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Items: 1 to 50 of 100

1.

Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.

Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11502-11507. doi: 10.1073/pnas.1905028116. Epub 2019 May 20.

PMID:
31110001
2.

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity.

Mijailovich SM, Stojanovic B, Nedic D, Svicevic M, Geeves MA, Irving TC, Granzier HL.

J Gen Physiol. 2019 May 6;151(5):680-704. doi: 10.1085/jgp.201812165. Epub 2019 Apr 4.

PMID:
30948421
3.

Getting into the thick (and thin) of it.

Irving TC, Craig R.

J Gen Physiol. 2019 May 6;151(5):610-613. doi: 10.1085/jgp.201812307. Epub 2019 Feb 21. No abstract available.

PMID:
30792184
4.

Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.

Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D.

FASEB J. 2019 Mar;33(3):3152-3166. doi: 10.1096/fj.201801402R. Epub 2018 Oct 26.

PMID:
30365366
5.

Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle.

Kiss B, Lee EJ, Ma W, Li FW, Tonino P, Mijailovich SM, Irving TC, Granzier HL.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10369-10374. doi: 10.1073/pnas.1804726115. Epub 2018 Sep 24.

6.

Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle.

Gonzalez-Martinez D, Johnston JR, Landim-Vieira M, Ma W, Antipova O, Awan O, Irving TC, Bryant Chase P, Pinto JR.

J Mol Cell Cardiol. 2018 Oct;123:26-37. doi: 10.1016/j.yjmcc.2018.08.015. Epub 2018 Aug 21.

PMID:
30138628
7.

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.

Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, Spudich JA.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8143-E8152. doi: 10.1073/pnas.1809540115. Epub 2018 Aug 13.

8.

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice.

Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2338-E2347. doi: 10.1073/pnas.1716925115. Epub 2018 Feb 20.

9.

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Joureau B, de Winter JM, Conijn S, Bogaards SJP, Kovacevic I, Kalganov A, Persson M, Lindqvist J, Stienen GJM, Irving TC, Ma W, Yuen M, Clarke NF, Rassier DE, Malfatti E, Romero NB, Beggs AH, Ottenheijm CAC.

Ann Neurol. 2018 Feb;83(2):269-282. doi: 10.1002/ana.25144. Epub 2018 Feb 6.

10.

Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.

Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG.

Structure. 2018 Jan 2;26(1):106-117.e6. doi: 10.1016/j.str.2017.11.019. Epub 2017 Dec 21.

11.

Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice.

Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D.

Cardiovasc Res. 2017 Aug 1;113(10):1124-1136. doi: 10.1093/cvr/cvx060.

12.

Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS).

Perkins SJ, Wright DW, Zhang H, Brookes EH, Chen J, Irving TC, Krueger S, Barlow DJ, Edler KJ, Scott DJ, Terrill NJ, King SM, Butler PD, Curtis JE.

J Appl Crystallogr. 2016 Oct 14;49(Pt 6):1861-1875. eCollection 2016 Dec 1.

13.

Three-dimensional stochastic model of actin-myosin binding in the sarcomere lattice.

Mijailovich SM, Kayser-Herold O, Stojanovic B, Nedic D, Irving TC, Geeves MA.

J Gen Physiol. 2016 Dec;148(6):459-488. Epub 2016 Nov 18.

14.

X-ray diffraction from nonuniformly stretched helical molecules.

Prodanovic M, Irving TC, Mijailovich SM.

J Appl Crystallogr. 2016 Apr 18;49(Pt 3):784-797. eCollection 2016 Jun 1.

15.

Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.

Ait-Mou Y, Hsu K, Farman GP, Kumar M, Greaser ML, Irving TC, de Tombe PP.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2306-11. doi: 10.1073/pnas.1516732113. Epub 2016 Feb 8.

16.

Methods for analysis of size-exclusion chromatography-small-angle X-ray scattering and reconstruction of protein scattering.

Malaby AW, Chakravarthy S, Irving TC, Kathuria SV, Bilsel O, Lambright DG.

J Appl Crystallogr. 2015 Jul 8;48(Pt 4):1102-1113. eCollection 2015 Aug 1.

17.

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

Yuan CC, Muthu P, Kazmierczak K, Liang J, Huang W, Irving TC, Kanashiro-Takeuchi RM, Hare JM, Szczesna-Cordary D.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4138-46. doi: 10.1073/pnas.1505819112. Epub 2015 Jun 29.

18.

Elastic proteins in the flight muscle of Manduca sexta.

Yuan CC, Ma W, Schemmel P, Cheng YS, Liu J, Tsaprailis G, Feldman S, Ayme Southgate A, Irving TC.

Arch Biochem Biophys. 2015 Feb 15;568:16-27. doi: 10.1016/j.abb.2014.12.033. Epub 2015 Jan 17.

19.

Hugh E. Huxley: the compleat biophysicist.

Hitchcock-DeGregori SE, Irving TC.

Biophys J. 2014 Oct 7;107(7):1493-501. doi: 10.1016/j.bpj.2014.07.069.

20.

X-ray micro-diffraction studies on biological samples at the BioCAT Beamline 18-ID at the Advanced Photon Source.

Barrea RA, Antipova O, Gore D, Heurich R, Vukonich M, Kujala NG, Irving TC, Orgel JP.

J Synchrotron Radiat. 2014 Sep;21(Pt 5):1200-5. doi: 10.1107/S1600577514012259. Epub 2014 Aug 8.

21.

Modulation of frustration in folding by sequence permutation.

Nobrega RP, Arora K, Kathuria SV, Graceffa R, Barrea RA, Guo L, Chakravarthy S, Bilsel O, Irving TC, Brooks CL 3rd, Matthews CR.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10562-7. doi: 10.1073/pnas.1324230111. Epub 2014 Jul 7.

22.

Microsecond barrier-limited chain collapse observed by time-resolved FRET and SAXS.

Kathuria SV, Kayatekin C, Barrea R, Kondrashkina E, Graceffa R, Guo L, Nobrega RP, Chakravarthy S, Matthews CR, Irving TC, Bilsel O.

J Mol Biol. 2014 May 1;426(9):1980-94. doi: 10.1016/j.jmb.2014.02.020. Epub 2014 Mar 4.

23.

High-speed detector for time-resolved diffraction studies.

Singh B, Miller SR, Bhandari HB, Graceffa R, Irving TC, Nagarkar VV.

J Phys Conf Ser. 2013;425(9). pii: 092005.

24.

Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam.

Graceffa R, Nobrega RP, Barrea RA, Kathuria SV, Chakravarthy S, Bilsel O, Irving TC.

J Synchrotron Radiat. 2013 Nov;20(Pt 6):820-5. doi: 10.1107/S0909049513021833. Epub 2013 Oct 1.

25.

Advances in turbulent mixing techniques to study microsecond protein folding reactions.

Kathuria SV, Chan A, Graceffa R, Paul Nobrega R, Robert Matthews C, Irving TC, Perot B, Bilsel O.

Biopolymers. 2013 Nov;99(11):888-96. doi: 10.1002/bip.22355.

26.

The length-tension curve in muscle depends on lattice spacing.

Williams CD, Salcedo MK, Irving TC, Regnier M, Daniel TL.

Proc Biol Sci. 2013 Sep 7;280(1766):20130697. doi: 10.1098/rspb.2013.0697. Print 2013 Sep 7.

27.

The cross-bridge spring: can cool muscles store elastic energy?

George NT, Irving TC, Williams CD, Daniel TL.

Science. 2013 Jun 7;340(6137):1217-20. doi: 10.1126/science.1229573. Epub 2013 Apr 25.

28.

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy.

Lassche S, Stienen GJ, Irving TC, van der Maarel SM, Voermans NC, Padberg GW, Granzier H, van Engelen BG, Ottenheijm CA.

Neurology. 2013 Feb 19;80(8):733-7. doi: 10.1212/WNL.0b013e318282513b. Epub 2013 Jan 30.

29.

Head-head interactions of resting myosin crossbridges in intact frog skeletal muscles, revealed by synchrotron x-ray fiber diffraction.

Oshima K, Sugimoto Y, Irving TC, Wakabayashi K.

PLoS One. 2012;7(12):e52421. doi: 10.1371/journal.pone.0052421. Epub 2012 Dec 20. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/05f7579b-d2c6-43cd-b5b3-f883b4746474.

30.

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.

Lee EJ, Nedrud J, Schemmel P, Gotthardt M, Irving TC, Granzier HL.

Arch Biochem Biophys. 2013 Jul 1;535(1):76-83. doi: 10.1016/j.abb.2012.12.004. Epub 2012 Dec 14.

31.

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.

Rao VS, Korte FS, Razumova MV, Feest ER, Hsu H, Irving TC, Regnier M, Martyn DA.

J Physiol. 2013 Jan 15;591(2):475-90. doi: 10.1113/jphysiol.2012.241604. Epub 2012 Nov 5.

32.

Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle.

Tanner BC, Farman GP, Irving TC, Maughan DW, Palmer BM, Miller MS.

Biophys J. 2012 Sep 19;103(6):1275-84. doi: 10.1016/j.bpj.2012.08.014.

33.

Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.

Colson BA, Patel JR, Chen PP, Bekyarova T, Abdalla MI, Tong CW, Fitzsimons DP, Irving TC, Moss RL.

J Mol Cell Cardiol. 2012 Nov;53(5):609-16. doi: 10.1016/j.yjmcc.2012.07.012. Epub 2012 Jul 28.

34.

Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.

Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW.

Biophys J. 2011 Oct 5;101(7):1661-9. doi: 10.1016/j.bpj.2011.08.047.

35.

Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction.

Muthu P, Wang L, Yuan CC, Kazmierczak K, Huang W, Hernandez OM, Kawai M, Irving TC, Szczesna-Cordary D.

FASEB J. 2011 Dec;25(12):4394-405. doi: 10.1096/fj.11-191973. Epub 2011 Sep 1.

36.

COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.

Tanner BC, Miller MS, Miller BM, Lekkas P, Irving TC, Maughan DW, Vigoreaux JO.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C383-91. doi: 10.1152/ajpcell.00016.2011. Epub 2011 May 18.

37.

Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacing.

Miller MS, Farman GP, Braddock JM, Soto-Adames FN, Irving TC, Vigoreaux JO, Maughan DW.

Biophys J. 2011 Apr 6;100(7):1737-46. doi: 10.1016/j.bpj.2011.02.028.

38.

Myosin head orientation: a structural determinant for the Frank-Starling relationship.

Farman GP, Gore D, Allen E, Schoenfelt K, Irving TC, de Tombe PP.

Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2155-60. doi: 10.1152/ajpheart.01221.2010. Epub 2011 Apr 1.

39.

Minireview: structural insights into early folding events using continuous-flow time-resolved small-angle X-ray scattering.

Kathuria SV, Guo L, Graceffa R, Barrea R, Nobrega RP, Matthews CR, Irving TC, Bilsel O.

Biopolymers. 2011 Aug;95(8):550-8. doi: 10.1002/bip.21628. Epub 2011 Mar 25. Review.

40.

Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity.

Baldock C, Oberhauser AF, Ma L, Lammie D, Siegler V, Mithieux SM, Tu Y, Chow JY, Suleman F, Malfois M, Rogers S, Guo L, Irving TC, Wess TJ, Weiss AS.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4322-7. doi: 10.1073/pnas.1014280108. Epub 2011 Feb 28.

41.

X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle.

Perz-Edwards RJ, Irving TC, Baumann BA, Gore D, Hutchinson DC, Kržič U, Porter RL, Ward AB, Reedy MK.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):120-5. doi: 10.1073/pnas.1014599107. Epub 2010 Dec 9.

42.

Fast-scanning high-flux microprobe for biological X-ray fluorescence microscopy and microXAS.

Barrea RA, Gore D, Kujala N, Karanfil C, Kozyrenko S, Heurich R, Vukonich M, Huang R, Paunesku T, Woloschak G, Irving TC.

J Synchrotron Radiat. 2010 Jul;17(4):522-9. doi: 10.1107/S0909049510016869. Epub 2010 May 26.

43.

Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development.

Colson BA, Locher MR, Bekyarova T, Patel JR, Fitzsimons DP, Irving TC, Moss RL.

J Physiol. 2010 Mar 15;588(Pt 6):981-93. doi: 10.1113/jphysiol.2009.183897. Epub 2010 Feb 1.

44.

Myofilament length dependent activation.

de Tombe PP, Mateja RD, Tachampa K, Ait Mou Y, Farman GP, Irving TC.

J Mol Cell Cardiol. 2010 May;48(5):851-8. doi: 10.1016/j.yjmcc.2009.12.017. Epub 2010 Jan 4. Review.

45.

Biological applications of X-ray microprobes.

Paunesku T, Vogt S, Irving TC, Lai B, Barrea RA, Maser J, Woloschak GE.

Int J Radiat Biol. 2009 Aug;85(8):710-3. doi: 10.1080/09553000903009514.

PMID:
19637082
46.

Phosphorylation and the N-terminal extension of the regulatory light chain help orient and align the myosin heads in Drosophila flight muscle.

Farman GP, Miller MS, Reedy MC, Soto-Adames FN, Vigoreaux JO, Maughan DW, Irving TC.

J Struct Biol. 2009 Nov;168(2):240-9. doi: 10.1016/j.jsb.2009.07.020. Epub 2009 Jul 25.

47.

Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol's anticancer activity.

Barrea RA, Chen D, Irving TC, Dou QP.

J Cell Biochem. 2009 Sep 1;108(1):96-105. doi: 10.1002/jcb.22231.

48.

Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics.

Miller MS, Dambacher CM, Knowles AF, Braddock JM, Farman GP, Irving TC, Swank DM, Bernstein SI, Maughan DW.

Biophys J. 2009 May 20;96(10):4132-43. doi: 10.1016/j.bpj.2009.02.034.

49.

High-flux hard X-ray microbeam using a single-bounce capillary with doubly focused undulator beam.

Barrea RA, Huang R, Cornaby S, Bilderback DH, Irving TC.

J Synchrotron Radiat. 2009 Jan;16(Pt 1):76-82. doi: 10.1107/S0909049508039782. Epub 2008 Dec 21.

50.

Cost-effective EMCCD-based detector for time-resolved biological SAXS applications.

Nagarkar VV, Singh B, Guo L, Gore D, Irving TC.

Nucl Instrum Methods Phys Res A. 2007 Jun 11;576(1):38-42.

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