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Items: 1 to 50 of 234

1.

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.

Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123.

2.

A short history of inositol lipids.

Irvine RF.

J Lipid Res. 2016 Nov;57(11):1987-1994. Epub 2016 Sep 13. Review.

3.

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley SJ, Droubi A, Clarke JH, Anderson KE, Stephens LR, Hawkins PT, Irvine RF.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10571-6. doi: 10.1073/pnas.1522478113. Epub 2016 Sep 6.

4.

Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress.

Droubi A, Bulley SJ, Clarke JH, Irvine RF.

Biochem J. 2016 Jul 15;473(14):2155-63. doi: 10.1042/BCJ20160380. Epub 2016 May 16.

PMID:
27208178
5.

Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma.

Giudici ML, Clarke JH, Irvine RF.

Adv Biol Regul. 2016 May;61:47-50. doi: 10.1016/j.jbior.2015.11.007. Epub 2015 Dec 2. Review.

6.

There is no 'Conundrum' of InsP6.

Irvine RF, Bulley SJ, Wilson MS, Saiardi A.

Open Biol. 2015 Nov;5(11). pii: 150181. doi: 10.1098/rsob.150181.

7.

A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine.

Wilson MS, Bulley SJ, Pisani F, Irvine RF, Saiardi A.

Open Biol. 2015 Mar;5(3):150014. doi: 10.1098/rsob.150014.

8.

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.

Clarke JH, Giudici ML, Burke JE, Williams RL, Maloney DJ, Marugan J, Irvine RF.

Biochem J. 2015 Mar 1;466(2):359-67. doi: 10.1042/BJ20141333.

9.

Exploring phosphatidylinositol 5-phosphate 4-kinase function.

Bulley SJ, Clarke JH, Droubi A, Giudici ML, Irvine RF.

Adv Biol Regul. 2015 Jan;57:193-202. doi: 10.1016/j.jbior.2014.09.007. Epub 2014 Oct 2. Review.

10.

Absence of detectable inositol hexakisphosphate (phytate) in plasma.

Irvine RF.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1;960:253-4. doi: 10.1016/j.jchromb.2013.12.015. Epub 2013 Dec 27.

11.

Enzyme activity of the PIP4K2A gene product polymorphism that is implicated in schizophrenia.

Clarke JH, Irvine RF.

Psychopharmacology (Berl). 2013 Nov;230(2):329-31. doi: 10.1007/s00213-013-3299-y. Epub 2013 Oct 1. No abstract available.

13.

PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity.

Hammond GR, Fischer MJ, Anderson KE, Holdich J, Koteci A, Balla T, Irvine RF.

Science. 2012 Aug 10;337(6095):727-30. doi: 10.1126/science.1222483. Epub 2012 Jun 21.

14.

Cell biology. Pyro-technic control of metabolism.

Irvine RF, Denton RM.

Science. 2011 Nov 11;334(6057):770-1. doi: 10.1126/science.1214727. No abstract available.

PMID:
22076369
15.

The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases.

Clarke JH, Irvine RF.

Adv Biol Regul. 2012 Jan;52(1):40-5. No abstract available.

PMID:
21945524
16.

Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans.

Xia Y, Irvine RF, Giudici ML.

Biochem Biophys Res Commun. 2011 Jul 29;411(2):416-20. doi: 10.1016/j.bbrc.2011.06.168. Epub 2011 Jul 2.

17.

A femtomole-sensitivity mass assay for inositol hexakisphosphate.

Letcher AJ, Schell MJ, Irvine RF.

Methods Mol Biol. 2010;645:61-71. doi: 10.1007/978-1-60327-175-2_4.

PMID:
20645181
18.

Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform.

Wang M, Bond NJ, Letcher AJ, Richardson JP, Lilley KS, Irvine RF, Clarke JH.

Biochem J. 2010 Sep 1;430(2):215-21. doi: 10.1042/BJ20100340.

19.

Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases.

Clarke JH, Wang M, Irvine RF.

Adv Enzyme Regul. 2010;50(1):12-8. doi: 10.1016/j.advenzreg.2009.10.006. Epub 2009 Nov 6. Review. No abstract available.

20.

Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.

Clarke JH, Emson PC, Irvine RF.

J Comp Neurol. 2009 Nov 20;517(3):296-312. doi: 10.1002/cne.22161.

21.

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2).

Hammond GR, Schiavo G, Irvine RF.

Biochem J. 2009 Jul 29;422(1):23-35. doi: 10.1042/BJ20090428.

22.

Reversible binding and rapid diffusion of proteins in complex with inositol lipids serves to coordinate free movement with spatial information.

Hammond GR, Sim Y, Lagnado L, Irvine RF.

J Cell Biol. 2009 Jan 26;184(2):297-308. doi: 10.1083/jcb.200809073. Epub 2009 Jan 19.

23.

Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.

Clarke JH, Emson PC, Irvine RF.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1422-30. doi: 10.1152/ajprenal.90310.2008. Epub 2008 Aug 27.

24.

Do mammals make all their own inositol hexakisphosphate?

Letcher AJ, Schell MJ, Irvine RF.

Biochem J. 2008 Dec 1;416(2):263-70. doi: 10.1042/BJ20081417.

25.

Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation.

Richardson JP, Wang M, Clarke JH, Patel KJ, Irvine RF.

Cell Signal. 2007 Jun;19(6):1309-14. Epub 2007 Jan 20.

26.

Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells.

Lloyd-Burton SM, Yu JC, Irvine RF, Schell MJ.

J Biol Chem. 2007 Mar 30;282(13):9526-35. Epub 2007 Feb 6.

27.

Type II PtdInsP kinases: location, regulation and function.

Clarke JH, Richardson JP, Hinchliffe KA, Irvine RF.

Biochem Soc Symp. 2007;(74):149-59. Review.

PMID:
17233588
28.

The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants.

Giudici ML, Lee K, Lim R, Irvine RF.

FEBS Lett. 2006 Dec 22;580(30):6933-7. Epub 2006 Nov 30.

29.
30.

The behaviour of myo-inositol hexakisphosphate in the presence of magnesium(II) and calcium(II): protein-free soluble InsP6 is limited to 49 microM under cytosolic/nuclear conditions.

Veiga N, Torres J, Domínguez S, Mederos A, Irvine RF, Díaz A, Kremer C.

J Inorg Biochem. 2006 Nov;100(11):1800-10. Epub 2006 Jul 20.

31.

The regulation and function of inositol 1,4,5-trisphosphate 3-kinases.

Irvine RF, Lloyd-Burton SM, Yu JC, Letcher AJ, Schell MJ.

Adv Enzyme Regul. 2006;46:314-23. Epub 2006 Jul 20. No abstract available.

32.

Nuclear inositide signalling -- expansion, structures and clarification.

Irvine RF.

Biochim Biophys Acta. 2006 May-Jun;1761(5-6):505-8. Epub 2006 Mar 15. Review.

33.

Regulation of type II PIP kinase by PKD phosphorylation.

Hinchliffe KA, Irvine RF.

Cell Signal. 2006 Nov;18(11):1906-13. Epub 2006 Mar 6.

34.

Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis.

Yu JC, Lloyd-Burton SM, Irvine RF, Schell MJ.

Biochem J. 2005 Dec 15;392(Pt 3):435-41.

35.
36.

Mobility of proteins associated with the plasma membrane by interaction with inositol lipids.

Brough D, Bhatti F, Irvine RF.

J Cell Sci. 2005 Jul 15;118(Pt 14):3019-25. Epub 2005 Jun 28.

37.

Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility.

Brough D, Schell MJ, Irvine RF.

Biochem J. 2005 Dec 1;392(Pt 2):291-7.

38.

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b.

Powner DJ, Payne RM, Pettitt TR, Giudici ML, Irvine RF, Wakelam MJ.

J Cell Sci. 2005 Jul 1;118(Pt 13):2975-86.

39.

Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines.

Roberts HF, Clarke JH, Letcher AJ, Irvine RF, Hinchliffe KA.

FEBS Lett. 2005 May 23;579(13):2868-72.

40.

Inositide evolution - towards turtle domination?

Irvine RF.

J Physiol. 2005 Jul 15;566(Pt 2):295-300. Epub 2005 Apr 28.

41.

Solution behaviour of myo-inositol hexakisphosphate in the presence of multivalent cations. Prediction of a neutral pentamagnesium species under cytosolic/nuclear conditions.

Torres J, Domínguez S, Cerdá MF, Obal G, Mederos A, Irvine RF, Díaz A, Kremer C.

J Inorg Biochem. 2005 Mar;99(3):828-40.

PMID:
15708805
42.

Phosphatidylinositol phosphate kinases.

Giudici ML, Hinchliffe KA, Irvine RF.

J Endocrinol Invest. 2004;27(6 Suppl):137-42. Review.

PMID:
15481814
43.

Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase.

González B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, Williams RL.

Mol Cell. 2004 Sep 10;15(5):689-701.

44.
45.

20 years of Ins(1,4,5)P3, and 40 years before.

Irvine RF.

Nat Rev Mol Cell Biol. 2003 Jul;4(7):586-90. Review.

PMID:
12838341
46.

Nuclear lipid signalling.

Irvine RF.

Nat Rev Mol Cell Biol. 2003 May;4(5):349-60. Review.

PMID:
12728269
48.

Nuclear lipid signaling.

Irvine RF.

Sci STKE. 2002 Sep 17;2002(150):re13. Review.

PMID:
12237449
49.

Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms.

Hinchliffe KA, Giudici ML, Letcher AJ, Irvine RF.

Biochem J. 2002 May 1;363(Pt 3):563-70.

50.

Tissue distribution of GAP1(IP4BP) and GAP1(m): two inositol 1,3,4,5-tetrakisphosphate-binding proteins.

McNulty TJ, Letcher AJ, Dawson AP, Irvine RF.

Cell Signal. 2001 Dec;13(12):877-86.

PMID:
11728827

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