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Items: 43

1.

Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug.

Costa SA, Mozhdehi D, Dzuricky MJ, Isaacs FJ, Brustad EM, Chilkoti A.

Nano Lett. 2019 Jan 9;19(1):247-254. doi: 10.1021/acs.nanolett.8b03837. Epub 2018 Dec 14.

PMID:
30540482
2.

Organisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue.

Ma NJ, Hemez CF, Barber KW, Rinehart J, Isaacs FJ.

Elife. 2018 Oct 30;7. pii: e34878. doi: 10.7554/eLife.34878.

3.

Next-generation genetic code expansion.

Arranz-Gibert P, Vanderschuren K, Isaacs FJ.

Curr Opin Chem Biol. 2018 Oct;46:203-211. doi: 10.1016/j.cbpa.2018.07.020. Epub 2018 Jul 30. Review.

PMID:
30072242
4.

Encoding human serine phosphopeptides in bacteria for proteome-wide identification of phosphorylation-dependent interactions.

Barber KW, Muir P, Szeligowski RV, Rogulina S, Gerstein M, Sampson JR, Isaacs FJ, Rinehart J.

Nat Biotechnol. 2018 Aug;36(7):638-644. doi: 10.1038/nbt.4150. Epub 2018 Jun 11.

PMID:
29889213
5.

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids.

Martin RW, Des Soye BJ, Kwon YC, Kay J, Davis RG, Thomas PM, Majewska NI, Chen CX, Marcum RD, Weiss MG, Stoddart AE, Amiram M, Ranji Charna AK, Patel JR, Isaacs FJ, Kelleher NL, Hong SH, Jewett MC.

Nat Commun. 2018 Mar 23;9(1):1203. doi: 10.1038/s41467-018-03469-5.

6.

Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.

Costa SA, Simon JR, Amiram M, Tang L, Zauscher S, Brustad EM, Isaacs FJ, Chilkoti A.

Adv Mater. 2018 Feb;30(5). doi: 10.1002/adma.201704878. Epub 2017 Dec 11.

7.

Precise Editing at DNA Replication Forks Enables Multiplex Genome Engineering in Eukaryotes.

Barbieri EM, Muir P, Akhuetie-Oni BO, Yellman CM, Isaacs FJ.

Cell. 2017 Nov 30;171(6):1453-1467.e13. doi: 10.1016/j.cell.2017.10.034. Epub 2017 Nov 16.

8.

Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins.

Gan R, Perez JG, Carlson ED, Ntai I, Isaacs FJ, Kelleher NL, Jewett MC.

Biotechnol Bioeng. 2017 May;114(5):1074-1086. doi: 10.1002/bit.26239. Epub 2017 Feb 2.

9.

Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli.

Napolitano MG, Landon M, Gregg CJ, Lajoie MJ, Govindarajan L, Mosberg JA, Kuznetsov G, Goodman DB, Vargas-Rodriguez O, Isaacs FJ, Söll D, Church GM.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5588-97. doi: 10.1073/pnas.1605856113. Epub 2016 Sep 6.

10.

Genomic Recoding Broadly Obstructs the Propagation of Horizontally Transferred Genetic Elements.

Ma NJ, Isaacs FJ.

Cell Syst. 2016 Aug;3(2):199-207. doi: 10.1016/j.cels.2016.06.009. Epub 2016 Jul 14.

11.

GENOME ENGINEERING. The Genome Project-Write.

Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L.

Science. 2016 Jul 8;353(6295):126-7. doi: 10.1126/science.aaf6850. Epub 2016 Jun 2. No abstract available.

PMID:
27256881
12.

Merlin: Computer-Aided Oligonucleotide Design for Large Scale Genome Engineering with MAGE.

Quintin M, Ma NJ, Ahmed S, Bhatia S, Lewis A, Isaacs FJ, Densmore D.

ACS Synth Biol. 2016 Jun 17;5(6):452-8. doi: 10.1021/acssynbio.5b00219. Epub 2016 May 11.

PMID:
27054880
13.

Engineering an allosteric transcription factor to respond to new ligands.

Taylor ND, Garruss AS, Moretti R, Chan S, Arbing MA, Cascio D, Rogers JK, Isaacs FJ, Kosuri S, Baker D, Fields S, Church GM, Raman S.

Nat Methods. 2016 Feb;13(2):177-83. doi: 10.1038/nmeth.3696. Epub 2015 Dec 21.

14.

Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids.

Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ.

Nat Biotechnol. 2015 Dec;33(12):1272-1279. doi: 10.1038/nbt.3372. Epub 2015 Nov 16.

15.

Corrigendum: Recoded organisms engineered to depend on synthetic amino acids.

Rovner AJ, Haimovich AD, Katz SR, Li Z, Grome MW, Gassaway BM, Amiram M, Patel JR, Gallagher RR, Rinehart J, Isaacs FJ.

Nature. 2015 Nov 12;527(7577):264. doi: 10.1038/nature15537. Epub 2015 Sep 23. No abstract available.

PMID:
26416756
16.

Robust production of recombinant phosphoproteins using cell-free protein synthesis.

Oza JP, Aerni HR, Pirman NL, Barber KW, Ter Haar CM, Rogulina S, Amrofell MB, Isaacs FJ, Rinehart J, Jewett MC.

Nat Commun. 2015 Sep 9;6:8168. doi: 10.1038/ncomms9168.

17.

A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylation.

Pirman NL, Barber KW, Aerni HR, Ma NJ, Haimovich AD, Rogulina S, Isaacs FJ, Rinehart J.

Nat Commun. 2015 Sep 9;6:8130. doi: 10.1038/ncomms9130.

18.

Genomes by design.

Haimovich AD, Muir P, Isaacs FJ.

Nat Rev Genet. 2015 Sep;16(9):501-16. doi: 10.1038/nrg3956. Epub 2015 Aug 11. Review.

19.

Repurposing the translation apparatus for synthetic biology.

Soye BJD, Patel JR, Isaacs FJ, Jewett MC.

Curr Opin Chem Biol. 2015 Oct;28:83-90. doi: 10.1016/j.cbpa.2015.06.008. Epub 2015 Jul 15. Review.

20.

Recoded organisms engineered to depend on synthetic amino acids.

Rovner AJ, Haimovich AD, Katz SR, Li Z, Grome MW, Gassaway BM, Amiram M, Patel JR, Gallagher RR, Rinehart J, Isaacs FJ.

Nature. 2015 Feb 5;518(7537):89-93. doi: 10.1038/nature14095. Epub 2015 Jan 21. Erratum in: Nature. 2015 Nov 12;527(7577):264.

21.

Multilayered genetic safeguards limit growth of microorganisms to defined environments.

Gallagher RR, Patel JR, Interiano AL, Rovner AJ, Isaacs FJ.

Nucleic Acids Res. 2015 Feb 18;43(3):1945-54. doi: 10.1093/nar/gku1378. Epub 2015 Jan 7.

22.

Designed phosphoprotein recognition in Escherichia coli.

Sawyer N, Gassaway BM, Haimovich AD, Isaacs FJ, Rinehart J, Regan L.

ACS Chem Biol. 2014 Nov 21;9(11):2502-7. doi: 10.1021/cb500658w. Epub 2014 Oct 6.

23.

Rapid editing and evolution of bacterial genomes using libraries of synthetic DNA.

Gallagher RR, Li Z, Lewis AO, Isaacs FJ.

Nat Protoc. 2014 Oct;9(10):2301-16. doi: 10.1038/nprot.2014.082. Epub 2014 Sep 4.

PMID:
25188632
24.

Precise manipulation of bacterial chromosomes by conjugative assembly genome engineering.

Ma NJ, Moonan DW, Isaacs FJ.

Nat Protoc. 2014 Oct;9(10):2285-300. doi: 10.1038/nprot.2014.081. Epub 2014 Sep 4.

25.

Rational optimization of tolC as a powerful dual selectable marker for genome engineering.

Gregg CJ, Lajoie MJ, Napolitano MG, Mosberg JA, Goodman DB, Aach J, Isaacs FJ, Church GM.

Nucleic Acids Res. 2014 Apr;42(7):4779-90. doi: 10.1093/nar/gkt1374. Epub 2014 Jan 22.

26.

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes.

Bazak L, Haviv A, Barak M, Jacob-Hirsch J, Deng P, Zhang R, Isaacs FJ, Rechavi G, Li JB, Eisenberg E, Levanon EY.

Genome Res. 2014 Mar;24(3):365-76. doi: 10.1101/gr.164749.113. Epub 2013 Dec 17.

27.

Cell-free protein synthesis from a release factor 1 deficient Escherichia coli activates efficient and multiple site-specific nonstandard amino acid incorporation.

Hong SH, Ntai I, Haimovich AD, Kelleher NL, Isaacs FJ, Jewett MC.

ACS Synth Biol. 2014 Jun 20;3(6):398-409. doi: 10.1021/sb400140t. Epub 2014 Jan 2.

28.

Genomically recoded organisms expand biological functions.

Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ.

Science. 2013 Oct 18;342(6156):357-60. doi: 10.1126/science.1241459.

29.

Crystal structure of an insect antifreeze protein and its implications for ice binding.

Hakim A, Nguyen JB, Basu K, Zhu DF, Thakral D, Davies PL, Isaacs FJ, Modis Y, Meng W.

J Biol Chem. 2013 Apr 26;288(17):12295-304. doi: 10.1074/jbc.M113.450973. Epub 2013 Mar 12.

30.

Enhanced phosphoserine insertion during Escherichia coli protein synthesis via partial UAG codon reassignment and release factor 1 deletion.

Heinemann IU, Rovner AJ, Aerni HR, Rogulina S, Cheng L, Olds W, Fischer JT, Söll D, Isaacs FJ, Rinehart J.

FEBS Lett. 2012 Oct 19;586(20):3716-22. doi: 10.1016/j.febslet.2012.08.031. Epub 2012 Sep 13.

31.

Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection.

Carr PA, Wang HH, Sterling B, Isaacs FJ, Lajoie MJ, Xu G, Church GM, Jacobson JM.

Nucleic Acids Res. 2012 Sep 1;40(17):e132. Epub 2012 May 25.

32.

Synthetic biology: Automated design of RNA devices.

Isaacs FJ.

Nat Chem Biol. 2012 Apr 17;8(5):413-5. doi: 10.1038/nchembio.942. No abstract available.

PMID:
22510661
33.

Precise manipulation of chromosomes in vivo enables genome-wide codon replacement.

Isaacs FJ, Carr PA, Wang HH, Lajoie MJ, Sterling B, Kraal L, Tolonen AC, Gianoulis TA, Goodman DB, Reppas NB, Emig CJ, Bang D, Hwang SJ, Jewett MC, Jacobson JM, Church GM.

Science. 2011 Jul 15;333(6040):348-53. doi: 10.1126/science.1205822.

34.

Tracking, tuning, and terminating microbial physiology using synthetic riboregulators.

Callura JM, Dwyer DJ, Isaacs FJ, Cantor CR, Collins JJ.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15898-903. doi: 10.1073/pnas.1009747107. Epub 2010 Aug 16.

35.

Programming cells by multiplex genome engineering and accelerated evolution.

Wang HH, Isaacs FJ, Carr PA, Sun ZZ, Xu G, Forest CR, Church GM.

Nature. 2009 Aug 13;460(7257):894-898. doi: 10.1038/nature08187. Epub 2009 Jul 26.

36.

A brave new synthetic world. A report of the first meeting on 'Frontiers in Synthetic Biology', Boston, USA, 1-2 December 2008.

Isaacs FJ, You L.

Genome Biol. 2009 Feb 3;10(2):302. doi: 10.1186/gb-2009-10-2-302. No abstract available.

37.

Phenotypic consequences of promoter-mediated transcriptional noise.

Blake WJ, Balázsi G, Kohanski MA, Isaacs FJ, Murphy KF, Kuang Y, Cantor CR, Walt DR, Collins JJ.

Mol Cell. 2006 Dec 28;24(6):853-65.

38.

RNA synthetic biology.

Isaacs FJ, Dwyer DJ, Collins JJ.

Nat Biotechnol. 2006 May;24(5):545-54. Review.

PMID:
16680139
39.

Molecular biology. Signal processing in single cells.

Isaacs FJ, Blake WJ, Collins JJ.

Science. 2005 Mar 25;307(5717):1886-8. No abstract available.

PMID:
15790834
40.

Plug-and-play with RNA.

Isaacs FJ, Collins JJ.

Nat Biotechnol. 2005 Mar;23(3):306-7. No abstract available.

PMID:
15765083
41.

Synthetic biology evolves.

Blake WJ, Isaacs FJ.

Trends Biotechnol. 2004 Jul;22(7):321-4.

PMID:
15245901
42.

Engineered riboregulators enable post-transcriptional control of gene expression.

Isaacs FJ, Dwyer DJ, Ding C, Pervouchine DD, Cantor CR, Collins JJ.

Nat Biotechnol. 2004 Jul;22(7):841-7. Epub 2004 Jun 20.

PMID:
15208640
43.

Prediction and measurement of an autoregulatory genetic module.

Isaacs FJ, Hasty J, Cantor CR, Collins JJ.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7714-9. Epub 2003 Jun 13.

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