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Items: 1 to 50 of 62

1.

Effects of LL-37 on Gingival Fibroblasts: A Role in Periodontal Tissue Remodeling?

McCrudden MTC, O'Donnell K, Irwin CR, Lundy FT.

Vaccines (Basel). 2018 Jul 23;6(3). pii: E44. doi: 10.3390/vaccines6030044.

2.

Vaccinia-based vaccines to biothreat and emerging viruses.

Nagata LP, Irwin CR, Hu WG, Evans DH.

Biotechnol Genet Eng Rev. 2018 Apr;34(1):107-121. doi: 10.1080/02648725.2018.1471643. Epub 2018 May 21. Review.

PMID:
29779454
3.

Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses.

Irwin CR, Hitt MM, Evans DH.

Front Oncol. 2017 Sep 26;7:229. doi: 10.3389/fonc.2017.00229. eCollection 2017. Review.

4.

Characterisation of eppin function: expression and activity in the lung.

Scott A, Glasgow A, Small D, Carlile S, McCrudden M, McLean D, Brown R, Doherty D, Lundy FT, Hamid UI, O'Kane CM, McAuley DF, Brodlie M, Tunney M, Elborn JS, Irwin CR, Timson DJ, Taggart CC, Weldon S.

Eur Respir J. 2017 Jul 13;50(1). pii: 1601937. doi: 10.1183/13993003.01937-2016. Print 2017 Jul.

5.

Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti-tumor immunity with superior safety in bladder cancer models.

Potts KG, Irwin CR, Favis NA, Pink DB, Vincent KM, Lewis JD, Moore RB, Hitt MM, Evans DH.

EMBO Mol Med. 2017 May;9(5):638-654. doi: 10.15252/emmm.201607296.

6.

Sialylation of Porphyromonas gingivalis LPS and its effect on bacterial-host interactions.

Zaric SS, Lappin MJ, Fulton CR, Lundy FT, Coulter WA, Irwin CR.

Innate Immun. 2017 Apr;23(3):319-326. doi: 10.1177/1753425917694245. Epub 2017 Feb 16.

PMID:
28205451
7.

Matrix metalloproteinase-8 activity in gingival crevicular fluid: development of a novel assay.

Mc Crudden MTC, Irwin CR, El Karim I, Linden GJ, Lundy FT.

J Periodontal Res. 2017 Jun;52(3):556-561. doi: 10.1111/jre.12423. Epub 2016 Sep 24.

PMID:
27663905
8.

Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells.

El Karim IA, McCrudden MT, McGahon MK, Curtis TM, Jeanneau C, Giraud T, Irwin CR, Linden GJ, Lundy FT, About I.

J Endod. 2016 Apr;42(4):589-95. doi: 10.1016/j.joen.2015.12.017. Epub 2016 Feb 11.

PMID:
26874643
9.

Interferon-╬│ stimulates CD14, TLR2 and TLR4 mRNA expression in gingival fibroblasts increasing responsiveness to bacterial challenge.

Lappin MJ, Brown V, Zaric SS, Lundy FT, Coulter WA, Irwin CR.

Arch Oral Biol. 2016 Jan;61:36-43. doi: 10.1016/j.archoralbio.2015.10.005. Epub 2015 Oct 9.

PMID:
26513680
10.

Antimicrobial and immunomodulatory properties of PGLa-AM1, CPF-AM1, and magainin-AM1: potent activity against oral pathogens.

McLean DT, McCrudden MT, Linden GJ, Irwin CR, Conlon JM, Lundy FT.

Regul Pept. 2014 Nov;194-195:63-8. doi: 10.1016/j.regpep.2014.11.002. Epub 2014 Nov 13.

PMID:
25447193
11.

Initial characterization of vaccinia virus B4 suggests a role in virus spread.

Burles K, Irwin CR, Burton RL, Schriewer J, Evans DH, Buller RM, Barry M.

Virology. 2014 May;456-457:108-20. doi: 10.1016/j.virol.2014.03.019. Epub 2014 Apr 4.

12.

Myxoma virus oncolytic efficiency can be enhanced through chemical or genetic disruption of the actin cytoskeleton.

Irwin CR, Favis NA, Agopsowicz KC, Hitt MM, Evans DH.

PLoS One. 2013 Dec 31;8(12):e84134. doi: 10.1371/journal.pone.0084134. eCollection 2013.

13.

LL-37 in periodontal health and disease and its susceptibility to degradation by proteinases present in gingival crevicular fluid.

McCrudden MT, Orr DF, Yu Y, Coulter WA, Manning G, Irwin CR, Lundy FT.

J Clin Periodontol. 2013 Oct;40(10):933-41. doi: 10.1111/jcpe.12141. Epub 2013 Aug 18.

PMID:
23952216
14.

In-fusion® cloning with vaccinia virus DNA polymerase.

Irwin CR, Farmer A, Willer DO, Evans DH.

Methods Mol Biol. 2012;890:23-35. doi: 10.1007/978-1-61779-876-4_2.

PMID:
22688759
15.

Modulation of the myxoma virus plaque phenotype by vaccinia virus protein F11.

Irwin CR, Evans DH.

J Virol. 2012 Jul;86(13):7167-79. doi: 10.1128/JVI.06936-11. Epub 2012 Apr 18.

16.

Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo.

Scott A, Weldon S, Buchanan PJ, Schock B, Ernst RK, McAuley DF, Tunney MM, Irwin CR, Elborn JS, Taggart CC.

PLoS One. 2011;6(10):e26525. doi: 10.1371/journal.pone.0026525. Epub 2011 Oct 18.

17.

Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production.

Zaric SS, Coulter WA, Shelburne CE, Fulton CR, Zaric MS, Scott A, Lappin MJ, Fitzgerald DC, Irwin CR, Taggart CC.

J Biol Chem. 2011 Aug 26;286(34):29492-500. doi: 10.1074/jbc.M111.252791. Epub 2011 Jun 24.

18.

Periodontal disease in the older patient.

Irwin CR.

Dent Update. 2011 Mar;38(2):94-6, 99-100.

PMID:
21500618
19.

The effect of topical phenytoin on healing in diabetic foot ulcers: a randomized controlled trial.

Shaw J, Hughes CM, Lagan KM, Stevenson MR, Irwin CR, Bell PM.

Diabet Med. 2011 Oct;28(10):1154-7. doi: 10.1111/j.1464-5491.2011.03309.x.

PMID:
21480976
20.

Human dental pulp fibroblasts express the "cold-sensing" transient receptor potential channels TRPA1 and TRPM8.

El Karim IA, Linden GJ, Curtis TM, About I, McGahon MK, Irwin CR, Killough SA, Lundy FT.

J Endod. 2011 Apr;37(4):473-8. doi: 10.1016/j.joen.2010.12.017.

PMID:
21419293
21.

Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity.

El Karim IA, Linden GJ, Curtis TM, About I, McGahon MK, Irwin CR, Lundy FT.

Pain. 2011 Oct;152(10):2211-23. doi: 10.1016/j.pain.2010.10.016. Epub 2010 Dec 17.

PMID:
21168271
22.

Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y.

Killough SA, Lundy FT, Irwin CR.

Int Endod J. 2010 Oct;43(10):835-42. doi: 10.1111/j.1365-2591.2010.01741.x. Epub 2010 Jul 15.

PMID:
20636351
23.

PAR-2 regulates dental pulp inflammation associated with caries.

Lundy FT, About I, Curtis TM, McGahon MK, Linden GJ, Irwin CR, El Karim IA.

J Dent Res. 2010 Jul;89(7):684-8. doi: 10.1177/0022034510365652. Epub 2010 May 26.

PMID:
20505052
24.

Neuropeptides regulate expression of angiogenic growth factors in human dental pulp fibroblasts.

El Karim IA, Linden GJ, Irwin CR, Lundy FT.

J Endod. 2009 Jun;35(6):829-33. doi: 10.1016/j.joen.2009.03.005. Epub 2009 Apr 19.

PMID:
19482180
25.

Substance P expression by human dental pulp fibroblasts: a potential role in neurogenic inflammation.

Killough SA, Lundy FT, Irwin CR.

J Endod. 2009 Jan;35(1):73-7. doi: 10.1016/j.joen.2008.10.010.

PMID:
19084129
26.

Modulation of gingival epithelial phenotypes by interactions with regionally defined populations of fibroblasts.

Locke M, Hyland PL, Irwin CR, Mackenzie IC.

J Periodontal Res. 2008 Jun;43(3):279-89. doi: 10.1111/j.1600-0765.2007.01028.x.

PMID:
18447855
27.

Vaccinia virus DNA ligase recruits cellular topoisomerase II to sites of viral replication and assembly.

Lin YC, Li J, Irwin CR, Jenkins H, DeLange L, Evans DH.

J Virol. 2008 Jun;82(12):5922-32. doi: 10.1128/JVI.02723-07. Epub 2008 Apr 16.

28.

Regulation of HGF and SDF-1 expression by oral fibroblasts--implications for invasion of oral cancer.

Daly AJ, McIlreavey L, Irwin CR.

Oral Oncol. 2008 Jul;44(7):646-51. Epub 2007 Nov 9.

PMID:
17996483
29.

Matrix metalloproteinase-3 differences in oral and skin fibroblasts.

McKeown ST, Barnes JJ, Hyland PL, Lundy FT, Fray MJ, Irwin CR.

J Dent Res. 2007 May;86(5):457-62.

PMID:
17452568
30.

Phenotypic differences between oral and skin fibroblasts in wound contraction and growth factor expression.

Shannon DB, McKeown ST, Lundy FT, Irwin CR.

Wound Repair Regen. 2006 Mar-Apr;14(2):172-8.

PMID:
16630106
31.

The cytotoxic effects of human neutrophil peptide-1 (HNP1) and lactoferrin on oral squamous cell carcinoma (OSCC) in vitro.

McKeown ST, Lundy FT, Nelson J, Lockhart D, Irwin CR, Cowan CG, Marley JJ.

Oral Oncol. 2006 Aug;42(7):685-90. Epub 2006 Feb 17.

PMID:
16483834
33.

Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth.

Hyland PL, McKeown ST, Mackenzie IC, Irwin CR.

J Oral Pathol Med. 2004 Aug;33(7):391-7.

PMID:
15250830
34.

Construction of large area organotypical cultures of oral mucosa and skin.

Igarashi M, Irwin CR, Locke M, Mackenzie IC.

J Oral Pathol Med. 2003 Aug;32(7):422-30.

PMID:
12846789
35.

The effects of cyclosporin on the collagenolytic activity of gingival fibroblasts.

Hyland PL, Traynor PS, Myrillas TT, Marley JJ, Linden GJ, Winter P, Leadbetter N, Cawston TE, Irwin CR.

J Periodontol. 2003 Apr;74(4):437-45.

PMID:
12747447
36.

Invasive front grading: reliability and usefulness in the management of oral squamous cell carcinoma.

Sawair FA, Irwin CR, Gordon DJ, Leonard AG, Stephenson M, Napier SS.

J Oral Pathol Med. 2003 Jan;32(1):1-9.

PMID:
12558952
37.

Keratinocyte growth factor and scatter factor expression by regionally defined oral fibroblasts.

McKeown ST, Hyland PL, Locke M, Mackenzie IC, Irwin CR.

Eur J Oral Sci. 2003 Feb;111(1):42-50.

PMID:
12558807
39.

The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker.

Linden GJ, Haworth SE, Maxwell AP, Poulton KV, Dyer PA, Middleton D, Irwin CR, Marley JJ, McNamee P, Short CD, Hull PS, James JA.

J Periodontol. 2001 Jun;72(6):808-14.

PMID:
11453244
40.

Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease.

Jones DS, Woolfson AD, Brown AF, Coulter WA, McClelland C, Irwin CR.

J Control Release. 2000 Jul 3;67(2-3):357-68.

PMID:
10825567
41.

Reduction in gingival overgrowth associated with conversion from cyclosporin A to tacrolimus.

James JA, Boomer S, Maxwell AP, Hull PS, Short CD, Campbell BA, Johnson RW, Irwin CR, Marley JJ, Spratt H, Linden GJ.

J Clin Periodontol. 2000 Feb;27(2):144-8. Review.

PMID:
10703661
42.

The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth.

James JA, Marley JJ, Jamal S, Campbell BA, Short CD, Johnson RW, Hull PS, Spratt H, Irwin CR, Boomer S, Maxwell AP, Linden GJ.

J Clin Periodontol. 2000 Feb;27(2):109-15.

PMID:
10703656
43.

Signal recognition particle receptor (SRPR) is downregulated in a rat model of cyclosporin A-induced gingival overgrowth.

Marley JJ, Phenix KV, Irwin CR, Thompson J, Robinson PA, Linden GJ.

J Periodontal Res. 1999 May;34(4):188-96.

PMID:
10444742
44.
45.

Cyclosporin A regulates interleukin-1beta and interleukin-6 expression in gingiva: implications for gingival overgrowth.

Myrillas TT, Linden GJ, Marley JJ, Irwin CR.

J Periodontol. 1999 Mar;70(3):294-300.

PMID:
10225546
46.

Cyclosporin associated gingival overgrowth in renal transplant recipients.

Spratt H, Boomer S, Irwin CR, Marley JJ, James JA, Maxwell P, Middleton D, Linden GJ.

Oral Dis. 1999 Jan;5(1):27-31.

PMID:
10218038
47.

Regulation of fibroblast-induced collagen gel contraction by interleukin-1beta.

Irwin CR, Myrillas T, Smyth M, Doogan J, Rice C, Schor SL.

J Oral Pathol Med. 1998 Jul;27(6):255-9.

PMID:
9707277
48.

The role of IL-6 in the pathogenesis of periodontal disease.

Irwin CR, Myrillas TT.

Oral Dis. 1998 Mar;4(1):43-7. Review.

PMID:
9655045
49.

Gingival fibroblast response to cyclosporin A and transforming growth factor beta 1.

James JA, Irwin CR, Linden GJ.

J Periodontal Res. 1998 Jan;33(1):40-8.

PMID:
9524320
50.

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