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Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Porter LH, Lawrence MG, Wang H, Clark AK, Bakshi A, Obinata D, Goode D, Papargiris M, Mural, Clouston D, Ryan A, Norden S, Corey E, Nelson PS, Isaacs JT, Grummet J, Kourambas J, Sandhu S, Murphy DG, Pook D, Frydenberg M, Taylor RA, Risbridger GP.

Prostate. 2019 Jun 18. doi: 10.1002/pros.23839. [Epub ahead of print]


Potential Pharmacologic Targets for the Prevention of Rheumatoid Arthritis.

Isaacs JD, Iqbal K.

Clin Ther. 2019 May 16. pii: S0149-2918(19)30184-5. doi: 10.1016/j.clinthera.2019.04.020. [Epub ahead of print]


Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan TL, Huang J, Davicioni E, An SS, Riddle RC, Thorek DL, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ.

Cancer Res. 2019 May 23. pii: canres.2931.2018. doi: 10.1158/0008-5472.CAN-18-2931. [Epub ahead of print]


Keratinocyte growth factor impairs human thymic recovery from lymphopenia.

Coles AJ, Azzopardi L, Kousin-Ezewu O, Mullay HK, Thompson SA, Jarvis L, Davies J, Howlett S, Rainbow D, Babar J, Sadler TJ, Brown JWL, Needham E, May K, Georgieva ZG, Handel AE, Maio S, Deadman M, Rota I, Holländer G, Dawson S, Jayne D, Seggewiss-Bernhardt R, Douek DC, Isaacs JD, Jones JL.

JCI Insight. 2019 May 7;5. pii: 125377. doi: 10.1172/jci.insight.125377.


Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39.

Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJ, Ikari K, Yamanaka H, Saevarsdottir S, Padyukov L, Bridges SL Jr, Kimberly RP, Okada Y, van Riel PLC, Wolbink G, van der Horst-Bruinsma IE, de Vries N, Tak PP, Ohmura K, Canhão H, Guchelaar HJ, Huizinga TW, Criswell LA, Raychaudhuri S, Weinblatt ME, Wilson AG, Mariette X, Isaacs JD, Morgan AW, Pitzalis C, Barton A, McKeigue P.

Ann Rheum Dis. 2019 Apr 29. pii: annrheumdis-2018-214877. doi: 10.1136/annrheumdis-2018-214877. [Epub ahead of print]


White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH.

Alzheimers Dement (N Y). 2019 Apr 9;5:107-117. doi: 10.1016/j.trci.2019.02.001. eCollection 2019. Review.


Adoption of New Medical Technologies: The Case of Customized Individually Made Knee Implants.

Namin AT, Jalali MS, Vahdat V, Bedair HS, O'Connor MI, Kamarthi S, Isaacs JA.

Value Health. 2019 Apr;22(4):423-430. doi: 10.1016/j.jval.2019.01.008. Epub 2019 Mar 6.


In Reply to the Letter to the Editor from Raj et al.: Clinical Evidence Indicates Allogeneic Mesenchymal Stem Cells Do Not Pose a Significant Risk for Cancer Progression in the Context of Cell-Based Drug Delivery.

Brennen WN, Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Denmeade SR.

Stem Cells Transl Med. 2019 Mar 29. doi: 10.1002/sctm.19-0068. [Epub ahead of print] No abstract available.


Remote detection of radioactive material using mid-IR laser-driven electron avalanche.

Schwartz RM, Woodbury D, Isaacs J, Sprangle P, Milchberg HM.

Sci Adv. 2019 Mar 22;5(3):eaav6804. doi: 10.1126/sciadv.aav6804. eCollection 2019 Mar.


The London memory service audit and quality improvement programme.

Cook LD, Nichol KE, Isaacs JD.

BJPsych Bull. 2019 Mar 22:1-6. doi: 10.1192/bjb.2019.18. [Epub ahead of print]


Design of experiments and the virtual PCR simulator: An online game for pharmaceutical scientists and biotechnologists.

Fellermann H, Shirt-Ediss B, Kozyra J, Linsley M, Lendrem D, Isaacs J, Howard T.

Pharm Stat. 2019 Feb 21. doi: 10.1002/pst.1932. [Epub ahead of print] No abstract available.


Implantation of Acellular Nerve Allograft Using Nerve Connectors.

Isaacs J, Mallu S, Patel G, Kite A, Shah S, Graham GP.

Hand (N Y). 2019 Feb 19:1558944719828009. doi: 10.1177/1558944719828009. [Epub ahead of print]


Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer.

Akinboye ES, Brennen WN, Denmeade SR, Isaacs JT.

Asian J Urol. 2019 Jan;6(1):99-108. doi: 10.1016/j.ajur.2018.11.004. Epub 2018 Nov 28. Review.


Routine musculoskeletal ultrasound findings impact diagnostic decisions maximally in autoantibody-seronegative early arthritis patients.

Iqbal K, Lendrem DW, Hargreaves B, Isaacs JD, Thompson B, Pratt AG.

Rheumatology (Oxford). 2019 Feb 8. doi: 10.1093/rheumatology/kez008. [Epub ahead of print]


Expression of STAT3-regulated genes in circulating CD4+ T cells discriminates rheumatoid arthritis independently of clinical parameters in early arthritis.

Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG.

Rheumatology (Oxford). 2019 Feb 8. doi: 10.1093/rheumatology/kez003. [Epub ahead of print]


A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.

Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Brennen WN, Denmeade SR.

Stem Cells Transl Med. 2019 May;8(5):441-449. doi: 10.1002/sctm.18-0230. Epub 2019 Feb 8.


Nerve transfers for peripheral nerve injury in the upper limb: a case-based review.

Isaacs J, Cochran AR.

Bone Joint J. 2019 Feb;101-B(2):124-131. doi: 10.1302/0301-620X.101B2.BJJ-2018-0839.R1. Review.


Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients.

Wood MJ, Leckenby A, Reynolds G, Spiering R, Pratt AG, Rankin KS, Isaacs JD, Haniffa MA, Milling S, Hilkens CM.

JCI Insight. 2019 Jan 24;4(2). pii: 125325. doi: 10.1172/jci.insight.125325. [Epub ahead of print]


Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Krueger TE, Thorek DLJ, Meeker AK, Isaacs JT, Brennen WN.

Prostate. 2019 Feb;79(3):320-330. doi: 10.1002/pros.23738. Epub 2018 Nov 28.


Pharmacologic Exhaustion of Suppressor Cells with Tasquinimod Enhances Bacterial Clearance during Tuberculosis.

Gupta S, Krug S, Pokkali S, Leanderson T, Isaacs JT, Srikrishna G, Bishai WR.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):386-389. doi: 10.1164/rccm.201805-0820LE. No abstract available.


Tolerising cellular therapies: what is their promise for autoimmune disease?

Mosanya CH, Isaacs JD.

Ann Rheum Dis. 2019 Mar;78(3):297-310. doi: 10.1136/annrheumdis-2018-214024. Epub 2018 Nov 2.


Therapeutic tolerance in autoimmune disease.

Rayner F, Isaacs JD.

Semin Arthritis Rheum. 2018 Dec;48(3):558-562. doi: 10.1016/j.semarthrit.2018.09.008. Epub 2018 Sep 28. Review.


Checks and balances occur not only in government, but also in biology.

Isaacs JT.

Oncotarget. 2018 Sep 4;9(69):33054-33055. doi: 10.18632/oncotarget.25876. eCollection 2018 Sep 4. No abstract available.


Mesenchymal stem cells and the embryonic reawakening theory of BPH.

Brennen WN, Isaacs JT.

Nat Rev Urol. 2018 Nov;15(11):703-715. doi: 10.1038/s41585-018-0087-9. Review.


Effect of Reverse End-to-Side (Supercharging) Neurotization in Long Processed Acellular Nerve Allograft in a Rat Model.

Isaacs J, Patel G, Mallu S, Ugwu-Oju O, Desai A, Borschel G, David D, Protzuk O, Shah S, Semus R.

J Hand Surg Am. 2019 May;44(5):419.e1-419.e10. doi: 10.1016/j.jhsa.2018.07.008. Epub 2018 Aug 29.


Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P, Isaacs J, Cordell H, Pitzalis C, Barton A; BRAGGSS, MATURA Consortium.

Pharmacogenomics J. 2018 Sep;18(5):657-664. doi: 10.1038/s41397-018-0040-6. Epub 2018 Aug 31.


Environmental Calcium Initiates a Feed-Forward Signaling Circuit That Regulates Biofilm Formation and Rugosity in Vibrio vulnificus.

Chodur DM, Coulter P, Isaacs J, Pu M, Fernandez N, Waters CM, Rowe-Magnus DA.

MBio. 2018 Aug 28;9(4). pii: e01377-18. doi: 10.1128/mBio.01377-18.


Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models.

Navone NM, van Weerden WM, Vessella RL, Williams ED, Wang Y, Isaacs JT, Nguyen HM, Culig Z, van der Pluijm G, Rentsch CA, Marques RB, de Ridder CMA, Bubendorf L, Thalmann GN, Brennen WN, Santer FR, Moser PL, Shepherd P, Efstathiou E, Xue H, Lin D, Buijs J, Bosse T, Collins A, Maitland N, Buzza M, Kouspou M, Achtman A, Taylor RA, Risbridger G, Corey E.

Prostate. 2018 Dec;78(16):1262-1282. doi: 10.1002/pros.23701. Epub 2018 Aug 2.


Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.

Krueger TEG, Thorek DLJ, Denmeade SR, Isaacs JT, Brennen WN.

Stem Cells Transl Med. 2018 Sep;7(9):651-663. doi: 10.1002/sctm.18-0024. Epub 2018 Aug 1. Review.


Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

Williams NH, Jenkins A, Goulden N, Hoare Z, Hughes DA, Wood E, Foster NE, Walsh D, Carnes D, Sparkes V, Hay EM, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S, Wilkinson C.

Trials. 2018 Jul 31;19(1):408. doi: 10.1186/s13063-018-2801-6.


Correction to: The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer's disease.

Ritchie CW, Russ TC, Banerjee S, Barber B, Boaden A, Fox NC, Holmes C, Isaacs JD, Leroi I, Lovestone S, Norton M, O'Brien J, Pearson J, Perry R, Pickett J, Waldman AD, Wong WL, Rossor MN, Burns A.

Alzheimers Res Ther. 2018 Jul 30;10(1):73. doi: 10.1186/s13195-018-0372-0.


Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Kearsley-Fleet L, Davies R, De Cock D, Watson KD, Lunt M, Buch MH, Isaacs JD, Hyrich KL; BSRBR-RA Contributors Group.

Ann Rheum Dis. 2018 Oct;77(10):1405-1412. doi: 10.1136/annrheumdis-2018-213378. Epub 2018 Jul 6.


Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis.

Cooles FAH, Anderson AE, Skelton A, Pratt AG, Kurowska-Stolarska MS, McInnes I, Hilkens CMU, Isaacs JD.

Front Immunol. 2018 May 9;9:755. doi: 10.3389/fimmu.2018.00755. eCollection 2018.


Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients.

Taylor JC, Bongartz T, Massey J, Mifsud B, Spiliopoulou A, Scott IC, Wang J, Morgan M, Plant D, Colombo M, Orchard P, Twigg S, McInnes IB, Porter D, Freeston JE, Nam JL, Cordell HJ, Isaacs JD, Strathdee JL, Arnett D, de Hair MJH, Tak PP, Aslibekyan S, van Vollenhoven RF, Padyukov L, Bridges SL, Pitzalis C, Cope AP, Verstappen SMM, Emery P, Barnes MR, Agakov F, McKeigue P, Mushiroda T, Kubo M, Weinshilboum R, Barton A, Morgan AW, Barrett JH; MATURA; and PAMERA; Consortia.

Pharmacogenomics J. 2018 Jul;18(4):528-538. doi: 10.1038/s41397-018-0025-5. Epub 2018 May 25. Review.


A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review.

Teodoro T, Edwards MJ, Isaacs JD.

J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):1308-1319. doi: 10.1136/jnnp-2017-317823. Epub 2018 May 7. Review.


Soft Tissue Atrophy Related to Corticosteroid Injection: Review of the Literature and Implications for Hand Surgeons.

Pace CS, Blanchet NP, Isaacs JE.

J Hand Surg Am. 2018 Jun;43(6):558-563. doi: 10.1016/j.jhsa.2018.03.004. Epub 2018 Apr 3. Review.


Tendon Adhesions: A Novel Method of Objectively Measuring Adhesions by Assessing Tendon Glide Through a Soft Tissue Envelope in a Rat Model.

Riley A, Isaacs JE, Cotterell I, Stromberg J, Mallu S, Patel G.

J Hand Surg Am. 2018 Dec;43(12):1134.e1-1134.e6. doi: 10.1016/j.jhsa.2018.02.033. Epub 2018 Mar 28.


The what, when, and why of human prostate cancer xenografts.

Brennen WN, Isaacs JT.

Prostate. 2018 Jun;78(9):646-654. doi: 10.1002/pros.23510. Epub 2018 Mar 24. Review.


2-fluoro-5-maleimidobenzoic acid-linked albumin drug (MAD) delivery for selective systemic targeting of metastatic prostate cancer.

Akinboye ES, Rogers OC, Isaacs JT.

Prostate. 2018 Jun;78(9):655-663. doi: 10.1002/pros.23494. Epub 2018 Mar 24.


Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury.

McClure MJ, Cohen DJ, Ramey AN, Bivens CB, Mallu S, Isaacs JE, Imming E, Huang YC, Sunwoo M, Schwartz Z, Boyan BD.

Tissue Eng Part A. 2018 Aug;24(15-16):1228-1241. doi: 10.1089/ten.TEA.2017.0386. Epub 2018 Mar 27.


Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.


Appropriateness of patients transferred with orthopedic injuries: experience of a level I trauma center.

O'Connell RS, Haug EC, Malasitt P, Mallu S, Satpathy J, Isaacs J, Mounasamy V.

Eur J Orthop Surg Traumatol. 2018 May;28(4):551-554. doi: 10.1007/s00590-018-2134-x. Epub 2018 Jan 27.


Corrigendum: The RA-MAP Consortium: a working model for academia-industry collaboration.

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulze-Knappe P, Sleeman MA, Symmons D, Taylor PC, Tom B, Tsuji W, Verbeeck D, Isaacs JD; RA-MAP Consortium.

Nat Rev Rheumatol. 2018 Jan 24;14(2):119. doi: 10.1038/nrrheum.2018.6.


Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling.

Daoud A, Gopal U, Kaur J, Isaacs JS.

Oncotarget. 2017 Nov 3;8(63):106807-106819. doi: 10.18632/oncotarget.22370. eCollection 2017 Dec 5.


The effect of phosphodiesterase-5 inhibitors on cerebral blood flow in humans: A systematic review.

Pauls MM, Moynihan B, Barrick TR, Kruuse C, Madigan JB, Hainsworth AH, Isaacs JD.

J Cereb Blood Flow Metab. 2018 Feb;38(2):189-203. doi: 10.1177/0271678X17747177. Epub 2017 Dec 19.


Corrigendum: Synovial tissue research: a state-of-the-art review.

Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Goff BL, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Tas SW, Thurlings R, Fonseca JE, Veale DJ.

Nat Rev Rheumatol. 2017 Dec 19;14(1):60. doi: 10.1038/nrrheum.2017.206.


The RA-MAP Consortium: a working model for academia-industry collaboration.

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA, Symmons D, Taylor PC, Tom B, Tsuji W, Verbeeck D, Isaacs JD; RA-MAP Consortium.

Nat Rev Rheumatol. 2018 Jan;14(1):53-60. doi: 10.1038/nrrheum.2017.200. Epub 2017 Dec 7. Review. Erratum in: Nat Rev Rheumatol. 2018 Jan 24;14 (2):119.


CD4+ and B Lymphocyte Expression Quantitative Traits at Rheumatoid Arthritis Risk Loci in Patients With Untreated Early Arthritis: Implications for Causal Gene Identification.

Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG.

Arthritis Rheumatol. 2018 Mar;70(3):361-370. doi: 10.1002/art.40393. Epub 2018 Jan 30.


Retrospective cohort study on Angio-Seal closure device safety and effectiveness in antegrade superficial femoral artery punctures: A comparison with antegrade common femoral artery punctures.

Adlan T, Shahin Y, Kember P, Isaacs J, Seymour R.

Int J Surg. 2017 Dec;48:225-227. doi: 10.1016/j.ijsu.2017.11.003. Epub 2017 Nov 13.


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