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Items: 1 to 50 of 930

1.

Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.

Spiering R, Jansen MAA, Wood MJ, Fath AA, Eltherington O, Anderson AE, Pratt AG, van Eden W, Isaacs JD, Broere F, Hilkens CMU.

J Transl Med. 2019 Nov 14;17(1):375. doi: 10.1186/s12967-019-2128-4.

2.

Side-to-side supercharging nerve allograft enhances neurotrophic potential.

Isaacs J, Feger MA, Mallu S, Patel G, Debkowska M, Yager D, Ernst B, Chilukuri S, Moser M, Kurtz C.

Muscle Nerve. 2019 Nov 14. doi: 10.1002/mus.26753. [Epub ahead of print]

PMID:
31724205
3.

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents.

Strand V, Gonçalves J, Hickling TP, Jones HE, Marshall L, Isaacs JD.

BioDrugs. 2019 Nov 13. doi: 10.1007/s40259-019-00394-x. [Epub ahead of print] Review.

PMID:
31721107
4.

Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.

Nair N, Plant D, Verstappen SM, Isaacs JD, Morgan AW, Hyrich KL, Barton A, Wilson AG.

Rheumatology (Oxford). 2019 Oct 10. pii: kez411. doi: 10.1093/rheumatology/kez411. [Epub ahead of print]

5.

Brain pseudotumour secondary to Behçet's disease.

Mousa AE, Okasha M, Isaacs JD, Price DA, Bhatnagar P, Joshi A, Surash S.

Ann R Coll Surg Engl. 2019 Nov;101(8):e164-e168. doi: 10.1308/rcsann.2019.0134. Epub 2019 Sep 20.

PMID:
31537109
6.

Efficacy and safety of subcutaneous tocilizumab in rheumatoid arthritis over 1 year: a UK real-world, open-label study.

Isaacs JD, Salih A, Sheeran T, Patel YI, Douglas K, McKay ND, Naisbett-Groet B, Choy E.

Rheumatol Adv Pract. 2019 Apr 19;3(1):rkz010. doi: 10.1093/rap/rkz010. eCollection 2019.

7.

Viral vector delivery of follistatin enhances recovery of reinnervated muscle.

Isaacs J, Feger MA, Mallu S, Yager D, Shall M, Patel G, Protzuk O, Graham L.

Muscle Nerve. 2019 Oct;60(4):474-483. doi: 10.1002/mus.26653. Epub 2019 Aug 14.

PMID:
31365129
8.

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance.

Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs J, Yu EY, Kelly K, Lin D, Dicker A, Arnold J, Hecht T, Wicha M, Sears R, Rowley D, White R, Gulley JL, Lee J, Diaz Meco M, Small EJ, Shen M, Knudsen K, Goodrich DW, Lotan T, Zoubeidi A, Sawyers CL, Rudin CM, Loda M, Thompson T, Rubin MA, Tawab-Amiri A, Dahut W, Nelson PS.

Clin Cancer Res. 2019 Dec 1;25(23):6916-6924. doi: 10.1158/1078-0432.CCR-19-1423. Epub 2019 Jul 30.

PMID:
31363002
9.

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG.

Front Immunol. 2019 Jul 3;10:1535. doi: 10.3389/fimmu.2019.01535. eCollection 2019.

10.

Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.

Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino MA, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP.

Trials. 2019 Jul 15;20(1):429. doi: 10.1186/s13063-019-3403-7.

11.

The Use of a Lumbrical Muscle Flap for Treatment of Chronic Tenocutaneous Fistula.

Nigro LC, Isaacs JE.

J Hand Surg Am. 2019 Oct;44(10):906.e1-906.e4. doi: 10.1016/j.jhsa.2019.05.019. Epub 2019 Jul 9. Review.

PMID:
31300227
12.

Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.

Baker KF, Skelton AJ, Lendrem DW, Scadeng A, Thompson B, Pratt AG, Isaacs JD.

J Autoimmun. 2019 Dec;105:102298. doi: 10.1016/j.jaut.2019.06.009. Epub 2019 Jul 4.

13.

Between a ROC and a hard place: Teaching prevalence plots to understand real world biomarker performance in the clinic.

Lendrem BC, Lendrem DW, Pratt AG, Naamane N, McMeekin P, Ng WF, Allen AJ, Power M, Isaacs JD.

Pharm Stat. 2019 Nov;18(6):632-635. doi: 10.1002/pst.1963. Epub 2019 Jun 23.

PMID:
31231892
14.

"Living a normal life": a qualitative study of patients' views of medication withdrawal in rheumatoid arthritis.

Baker KF, Isaacs JD, Thompson B.

BMC Rheumatol. 2019 Jun 13;3:2. doi: 10.1186/s41927-019-0070-y. eCollection 2019. Erratum in: BMC Rheumatol. 2019 Aug 20;3:35.

15.

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Porter LH, Lawrence MG, Wang H, Clark AK, Bakshi A, Obinata D, Goode D, Papargiris M, Mural, Clouston D, Ryan A, Norden S, Corey E, Nelson PS, Isaacs JT, Grummet J, Kourambas J, Sandhu S, Murphy DG, Pook D, Frydenberg M, Taylor RA, Risbridger GP.

Prostate. 2019 Aug;79(11):1326-1337. doi: 10.1002/pros.23839. Epub 2019 Jun 18.

PMID:
31212368
16.

Potential Pharmacologic Targets for the Prevention of Rheumatoid Arthritis.

Isaacs JD, Iqbal K.

Clin Ther. 2019 Jul;41(7):1312-1322. doi: 10.1016/j.clinthera.2019.04.020. Epub 2019 Jun 10.

PMID:
31196649
17.

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ.

Cancer Res. 2019 Jul 15;79(14):3636-3650. doi: 10.1158/0008-5472.CAN-18-2931. Epub 2019 May 23.

PMID:
31123087
18.

Keratinocyte growth factor impairs human thymic recovery from lymphopenia.

Coles AJ, Azzopardi L, Kousin-Ezewu O, Mullay HK, Thompson SA, Jarvis L, Davies J, Howlett S, Rainbow D, Babar J, Sadler TJ, Brown JWL, Needham E, May K, Georgieva ZG, Handel AE, Maio S, Deadman M, Rota I, Holländer G, Dawson S, Jayne D, Seggewiss-Bernhardt R, Douek DC, Isaacs JD, Jones JL.

JCI Insight. 2019 May 7;5. pii: 125377. doi: 10.1172/jci.insight.125377.

19.

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39.

Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJ, Ikari K, Yamanaka H, Saevarsdottir S, Padyukov L, Bridges SL Jr, Kimberly RP, Okada Y, van Riel PLC, Wolbink G, van der Horst-Bruinsma IE, de Vries N, Tak PP, Ohmura K, Canhão H, Guchelaar HJ, Huizinga TW, Criswell LA, Raychaudhuri S, Weinblatt ME, Wilson AG, Mariette X, Isaacs JD, Morgan AW, Pitzalis C, Barton A, McKeigue P.

Ann Rheum Dis. 2019 Aug;78(8):1055-1061. doi: 10.1136/annrheumdis-2018-214877. Epub 2019 Apr 29.

20.

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH.

Alzheimers Dement (N Y). 2019 Apr 9;5:107-117. doi: 10.1016/j.trci.2019.02.001. eCollection 2019. Review.

21.

Adoption of New Medical Technologies: The Case of Customized Individually Made Knee Implants.

Namin AT, Jalali MS, Vahdat V, Bedair HS, O'Connor MI, Kamarthi S, Isaacs JA.

Value Health. 2019 Apr;22(4):423-430. doi: 10.1016/j.jval.2019.01.008. Epub 2019 Mar 6.

PMID:
30975393
22.

In Reply.

Brennen WN, Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Denmeade SR.

Stem Cells Transl Med. 2019 Jul;8(7):739-740. doi: 10.1002/sctm.19-0068. Epub 2019 Mar 29. No abstract available.

23.

Remote detection of radioactive material using mid-IR laser-driven electron avalanche.

Schwartz RM, Woodbury D, Isaacs J, Sprangle P, Milchberg HM.

Sci Adv. 2019 Mar 22;5(3):eaav6804. doi: 10.1126/sciadv.aav6804. eCollection 2019 Mar.

24.

The London memory service audit and quality improvement programme.

Cook LD, Nichol KE, Isaacs JD.

BJPsych Bull. 2019 Mar 22:215-220. doi: 10.1192/bjb.2019.18. [Epub ahead of print]

25.

Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologists.

Fellermann H, Shirt-Ediss B, Kozyra J, Linsley M, Lendrem D, Isaacs J, Howard T.

Pharm Stat. 2019 Jul;18(4):402-406. doi: 10.1002/pst.1932. Epub 2019 Feb 21. No abstract available.

26.

Implantation of Acellular Nerve Allograft Using Nerve Connectors.

Isaacs J, Mallu S, Patel G, Kite A, Shah S, Graham GP.

Hand (N Y). 2019 Feb 19:1558944719828009. doi: 10.1177/1558944719828009. [Epub ahead of print]

PMID:
30782010
27.

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer.

Akinboye ES, Brennen WN, Denmeade SR, Isaacs JT.

Asian J Urol. 2019 Jan;6(1):99-108. doi: 10.1016/j.ajur.2018.11.004. Epub 2018 Nov 28. Review.

28.

Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.

Iqbal K, Lendrem DW, Hargreaves B, Isaacs JD, Thompson B, Pratt AG.

Rheumatology (Oxford). 2019 Jul 1;58(7):1268-1273. doi: 10.1093/rheumatology/kez008.

PMID:
30753709
29.

Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.

Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG.

Rheumatology (Oxford). 2019 Jul 1;58(7):1250-1258. doi: 10.1093/rheumatology/kez003.

30.

A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.

Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Brennen WN, Denmeade SR.

Stem Cells Transl Med. 2019 May;8(5):441-449. doi: 10.1002/sctm.18-0230. Epub 2019 Feb 8.

31.

Nerve transfers for peripheral nerve injury in the upper limb: a case-based review.

Isaacs J, Cochran AR.

Bone Joint J. 2019 Feb;101-B(2):124-131. doi: 10.1302/0301-620X.101B2.BJJ-2018-0839.R1. Review.

PMID:
30700118
32.

Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients.

Wood MJ, Leckenby A, Reynolds G, Spiering R, Pratt AG, Rankin KS, Isaacs JD, Haniffa MA, Milling S, Hilkens CM.

JCI Insight. 2019 Jan 24;4(2). pii: 125325. doi: 10.1172/jci.insight.125325. [Epub ahead of print]

33.

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Krueger TE, Thorek DLJ, Meeker AK, Isaacs JT, Brennen WN.

Prostate. 2019 Feb;79(3):320-330. doi: 10.1002/pros.23738. Epub 2018 Nov 28.

34.

Pharmacologic Exhaustion of Suppressor Cells with Tasquinimod Enhances Bacterial Clearance during Tuberculosis.

Gupta S, Krug S, Pokkali S, Leanderson T, Isaacs JT, Srikrishna G, Bishai WR.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):386-389. doi: 10.1164/rccm.201805-0820LE. No abstract available.

PMID:
30395729
35.

Tolerising cellular therapies: what is their promise for autoimmune disease?

Mosanya CH, Isaacs JD.

Ann Rheum Dis. 2019 Mar;78(3):297-310. doi: 10.1136/annrheumdis-2018-214024. Epub 2018 Nov 2. Review.

36.

Therapeutic tolerance in autoimmune disease.

Rayner F, Isaacs JD.

Semin Arthritis Rheum. 2018 Dec;48(3):558-562. doi: 10.1016/j.semarthrit.2018.09.008. Epub 2018 Sep 28. Review.

PMID:
30348449
37.

Checks and balances occur not only in government, but also in biology.

Isaacs JT.

Oncotarget. 2018 Sep 4;9(69):33054-33055. doi: 10.18632/oncotarget.25876. eCollection 2018 Sep 4. No abstract available.

38.

Mesenchymal stem cells and the embryonic reawakening theory of BPH.

Brennen WN, Isaacs JT.

Nat Rev Urol. 2018 Nov;15(11):703-715. doi: 10.1038/s41585-018-0087-9. Review.

PMID:
30214054
39.

Effect of Reverse End-to-Side (Supercharging) Neurotization in Long Processed Acellular Nerve Allograft in a Rat Model.

Isaacs J, Patel G, Mallu S, Ugwu-Oju O, Desai A, Borschel G, David D, Protzuk O, Shah S, Semus R.

J Hand Surg Am. 2019 May;44(5):419.e1-419.e10. doi: 10.1016/j.jhsa.2018.07.008. Epub 2018 Aug 29.

PMID:
30172450
40.

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P, Isaacs J, Cordell H, Pitzalis C, Barton A; BRAGGSS, MATURA Consortium.

Pharmacogenomics J. 2018 Sep;18(5):657-664. doi: 10.1038/s41397-018-0040-6. Epub 2018 Aug 31.

41.

Environmental Calcium Initiates a Feed-Forward Signaling Circuit That Regulates Biofilm Formation and Rugosity in Vibrio vulnificus.

Chodur DM, Coulter P, Isaacs J, Pu M, Fernandez N, Waters CM, Rowe-Magnus DA.

MBio. 2018 Aug 28;9(4). pii: e01377-18. doi: 10.1128/mBio.01377-18.

42.

Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models.

Navone NM, van Weerden WM, Vessella RL, Williams ED, Wang Y, Isaacs JT, Nguyen HM, Culig Z, van der Pluijm G, Rentsch CA, Marques RB, de Ridder CMA, Bubendorf L, Thalmann GN, Brennen WN, Santer FR, Moser PL, Shepherd P, Efstathiou E, Xue H, Lin D, Buijs J, Bosse T, Collins A, Maitland N, Buzza M, Kouspou M, Achtman A, Taylor RA, Risbridger G, Corey E.

Prostate. 2018 Dec;78(16):1262-1282. doi: 10.1002/pros.23701. Epub 2018 Aug 2.

PMID:
30073676
43.

Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.

Krueger TEG, Thorek DLJ, Denmeade SR, Isaacs JT, Brennen WN.

Stem Cells Transl Med. 2018 Sep;7(9):651-663. doi: 10.1002/sctm.18-0024. Epub 2018 Aug 1. Review.

44.

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

Williams NH, Jenkins A, Goulden N, Hoare Z, Hughes DA, Wood E, Foster NE, Walsh D, Carnes D, Sparkes V, Hay EM, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S, Wilkinson C.

Trials. 2018 Jul 31;19(1):408. doi: 10.1186/s13063-018-2801-6.

45.

Correction to: The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease.

Ritchie CW, Russ TC, Banerjee S, Barber B, Boaden A, Fox NC, Holmes C, Isaacs JD, Leroi I, Lovestone S, Norton M, O'Brien J, Pearson J, Perry R, Pickett J, Waldman AD, Wong WL, Rossor MN, Burns A.

Alzheimers Res Ther. 2018 Jul 30;10(1):73. doi: 10.1186/s13195-018-0372-0.

46.

Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Kearsley-Fleet L, Davies R, De Cock D, Watson KD, Lunt M, Buch MH, Isaacs JD, Hyrich KL; BSRBR-RA Contributors Group.

Ann Rheum Dis. 2018 Oct;77(10):1405-1412. doi: 10.1136/annrheumdis-2018-213378. Epub 2018 Jul 6.

47.

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.

Cooles FAH, Anderson AE, Skelton A, Pratt AG, Kurowska-Stolarska MS, McInnes I, Hilkens CMU, Isaacs JD.

Front Immunol. 2018 May 9;9:755. doi: 10.3389/fimmu.2018.00755. eCollection 2018.

48.

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.

Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M, Plant D, Colombo M, Orchard P, Twigg S, McInnes IB, Porter D, Freeston JE, Nam JL, Cordell HJ, Isaacs JD, Strathdee JL, Arnett D, de Hair MJH, Tak PP, Aslibekyan S, van Vollenhoven RF, Padyukov L, Bridges SL, Pitzalis C, Cope AP, Verstappen SMM, Emery P, Barnes MR, Agakov F, McKeigue P, Mushiroda T, Kubo M, Weinshilboum R, Barton A, Morgan AW, Barrett JH; MATURA; and PAMERA; Consortia.

Pharmacogenomics J. 2018 Jul;18(4):528-538. doi: 10.1038/s41397-018-0025-5. Epub 2018 May 25. Review.

49.

A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review.

Teodoro T, Edwards MJ, Isaacs JD.

J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):1308-1319. doi: 10.1136/jnnp-2017-317823. Epub 2018 May 7.

50.

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