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Items: 1 to 50 of 231

1.

Unexpected mitochondrial genome diversity revealed by targeted single-cell genomics of heterotrophic flagellated protists.

Wideman JG, Monier A, Rodríguez-Martínez R, Leonard G, Cook E, Poirier C, Maguire F, Milner DS, Irwin NAT, Moore K, Santoro AE, Keeling PJ, Worden AZ, Richards TA.

Nat Microbiol. 2019 Nov 25. doi: 10.1038/s41564-019-0605-4. [Epub ahead of print]

PMID:
31768028
2.

GIP analogues augment bone strength by modulating bone composition in diet-induced obesity in mice.

Vyavahare SS, Mieczkowska A, Flatt PR, Chappard D, Irwin N, Mabilleau G.

Peptides. 2019 Nov 22:170207. doi: 10.1016/j.peptides.2019.170207. [Epub ahead of print] Review.

PMID:
31765668
3.

Saturated Raman scattering for sub-diffraction-limited imaging.

Würthwein T, Irwin N, Fallnich C.

J Chem Phys. 2019 Nov 21;151(19):194201. doi: 10.1063/1.5128874.

PMID:
31757159
4.

A GIP/xenin hybrid in combination with exendin-4 improves metabolic status in db/db diabetic mice and promotes enduring antidiabetic benefits in high fat fed mice.

Craig SL, Perry RA, Vyavahare SS, Ng MT, Gault VA, Flatt PR, Irwin N.

Biochem Pharmacol. 2019 Nov 20;171:113723. doi: 10.1016/j.bcp.2019.113723. [Epub ahead of print]

PMID:
31756326
5.

Time-Resolved Dynamics of Struvite Crystallization: Insights from the Macroscopic to Molecular Scale.

Kim D, Olympiou C, McCoy CP, Irwin NJ, Rimer JD.

Chemistry. 2019 Nov 19. doi: 10.1002/chem.201904347. [Epub ahead of print]

PMID:
31742800
6.

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice.

Sarnobat D, Moffett RC, Gault VA, Tanday N, Reimann F, Gribble FM, Flatt PR, Irwin N.

Peptides. 2019 Nov 16:170205. doi: 10.1016/j.peptides.2019.170205. [Epub ahead of print] Review.

PMID:
31738969
7.

Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes.

Irwin N, Gault VA, O'Harte FPM, Flatt PR.

Peptides. 2019 Nov 13:170203. doi: 10.1016/j.peptides.2019.170203. [Epub ahead of print] Review.

PMID:
31733230
8.

Peptide YY (1-36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β-cell function, growth and survival.

Lafferty RA, Tanday N, McCloskey A, Bompada P, De Marinis Y, Flatt PR, Irwin N.

Diabetes Obes Metab. 2019 Nov 6. doi: 10.1111/dom.13908. [Epub ahead of print]

PMID:
31692207
9.

Antidiabetic effects and sustained metabolic benefits of sub-chronic co-administration of exendin-4/gastrin and xenin-8-Gln in high fat fed mice.

Hasib A, Khan D, Craig SL, Gault VA, Flatt PR, Irwin N.

Eur J Pharmacol. 2019 Dec 15;865:172733. doi: 10.1016/j.ejphar.2019.172733. Epub 2019 Oct 12.

PMID:
31614140
10.

Characterisation of Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonists in Rodent Pancreatic Beta Cells and Mice.

Perry RA, Craig SL, Ng MT, Gault VA, Flatt PR, Irwin N.

Clin Med Insights Endocrinol Diabetes. 2019 Sep 12;12:1179551419875453. doi: 10.1177/1179551419875453. eCollection 2019.

11.

A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators.

Needham DM, Yoshizawa S, Hosaka T, Poirier C, Choi CJ, Hehenberger E, Irwin NAT, Wilken S, Yung CM, Bachy C, Kurihara R, Nakajima Y, Kojima K, Kimura-Someya T, Leonard G, Malmstrom RR, Mende DR, Olson DK, Sudo Y, Sudek S, Richards TA, DeLong EF, Keeling PJ, Santoro AE, Shirouzu M, Iwasaki W, Worden AZ.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20574-20583. doi: 10.1073/pnas.1907517116. Epub 2019 Sep 23.

12.

Multiple Independent Origins of Apicomplexan-Like Parasites.

Mathur V, Kolísko M, Hehenberger E, Irwin NAT, Leander BS, Kristmundsson Á, Freeman MA, Keeling PJ.

Curr Biol. 2019 Sep 9;29(17):2936-2941.e5. doi: 10.1016/j.cub.2019.07.019. Epub 2019 Aug 15.

PMID:
31422883
13.

Short-term CFTR inhibition reduces islet area in C57BL/6 mice.

Khan D, Kelsey R, Maheshwari RR, Stone VM, Hasib A, Manderson Koivula FN, Watson A, Harkin S, Irwin N, Shaw JA, McClenaghan NH, Venglovecz V, Ébert A, Flodström-Tullberg M, White MG, Kelly C.

Sci Rep. 2019 Aug 2;9(1):11244. doi: 10.1038/s41598-019-47745-w.

14.

Effects of an enzymatically stable C-terminal hexapseudopeptide fragment peptide of xenin-25, ψ-xenin-6, on pancreatic islet function and metabolism.

Craig SL, Gault VA, McClean S, Hamscher G, Irwin N.

Mol Cell Endocrinol. 2019 Oct 1;496:110523. doi: 10.1016/j.mce.2019.110523. Epub 2019 Jul 25.

PMID:
31352038
15.

Probiotic supplementation in well children: A scoping review.

Irwin N, Davis D, Currie M.

J Child Health Care. 2019 Jul 25:1367493519864750. doi: 10.1177/1367493519864750. [Epub ahead of print]

PMID:
31345053
16.

Effects of 2 Novel PYY(1-36) Analogues, (P3L31P34)PYY(1-36) and PYY(1-36)(Lys12PAL), on Pancreatic Beta-Cell Function, Growth, and Survival.

Lafferty RA, Gault VA, Flatt PR, Irwin N.

Clin Med Insights Endocrinol Diabetes. 2019 Jun 17;12:1179551419855626. doi: 10.1177/1179551419855626. eCollection 2019.

17.

Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications.

Domínguez-Robles J, Martin NK, Fong ML, Stewart SA, Irwin NJ, Rial-Hermida MI, Donnelly RF, Larrañeta E.

Pharmaceutics. 2019 Apr 4;11(4). pii: E165. doi: 10.3390/pharmaceutics11040165.

18.

The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice.

Mansur SA, Mieczkowska A, Flatt PR, Chappard D, Irwin N, Mabilleau G.

Front Endocrinol (Lausanne). 2019 Feb 12;10:51. doi: 10.3389/fendo.2019.00051. eCollection 2019.

19.

Extensive Reduction of the Nuclear Pore Complex in Nucleomorphs.

Irwin NAT, Keeling PJ.

Genome Biol Evol. 2019 Mar 1;11(3):678-687. doi: 10.1093/gbe/evz029.

20.

Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival.

Mohan S, Moffett RC, Thomas KG, Irwin N, Flatt PR.

Biochimie. 2019 Mar;158:191-198. doi: 10.1016/j.biochi.2019.01.008. Epub 2019 Jan 21.

PMID:
30677431
21.

Sitagliptin Alters Bone Composition in High-Fat-Fed Mice.

Mansur SA, Mieczkowska A, Flatt PR, Chappard D, Irwin N, Mabilleau G.

Calcif Tissue Int. 2019 Apr;104(4):437-448. doi: 10.1007/s00223-018-0507-0. Epub 2018 Dec 18.

PMID:
30564859
22.

Exendin-4(Lys27 PAL)/gastrin/xenin-8-Gln: A novel acylated GLP-1/gastrin/xenin hybrid peptide that improves metabolic status in obese-diabetic (ob/ob) mice.

Hasib A, Ng MT, Tanday N, Craig SL, Gault VA, Flatt PR, Irwin N.

Diabetes Metab Res Rev. 2019 Mar;35(3):e3106. doi: 10.1002/dmrr.3106. Epub 2018 Dec 19.

PMID:
30499633
23.

Phylogenomics supports the monophyly of the Cercozoa.

Irwin NAT, Tikhonenkov DV, Hehenberger E, Mylnikov AP, Burki F, Keeling PJ.

Mol Phylogenet Evol. 2019 Jan;130:416-423. doi: 10.1016/j.ympev.2018.09.004. Epub 2018 Oct 11.

PMID:
30318266
24.

C-terminal degradation of PYY peptides in plasma abolishes effects on satiety and beta-cell function.

Lafferty RA, Flatt PR, Irwin N.

Biochem Pharmacol. 2018 Dec;158:95-102. doi: 10.1016/j.bcp.2018.10.004. Epub 2018 Oct 5.

PMID:
30292757
25.

Constructed wetlands for water quality improvements: Benefit transfer analysis from Ohio.

Irwin NB, Irwin EG, Martin JF, Aracena P.

J Environ Manage. 2018 Jan 15;206:1063-1071. doi: 10.1016/j.jenvman.2017.10.050. Epub 2017 Dec 7.

PMID:
30029340
26.

Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential.

Pathak NM, Pathak V, Gault VA, McClean S, Irwin N, Flatt PR.

Biochem Pharmacol. 2018 Sep;155:264-274. doi: 10.1016/j.bcp.2018.07.021. Epub 2018 Jul 18.

PMID:
30028989
27.

What Can Environmental Sequences Tell Us About the Distribution of Low-Rank Taxa? The Case of Euplotes (Ciliophora, Spirotrichea), Including a Description of Euplotes enigma sp. nov.

Boscaro V, Syberg-Olsen MJ, Irwin NAT, Del Campo J, Keeling PJ.

J Eukaryot Microbiol. 2019 Mar;66(2):281-293. doi: 10.1111/jeu.12669. Epub 2018 Aug 13.

PMID:
30028565
28.

Characterisation and antidiabetic utility of a novel hybrid peptide, exendin-4/gastrin/xenin-8-Gln.

Hasib A, Ng MT, Khan D, Gault VA, Flatt PR, Irwin N.

Eur J Pharmacol. 2018 Sep 5;834:126-135. doi: 10.1016/j.ejphar.2018.07.027. Epub 2018 Jul 17.

PMID:
30025814
29.

Synthesis and Characterization of Lignin Hydrogels for Potential Applications as Drug Eluting Antimicrobial Coatings for Medical Materials.

Larrañeta E, Imízcoz M, Toh JX, Irwin NJ, Ripolin A, Perminova A, Domínguez-Robles J, Rodríguez A, Donnelly RF.

ACS Sustain Chem Eng. 2018 Jul 2;6(7):9037-9046. doi: 10.1021/acssuschemeng.8b01371. Epub 2018 Jun 1.

30.

Association between attendance and overall academic performance on a module within a professional pharmacy degree.

Irwin N, Burnett KM, McCarron PA.

Curr Pharm Teach Learn. 2018 Mar;10(3):396-401. doi: 10.1016/j.cptl.2017.11.008. Epub 2017 Dec 8.

PMID:
29764646
31.

Viral proteins as a potential driver of histone depletion in dinoflagellates.

Irwin NAT, Martin BJE, Young BP, Browne MJG, Flaus A, Loewen CJR, Keeling PJ, Howe LJ.

Nat Commun. 2018 Apr 18;9(1):1535. doi: 10.1038/s41467-018-03993-4.

32.

Emerging therapeutic potential for xenin and related peptides in obesity and diabetes.

Craig SL, Gault VA, Irwin N.

Diabetes Metab Res Rev. 2018 Sep;34(6):e3006. doi: 10.1002/dmrr.3006. Epub 2018 Apr 26. Review.

PMID:
29633491
33.

Emerging therapeutic potential for peptide YY for obesity-diabetes.

Lafferty RA, Flatt PR, Irwin N.

Peptides. 2018 Feb;100:269-274. doi: 10.1016/j.peptides.2017.11.005. Review.

PMID:
29412828
34.

Cholecystokinin (CCK) and related adjunct peptide therapies for the treatment of obesity and type 2 diabetes.

Pathak V, Flatt PR, Irwin N.

Peptides. 2018 Feb;100:229-235. doi: 10.1016/j.peptides.2017.09.007. Review.

PMID:
29412823
35.

A novel GLP-1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice.

Hasib A, Ng MT, Khan D, Gault VA, Flatt PR, Irwin N.

Peptides. 2018 Feb;100:202-211. doi: 10.1016/j.peptides.2017.10.015.

PMID:
29412820
36.

Use of in vitro and haptic assessments in the characterisation of surface lubricity.

Irwin NJ, McCoy CP, McCullough AR, Corbett DJ.

Proc Inst Mech Eng H. 2019 Jan;233(1):84-90. doi: 10.1177/0954411918756155. Epub 2018 Feb 2.

PMID:
29393009
37.

Expression of Gastrin Family Peptides in Pancreatic Islets and Their Role in β-Cell Function and Survival.

Khan D, Vasu S, Moffett RC, Irwin N, Flatt PR.

Pancreas. 2018 Feb;47(2):190-199. doi: 10.1097/MPA.0000000000000983.

PMID:
29329158
38.

Oxytocin is present in islets and plays a role in beta-cell function and survival.

Mohan S, Khan D, Moffett RC, Irwin N, Flatt PR.

Peptides. 2018 Feb;100:260-268. doi: 10.1016/j.peptides.2017.12.019. Epub 2017 Dec 20. Review.

PMID:
29274352
39.

Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications.

Larrañeta E, Henry M, Irwin NJ, Trotter J, Perminova AA, Donnelly RF.

Carbohydr Polym. 2018 Feb 1;181:1194-1205. doi: 10.1016/j.carbpol.2017.12.015. Epub 2017 Dec 7.

40.

Pseudotrichonympha leei, Pseudotrichonympha lifesoni, and Pseudotrichonympha pearti, new species of parabasalian flagellates and the description of a rotating subcellular structure.

Del Campo J, James ER, Hirakawa Y, Fiorito R, Kolisko M, Irwin NAT, Mathur V, Boscaro V, Hehenberger E, Karnkowska A, Scheffrahn RH, Keeling PJ.

Sci Rep. 2017 Nov 27;7(1):16349. doi: 10.1038/s41598-017-16259-8.

41.

Anti-Adherent Biomaterials for Prevention of Catheter Biofouling.

McCoy CP, Irwin NJ, Donnelly L, Jones DS, Hardy JG, Carson L.

Int J Pharm. 2018 Jan 15;535(1-2):420-427. doi: 10.1016/j.ijpharm.2017.11.043. Epub 2017 Nov 21.

PMID:
29170113
42.

Molecular characterization and phylogeny of four new species of the genus Trichonympha (Parabasalia, Trichonymphea) from lower termite hindguts.

Boscaro V, James ER, Fiorito R, Hehenberger E, Karnkowska A, Del Campo J, Kolisko M, Irwin NAT, Mathur V, Scheffrahn RH, Keeling PJ.

Int J Syst Evol Microbiol. 2017 Sep;67(9):3570-3575. doi: 10.1099/ijsem.0.002169. Epub 2017 Aug 25.

PMID:
28840814
43.

Diversification and Phylogenetics of Mobilid Peritrichs (Ciliophora) with Description of Urceolaria parakorschelti sp. nov.

Irwin NAT, Sabetrasekh M, Lynn DH.

Protist. 2017 Aug;168(4):481-493. doi: 10.1016/j.protis.2017.07.003. Epub 2017 Jul 14.

PMID:
28826079
44.

Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival.

Khan D, Vasu S, Moffett RC, Gault VA, Flatt PR, Irwin N.

Biol Chem. 2017 Dec 20;399(1):79-92. doi: 10.1515/hsz-2017-0136.

PMID:
28822218
45.

Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and beta-cell survival.

Khan D, Vasu S, Moffett RC, Irwin N, Flatt PR.

Peptides. 2017 Sep;95:68-75. doi: 10.1016/j.peptides.2017.07.011. Epub 2017 Jul 23.

PMID:
28746825
46.

Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae.

Lawrence MBD, Coutin N, Choi JK, Martin BJE, Irwin NAT, Young B, Loewen C, Howe LJ.

Genetics. 2017 Sep;207(1):347-355. doi: 10.1534/genetics.117.1132. Epub 2017 Jul 24.

47.

Photochemically Controlled Drug Dosing from a Polymeric Scaffold.

Donnelly L, Hardy JG, Gorman SP, Jones DS, Irwin NJ, McCoy CP.

Pharm Res. 2017 Jul;34(7):1469-1476. doi: 10.1007/s11095-017-2164-9. Epub 2017 May 15.

48.

Effect of poly(ethylene glycol) content and formulation parameters on particulate properties and intraperitoneal delivery of insulin from PLGA nanoparticles prepared using the double-emulsion evaporation procedure.

Haggag YA, Faheem AM, Tambuwala MM, Osman MA, El-Gizawy SA, O'Hagan B, Irwin N, McCarron PA.

Pharm Dev Technol. 2018 Apr;23(4):370-381. doi: 10.1080/10837450.2017.1295066. Epub 2017 Mar 6.

PMID:
28285551
49.

Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival.

Khan D, Vasu S, Moffett RC, Irwin N, Flatt PR.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):749-758. doi: 10.1016/j.bbagen.2017.01.005. Epub 2017 Jan 7.

PMID:
28069397
50.

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.

Hasib A, Ng MT, Gault VA, Khan D, Parthsarathy V, Flatt PR, Irwin N.

Diabetologia. 2017 Mar;60(3):541-552. doi: 10.1007/s00125-016-4186-y. Epub 2016 Dec 21.

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