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Items: 1 to 50 of 55

1.

Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia.

Al-Aamri HM, Ku H, Irving HR, Tucci J, Meehan-Andrews T, Bradley C.

BMC Cancer. 2019 Feb 27;19(1):179. doi: 10.1186/s12885-019-5377-y.

2.

Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract.

Nedi T, White PJ, Coupar IM, Irving HR.

BMC Res Notes. 2018 Jun 8;11(1):362. doi: 10.1186/s13104-018-3495-2.

3.

The C and E subunits of the serotonin 5-HT3 receptor subtly modulate electrical properties of the receptor.

Yaakob NS, Nguyen DT, Exintaris B, Irving HR.

Biomed Pharmacother. 2018 Jan;97:1701-1709. doi: 10.1016/j.biopha.2017.12.010. Epub 2017 Dec 8.

PMID:
29793334
4.

Moonlighting Proteins and Their Role in the Control of Signaling Microenvironments, as Exemplified by cGMP and Phytosulfokine Receptor 1 (PSKR1).

Irving HR, Cahill DM, Gehring C.

Front Plant Sci. 2018 Mar 28;9:415. doi: 10.3389/fpls.2018.00415. eCollection 2018.

5.

Intramolecular crosstalk between catalytic activities of receptor kinases.

Kwezi L, Wheeler JI, Marondedze C, Gehring C, Irving HR.

Plant Signal Behav. 2018 Feb 1;13(2):e1430544. doi: 10.1080/15592324.2018.1430544. Epub 2018 Feb 15.

6.

The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling.

Wheeler JI, Wong A, Marondedze C, Groen AJ, Kwezi L, Freihat L, Vyas J, Raji MA, Irving HR, Gehring C.

Plant J. 2017 Aug;91(4):590-600. doi: 10.1111/tpj.13589. Epub 2017 Jun 12.

7.

High Molecular Weight DNA Enrichment with Peptide Nucleic Acid Probes.

Murphy NM, Pouton CW, Irving HR.

Methods Mol Biol. 2017;1551:73-85. doi: 10.1007/978-1-4939-6750-6_4.

PMID:
28138841
8.

Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1.

Muleya V, Marondedze C, Wheeler JI, Thomas L, Mok YF, Griffin MD, Manallack DT, Kwezi L, Lilley KS, Gehring C, Irving HR.

Biochem J. 2016 Oct 1;473(19):3081-98. doi: 10.1042/BCJ20160593. Epub 2016 Aug 3.

PMID:
27487840
9.

Haplotyping the human leukocyte antigen system from single chromosomes.

Murphy NM, Burton M, Powell DR, Rossello FJ, Cooper D, Chopra A, Hsieh MJ, Sayer DC, Gordon L, Pertile MD, Tait BD, Irving HR, Pouton CW.

Sci Rep. 2016 Jul 27;6:30381. doi: 10.1038/srep30381.

10.

Quantitative proteome changes in Arabidopsis thaliana suspension-cultured cells in response to plant natriuretic peptides.

Turek I, Wheeler JI, Gehring C, Irving HR, Marondedze C.

Data Brief. 2015 Jun 30;4:336-43. doi: 10.1016/j.dib.2015.06.013. eCollection 2015 Sep.

11.

Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon.

Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR.

J Neurogastroenterol Motil. 2015 Jul 30;21(3):361-9. doi: 10.5056/jnm14157.

12.

Conserved Functional Motifs and Homology Modeling to Predict Hidden Moonlighting Functional Sites.

Wong A, Gehring C, Irving HR.

Front Bioeng Biotechnol. 2015 Jun 9;3:82. doi: 10.3389/fbioe.2015.00082. eCollection 2015. Review.

13.

Plant natriuretic peptides induce proteins diagnostic for an adaptive response to stress.

Turek I, Marondedze C, Wheeler JI, Gehring C, Irving HR.

Front Plant Sci. 2014 Nov 26;5:661. doi: 10.3389/fpls.2014.00661. eCollection 2014.

14.

Comparison of moonlighting guanylate cyclases: roles in signal direction?

Freihat L, Muleya V, Manallack DT, Wheeler JI, Irving HR.

Biochem Soc Trans. 2014 Dec;42(6):1773-9. doi: 10.1042/BST20140223. Review.

PMID:
25399605
15.

Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1.

Muleya V, Wheeler JI, Ruzvidzo O, Freihat L, Manallack DT, Gehring C, Irving HR.

Cell Commun Signal. 2014 Sep 23;12:60. doi: 10.1186/s12964-014-0060-z.

16.

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes.

Murphy NM, Pouton CW, Irving HR.

Mol Genet Genomic Med. 2014 May;2(3):245-53. doi: 10.1002/mgg3.65. Epub 2014 Jan 19.

17.

A cyclic nucleotide sensitive promoter reporter system suitable for bacteria and plant cells.

Wheeler JI, Freihat L, Irving HR.

BMC Biotechnol. 2013 Nov 9;13:97. doi: 10.1186/1472-6750-13-97.

18.

Structural and functional characterization of receptor kinases with nucleotide cyclase activity.

Muleya V, Wheeler JI, Irving HR.

Methods Mol Biol. 2013;1016:175-94. doi: 10.1007/978-1-62703-441-8_12.

PMID:
23681579
19.

Molecular methods for the study of signal transduction in plants.

Irving HR, Gehring C.

Methods Mol Biol. 2013;1016:1-11. doi: 10.1007/978-1-62703-441-8_1. Review.

PMID:
23681568
20.

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.

Mellor JD, Brown MP, Irving HR, Zalcberg JR, Dobrovic A.

J Hematol Oncol. 2013 Jan 4;6:1. doi: 10.1186/1756-8722-6-1. Review.

21.

Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.

Coupar IM, Irving HR, Manallack DT, Tan YY, Ayad F, Iulio JD, Tochon-Danguy N, Iskander MN.

J Pharm Pharmacol. 2012 Aug;64(8):1099-106. doi: 10.1111/j.2042-7158.2012.01500.x. Epub 2012 Mar 16.

PMID:
22775213
22.

Moonlighting kinases with guanylate cyclase activity can tune regulatory signal networks.

Irving HR, Kwezi L, Wheeler J, Gehring C.

Plant Signal Behav. 2012 Feb;7(2):201-4. doi: 10.4161/psb.18891. Epub 2012 Feb 1.

23.

Plant natriuretic peptides: control of synthesis and systemic effects.

Wang YH, Donaldson L, Gehring C, Irving HR.

Plant Signal Behav. 2011 Oct;6(10):1606-8. doi: 10.4161/psb.6.10.17304. Epub 2011 Oct 1.

24.

The phytosulfokine (PSK) receptor is capable of guanylate cyclase activity and enabling cyclic GMP-dependent signaling in plants.

Kwezi L, Ruzvidzo O, Wheeler JI, Govender K, Iacuone S, Thompson PE, Gehring C, Irving HR.

J Biol Chem. 2011 Jun 24;286(25):22580-8. doi: 10.1074/jbc.M110.168823. Epub 2011 Apr 19.

25.

Plant natriuretic peptides are apoplastic and paracrine stress response molecules.

Wang YH, Gehring C, Irving HR.

Plant Cell Physiol. 2011 May;52(5):837-50. doi: 10.1093/pcp/pcr036. Epub 2011 Apr 7.

PMID:
21478192
26.

Developing a model of plant hormone interactions.

Wang YH, Irving HR.

Plant Signal Behav. 2011 Apr;6(4):494-500. Epub 2011 Apr 1. Review.

27.

Heterogeneity amongst 5-HT₃ receptor subunits: is this significant?

Yaakob N, Malone DT, Exintaris B, Irving HR.

Curr Mol Med. 2011 Feb;11(1):57-68. Review.

PMID:
21189117
28.

Synthesis, testing and structure-activity studies on a library of 5-HT₄ ligands.

Hanna-Elias A, Manallack DT, Levit A, Nguyen W, Ayad F, Perera G, Shapiro M, Irving HR, Coupar IM, Iskander MN.

Med Chem. 2010 Nov;6(6):344-54.

PMID:
21175422
29.

Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract.

Nedi T, White PJ, Coupar IM, Irving HR.

Biochem Pharmacol. 2011 Jan 1;81(1):123-33. doi: 10.1016/j.bcp.2010.09.003. Epub 2010 Sep 15.

PMID:
20836992
30.

Synthesis and preliminary screening of novel tryptamines as 5-HT4 receptor ligands.

Hanna-Elias A, Manallack DT, Berque-Bestel I, Irving HR, Coupar IM, Iskander MN.

Curr Med Chem. 2010;17(25):2775-87.

PMID:
20586717
31.

Induction of apoptosis by plant natriuretic peptides in rat cardiomyoblasts.

Wang YH, Ahmar H, Irving HR.

Peptides. 2010 Jun;31(6):1213-8. doi: 10.1016/j.peptides.2010.03.011. Epub 2010 Mar 20.

PMID:
20307601
32.

Investigations into the binding affinities of different human 5-HT4 receptor splice variants.

Irving HR, Tochon-Danguy N, Chinkwo KA, Li JG, Grabbe C, Shapiro M, Pouton CW, Coupar IM.

Pharmacology. 2010;85(4):224-33. doi: 10.1159/000280418. Epub 2010 Mar 17.

PMID:
20299822
33.

The use of tripeptides for lead discovery of 5-HT4 receptor ligands.

Hanna-Elias A, Thompson PE, Manallack DT, Irving HR, Coupar IM, Berque-Bestel I, Iskander MN.

Protein Pept Lett. 2009;16(7):805-9.

PMID:
19601910
34.

Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands.

Hanna-Elias A, Manallack DT, Berque-Bestel I, Irving HR, Coupar IM, Iskander MN.

Eur J Med Chem. 2009 Jul;44(7):2952-9. doi: 10.1016/j.ejmech.2009.01.015. Epub 2009 Jan 24.

PMID:
19223092
35.

Distribution of serotonin receptors and interacting proteins in the human sigmoid colon.

Chetty N, Coupar IM, Tan YY, Desmond PV, Irving HR.

Neurogastroenterol Motil. 2009 May;21(5):551-8, e14-5. doi: 10.1111/j.1365-2982.2008.01223.x. Epub 2008 Dec 5.

PMID:
19126183
36.

Human 5-HT(4) and 5-HT(7) receptor splice variants: are they important?

Coupar IM, Desmond PV, Irving HR.

Curr Neuropharmacol. 2007 Dec;5(4):224-31. doi: 10.2174/157015907782793621.

37.

Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract.

Chetty N, Irving HR, Coupar IM.

Pharmacology. 2008;81(2):104-9. Epub 2007 Oct 19.

PMID:
17952012
38.

Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon.

Irving HR, Tan YY, Tochon-Danguy N, Liu H, Chetty N, Desmond PV, Pouton CW, Coupar IM.

Life Sci. 2007 Mar 6;80(13):1198-205. Epub 2007 Jan 12.

PMID:
17258778
39.
40.

Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study.

Chetty N, Irving HR, Coupar IM.

Br J Pharmacol. 2006 Aug;148(7):1012-21. Epub 2006 Jun 12.

41.

Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors.

Kelly-Skupek MN, Irving HR.

Plant Physiol Biochem. 2006 Feb-Mar;44(2-3):132-42. Epub 2006 Mar 31.

PMID:
16647267
42.

Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine.

Poole DP, Xu B, Koh SL, Hunne B, Coupar IM, Irving HR, Shinjo K, Furness JB.

Cell Tissue Res. 2006 Sep;325(3):413-22. Epub 2006 Apr 21.

PMID:
16628410
43.

Influences of gender and region on responses to 5-HT in the rat small intestine.

Liu H, Irving HR, Tan YY, Meng L, Chetty N, Coupar IM.

Pharmacology. 2004 Dec;72(4):220-4.

PMID:
15539881
44.

Effects of some antidepressant drugs on tryptaminergic responses of the rat jejunum.

Liu H, Coupar IM, Irving HR.

Pharmacology. 2003 Oct;69(2):88-92.

PMID:
12928582
45.

Natriuretic peptides--a class of heterologous molecules in plants.

Gehring CA, Irving HR.

Int J Biochem Cell Biol. 2003 Sep;35(9):1318-22. Review.

PMID:
12798346
46.

In situ localization associates biologically active plant natriuretic peptide immuno-analogues with conductive tissue and stomata.

Maryani MM, Morse MV, Bradley G, Irving HR, Cahill DM, Gehring CA.

J Exp Bot. 2003 Jun;54(387):1553-64. Epub 2003 Apr 28.

PMID:
12730261
47.

Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.

Kelly MN, Irving HR.

Planta. 2003 Feb;216(4):674-85. Epub 2002 Sep 26.

PMID:
12569410
48.

Expansin-like molecules: novel functions derived from common domains.

Ludidi NN, Heazlewood JL, Seoighe C, Irving HR, Gehring CA.

J Mol Evol. 2002 May;54(5):587-94.

PMID:
11965432
49.

Expression patterns of 5-HT7 receptor isoforms in the rat digestive tract.

Liu H, Irving HR, Coupar IM.

Life Sci. 2001 Oct 12;69(21):2467-75.

PMID:
11693255
50.

Characterisation of muscarinic receptor subtypes in avian smooth muscle.

Darroch S, Irving HR, Mitchelson FJ.

Eur J Pharmacol. 2000 Aug 18;402(1-2):161-9.

PMID:
10940370

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