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Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia.

Irving AT, Rozario P, Kong PS, Luko K, Gorman JJ, Hastie ML, Chia WN, Mani S, Lee BP, Smith GJD, Mendenhall IH, Larman HB, Elledge SJ, Wang LF.

Cell Mol Life Sci. 2019 Jul 27. doi: 10.1007/s00018-019-03242-x. [Epub ahead of print]


High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress.

Chionh YT, Cui J, Koh J, Mendenhall IH, Ng JHJ, Low D, Itahana K, Irving AT, Wang LF.

Cell Stress Chaperones. 2019 Jul;24(4):835-849. doi: 10.1007/s12192-019-01013-y. Epub 2019 Jun 22.


Why do parents present to the Paediatric Emergency Department with conditions suitable for management in less acute settings? A Qualitative Study.

McLauchlan K, Ramlakhan S, Irving A.

Eur J Emerg Med. 2019 May 20. doi: 10.1097/MEJ.0000000000000611. [Epub ahead of print]


Developing new ways of measuring the quality and impact of ambulance service care: the PhOEBE mixed-methods research programme.

Turner J, Siriwardena AN, Coster J, Jacques R, Irving A, Crum A, Gorrod HB, Nicholl J, Phung VH, Togher F, Wilson R, O’Cathain A, Booth A, Bradbury D, Goodacre S, Spaight A, Shewan J, Pilbery R, Fall D, Marsh M, Broadway-Parkinson A, Lyons R, Snooks H, Campbell M.

Southampton (UK): NIHR Journals Library; 2019 Apr.


Fresh Red Cells for Transfusion in Critically Ill Adults: An Economic Evaluation of the Standard Issue Transfusion Versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Clinical Trial.

Irving A, Higgins A, Ady B, Bellomo R, Cooper DJ, French C, Gantner D, Harris A, Irving DO, Murray L, Nichol A, Petrie D, McQuilten ZK; Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group.

Crit Care Med. 2019 Jul;47(7):e572-e579. doi: 10.1097/CCM.0000000000003781.


The origin of the unique achondrite Northwest Africa 6704: Constraints from petrology, chemistry and Re-Os, O and Ti isotope systematics.

Hibiya Y, Archer GJ, Tanaka R, Sanborn ME, Sato Y, Iizuka T, Ozawa K, Walker RJ, Yamaguchi A, Yin QZ, Nakamura T, Irving AJ.

Geochim Cosmochim Acta. 2019 Jan 15;245:597-627. doi: 10.1016/j.gca.2018.04.031. Epub 2018 May 9.


Studies on B Cells in the Fruit-Eating Black Flying Fox (Pteropus alecto).

Periasamy P, Hutchinson PE, Chen J, Bonne I, Shahul Hameed SS, Selvam P, Hey YY, Fink K, Irving AT, Dutertre CA, Baker M, Crameri G, Wang LF, Alonso S.

Front Immunol. 2019 Mar 14;10:489. doi: 10.3389/fimmu.2019.00489. eCollection 2019.


GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.

Korchynska S, Lutz MI, Borók E, Pammer J, Cinquina V, Fedirko N, Irving AJ, Mackie K, Harkany T, Keimpema E.

JCI Insight. 2019 Feb 21;4(4). pii: 122947. doi: 10.1172/jci.insight.122947. eCollection 2019 Feb 21.


Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.

Ahn M, Anderson DE, Zhang Q, Tan CW, Lim BL, Luko K, Wen M, Chia WN, Mani S, Wang LC, Ng JHJ, Sobota RM, Dutertre CA, Ginhoux F, Shi ZL, Irving AT, Wang LF.

Nat Microbiol. 2019 May;4(5):789-799. doi: 10.1038/s41564-019-0371-3. Epub 2019 Feb 25.


Exploring the genome and transcriptome of the cave nectar bat Eonycteris spelaea with PacBio long-read sequencing.

Wen M, Ng JHJ, Zhu F, Chionh YT, Chia WN, Mendenhall IH, Lee BP, Irving AT, Wang LF.

Gigascience. 2018 Oct 1;7(10). doi: 10.1093/gigascience/giy116.


The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer.

Pleiman JK, Irving AA, Wang Z, Toraason E, Clipson L, Dove WF, Deming DA, Newton MA.

PLoS Genet. 2018 Sep 6;14(9):e1007611. doi: 10.1371/journal.pgen.1007611. eCollection 2018 Sep.


Clinical pearls of gender-affirming hormone therapy in transgender patients.

Irving A, Lehault WB.

Ment Health Clin. 2018 Mar 26;7(4):164-167. doi: 10.9740/mhc.2017.07.164. eCollection 2017 Jul.


Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin.

McGregor G, Clements L, Farah A, Irving AJ, Harvey J.

Neurobiol Aging. 2018 Sep;69:76-93. doi: 10.1016/j.neurobiolaging.2018.05.007. Epub 2018 May 14.


Vitamin D deficiency in the ApcPirc/+ rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective.

Irving AA, Duchow EG, Plum LA, DeLuca HF.

Dis Model Mech. 2018 Mar 7;11(3). pii: dmm032300. doi: 10.1242/dmm.032300.


Important patient and public (PPI) perspectives on addiction as a reason for performing euthanasia.

Irving A.

Addiction. 2018 Jul;113(7):1185-1186. doi: 10.1111/add.14193. Epub 2018 Mar 24. No abstract available.


Correction: IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection.

Zhang Q, Zeng LP, Zhou P, Irving AT, Li S, Shi ZL, Wang LF.

PLoS One. 2018 Jan 17;13(1):e0191578. doi: 10.1371/journal.pone.0191578. eCollection 2018.


Managing alcohol-related attendances in emergency care: can diversion to bespoke services lessen the burden?

Irving A, Goodacre S, Blake J, Allen D, Moore SC.

Emerg Med J. 2018 Feb;35(2):79-82. doi: 10.1136/emermed-2016-206451. Epub 2017 Nov 28.


Use of iDXA spine scans to evaluate total and visceral abdominal fat.

Bea JW, Hsu CH, Blew RM, Irving AP, Caan BJ, Kwan ML, Abraham I, Going SB.

Am J Hum Biol. 2018 Jan;30(1). doi: 10.1002/ajhb.23057. Epub 2017 Sep 8.


A coproduced patient and public event: An approach to developing and prioritizing ambulance performance measures.

Irving A, Turner J, Marsh M, Broadway-Parkinson A, Fall D, Coster J, Siriwardena AN.

Health Expect. 2018 Feb;21(1):230-238. doi: 10.1111/hex.12606. Epub 2017 Aug 25.


Prioritizing novel and existing ambulance performance measures through expert and lay consensus: A three-stage multimethod consensus study.

Coster JE, Irving AD, Turner JK, Phung VH, Siriwardena AN.

Health Expect. 2018 Feb;21(1):249-260. doi: 10.1111/hex.12610. Epub 2017 Aug 25.


Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors.

Irving A, Abdulrazzaq G, Chan SLF, Penman J, Harvey J, Alexander SPH.

Adv Pharmacol. 2017;80:223-247. doi: 10.1016/bs.apha.2017.04.004. Epub 2017 Jun 12. Review.


Potential mechanisms of calcium dependent regulation of the mammalian cell cycle revealed by comprehensive unbiased label-free nLC-MS/MS quantitative proteomics.

Kwasnik A, von Kriegsheim A, Irving A, Pennington SR.

J Proteomics. 2018 Jan 6;170:151-166. doi: 10.1016/j.jprot.2017.08.006. Epub 2017 Aug 18.


IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection.

Zhang Q, Zeng LP, Zhou P, Irving AT, Li S, Shi ZL, Wang LF.

PLoS One. 2017 Aug 9;12(8):e0182866. doi: 10.1371/journal.pone.0182866. eCollection 2017. Erratum in: PLoS One. 2018 Jan 17;13(1):e0191578.


Big conductance calcium-activated potassium channel openers control spasticity without sedation.

Baker D, Pryce G, Visintin C, Sisay S, Bondarenko AI, Vanessa Ho WS, Jackson SJ, Williams TE, Al-Izki S, Sevastou I, Okuyama M, Graier WF, Stevenson LA, Tanner C, Ross R, Pertwee RG, Henstridge CM, Irving AJ, Schulman J, Powell K, Baker MD, Giovannoni G, Selwood DL.

Br J Pharmacol. 2017 Aug;174(16):2662-2681. doi: 10.1111/bph.13889. Epub 2017 Jul 7.


Testing for thresholds of ecosystem collapse in seagrass meadows.

Connell SD, Fernandes M, Burnell OW, Doubleday ZA, Griffin KJ, Irving AD, Leung JYS, Owen S, Russell BD, Falkenberg LJ.

Conserv Biol. 2017 Oct;31(5):1196-1201. doi: 10.1111/cobi.12951. Epub 2017 Jul 28.


Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses.

McGregor G, Irving AJ, Harvey J.

FASEB J. 2017 Aug;31(8):3449-3466. doi: 10.1096/fj.201601293RR. Epub 2017 May 1.


Species coexistence and the superior ability of an invasive species to exploit a facilitation cascade habitat.

Altieri AH, Irving AD.

PeerJ. 2017 Feb 21;5:e2848. doi: 10.7717/peerj.2848. eCollection 2017.


Two billion years of magmatism recorded from a single Mars meteorite ejection site.

Lapen TJ, Righter M, Andreasen R, Irving AJ, Satkoski AM, Beard BL, Nishiizumi K, Jull AJ, Caffee MW.

Sci Adv. 2017 Feb 1;3(2):e1600922. doi: 10.1126/sciadv.1600922. eCollection 2017 Feb.


Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid.

Irving AA, Marling SJ, Plum LA, DeLuca HF.

BMC Neurosci. 2017 Jan 5;18(1):8. doi: 10.1186/s12868-016-0323-2.


Lipid sensing G protein-coupled receptors in the CNS.

Dev KK, Irving AJ.

Neuropharmacology. 2017 Feb;113(Pt B):595-596. doi: 10.1016/j.neuropharm.2016.10.030. No abstract available.


Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages.

Zhou P, Chionh YT, Irac SE, Ahn M, Jia Ng JH, Fossum E, Bogen B, Ginhoux F, Irving AT, Dutertre CA, Wang LF.

Sci Rep. 2016 Dec 9;6:38597. doi: 10.1038/srep38597.


Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto.

Martínez Gómez JM, Periasamy P, Dutertre CA, Irving AT, Ng JH, Crameri G, Baker ML, Ginhoux F, Wang LF, Alonso S.

Sci Rep. 2016 Nov 24;6:37796. doi: 10.1038/srep37796.


Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS.

Alexander A, Irving AJ, Harvey J.

Neuropharmacology. 2017 Feb;113(Pt B):652-660. doi: 10.1016/j.neuropharm.2016.07.003. Epub 2016 Jul 5. Review.


Identifying knowledge gaps in seagrass research and management: An Australian perspective.

York PH, Smith TM, Coles RG, McKenna SA, Connolly RM, Irving AD, Jackson EL, McMahon K, Runcie JW, Sherman CDH, Sullivan BK, Trevathan-Tackett SM, Brodersen KE, Carter AB, Ewers CJ, Lavery PS, Roelfsema CM, Sinclair EA, Strydom S, Tanner JE, van Dijk KJ, Warry FY, Waycott M, Whitehead S.

Mar Environ Res. 2017 Jun;127:163-172. doi: 10.1016/j.marenvres.2016.06.006. Epub 2016 Jun 16.


Modulation of l-α-lysophosphatidylinositol/GPR55 MAP kinase signalling by CB2 receptor agonists: identifying novel GPR55 inhibitors.

Anavi-Goffer S, Irving AJ, Ross RA.

J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):303-10. doi: 10.1515/jbcpp-2015-0142.


Patient and public involvement in emergency care research.

Hirst E, Irving A, Goodacre S.

Emerg Med J. 2016 Sep;33(9):665-70. doi: 10.1136/emermed-2016-205700. Epub 2016 Apr 4.


Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing.

Ahn M, Cui J, Irving AT, Wang LF.

Sci Rep. 2016 Feb 24;6:21722. doi: 10.1038/srep21722.


The Cost-Effectiveness of the Integration of Nalmefene within the UK Healthcare System Treatment Pathway for Alcohol Dependence.

Laramée P, Bell M, Irving A, Brodtkorb TH.

Alcohol Alcohol. 2016 May;51(3):283-90. doi: 10.1093/alcalc/agv140. Epub 2016 Jan 28.


Challenges in rural GP research.

Irving A.

Can Fam Physician. 2016 Jan;62(1):91. No abstract available.


Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology.

Morales P, Whyte LS, Chicharro R, Gómez-Cañas M, Pazos MR, Goya P, Irving AJ, Fernández-Ruiz J, Ross RA, Jagerovic N.

J Med Chem. 2016 Mar 10;59(5):1840-53. doi: 10.1021/acs.jmedchem.5b01331. Epub 2016 Feb 5.


How do patients feel about taking part in clinical trials in emergency care?

Buckley JM, Irving AD, Goodacre S.

Emerg Med J. 2016 Jun;33(6):376-80. doi: 10.1136/emermed-2015-205146. Epub 2016 Jan 12.


The Emerging Role of the Cannabinoid Receptor Family in Peripheral and Neuro-immune Interactions.

Haugh O, Penman J, Irving AJ, Campbell VA.

Curr Drug Targets. 2016;17(16):1834-1840. Review.


CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction.

Lipina C, Vaanholt LM, Davidova A, Mitchell SE, Storey-Gordon E, Hambly C, Irving AJ, Speakman JR, Hundal HS.

Aging Cell. 2016 Apr;15(2):325-35. doi: 10.1111/acel.12438. Epub 2016 Jan 13.


Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.

Yrjölä S, Parkkari T, Navia-Paldanius D, Laitinen T, Kaczor AA, Kokkola T, Adusei-Mensah F, Savinainen JR, Laitinen JT, Poso A, Alexander A, Penman J, Stott L, Anskat M, Irving AJ, Nevalainen TJ.

Eur J Med Chem. 2016 Jan 1;107:119-32. doi: 10.1016/j.ejmech.2015.10.050. Epub 2015 Nov 2.


Leptin Induces a Novel Form of NMDA Receptor-Dependent LTP at Hippocampal Temporoammonic-CA1 Synapses

Luo X, McGregor G, Irving AJ, Harvey J.

eNeuro. 2015 Jun 10;2(3). pii: ENEURO.0007-15.2015. doi: 10.1523/ENEURO.0007-15.2015. eCollection 2015 May-Jun.


NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.

Xie M, Vesuna F, Botlagunta M, Bol GM, Irving A, Bergman Y, Hosmane RS, Kato Y, Winnard PT Jr, Raman V.

Oncotarget. 2015 Oct 6;6(30):29901-13. doi: 10.18632/oncotarget.4898.


Using EMR data to evaluate a physician-developed lifestyle plan for obese patients in primary care.

Garies S, Irving A, Williamson T, Drummond N.

Can Fam Physician. 2015 May;61(5):e225-31.


The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, Xu D.

Nat Commun. 2015 Apr 13;6:6795. doi: 10.1038/ncomms7795.


Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

Bol GM, Vesuna F, Xie M, Zeng J, Aziz K, Gandhi N, Levine A, Irving A, Korz D, Tantravedi S, Heerma van Voss MR, Gabrielson K, Bordt EA, Polster BM, Cope L, van der Groep P, Kondaskar A, Rudek MA, Hosmane RS, van der Wall E, van Diest PJ, Tran PT, Raman V.

EMBO Mol Med. 2015 May;7(5):648-69. doi: 10.15252/emmm.201404368.

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