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Items: 43


Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling.

Daoud A, Gopal U, Kaur J, Isaacs JS.

Oncotarget. 2017 Nov 3;8(63):106807-106819. doi: 10.18632/oncotarget.22370. eCollection 2017 Dec 5.


Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity.

Nolan KD, Kaur J, Isaacs JS.

Oncotarget. 2017 Mar 21;8(12):19323-19341. doi: 10.18632/oncotarget.14252.


Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS.

Dang X, Singh A, Spetman BD, Nolan KD, Isaacs JS, Dennis JH, Dalton S, Marshall AG, Young NL.

J Proteome Res. 2016 Sep 2;15(9):3196-203. doi: 10.1021/acs.jproteome.6b00414. Epub 2016 Aug 3.


Hsp90 as a "Chaperone" of the Epigenome: Insights and Opportunities for Cancer Therapy.

Isaacs JS.

Adv Cancer Res. 2016;129:107-40. doi: 10.1016/bs.acr.2015.09.003. Epub 2015 Nov 24. Review.


Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion.

Nolan KD, Franco OE, Hance MW, Hayward SW, Isaacs JS.

J Biol Chem. 2015 Mar 27;290(13):8271-82. doi: 10.1074/jbc.M115.637496. Epub 2015 Feb 10.


The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer.

Hance MW, Nolan KD, Isaacs JS.

Cancers (Basel). 2014 May 6;6(2):1065-97. doi: 10.3390/cancers6021065.


Extracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: implications for the prostate tumor microenvironment.

Bohonowych JE, Hance MW, Nolan KD, Defee M, Parsons CH, Isaacs JS.

Prostate. 2014 Apr;74(4):395-407. doi: 10.1002/pros.22761. Epub 2013 Dec 16.


Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.

Hance MW, Dole K, Gopal U, Bohonowych JE, Jezierska-Drutel A, Neumann CA, Liu H, Garraway IP, Isaacs JS.

J Biol Chem. 2012 Nov 2;287(45):37732-44. doi: 10.1074/jbc.M112.389015. Epub 2012 Sep 18.


Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.

Bohonowych JE, Peng S, Gopal U, Hance MW, Wing SB, Argraves KM, Lundgren K, Isaacs JS.

BMC Cancer. 2011 Dec 15;11:520. doi: 10.1186/1471-2407-11-520.


Interactions between Hsp90 and oncogenic viruses: implications for viral cancer therapeutics.

Defee MR, Qin Z, Dai L, Isaacs JS, Parsons CH.

Am J Cancer Res. 2011;1(6):763-72. Epub 2011 Jun 5.


Extracellular Hsp90 serves as a co-factor for NF-κB activation and cellular pathogenesis induced by an oncogenic herpesvirus.

Defee MR, Qin Z, Dai L, Toole BP, Isaacs JS, Parsons CH.

Am J Cancer Res. 2011;1(5):687-700. Epub 2011 Apr 27.


A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.

Gopal U, Bohonowych JE, Lema-Tome C, Liu A, Garrett-Mayer E, Wang B, Isaacs JS.

PLoS One. 2011 Mar 8;6(3):e17649. doi: 10.1371/journal.pone.0017649.


Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.

Bohonowych JE, Gopal U, Isaacs JS.

J Oncol. 2010;2010:412985. doi: 10.1155/2010/412985. Epub 2010 Jun 24.


Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.

Qin Z, DeFee M, Isaacs JS, Parsons C.

Virology. 2010 Jul 20;403(1):92-102. doi: 10.1016/j.virol.2010.03.052. Epub 2010 May 6.


Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.

Annamalai B, Liu X, Gopal U, Isaacs JS.

Mol Cancer Res. 2009 Jul;7(7):1021-32. doi: 10.1158/1541-7786.MCR-08-0582. Epub 2009 Jun 30.


A study of the treatment of Rett syndrome with folate and betaine.

Glaze DG, Percy AK, Motil KJ, Lane JB, Isaacs JS, Schultz RJ, Barrish JO, Neul JL, O'Brien WE, Smith EO.

J Child Neurol. 2009 May;24(5):551-6. doi: 10.1177/0883073808327827. Epub 2009 Feb 18.


BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression.

Kang HJ, Kim HJ, Rih JK, Mattson TL, Kim KW, Cho CH, Isaacs JS, Bae I.

J Biol Chem. 2006 May 12;281(19):13047-56. Epub 2006 Mar 16.


HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L.

Cancer Cell. 2005 Aug;8(2):143-53.


Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?

Isaacs JS.

Expert Opin Investig Drugs. 2005 Jun;14(6):569-89. Review.


Effects of long-term psychostimulant medication on growth of children with ADHD.

Zachor DA, Roberts AW, Hodgens JB, Isaacs JS, Merrick J.

Res Dev Disabil. 2006 Mar-Apr;27(2):162-74. Epub 2005 Jun 13.


Genetic basis of cancer of the kidney: disease-specific approaches to therapy.

Linehan WM, Vasselli J, Srinivasan R, Walther MM, Merino M, Choyke P, Vocke C, Schmidt L, Isaacs JS, Glenn G, Toro J, Zbar B, Bottaro D, Neckers L.

Clin Cancer Res. 2004 Sep 15;10(18 Pt 2):6282S-9S. Review.


Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Bisht KS, Bradbury CM, Mattson D, Kaushal A, Sowers A, Markovina S, Ortiz KL, Sieck LK, Isaacs JS, Brechbiel MW, Mitchell JB, Neckers LM, Gius D.

Cancer Res. 2003 Dec 15;63(24):8984-95.


IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.

Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L.

FASEB J. 2003 Nov;17(14):2115-7. Epub 2003 Sep 4.


Heat shock protein 90 as a molecular target for cancer therapeutics.

Isaacs JS, Xu W, Neckers L.

Cancer Cell. 2003 Mar;3(3):213-7. Review. No abstract available.


Eating difficulties in girls with Rett syndrome compared with other developmental disabilities.

Isaacs JS, Murdock M, Lane J, Percy AK.

J Am Diet Assoc. 2003 Feb;103(2):224-30.


Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein.

Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L.

J Biol Chem. 2003 Feb 28;278(9):7445-52. Epub 2002 Dec 17. Erratum in: J Biol Chem. 2004 Aug 13;279(33):35121.


Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.

Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM.

J Biol Chem. 2002 Aug 16;277(33):29936-44. Epub 2002 Jun 6.


Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma.

Isaacs JS, Saito S, Neckers LM.

J Biol Chem. 2001 May 25;276(21):18497-506. Epub 2001 Feb 26.


Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines.

Isaacs JS, Hardman R, Carman TA, Barrett JC, Weissman BE.

Cell Growth Differ. 1998 Jul;9(7):545-55.


p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral neuroepithelioma cell line.

Isaacs JS, Chiao C, Merrick BA, Selkirk JK, Barrett JC, Weissman BE.

Cancer Res. 1997 Jul 15;57(14):2986-92.


Failure of HPV E6 to rapidly degrade p53 in human HeLa x PNET cell hybrids.

Isaacs JS, Chen P, Garza A, Hansen MF, Barrett JC, Weissman BE.

Oncogene. 1997 Apr 10;14(14):1669-78.


Weight and length increases in children after gastrostomy placement.

Corwin DS, Isaacs JS, Georgeson KE, Bartolucci AA, Cloud HH, Craig CB.

J Am Diet Assoc. 1996 Sep;96(9):874-9.


Weight gain and triceps skinfolds fat mass after gastrostomy placement in children with developmental disabilities.

Isaacs JS, Georgeson KE, Cloud HH, Woodall N.

J Am Diet Assoc. 1994 Aug;94(8):849-54.


Transitioning the child fed by gastrostomy into school.

Isaacs JS, Davis BD, La Montagne MJ.

J Am Diet Assoc. 1990 Jul;90(7):982-5.


Serum creatine phosphokinase levels and assaultive behaviour of psychotic patients.

Isaacs JS, Yesavage JA.

Psychol Med. 1984 Feb;14(1):229-31.


Hostile words and assaultive behavior on an acute inpatient psychiatric unit.

Werner PD, Yesavage JA, Becker JM, Brunsting DW, Isaacs JS.

J Nerv Ment Dis. 1983 Jun;171(6):385-7.


Analysis of responses to the Personal Opinion Survey by a sample of inpatients.

Werner PD, Becker JM, Yesavage JA, Isaacs JS.

Psychol Rep. 1982 Oct;51(2):423-9. No abstract available.


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