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Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation.

Caremani M, Brunello E, Linari M, Fusi L, Irving TC, Gore D, Piazzesi G, Irving M, Lombardi V, Reconditi M.

J Gen Physiol. 2019 Sep 25. pii: jgp.201912424. doi: 10.1085/jgp.201912424. [Epub ahead of print]


C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia. Reply.

Savarirayan R, Irving M, Day J.

N Engl J Med. 2019 Sep 26;381(13):1291-1292. doi: 10.1056/NEJMc1910394. No abstract available.


Improving oral-health-related quality-of-life for rural Aboriginal communities in Australia utilising a novel mobile denture service.

Irving M, Kumar N, Gwynne K, Talbot F, Blinkhorn AS.

Rural Remote Health. 2019 Sep;19(3):5063. doi: 10.22605/RRH5063. Epub 2019 Sep 11. No abstract available.


The phenotype of Sotos syndrome in adulthood: A review of 44 individuals.

Foster A, Zachariou A, Loveday C, Ashraf T, Blair E, Clayton-Smith J, Dorkins H, Fryer A, Gener B, Goudie D, Henderson A, Irving M, Joss S, Keeley V, Lahiri N, Lynch SA, Mansour S, McCann E, Morton J, Motton N, Murray A, Riches K, Shears D, Stark Z, Thompson E, Vogt J, Wright M, Cole T, Tatton-Brown K.

Am J Med Genet C Semin Med Genet. 2019 Sep 3. doi: 10.1002/ajmg.c.31738. [Epub ahead of print]


The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype-phenotype correlations, and molecular basis.

Weiss K, Lazar HP, Kurolap A, Martinez AF, Paperna T, Cohen L, Smeland MF, Wallen S, Solveig H, Keren B, Terhal P, Irving M, Takaku M, Roberts JD, Petrovich RM, Schrier Vergano SA, Kenney A, Hove H, DeChene E, Quinonez SC, Colin E, Ziegler A, Rumple M, Jain M, Monteil D, Roeder ER, Nugent K, van Haeringen A, Gambello M, Santani A, Medne L, Krock B, Skraban CM, Zackai EH, Dubbs HA, Smol T, Ghoumid J, Parker MJ, Wright M, Turnpenny P, Clayton-Smith J, Metcalfe K, Kurumizaka H, Gelb BD, Baris Feldman H, Campeau PM, Muenke M, Wade PA, Lachlan K.

Genet Med. 2019 Aug 7. doi: 10.1038/s41436-019-0612-0. [Epub ahead of print]


Rational combinations of immunotherapy with radiotherapy in ovarian cancer.

Herrera FG, Irving M, Kandalaft LE, Coukos G.

Lancet Oncol. 2019 Aug;20(8):e417-e433. doi: 10.1016/S1470-2045(19)30401-2. Epub 2019 Jul 29. Review. Erratum in: Lancet Oncol. 2019 Sep;20(9):e468.


Oral health outcomes for people with cerebral palsy: a scoping review protocol.

Lansdown K, Smithers-Sheedy H, Mathieu Coulton K, Irving M.

JBI Database System Rev Implement Rep. 2019 Jul 26. doi: 10.11124/JBISRIR-2017-004037. [Epub ahead of print]


Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle.

Ponnam S, Sevrieva I, Sun YB, Irving M, Kampourakis T.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15485-15494. doi: 10.1073/pnas.1903033116. Epub 2019 Jul 15.


C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia.

Savarirayan R, Irving M, Bacino CA, Bostwick B, Charrow J, Cormier-Daire V, Le Quan Sang KH, Dickson P, Harmatz P, Phillips J, Owen N, Cherukuri A, Jayaram K, Jeha GS, Larimore K, Chan ML, Huntsman Labed A, Day J, Hoover-Fong J.

N Engl J Med. 2019 Jul 4;381(1):25-35. doi: 10.1056/NEJMoa1813446. Epub 2019 Jun 18.


Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function.

Vigano S, Alatzoglou D, Irving M, Ménétrier-Caux C, Caux C, Romero P, Coukos G.

Front Immunol. 2019 Jun 6;10:925. doi: 10.3389/fimmu.2019.00925. eCollection 2019. Review.


Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.

Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, Lanitis E, Duraiswamy J, Tanyi JL, Benencia F, Conejo-Garcia J, Ramay HR, Montone KT, Powell DJ Jr, Gimotty PA, Facciabene A, Jackson DG, Weber JS, Rodig SJ, Hodi SF, Kandalaft LE, Irving M, Zhang L, Foukas P, Rusakiewicz S, Delorenzi M, Coukos G.

Cancer Cell. 2019 Jun 10;35(6):885-900.e10. doi: 10.1016/j.ccell.2019.05.004.


Germline selection shapes human mitochondrial DNA diversity.

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC, Brennan P, Elliott P, Flinter FA, Floto RA, Houlden H, Irving M, Koziell A, Maher ER, Markus HS, Morrell NW, Newman WG, Roberts I, Sayer JA, Smith KGC, Taylor JC, Watkins H, Webster AR, Wilkie AOM, Williamson C; NIHR BioResource–Rare Diseases; 100,000 Genomes Project–Rare Diseases Pilot, Ashford S, Penkett CJ, Stirrups KE, Rendon A, Ouwehand WH, Bradley JR, Raymond FL, Caulfield M, Turro E, Chinnery PF.

Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520. Epub 2019 May 23.


Correction to: Bisphosphonate therapy for spinal osteoporosis in Hajdu-Cheney syndrome - new data and literature review.

Pittaway JFH, Harrison C, Rhee Y, Holder-Espinasse M, Fryer AE, Cundy T, Drake WM, Irving MD.

Orphanet J Rare Dis. 2019 May 10;14(1):104. doi: 10.1186/s13023-019-1084-7.


Phenotypic presentations of Hajdu-Cheney syndrome according to age - 5 distinct clinical presentations.

Graversen L, Handrup MM, Irving M, Hove H, Diness BR, Risom L, Svaneby D, Aagaard MM, Vogel I, Gjørup H, Davidsen M, Hellfritzsch MB, Lauridsen E, Gregersen PA.

Eur J Med Genet. 2019 Apr 11. pii: S1769-7212(18)30827-9. doi: 10.1016/j.ejmg.2019.04.007. [Epub ahead of print]


Students Don't Know What They Don't Know: Dental and Oral Health Students' Perspectives on Developing Cultural Competence Regarding Indigenous Peoples.

Forsyth C, Irving M, Short S, Tennant M, Gilroy J.

J Dent Educ. 2019 Jun;83(6):679-686. doi: 10.21815/JDE.019.078. Epub 2019 Mar 25.


Magnetic Field Patterning of Nickel Nanowire Film Realized by Printed Precursor Inks.

Mahajan CG, Alfadhel A, Irving M, Kahn BE, Borkholder DA, Williams SA, Cormier D.

Materials (Basel). 2019 Mar 20;12(6). pii: E928. doi: 10.3390/ma12060928.


Customised approaches to vocational education can dramatically improve completion rates of Australian Aboriginal students.

Gwynne K, Rojas J, Hines M, Bulkeley K, Irving M, McCowen D, Lincoln M.

Aust Health Rev. 2019 Mar 14. doi: 10.1071/AH18051. [Epub ahead of print]


Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components.

Reconditi M, Fusi L, Caremani M, Brunello E, Linari M, Piazzesi G, Lombardi V, Irving M.

Biophys J. 2019 Mar 19;116(6):983-984. doi: 10.1016/j.bpj.2019.02.009. Epub 2019 Mar 2. No abstract available.


Three M Syndrome.

Irving M, Holder-Espinasse M.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2002 Mar 25 [updated 2019 Feb 7].


Best practice guidelines regarding diagnosis and management of patients with type II collagen disorders.

Savarirayan R, Bompadre V, Bober MB, Cho TJ, Goldberg MJ, Hoover-Fong J, Irving M, Kamps SE, Mackenzie WG, Raggio C, Spencer SS, White KK; Skeletal Dysplasia Management Consortium.

Genet Med. 2019 Sep;21(9):2070-2080. doi: 10.1038/s41436-019-0446-9. Epub 2019 Jan 30.


Enabling Aboriginal dental assistants to apply fluoride varnish for school children in communities with a high Aboriginal population in New South Wales, Australia: a study protocol for a feasibility study.

Dimitropoulos Y, Blinkhorn A, Irving M, Skinner J, Naoum S, Holden A, Masoe A, Rambaldini B, Christie V, Spallek H, Gwynne K.

Pilot Feasibility Stud. 2019 Jan 22;5:15. doi: 10.1186/s40814-019-0399-4. eCollection 2019.


Safety and Tolerability of Adoptive Cell Therapy in Cancer.

Wolf B, Zimmermann S, Arber C, Irving M, Trueb L, Coukos G.

Drug Saf. 2019 Feb;42(2):315-334. doi: 10.1007/s40264-018-0779-3. Review.


Depression Among Alcohol Consuming, HIV Positive Men on ART Treatment in India.

Ha T, Schensul SL, Irving M, Brault MA, Schensul JJ, Prabhughate P, Vaz M.

AIDS Behav. 2019 Jun;23(6):1623-1633. doi: 10.1007/s10461-018-2339-3.


An assessment of strategies to control dental caries in Aboriginal children living in rural and remote communities in New South Wales, Australia.

Dimitropoulos Y, Holden A, Gwynne K, Irving M, Binge N, Blinkhorn A.

BMC Oral Health. 2018 Oct 29;18(1):177. doi: 10.1186/s12903-018-0643-y.


Strengthening Indigenous cultural competence in dentistry and oral health education: Academic perspectives.

Forsyth C, Irving M, Short S, Tennant M, Gilroy J.

Eur J Dent Educ. 2019 Feb;23(1):e37-e44. doi: 10.1111/eje.12398. Epub 2018 Oct 11.


Correction to: CART cells are prone to Fas- and DR5-mediated cell death.

Tschumi BO, Dumauthioz N, Marti B, Zhang L, Lanitis E, Irving M, Schneider P, Mach JP, Coukos G, Romero P, Donda A.

J Immunother Cancer. 2018 Sep 25;6(1):92. doi: 10.1186/s40425-018-0410-2.


Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions.

Kampourakis T, Ponnam S, Sun YB, Sevrieva I, Irving M.

J Biol Chem. 2018 Sep 14;293(37):14270-14275. doi: 10.1074/jbc.AC118.004816. Epub 2018 Aug 6.


A Diagnosis of Inflammatory Bowel Disease and Access to Psychotherapy: Rural Patients Who Accept Treatment Report Psychosomatic Benefits.

Watt PJ, Irving MA.

Inflamm Bowel Dis. 2019 Mar 14;25(4):e31-e32. doi: 10.1093/ibd/izy245. No abstract available.


Best practice guidelines regarding prenatal evaluation and delivery of patients with skeletal dysplasia.

Savarirayan R, Rossiter JP, Hoover-Fong JE, Irving M, Bompadre V, Goldberg MJ, Bober MB, Cho TJ, Kamps SE, Mackenzie WG, Raggio C, Spencer SS, White KK; Skeletal Dysplasia Management Consortium.

Am J Obstet Gynecol. 2018 Dec;219(6):545-562. doi: 10.1016/j.ajog.2018.07.017. Epub 2018 Jul 23. Review.


CART cells are prone to Fas- and DR5-mediated cell death.

Tschumi BO, Dumauthioz N, Marti B, Zhang L, Lanitis E, Irving M, Schneider P, Mach JP, Coukos G, Romero P, Donda A.

J Immunother Cancer. 2018 Jul 13;6(1):71. doi: 10.1186/s40425-018-0385-z. Erratum in: J Immunother Cancer. 2018 Sep 25;6(1):92.


WNT10A mutation results in severe tooth agenesis in a family of three sisters.

Abid MF, Simpson MA, Barbosa IA, Seppala M, Irving M, Sharpe PT, Cobourne MT.

Orthod Craniofac Res. 2018 Jun 21. doi: 10.1111/ocr.12231. [Epub ahead of print]


A collaboration with local Aboriginal communities in rural New South Wales, Australia to determine the oral health needs of their children and develop a community-owned oral health promotion program.

Dimitropoulos Y, Gunasekera H, Blinkhorn A, Byun R, Binge N, Gwynne K, Irving M.

Rural Remote Health. 2018 Jun;18(2):4453. doi: 10.22605/RRH4453. Epub 2018 Jun 12.


32 and you - genetic testing for dental disorders.

Harrison M, Bushell CJ, Irving M.

Br Dent J. 2018 May 25;224(10):829-832. doi: 10.1038/sj.bdj.2018.360.


Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW.

Angiogenesis. 2018 Aug;21(3):425-532. doi: 10.1007/s10456-018-9613-x. Review.


Bisphosphonate therapy for spinal osteoporosis in Hajdu-Cheney syndrome - new data and literature review.

Pittaway JFH, Harrison C, Rhee Y, Holder-Espinasse M, Fryer AE, Cundy T, Drake WM, Irving MD.

Orphanet J Rare Dis. 2018 Apr 4;13(1):47. doi: 10.1186/s13023-018-0795-5. Review. Erratum in: Orphanet J Rare Dis. 2019 May 10;14(1):104.


Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ.

Klein BA, Reiz B, Robertson IM, Irving M, Li L, Sun YB, Sykes BD.

Biochemistry. 2018 Apr 17;57(15):2256-2265. doi: 10.1021/acs.biochem.8b00109. Epub 2018 Mar 30.


Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.

Kampourakis T, Ponnam S, Irving M.

J Mol Cell Cardiol. 2018 Apr;117:72-81. doi: 10.1016/j.yjmcc.2018.02.009. Epub 2018 Feb 13.


Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma.

Guo Y, Hu J, Wang Y, Peng X, Min J, Wang J, Matthaiou E, Cheng Y, Sun K, Tong X, Fan Y, Zhang PJ, Kandalaft LE, Irving M, Coukos G, Li C.

Eur J Cancer. 2018 Feb;90:111-121. doi: 10.1016/j.ejca.2017.10.035. Epub 2018 Jan 4.


Indigenous cultural competence: A dental faculty curriculum review.

Forsyth C, Irving M, Tennant M, Short S, Gilroy J.

Eur J Dent Educ. 2018 Aug;22(3):e419-e426. doi: 10.1111/eje.12320. Epub 2017 Dec 30.


Regulation of Contraction by the Thick Filaments in Skeletal Muscle.

Irving M.

Biophys J. 2017 Dec 19;113(12):2579-2594. doi: 10.1016/j.bpj.2017.09.037. Review.


Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.

Kampourakis T, Zhang X, Sun YB, Irving M.

J Physiol. 2018 Jan 1;596(1):31-46. doi: 10.1113/JP275050. Epub 2017 Nov 21.


Mechanisms regulating T-cell infiltration and activity in solid tumors.

Lanitis E, Dangaj D, Irving M, Coukos G.

Ann Oncol. 2017 Dec 1;28(suppl_12):xii18-xii32. doi: 10.1093/annonc/mdx238.


Teaching Cultural Competence in Dental Education: A Systematic Review and Exploration of Implications for Indigenous Populations in Australia.

Forsyth CJ, Irving MJ, Tennant M, Short SD, Gilroy JA.

J Dent Educ. 2017 Aug;81(8):956-968. doi: 10.21815/JDE.017.049. Review.


Best practices in peri-operative management of patients with skeletal dysplasias.

White KK, Bompadre V, Goldberg MJ, Bober MB, Cho TJ, Hoover-Fong JE, Irving M, Mackenzie WG, Kamps SE, Raggio C, Redding GJ, Spencer SS, Savarirayan R, Theroux MC; Skeletal Dysplasia Management Consortium.

Am J Med Genet A. 2017 Oct;173(10):2584-2595. doi: 10.1002/ajmg.a.38357. Epub 2017 Aug 1.


Discovery of dual Axl/VEGF-R2 inhibitors as potential anti-angiogenic and anti-metastatic drugs for cancer chemotherapy.

Goff D, Zhang J, Heckrodt T, Yu J, Ding P, Singh R, Holland S, Li W, Irving M.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3766-3771. doi: 10.1016/j.bmcl.2017.06.071. Epub 2017 Jun 28.


The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

Merkle PS, Irving M, Hongjian S, Ferber M, Jørgensen TJD, Scholten K, Luescher I, Coukos G, Zoete V, Cuendet MA, Michielin O, Rand KD.

Biochemistry. 2017 Aug 1;56(30):3945-3961. doi: 10.1021/acs.biochem.7b00385. Epub 2017 Jul 19.


Oral Health Programmes in Indigenous Communities Worldwide-Lessons learned from the field: A qualitative systematic review.

Tsai C, Blinkhorn A, Irving M.

Community Dent Oral Epidemiol. 2017 Oct;45(5):389-397. doi: 10.1111/cdoe.12302. Epub 2017 Apr 20. Review.


Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel.

Irving M, Vuillefroy de Silly R, Scholten K, Dilek N, Coukos G.

Front Immunol. 2017 Apr 3;8:267. doi: 10.3389/fimmu.2017.00267. eCollection 2017. Review.


Enantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution.

Zhang J, Kolluri R, Alvarez SG, Irving MM, Singh R, Duncton MA.

Org Biomol Chem. 2017 Apr 5;15(14):2953-2961. doi: 10.1039/c7ob00192d.


Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle.

Zhang X, Kampourakis T, Yan Z, Sevrieva I, Irving M, Sun YB.

Elife. 2017 Feb 23;6. pii: e24081. doi: 10.7554/eLife.24081.

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