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In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus.

Abud MB, Louzada RN, Isaac DLC, Souza LG, Dos Reis RG, Lima EM, de Ávila MP.

Int J Retina Vitreous. 2019 Sep 24;5:35. doi: 10.1186/s40942-019-0186-7. eCollection 2019.



Lando L, Isaac DLC, Avila MP.

Retin Cases Brief Rep. 2019 Sep 10. doi: 10.1097/ICB.0000000000000927. [Epub ahead of print]


The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter.

Christenson ET, Isaac DT, Yoshida K, Lipo E, Kim JS, Ghirlando R, Isberg RR, Banerjee A.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17775-17785. doi: 10.1073/pnas.1902806116. Epub 2019 Aug 20.


Proposed guidelines for the management of ESBL in Prosthetic Joint Infections.

Antony S, Khan I, Chowdhury O, Heydemann J, Antony N, Heydemann J, Isaac D.

Infect Disord Drug Targets. 2019 Jun 13. doi: 10.2174/1871526519666190613121936. [Epub ahead of print]


Oct angiography compared to fluorescein angiography, indocyanine green angiography and optical coherence tomography in the detection of choroidal neovascularization in pigment epithelial detachment.

de Oliveira T, Isaac DLC, Garcia JMBB, Schelini MC, Avila MP.

Acta Ophthalmol. 2019 Apr 23. doi: 10.1111/aos.14117. [Epub ahead of print]


Mixed Lipid, Fish Oil, and Soybean Oil Parenteral Lipids Impact Cholestasis, Hepatic Phytosterol, and Lipid Composition.

Isaac DM, Alzaben AS, Mazurak VC, Yap J, Wizzard PR, Nation PN, Zhao YY, Curtis JM, Sergi C, Wales PW, Mager DR, Turner JM.

J Pediatr Gastroenterol Nutr. 2019 Jun;68(6):861-867. doi: 10.1097/MPG.0000000000002313.


Integrating preventive dental care into general Paediatric practice for Indigenous communities: paediatric residents' perceptions.

ElSalhy M, Gill M, Isaac DM, Littlechild R, Baydala L, Amin M.

Int J Circumpolar Health. 2019 Dec;78(1):1573162. doi: 10.1080/22423982.2019.1573162.


Management and outcomes of cardiac sarcoidosis: a 20-year experience in two tertiary care centres.

Fussner LA, Karlstedt E, Hodge DO, Fine NM, Kalra S, Carmona EM, Utz JP, Isaac DL, Cooper LT.

Eur J Heart Fail. 2018 Dec;20(12):1713-1720. doi: 10.1002/ejhf.1319. Epub 2018 Oct 31.


"B in IT" - a community-based model for the management of hepatitis B patients in primary care clinics using a novel web-based clinical tool.

O'Leary DA, Cropp E, Isaac D, Desmond PV, Bell S, Nguyen T, Wong D, Howell J, Richmond J, O'Neill J, Thompson AJ.

Hepatol Med Policy. 2018 Jan 4;3:1. doi: 10.1186/s41124-017-0031-2. eCollection 2018.


Retinal changes in rabbit after intravitreal injection of sunitinib encapsulated into solid lipid nanoparticles and polymeric nanocapsules.

Freitas LGA, Isaac DLC, Lima EM, Souza LG, Abud MA, Reis RGD, Tannure WT, Ávila MP.

Arq Bras Oftalmol. 2018 Sep-Oct;81(5):408-413. doi: 10.5935/0004-2749.20180079.


Implementation of a Multidisciplinary Inpatient Cardiology Service to Improve Heart Failure Outcomes in Guyana.

Klassen SL, Miller RJH, Hao R, Warnica JW, Fine NM, Carpen M, Isaac DL.

J Card Fail. 2018 Dec;24(12):835-841. doi: 10.1016/j.cardfail.2018.07.002. Epub 2018 Aug 17.


Impact of BRCA Mutation Status on Survival of Women With Triple-negative Breast Cancer.

Yadav S, Ladkany R, Yadav D, Alhalabi O, Khaddam S, Isaac D, Cardenas PY, Zakalik D.

Clin Breast Cancer. 2018 Oct;18(5):e1229-e1235. doi: 10.1016/j.clbc.2017.12.014. Epub 2017 Dec 30.


Qualitative Analysis of Pediatric Patient and Caregiver Perspectives After Recent Diagnosis With Inflammatory Bowel Disease.

Kluthe C, Isaac DM, Hiller K, Carroll M, Wine E, van Manen M, Huynh HQ.

J Pediatr Nurs. 2018 Jan - Feb;38:106-113. doi: 10.1016/j.pedn.2017.11.011. Epub 2017 Dec 7.


Benign familial fleck retina: multimodal imaging including optical coherence tomography angiography.

Garcia JMBB, Isaac DLC, Sardeiro T, Aquino É, Avila M.

Arq Bras Oftalmol. 2017 Sep-Oct;80(5):321-323. doi: 10.5935/0004-2749.20170078.


The Canada-Guyana medical education partnership: using videoconferencing to supplement post-graduate medical education among internal medicine trainees.

Stokes W, Ruzycki S, Jainarine R, Isaac D, Cole J.

Can Med Educ J. 2017 Apr 20;8(2):e18-e24. eCollection 2017 Apr.


Practices regarding human Papillomavirus counseling and vaccination in head and neck cancer: a Canadian physician questionnaire.

Anderson S, Isaac A, Jeffery CC, Robinson JL, Isaac DM, Korownyk C, Biron VL, Seikaly H.

J Otolaryngol Head Neck Surg. 2017 Oct 26;46(1):61. doi: 10.1186/s40463-017-0237-8.


Impact of a Pediatric Cardiology Clinical Program on Congenital Heart Disease Outcomes in Guyana.

Isaac D, Nagesh V, Bell A, Soto R, Seepersaud M, Myers K, Zahir S.

Glob Pediatr Health. 2017 Sep 19;4:2333794X17731667. doi: 10.1177/2333794X17731667. eCollection 2017.


Barriers to Goals of Care Discussions With Patients Who Have Advanced Heart Failure: Results of a Multicenter Survey of Hospital-Based Cardiology Clinicians.

You JJ, Aleksova N, Ducharme A, MacIver J, Mielniczuk L, Fowler RA, Demers C, Clarke B, Parent MC, Toma M, Strachan PH, Farand P, Isaac D, Zieroth S, Swinton M, Jiang X, Day AG, Heyland DK, Ross HJ.

J Card Fail. 2017 Nov;23(11):786-793. doi: 10.1016/j.cardfail.2017.06.003. Epub 2017 Jun 23.


Discharge on the day of surgery following unicompartmental knee arthroplasty within the United Kingdom NHS.

Bradley B, Middleton S, Davis N, Williams M, Stocker M, Hockings M, Isaac DL.

Bone Joint J. 2017 Jun;99-B(6):788-792. doi: 10.1302/0301-620X.99B6.BJJ-2016-0540.R2.


Increased left ventricular extracellular volume and enhanced twist function in type 1 diabetic individuals.

Vasanji Z, Sigal RJ, Eves ND, Isaac DL, Friedrich MG, Chow K, Thompson RB.

J Appl Physiol (1985). 2017 Aug 1;123(2):394-401. doi: 10.1152/japplphysiol.00012.2017. Epub 2017 May 18.


Patient-Reported Outcomes following Single- and Multiple-Radius Total Knee Replacement: A Randomized, Controlled Trial.

Mushtaq N, Liddle AD, Isaac D, Dillow K, Gill P.

J Knee Surg. 2018 Jan;31(1):87-91. doi: 10.1055/s-0037-1602132. Epub 2017 May 5.


Diabetic retinopathy and OCT angiography: clinical findings and future perspectives.

de Barros Garcia JMB, Isaac DLC, Avila M.

Int J Retina Vitreous. 2017 Mar 13;3:14. doi: 10.1186/s40942-017-0062-2. eCollection 2017. Review.


Multicenter evaluation of a national organ sharing policy for highly sensitized patients listed for heart transplantation in Canada.

Clarke B, Ducharme A, Giannetti N, Kim D, McDonald M, Pflugfelder P, Rajda M, Sénéchal M, Stadnick E, Toma M, Zieroth S, Isaac D.

J Heart Lung Transplant. 2017 May;36(5):491-498. doi: 10.1016/j.healun.2017.01.003. Epub 2017 Jan 6.


Orthostatic Hypotension After Continuous-Flow Left Ventricular Assist Device Implantation in a Patient With Longstanding Diabetes Mellitus.

Chew DS, Shaw BH, Isaac DL, Howlett JG, Raj SR.

Can J Cardiol. 2017 Apr;33(4):555.e5-555.e7. doi: 10.1016/j.cjca.2016.10.025. Epub 2016 Oct 28.


Antitissue Transglutaminase Normalization Postdiagnosis in Children With Celiac Disease.

Isaac DM, Rajani S, Yaskina M, Huynh HQ, Turner JM.

J Pediatr Gastroenterol Nutr. 2017 Aug;65(2):195-199. doi: 10.1097/MPG.0000000000001480.


Diabetic Macular Ischemia Diagnosis: Comparison between Optical Coherence Tomography Angiography and Fluorescein Angiography.

Garcia JM, Lima TT, Louzada RN, Rassi AT, Isaac DL, Avila M.

J Ophthalmol. 2016;2016:3989310. Epub 2016 Nov 7.


Managing the pediatric patient with celiac disease: a multidisciplinary approach.

Isaac DM, Wu J, Mager DR, Turner JM.

J Multidiscip Healthc. 2016 Oct 13;9:529-536. eCollection 2016. Review.


An Algorithm Measuring Donor Cell-Free DNA in Plasma of Cellular and Solid Organ Transplant Recipients That Does Not Require Donor or Recipient Genotyping.

Gordon PM, Khan A, Sajid U, Chang N, Suresh V, Dimnik L, Lamont RE, Parboosingh JS, Martin SR, Pon RT, Weatherhead J, Wegener S, Isaac D, Greenway SC.

Front Cardiovasc Med. 2016 Sep 22;3:33. eCollection 2016.


Dexamethasone 0.7 mg implants in the management of pseudophakic cystoid macular edema.

Garcia JM, Isaac DL, Ávila MP.

Arq Bras Oftalmol. 2016 Apr;79(2):113-5. doi: 10.5935/0004-2749.20160033.


Initial experience with ocriplasmin in the treatment of vitreomacular traction.

Garcia JM, Isaac DL, Ávila M.

Arq Bras Oftalmol. 2016 Apr;79(2):85-7. doi: 10.5935/0004-2749.20160026.


Cardiopulmonary Exercise Testing and Outcomes in Women With Heart Failure-Examining the "Female Advantage".

Isaac DL.

Can J Cardiol. 2016 Jun;32(6):720-1. doi: 10.1016/j.cjca.2015.10.018. Epub 2015 Nov 11. No abstract available.


Canadian Forum on Combined Organ Transplantation.

Cantarovich M, Blydt-Hansen TD, Gill J, Tinckam K, Schiff J, Alwayn I, Bain V, Dipchand AI, Isaac D, Kim SJ, Lien D, Zaltzman J, Young K, Nickerson P.

Transplantation. 2016 Jun;100(6):1339-48. doi: 10.1097/TP.0000000000000963.


The Effect of Transient Local Anti-inflammatory Treatment on the Survival of Pig Retinal Progenitor Cell Allotransplants.

Abud M, Baranov P, Hicks C, Patel S, Lieppman B, Regatieri C, Sinden J, Isaac D, Avila M, Young M.

Transl Vis Sci Technol. 2015 Sep 22;4(5):6. eCollection 2015 Sep.


MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth.

Isaac DT, Laguna RK, Valtz N, Isberg RR.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5208-17. doi: 10.1073/pnas.1511389112. Epub 2015 Sep 1.


Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 during H. capsulatum infection.

Isaac DT, Berkes CA, English BC, Murray DH, Lee YN, Coady A, Sil A.

Mol Microbiol. 2015 Dec;98(5):910-929. doi: 10.1111/mmi.13168. Epub 2015 Sep 29.


Let's talk chronic heart failure.

Slawnych M, Sharma N, Isaac D, Simon J.

CMAJ. 2015 Aug 11;187(11):828. doi: 10.1503/cmaj.1150052. No abstract available.


Cytotoxicity and genotoxicity of intravitreal adalimumab administration in rabbit retinal cells.

Paula ÁC, Ávila MP, Isaac DL, Salustiano R, Lima AP, Mello FM, Pereira Fde C, Silva PH, Lacerda Ede P.

Arq Bras Oftalmol. 2015 Mar-Apr;78(2):89-93. doi: 10.5935/0004-2749.20150024.


Hemorrhagic retinopathy in an infant with hemolytic-uremic syndrome.

Geraissate JC, Yamamoto RE, Isaac DL, Ávila MP.

Arq Bras Oftalmol. 2014 Nov-Dec;77(6):397-9. doi: 10.5935/0004-2749.20140099.


The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Focus Update: anemia, biomarkers, and recent therapeutic trial implications.

Moe GW, Ezekowitz JA, O'Meara E, Lepage S, Howlett JG, Fremes S, Al-Hesayen A, Heckman GA, Abrams H, Ducharme A, Estrella-Holder E, Grzeslo A, Harkness K, Koshman SL, McDonald M, McKelvie R, Rajda M, Rao V, Swiggum E, Virani S, Zieroth S, Arnold JM, Ashton T, D'Astous M, Chan M, De S, Dorian P, Giannetti N, Haddad H, Isaac DL, Kouz S, Leblanc MH, Liu P, Ross HJ, Sussex B, White M; Canadian Cardiovascular Society.

Can J Cardiol. 2015 Jan;31(1):3-16. doi: 10.1016/j.cjca.2014.10.022. Epub 2014 Dec 19. Erratum in: Can J Cardiol. 2016 Mar;32(3):394.


Satisfaction in open access versus traditional referral for upper endoscopy in children.

Isaac DM, Persad R, Huynh HQ, Shirton L, Turner JM.

J Pediatr Gastroenterol Nutr. 2015 May;60(5):637-41. doi: 10.1097/MPG.0000000000000677.


Transient spectral domain optical coherence tomography findings in classic MEWDS: a case report.

Lavigne LC, Isaac DL, Duarte Júnior JO, Avila MP.

Arq Bras Oftalmol. 2014 May-Jun;77(3):185-7.


The effect of obesity and increasing age on operative time and length of stay in primary hip and knee arthroplasty.

Bradley BM, Griffiths SN, Stewart KJ, Higgins GA, Hockings M, Isaac DL.

J Arthroplasty. 2014 Oct;29(10):1906-10. doi: 10.1016/j.arth.2014.06.002. Epub 2014 Jun 7.


Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets.

Isaac DT, Isberg R.

Future Microbiol. 2014;9(3):343-59. doi: 10.2217/fmb.13.162. Review.


Design of a comprehensive biochemistry and molecular biology experiment: phase variation caused by recombinational regulation of bacterial gene expression.

Sheng X, Xu S, Lu R, Isaac D, Zhang X, Zhang H, Wang H, Qiao Z, Huang X.

Biochem Mol Biol Educ. 2014 May-Jun;42(3):224-9. doi: 10.1002/bmb.20772. Epub 2014 Feb 17.


An Internet-Based Counseling Intervention With Email Reminders that Promotes Self-Care in Adults With Chronic Heart Failure: Randomized Controlled Trial Protocol.

Nolan RP, Payne AY, Ross H, White M, D'Antono B, Chan S, Barr SI, Gwadry-Sridhar F, Nigam A, Perreault S, Farkouh M, McDonald M, Goodman J, Thomas S, Zieroth S, Isaac D, Oh P, Rajda M, Chen M, Eysenbach G, Liu S, Zbib A.

JMIR Res Protoc. 2014 Jan 30;3(1):e5. doi: 10.2196/resprot.2957.


The 2013 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: focus on rehabilitation and exercise and surgical coronary revascularization.

Canadian Cardiovascular Society Heart Failure Management Primary Panel, Moe GW, Ezekowitz JA, O'Meara E, Howlett JG, Fremes SE, Al-Hesayen A, Heckman GA, Ducharme A, Estrella-Holder E, Grzeslo A, Harkness K, Lepage S, McDonald M, McKelvie RS, Nigam A, Rajda M, Rao V, Swiggum E, Virani S, Van Le V, Zieroth S; Canadian Cardiovascular Society Heart Failure Management Secondary Panel, Arnold JM, Ashton T, D'Astous M, Dorian P, Giannetti N, Haddad H, Isaac DL, Kouz S, Leblanc MH, Liu P, Ross HJ, Sussex B, White M.

Can J Cardiol. 2014 Mar;30(3):249-63. doi: 10.1016/j.cjca.2013.10.010. Epub 2013 Oct 19. Review.


Cardiac signaling molecules and plasma biomarkers after cardiac transplantation: impact of tacrolimus versus cyclosporine.

White M, Cantin B, Haddad H, Kobashigawa JA, Ross H, Carrier M, Pflugfelder PW, Isaac D, Cecere R, Whittom L, Ali IS, Wang SH, He Y, Groulx A, Touyz RM.

J Heart Lung Transplant. 2013 Dec;32(12):1222-32. doi: 10.1016/j.healun.2013.09.010.


Primary cardiac graft failure-defining, predicting, preventing.

Isaac D.

J Heart Lung Transplant. 2013 Dec;32(12):1168-9. doi: 10.1016/j.healun.2013.10.012. Epub 2013 Oct 14. No abstract available.


Intravitreal bevacizumab combined with infliximab in the treatment of choroidal neovascularization secondary to age-related macular degeneration: case report series.

Freitas LG, Isaac DL, Tannure WT, Gabriel LA, Reis RG, Rassi AR, Freitas CA, Ávila MP.

Arq Bras Oftalmol. 2013 May-Jun;76(3):180-4.


Culture-bound syndromes in mental health: a discussion paper.

Isaac D.

J Psychiatr Ment Health Nurs. 2013 Apr;20(4):355-61. doi: 10.1111/jpm.12016. No abstract available.


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