. No abstract available.


Rociletinib in EGFR-mutated non-small-cell lung cancer.

Sequist LV, Soria JC, Goldman JW, Wakelee HA, Gadgeel SM, Varga A, Papadimitrakopoulou V, Solomon BJ, Oxnard GR, Dziadziuszko R, Aisner DL, Doebele RC, Galasso C, Garon EB, Heist RS, Logan J, Neal JW, Mendenhall MA, Nichols S, Piotrowska Z, Wozniak AJ, Raponi M, Karlovich CA, Jaw-Tsai S, Isaacson J, Despain D, Matheny SL, Rolfe L, Allen AR, Camidge DR.

N Engl J Med. 2015 Apr 30;372(18):1700-9. doi: 10.1056/NEJMoa1413654.


Physiology of Mechanotransduction: How Do Muscle and Bone "Talk" to One Another?

Isaacson J, Brotto M.

Clin Rev Bone Miner Metab. 2014 Jun;12(2):77-85.


Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex.

Sturgill JF, Isaacson JS.

Nat Neurosci. 2015 Apr;18(4):531-5. doi: 10.1038/nn.3971. Epub 2015 Mar 9.


Broadcasting of cortical activity to the olfactory bulb.

Boyd AM, Kato HK, Komiyama T, Isaacson JS.

Cell Rep. 2015 Feb 24;10(7):1032-9. doi: 10.1016/j.celrep.2015.01.047. Epub 2015 Feb 19.


Creatine phosphokinase elevation exacerbated by levetiracetam therapy.

Isaacson JE, Choe DJ, Doherty MJ.

Epilepsy Behav Case Rep. 2014 Oct 22;2:189-91. doi: 10.1016/j.ebcr.2014.09.008. eCollection 2014.


Single dendrite-targeting interneurons generate branch-specific inhibition.

Stokes CC, Teeter CM, Isaacson JS.

Front Neural Circuits. 2014 Nov 25;8:139. doi: 10.3389/fncir.2014.00139. eCollection 2014.


Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.

Belmont PJ, Jiang P, McKee TD, Xie T, Isaacson J, Baryla NE, Roper J, Sinnamon MJ, Lee NV, Kan JL, Guicherit O, Wouters BG, O'Brien CA, Shields D, Olson P, VanArsdale T, Weinrich SL, Rejto P, Christensen JG, Fantin VR, Hung KE, Martin ES.

Sci Signal. 2014 Nov 11;7(351):ra107. doi: 10.1126/scisignal.2005516.


Robust detection of individual forensic profiles in DNA mixtures.

Isaacson J, Schwoebel E, Shcherbina A, Ricke D, Harper J, Petrovick M, Bobrow J, Boettcher T, Helfer B, Zook C, Wack E.

Forensic Sci Int Genet. 2015 Jan;14:31-7. doi: 10.1016/j.fsigen.2014.09.003. Epub 2014 Sep 16.


Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors.

Soria JC, DeBraud F, Bahleda R, Adamo B, Andre F, Dienstmann R, Delmonte A, Cereda R, Isaacson J, Litten J, Allen A, Dubois F, Saba C, Robert R, D'Incalci M, Zucchetti M, Camboni MG, Tabernero J.

Ann Oncol. 2014 Nov;25(11):2244-51. doi: 10.1093/annonc/mdu390. Epub 2014 Sep 5. Erratum in: Ann Oncol. 2015 Feb;26(2):445. Dientsmann, R [corrected to Dienstmann, R].


Extracellular Membrane Vesicles Derived from 143B Osteosarcoma Cells Contain Pro-Osteoclastogenic Cargo: A Novel Communication Mechanism in Osteosarcoma Bone Microenvironment.

Garimella R, Washington L, Isaacson J, Vallejo J, Spence M, Tawfik O, Rowe P, Brotto M, Perez R.

Transl Oncol. 2014 Jun 17;7(3):331-40. doi: 10.1016/j.tranon.2014.04.011. eCollection 2014 Jun.


Physicians caring for physicians: the perspective of the primary care physician.

Teng KA, Butler RS, Schramm S, Isaacson JH, Nielsen C, Paradis C.

South Med J. 2014 May;107(5):301-5. doi: 10.1097/SMJ.0000000000000095.


Human equilibrative nucleoside transporter 1 is not predictive for gemcitabine efficacy in advanced pancreatic cancer: translational results from the AIO-PK0104 phase III study with the clone SP120 rabbit antibody.

Ormanns S, Heinemann V, Raponi M, Isaacson J, Laubender RP, Haas M, Kruger S, Kleespies A, Mann E, Bartosiewicz M, Kirchner T, Boeck S.

Eur J Cancer. 2014 Jul;50(11):1891-9. doi: 10.1016/j.ejca.2014.04.023. Epub 2014 May 20.


Patient perceptions of having 1st- and 2nd-year medical students involved in their care.

Isaacson JH, Neides D, Mayer M, Nottingham K.

Teach Learn Med. 2014;26(2):164-7. doi: 10.1080/10401334.2014.883988.


Parvalbumin-expressing interneurons linearly control olfactory bulb output.

Kato HK, Gillet SN, Peters AJ, Isaacson JS, Komiyama T.

Neuron. 2013 Dec 4;80(5):1218-31. doi: 10.1016/j.neuron.2013.08.036. Epub 2013 Nov 14.


Randomized, multicenter, phase II study of CO-101 versus gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma: including a prospective evaluation of the role of hENT1 in gemcitabine or CO-101 sensitivity.

Poplin E, Wasan H, Rolfe L, Raponi M, Ikdahl T, Bondarenko I, Davidenko I, Bondar V, Garin A, Boeck S, Ormanns S, Heinemann V, Bassi C, Evans TR, Andersson R, Hahn H, Picozzi V, Dicker A, Mann E, Voong C, Kaur P, Isaacson J, Allen A.

J Clin Oncol. 2013 Dec 10;31(35):4453-61. doi: 10.1200/JCO.2013.51.0826. Epub 2013 Nov 12.


Cortical feedback control of olfactory bulb circuits.

Boyd AM, Sturgill JF, Poo C, Isaacson JS.

Neuron. 2012 Dec 20;76(6):1161-74. doi: 10.1016/j.neuron.2012.10.020.


Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience.

Kato HK, Chu MW, Isaacson JS, Komiyama T.

Neuron. 2012 Dec 6;76(5):962-75. doi: 10.1016/j.neuron.2012.09.037.


Jatropha curcas: from biodiesel generation to medicinal applications.

Paulillo LC, Mo C, Isaacson J, Lessa L, Lopes E, Romero-Suarez S, Brotto L, Abreu E, Gutheil W, Brotto M.

Recent Pat Biotechnol. 2012 Dec;6(3):192-9.


Toward "The Genius of the AND": Balancing Professionalism and Duty Hour Requirements in Graduate Medical Education.

Stoller JK, Isaacson JH, Nielsen C.

J Grad Med Educ. 2011 Sep;3(3):299-301. doi: 10.4300/JGME-D-11-00111.1.


Analysis of corpus callosum diffusion tensor imaging parameters in infants.

Provenzale JM, Isaacson J, Stinnett S, Chen S.

Neuroradiol J. 2012 Jul;25(3):342-50. Epub 2012 Jun 26.


Progression of corpus callosum diffusion-tensor imaging values during a period of signal changes consistent with myelination.

Provenzale JM, Isaacson J, Chen S.

AJR Am J Roentgenol. 2012 Jun;198(6):1403-8. doi: 10.2214/AJR.11.7849.


How dominant is the most efficient pathway through the potential energy landscape of a slowly diffusing disordered system?

Nguyen CN, Isaacson JI, Shimmyo KB, Chen A, Stratt RM.

J Chem Phys. 2012 May 14;136(18):184504. doi: 10.1063/1.4717460.


Overcoming health care disparities via better cross-cultural communication and health literacy.

Misra-Hebert AD, Isaacson JH.

Cleve Clin J Med. 2012 Feb;79(2):127-33. doi: 10.3949/ccjm.79a.11006.


How inhibition shapes cortical activity.

Isaacson JS, Scanziani M.

Neuron. 2011 Oct 20;72(2):231-43. doi: 10.1016/j.neuron.2011.09.027. Review.


A major role for intracortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex.

Poo C, Isaacson JS.

Neuron. 2011 Oct 6;72(1):41-8. doi: 10.1016/j.neuron.2011.08.015.


A 49-year-old woman with a persistent cough.

Doleh TY, Rehm SJ, Isaacson JH.

Cleve Clin J Med. 2011 Aug;78(8):521-8. doi: 10.3949/ccjm.78a.10144. Review. No abstract available.


Linking neuronal ensembles by associative synaptic plasticity.

Yuan Q, Isaacson JS, Scanziani M.

PLoS One. 2011;6(6):e20486. doi: 10.1371/journal.pone.0020486. Epub 2011 Jun 29.


Diffusion tensor imaging for evaluation of the childhood brain and pediatric white matter disorders.

Isaacson J, Provenzale J.

Neuroimaging Clin N Am. 2011 Feb;21(1):179-89, ix. doi: 10.1016/j.nic.2011.02.005. Review.


A 31-year-old man with abdominal pain and a rectal nodule.

Chu J, Isaacson JH.

Cleve Clin J Med. 2011 Jan;78(1):59-62. doi: 10.3949/ccjm.77a.10084. No abstract available.


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