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Items: 39

1.

Testing an aflatoxin B1 gene signature in rat archival tissues.

Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR.

Chem Res Toxicol. 2012 May 21;25(5):1132-44. doi: 10.1021/tx3000945. Epub 2012 May 4.

2.

Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.

Zheng C, Voutetakis A, Goldstein B, Afione S, Rivera VM, Clackson T, Wenk ML, Boyle M, Nyska A, Chiorini JA, Vallant M, Irwin RD, Baum BJ.

Toxicol Sci. 2011 Sep;123(1):247-55. doi: 10.1093/toxsci/kfr144. Epub 2011 May 30.

3.

Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning.

Auerbach SS, Shah RR, Mav D, Smith CS, Walker NJ, Vallant MK, Boorman GA, Irwin RD.

Toxicol Appl Pharmacol. 2010 Mar 15;243(3):300-14. doi: 10.1016/j.taap.2009.11.021. Epub 2009 Dec 11.

PMID:
20004213
4.

Gene set enrichment analysis for non-monotone association and multiple experimental categories.

Lin R, Dai S, Irwin RD, Heinloth AN, Boorman GA, Li L.

BMC Bioinformatics. 2008 Nov 14;9:481. doi: 10.1186/1471-2105-9-481.

5.

A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein.

Auerbach SS, Mahler J, Travlos GS, Irwin RD.

Toxicology. 2008 Nov 20;253(1-3):79-88. doi: 10.1016/j.tox.2008.08.014. Epub 2008 Sep 4.

6.

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS.

Genome Biol. 2008;9(6):R100. doi: 10.1186/gb-2008-9-6-r100. Epub 2008 Jun 20.

7.

Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.

Voutetakis A, Zheng C, Wang J, Goldsmith CM, Afione S, Chiorini JA, Wenk ML, Vallant M, Irwin RD, Baum BJ.

Hum Gene Ther. 2007 Nov;18(11):1109-18.

PMID:
17939749
8.

Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age.

Mori K, Blackshear PE, Lobenhofer EK, Parker JS, Orzech DP, Roycroft JH, Walker KL, Johnson KA, Marsh TA, Irwin RD, Boorman GA.

Toxicol Pathol. 2007 Feb;35(2):242-51.

PMID:
17366318
10.

Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.

Zheng C, Goldsmith CM, Mineshiba F, Chiorini JA, Kerr A, Wenk ML, Vallant M, Irwin RD, Baum BJ.

Hum Gene Ther. 2006 Nov;17(11):1122-33.

PMID:
17069536
11.

Gene interaction network analysis suggests differences between high and low doses of acetaminophen.

Toyoshiba H, Sone H, Yamanaka T, Parham FM, Irwin RD, Boorman GA, Portier CJ.

Toxicol Appl Pharmacol. 2006 Sep 15;215(3):306-16. Epub 2006 May 15.

PMID:
16701773
12.

Toxicity and biodistribution of a first-generation recombinant adenoviral vector, in the presence of hydroxychloroquine, following retroductal delivery to a single rat submandibular gland.

Zheng C, Voutetakis A, Kok MR, Goldsmith CM, Smith GB, Elmore S, Nyska A, Vallant M, Irwin RD, Baum BJ.

Oral Dis. 2006 Mar;12(2):137-44.

PMID:
16476034
13.

A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen.

Irwin RD.

J Appl Toxicol. 2006 Jan-Feb;26(1):72-80. Review.

PMID:
16193534
14.

Hepatic gene expression changes throughout the day in the Fischer rat: implications for toxicogenomic experiments.

Boorman GA, Blackshear PE, Parker JS, Lobenhofer EK, Malarkey DE, Vallant MK, Gerken DK, Irwin RD.

Toxicol Sci. 2005 Jul;86(1):185-93. Epub 2005 Apr 6.

PMID:
15814895
15.

Transcriptional profiling of the left and median liver lobes of male f344/n rats following exposure to acetaminophen.

Irwin RD, Parker JS, Lobenhofer EK, Burka LT, Blackshear PE, Vallant MK, Lebetkin EH, Gerken DF, Boorman GA.

Toxicol Pathol. 2005;33(1):111-7.

PMID:
15805062
16.

Variation in the hepatic gene expression in individual male Fischer rats.

Boorman GA, Irwin RD, Vallant MK, Gerken DK, Lobenhofer EK, Hejtmancik MR, Hurban P, Brys AM, Travlos GS, Parker JS, Portier CJ.

Toxicol Pathol. 2005;33(1):102-10.

PMID:
15805061
18.

Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data.

Irwin RD, Boorman GA, Cunningham ML, Heinloth AN, Malarkey DE, Paules RS.

Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:72-83. Review.

PMID:
15209406
19.

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

Heinloth AN, Irwin RD, Boorman GA, Nettesheim P, Fannin RD, Sieber SO, Snell ML, Tucker CJ, Li L, Travlos GS, Vansant G, Blackshear PE, Tennant RW, Cunningham ML, Paules RS.

Toxicol Sci. 2004 Jul;80(1):193-202. Epub 2004 Apr 14.

PMID:
15084756
20.

Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.

Hayashi SM, Ton TV, Hong HH, Irwin RD, Haseman JK, Devereux TR, Sills RC.

Chem Biol Interact. 2003 Dec 15;146(3):251-61.

PMID:
14642737
21.

Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice.

Irwin RD, French JE, Elwell M, Haseman J, Braun AG, Voelker FA.

J Appl Toxicol. 1999 Mar-Apr;19(2):125-32.

PMID:
10215184
22.

Glycine modulates the toxicity of benzyl acetate in F344 rats.

Abdo KM, Wenk ML, Harry GJ, Mahler J, Goehl TJ, Irwin RD.

Toxicol Pathol. 1998 May-Jun;26(3):395-402.

PMID:
9608646
23.

Toxicity of furfuryl alcohol to F344 rats and B6C3F1 mice exposed by inhalation.

Irwin RD, Chou BJ, Mellick PW, Miller RA, Mahler J, Roycroft J.

J Appl Toxicol. 1997 May-Jun;17(3):159-69.

PMID:
9250537
24.
25.

Carcinogenicity of glycidol in F344 rats and B6C3F1 mice.

Irwin RD, Eustis SL, Stefanski S, Haseman JK.

J Appl Toxicol. 1996 May-Jun;16(3):201-9.

PMID:
8818859
26.

Tumors of the bladder, kidney, and intestine of F344 rats and liver of B6C3F1 mice administered o-nitroanisole in feed.

Irwin RD, Chhabra R, Eustis S, Pinter A, Prejean JD.

Fundam Appl Toxicol. 1996 Mar;30(1):1-12.

PMID:
8812201
27.

Mixed dentition analysis: a review of methods and their accuracy.

Irwin RD, Herold JS, Richardson A.

Int J Paediatr Dent. 1995 Sep;5(3):137-42. Review.

PMID:
9601233
28.

Induction of thymic lymphoma in mice administered the dideoxynucleoside ddC.

Sanders VM, Elwell MR, Heath JE, Collins BJ, Dunnick JK, Rao GN, Prejean D, Lindamood C 3rd, Irwin RD.

Fundam Appl Toxicol. 1995 Sep;27(2):263-9.

PMID:
8529822
29.

1,2,3-Trichloropropane: a multisite carcinogen in rats and mice.

Irwin RD, Haseman JK, Eustis SL.

Fundam Appl Toxicol. 1995 May;25(2):241-52.

PMID:
7665008
30.

Toxicokinetics of pentachlorophenol in the F344 rat. Gavage and dosed feed studies.

Yuan JH, Goehl TJ, Murrill E, Moore R, Clark J, Hong HL, Irwin RD.

Xenobiotica. 1994 Jun;24(6):553-60.

PMID:
7975721
31.

Zidovudine bioavailability and linear pharmacokinetics in female B6C3F1 mice.

Trang JM, Prejean JD, James RH, Irwin RD, Goehl TJ, Page JG.

Drug Metab Dispos. 1993 Jan-Feb;21(1):189-93.

PMID:
8095218
32.

Disposition of [14C]furan in the male F344 rat.

Burka LT, Washburn KD, Irwin RD.

J Toxicol Environ Health. 1991 Oct;34(2):245-57.

PMID:
1920528
33.

Hematologic toxicity of AZT and ddC administered as single agents and in combination to rats and mice.

Thompson MB, Dunnick JK, Sutphin ME, Giles HD, Irwin RD, Prejean JD.

Fundam Appl Toxicol. 1991 Jul;17(1):159-76.

PMID:
1655546
34.

Furan-induced hepatic cholangiocarcinomas in Fischer 344 rats.

Maronpot RR, Giles HD, Dykes DJ, Irwin RD.

Toxicol Pathol. 1991;19(4 Pt 2):561-70.

PMID:
1668599
35.

Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione.

Lapadula DM, Irwin RD, Suwita E, Abou-Donia MB.

J Neurochem. 1986 Jun;46(6):1843-50.

PMID:
3084709
36.

The effect of 2450-MHz microwave radiation during microtubular polymerization in vitro.

Ortner MJ, Galvin MJ, Irwin RD.

Radiat Res. 1983 Feb;93(2):353-63.

PMID:
6823518
37.

Effects of ionizing radiation on the polymerization of microtubules in vitro.

Zaremba TG, Irwin RD.

Biochemistry. 1981 Mar 3;20(5):1323-32.

PMID:
7225332
38.

Effect of 60Co gamma irradiation on the polymerization of microtubules in vitro.

Zaremba TG, Irwin RD.

Radiat Res. 1977 Aug;71(2):300-10. No abstract available.

PMID:
897069
39.

Effect of chemically modified 70S RNA from avian myeloblastosis virus (AMV) upon the activity of AMV DNA polymerase.

Papas TS, Chirikjian JG, Pry TW, Massicot JG, Irwin RD, Chirigos MA.

J Virol. 1974 Nov;14(5):1108-14.

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