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Items: 1 to 50 of 69

1.

Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin.

McGregor G, Clements L, Farah A, Irving AJ, Harvey J.

Neurobiol Aging. 2018 May 14;69:76-93. doi: 10.1016/j.neurobiolaging.2018.05.007. [Epub ahead of print]

2.

Big conductance calcium-activated potassium channel openers control spasticity without sedation.

Baker D, Pryce G, Visintin C, Sisay S, Bondarenko AI, Vanessa Ho WS, Jackson SJ, Williams TE, Al-Izki S, Sevastou I, Okuyama M, Graier WF, Stevenson LA, Tanner C, Ross R, Pertwee RG, Henstridge CM, Irving AJ, Schulman J, Powell K, Baker MD, Giovannoni G, Selwood DL.

Br J Pharmacol. 2017 Aug;174(16):2662-2681. doi: 10.1111/bph.13889. Epub 2017 Jul 7.

3.

Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses.

McGregor G, Irving AJ, Harvey J.

FASEB J. 2017 Aug;31(8):3449-3466. doi: 10.1096/fj.201601293RR. Epub 2017 May 1.

PMID:
28461339
4.

Two billion years of magmatism recorded from a single Mars meteorite ejection site.

Lapen TJ, Righter M, Andreasen R, Irving AJ, Satkoski AM, Beard BL, Nishiizumi K, Jull AJ, Caffee MW.

Sci Adv. 2017 Feb 1;3(2):e1600922. doi: 10.1126/sciadv.1600922. eCollection 2017 Feb.

5.

Lipid sensing G protein-coupled receptors in the CNS.

Dev KK, Irving AJ.

Neuropharmacology. 2017 Feb;113(Pt B):595-596. doi: 10.1016/j.neuropharm.2016.10.030. No abstract available.

PMID:
27986103
6.

Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS.

Alexander A, Irving AJ, Harvey J.

Neuropharmacology. 2017 Feb;113(Pt B):652-660. doi: 10.1016/j.neuropharm.2016.07.003. Epub 2016 Jul 5. Review.

PMID:
27392633
7.

Modulation of l-α-lysophosphatidylinositol/GPR55 MAP kinase signalling by CB2 receptor agonists: identifying novel GPR55 inhibitors.

Anavi-Goffer S, Irving AJ, Ross RA.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):303-10. doi: 10.1515/jbcpp-2015-0142.

8.

Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.

Morales P, Whyte LS, Chicharro R, Gómez-Cañas M, Pazos MR, Goya P, Irving AJ, Fernández-Ruiz J, Ross RA, Jagerovic N.

J Med Chem. 2016 Mar 10;59(5):1840-53. doi: 10.1021/acs.jmedchem.5b01331. Epub 2016 Feb 5.

PMID:
26789378
9.

The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions.

Haugh O, Penman J, Irving AJ, Campbell VA.

Curr Drug Targets. 2016;17(16):1834-1840. Review.

PMID:
26758668
10.

CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction.

Lipina C, Vaanholt LM, Davidova A, Mitchell SE, Storey-Gordon E, Hambly C, Irving AJ, Speakman JR, Hundal HS.

Aging Cell. 2016 Apr;15(2):325-35. doi: 10.1111/acel.12438. Epub 2016 Jan 13.

11.

Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.

Yrjölä S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor AA, Kokkola T, Adusei-Mensah F, Savinainen JR, Laitinen JT, Poso A, Alexander A, Penman J, Stott L, Anskat M, Irving AJ, Nevalainen TJ.

Eur J Med Chem. 2016 Jan 1;107:119-32. doi: 10.1016/j.ejmech.2015.10.050. Epub 2015 Nov 2.

PMID:
26575458
12.

Leptin Induces a Novel Form of NMDA Receptor-Dependent LTP at Hippocampal Temporoammonic-CA1 Synapses

Luo X, McGregor G, Irving AJ, Harvey J.

eNeuro. 2015 Jun 10;2(3). pii: ENEURO.0007-15.2015. doi: 10.1523/ENEURO.0007-15.2015. eCollection 2015 May-Jun.

13.

Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.

J Biol Chem. 2014 Aug 8;289(32):21960-72. doi: 10.1074/jbc.M114.561761. Epub 2014 Jun 18.

14.

Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

Lipina C, Irving AJ, Hundal HS.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E1-13. doi: 10.1152/ajpendo.00100.2014. Epub 2014 May 6. Review.

15.

Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars.

Franz HB, Kim ST, Farquhar J, Day JM, Economos RC, McKeegan KD, Schmitt AK, Irving AJ, Hoek J, Dottin J 3rd.

Nature. 2014 Apr 17;508(7496):364-8. doi: 10.1038/nature13175.

16.

Leptin regulation of hippocampal synaptic function in health and disease.

Irving AJ, Harvey J.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130155. doi: 10.1098/rstb.2013.0155. Print 2014 Jan 5. Review.

17.

From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits.

Youssef FF, Irving AJ.

West Indian Med J. 2012 Jun;61(3):264-70. Review.

PMID:
23155985
18.

New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance.

Lipina C, Rastedt W, Irving AJ, Hundal HS.

Bioessays. 2012 Aug;34(8):681-91. doi: 10.1002/bies.201200031. Epub 2012 Jun 5. Review.

PMID:
22674489
19.

Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.

Anavi-Goffer S, Baillie G, Irving AJ, Gertsch J, Greig IR, Pertwee RG, Ross RA.

J Biol Chem. 2012 Jan 2;287(1):91-104. doi: 10.1074/jbc.M111.296020. Epub 2011 Oct 25.

20.

Differential trafficking of adenosine receptors in hippocampal neurons monitored using GFP- and super-ecliptic pHluorin-tagged receptors.

Baines AE, Corrêa SA, Irving AJ, Frenguelli BG.

Neuropharmacology. 2011 Jul-Aug;61(1-2):1-11. doi: 10.1016/j.neuropharm.2011.02.005. Epub 2011 Feb 17.

PMID:
21315741
21.

A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.

Ford LA, Roelofs AJ, Anavi-Goffer S, Mowat L, Simpson DG, Irving AJ, Rogers MJ, Rajnicek AM, Ross RA.

Br J Pharmacol. 2010 Jun;160(3):762-71. doi: 10.1111/j.1476-5381.2010.00743.x.

22.

GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?

Nevalainen T, Irving AJ.

Curr Top Med Chem. 2010;10(8):799-813. Review.

PMID:
20370712
23.

Leptin regulates AMPA receptor trafficking via PTEN inhibition.

Moult PR, Cross A, Santos SD, Carvalho AL, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J.

J Neurosci. 2010 Mar 17;30(11):4088-101. doi: 10.1523/JNEUROSCI.3614-09.2010.

24.

GPR55 ligands promote receptor coupling to multiple signalling pathways.

Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler JL, Kostenis E, Waldhoer M, Irving AJ.

Br J Pharmacol. 2010 Jun;160(3):604-14. doi: 10.1111/j.1476-5381.2009.00625.x. Epub 2010 Feb 5.

25.

Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.

Daly CJ, Ross RA, Whyte J, Henstridge CM, Irving AJ, McGrath JC.

Br J Pharmacol. 2010 Feb;159(4):787-96. doi: 10.1111/j.1476-5381.2009.00608.x. Epub 2010 Feb 5.

26.

We finally made it out of that darn hospital.

Irving AJ.

Midwifery Today Int Midwife. 2009-2010 Winter;(92):30-2. No abstract available.

PMID:
20092145
27.

Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells.

Lipina C, Stretton C, Hastings S, Hundal JS, Mackie K, Irving AJ, Hundal HS.

Diabetes. 2010 Feb;59(2):375-85. doi: 10.2337/db09-0979. Epub 2009 Nov 23.

28.

Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes.

Osborne KD, Lee W, Malarkey EB, Irving AJ, Parpura V.

ASN Neuro. 2009 Dec 8;1(5). pii: AN20090040. doi: 10.1042/AN20090040.

29.

Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.

Krzywkowski K, Davies PA, Irving AJ, Bräuner-Osborne H, Jensen AA.

Pharmacogenet Genomics. 2008 Dec;18(12):1027-40. doi: 10.1097/FPC.0b013e328310f950.

PMID:
19008750
30.

Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.

Etherington LA, Patterson GE, Meechan L, Boison D, Irving AJ, Dale N, Frenguelli BG.

Neuropharmacology. 2009 Feb;56(2):429-37. doi: 10.1016/j.neuropharm.2008.09.016. Epub 2008 Oct 10.

PMID:
18957298
31.

The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation.

Henstridge CM, Balenga NA, Ford LA, Ross RA, Waldhoer M, Irving AJ.

FASEB J. 2009 Jan;23(1):183-93. doi: 10.1096/fj.08-108670. Epub 2008 Aug 29.

PMID:
18757503
32.

Leptin promotes rapid dynamic changes in hippocampal dendritic morphology.

O'Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ, Harvey J.

Mol Cell Neurosci. 2007 Aug;35(4):559-72. Epub 2007 May 10.

33.

Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition.

Cheng A, Bollan KA, Greenwood SM, Irving AJ, Connolly CN.

J Biol Chem. 2007 Sep 7;282(36):26158-66. Epub 2007 Jul 3.

34.

Hardwiring the brain: endocannabinoids shape neuronal connectivity.

Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urbán GM, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T.

Science. 2007 May 25;316(5828):1212-6.

35.

Generation and functional characterization of fluorescent, N-terminally tagged CB1 receptor chimeras for live-cell imaging.

McDonald NA, Henstridge CM, Connolly CN, Irving AJ.

Mol Cell Neurosci. 2007 Jun;35(2):237-48. Epub 2007 Mar 3.

PMID:
17467290
36.

Cannabinoid modulation of neuronal function after oxygen/glucose deprivation in area CA1 of the rat hippocampus.

Youssef FF, Hormuzdi SG, Irving AJ, Frenguelli BG.

Neuropharmacology. 2007 May;52(6):1327-35. Epub 2006 Dec 23.

PMID:
17382973
37.

An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor.

McDonald NA, Henstridge CM, Connolly CN, Irving AJ.

Mol Pharmacol. 2007 Apr;71(4):976-84. Epub 2006 Dec 20.

38.

Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes.

Bushell TJ, Plevin R, Cobb S, Irving AJ.

Neuropharmacology. 2006 May;50(6):714-25. Epub 2006 Jan 20.

PMID:
16430928
39.
40.
41.

Leptin: a potential cognitive enhancer?

Harvey J, Shanley LJ, O'Malley D, Irving AJ.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1029-32. Review.

PMID:
16246038
42.

Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels.

O'Malley D, Irving AJ, Harvey J.

FASEB J. 2005 Nov;19(13):1917-9. Epub 2005 Sep 15.

PMID:
16166199
43.

Leptin induces a novel form of NMDA receptor-dependent long-term depression.

Durakoglugil M, Irving AJ, Harvey J.

J Neurochem. 2005 Oct;95(2):396-405. Epub 2005 Aug 8.

44.

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

Cole AR, Knebel A, Morrice NA, Robertson LA, Irving AJ, Connolly CN, Sutherland C.

J Biol Chem. 2004 Nov 26;279(48):50176-80. Epub 2004 Oct 5.

45.
46.

Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels.

White AM, Kylänpää RA, Christie LA, McIntosh SJ, Irving AJ, Platt B.

Br J Pharmacol. 2003 Dec;140(8):1421-33. Epub 2003 Nov 17.

47.

Cannabinoids on the brain.

Irving AJ, Rae MG, Coutts AA.

ScientificWorldJournal. 2002 Mar 9;2:632-48. Review.

48.

Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.

Shanley LJ, O'Malley D, Irving AJ, Ashford ML, Harvey J.

J Physiol. 2002 Dec 15;545(Pt 3):933-44.

49.

Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus.

Coutts AA, Irving AJ, Mackie K, Pertwee RG, Anavi-Goffer S.

J Comp Neurol. 2002 Jul 8;448(4):410-22.

PMID:
12115703
50.

Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels.

Shanley LJ, Irving AJ, Rae MG, Ashford ML, Harvey J.

Nat Neurosci. 2002 Apr;5(4):299-300. No abstract available.

PMID:
11889470

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