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Items: 1 to 50 of 102


Dchs1-Fat4 regulation of osteogenic differentiation in mouse.

Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD, Francis-West P.

Development. 2019 Jul 29;146(14). pii: dev176776. doi: 10.1242/dev.176776.


Organization and function of tension-dependent complexes at adherens junctions.

Rauskolb C, Cervantes E, Madere F, Irvine KD.

J Cell Sci. 2019 Apr 3;132(7). pii: jcs224063. doi: 10.1242/jcs.224063.


Oriented Cell Divisions Are Not Required for Drosophila Wing Shape.

Zhou Z, Alégot H, Irvine KD.

Curr Biol. 2019 Mar 4;29(5):856-864.e3. doi: 10.1016/j.cub.2019.01.044. Epub 2019 Feb 21.


Early girl is a novel component of the Fat signaling pathway.

Misra JR, Irvine KD.

PLoS Genet. 2019 Jan 30;15(1):e1007955. doi: 10.1371/journal.pgen.1007955. eCollection 2019 Jan.


Recruitment of Jub by α-catenin promotes Yki activity and Drosophila wing growth.

Alégot H, Markosian C, Rauskolb C, Yang J, Kirichenko E, Wang YC, Irvine KD.

J Cell Sci. 2019 Feb 25;132(5). pii: jcs222018. doi: 10.1242/jcs.222018.


Localization of Hippo Signaling Components in Drosophila by Fluorescence and Immunofluorescence.

Rauskolb C, Irvine KD.

Methods Mol Biol. 2019;1893:61-73. doi: 10.1007/978-1-4939-8910-2_5.


The dynamics of Hippo signaling during Drosophila wing development.

Pan Y, Alégot H, Rauskolb C, Irvine KD.

Development. 2018 Oct 17;145(20). pii: dev165712. doi: 10.1242/dev.165712.


Rapping about Mechanotransduction.

Ibar C, Irvine KD.

Dev Cell. 2018 Sep 24;46(6):678-679. doi: 10.1016/j.devcel.2018.09.007.


The Hippo Signaling Network and Its Biological Functions.

Misra JR, Irvine KD.

Annu Rev Genet. 2018 Nov 23;52:65-87. doi: 10.1146/annurev-genet-120417-031621. Epub 2018 Sep 5. Review.


Tension-dependent regulation of mammalian Hippo signaling through LIMD1.

Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine KD.

J Cell Sci. 2018 Mar 2;131(5). pii: jcs214700. doi: 10.1242/jcs.214700.


Role and regulation of Yap in KrasG12D-induced lung cancer.

Mao Y, Sun S, Irvine KD.

Oncotarget. 2017 Dec 2;8(67):110877-110889. doi: 10.18632/oncotarget.22865. eCollection 2017 Dec 19.


Mechanical control of growth: ideas, facts and challenges.

Irvine KD, Shraiman BI.

Development. 2017 Dec 1;144(23):4238-4248. doi: 10.1242/dev.151902. Review.


Taking Stock of the Drosophila Research Ecosystem.

Bilder D, Irvine KD.

Genetics. 2017 Jul;206(3):1227-1236. doi: 10.1534/genetics.117.202390. Review.


Differential growth triggers mechanical feedback that elevates Hippo signaling.

Pan Y, Heemskerk I, Ibar C, Shraiman BI, Irvine KD.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E6974-E6983. doi: 10.1073/pnas.1615012113. Epub 2016 Oct 26.


Vamana Couples Fat Signaling to the Hippo Pathway.

Misra JR, Irvine KD.

Dev Cell. 2016 Oct 24;39(2):254-266. doi: 10.1016/j.devcel.2016.09.017. Epub 2016 Oct 13.


Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.

Kuta A, Mao Y, Martin T, Ferreira de Sousa C, Whiting D, Zakaria S, Crespo-Enriquez I, Evans P, Balczerski B, Mankoo B, Irvine KD, Francis-West PH.

Development. 2016 Jul 1;143(13):2367-75. doi: 10.1242/dev.131037.


Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network.

Sun S, Irvine KD.

Trends Cell Biol. 2016 Sep;26(9):694-704. doi: 10.1016/j.tcb.2016.05.003. Epub 2016 Jun 4. Review.


Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.

Mao Y, Kuta A, Crespo-Enriquez I, Whiting D, Martin T, Mulvaney J, Irvine KD, Francis-West P.

Nat Commun. 2016 May 5;7:11469. doi: 10.1038/ncomms11469.


An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2.

Park GS, Oh H, Kim M, Kim T, Johnson RL, Irvine KD, Lim DS.

Oncotarget. 2016 Apr 26;7(17):24063-75. doi: 10.18632/oncotarget.8211.


Coordination of planar cell polarity pathways through Spiny-legs.

Ambegaonkar AA, Irvine KD.

Elife. 2015 Oct 27;4. pii: e09946. doi: 10.7554/eLife.09946.


Localization of Hippo signalling complexes and Warts activation in vivo.

Sun S, Reddy BV, Irvine KD.

Nat Commun. 2015 Sep 30;6:8402. doi: 10.1038/ncomms9402.


Mutations in DCHS1 cause mitral valve prolapse.

Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA.

Nature. 2015 Sep 3;525(7567):109-13. doi: 10.1038/nature14670. Epub 2015 Aug 10.


Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching.

Mao Y, Francis-West P, Irvine KD.

Development. 2015 Aug 1;142(15):2574-85. doi: 10.1242/dev.122630. Epub 2015 Jun 26.


Control of organ growth by patterning and hippo signaling in Drosophila.

Irvine KD, Harvey KF.

Cold Spring Harb Perspect Biol. 2015 Jun 1;7(6). pii: a019224. doi: 10.1101/cshperspect.a019224. Review.


Regulation of YAP by mechanical strain through Jnk and Hippo signaling.

Codelia VA, Sun G, Irvine KD.

Curr Biol. 2014 Sep 8;24(17):2012-7. doi: 10.1016/j.cub.2014.07.034. Epub 2014 Aug 7.


Notch-ligand binding assays in Drosophila cells.

Xu A, Irvine KD.

Methods Mol Biol. 2014;1187:277-84. doi: 10.1007/978-1-4939-1139-4_21.


Yorkie promotes transcription by recruiting a histone methyltransferase complex.

Oh H, Slattery M, Ma L, White KP, Mann RS, Irvine KD.

Cell Rep. 2014 Jul 24;8(2):449-59. doi: 10.1016/j.celrep.2014.06.017. Epub 2014 Jul 10.


Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity.

Zakaria S, Mao Y, Kuta A, de Sousa CF, Gaufo GO, McNeill H, Hindges R, Guthrie S, Irvine KD, Francis-West PH.

Curr Biol. 2014 Jul 21;24(14):1620-1627. doi: 10.1016/j.cub.2014.05.067. Epub 2014 Jul 3.


Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.

Rauskolb C, Sun S, Sun G, Pan Y, Irvine KD.

Cell. 2014 Jul 3;158(1):143-156. doi: 10.1016/j.cell.2014.05.035.


Control of growth during regeneration.

Sun G, Irvine KD.

Curr Top Dev Biol. 2014;108:95-120. doi: 10.1016/B978-0-12-391498-9.00003-6. Review.


Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling.

Mani M, Goyal S, Irvine KD, Shraiman BI.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20420-5. doi: 10.1073/pnas.1307459110. Epub 2013 Nov 26.


Ajuba family proteins link JNK to Hippo signaling.

Sun G, Irvine KD.

Sci Signal. 2013 Sep 10;6(292):ra81. doi: 10.1126/scisignal.2004324.


Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins.

Reddy BV, Irvine KD.

Dev Cell. 2013 Mar 11;24(5):459-71. doi: 10.1016/j.devcel.2013.01.020.


Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes.

Oh H, Slattery M, Ma L, Crofts A, White KP, Mann RS, Irvine KD.

Cell Rep. 2013 Feb 21;3(2):309-18. doi: 10.1016/j.celrep.2013.01.008. Epub 2013 Feb 8.


Signal transduction by the Fat cytoplasmic domain.

Pan G, Feng Y, Ambegaonkar AA, Sun G, Huff M, Rauskolb C, Irvine KD.

Development. 2013 Feb;140(4):831-42. doi: 10.1242/dev.088534. Epub 2013 Jan 14.


Hippo signaling goes long range.

Codelia VA, Irvine KD.

Cell. 2012 Aug 17;150(4):669-70. doi: 10.1016/j.cell.2012.07.020.


The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins.

Ishikawa HO, Xu A, Ogura E, Manning G, Irvine KD.

PLoS One. 2012;7(8):e42988. doi: 10.1371/journal.pone.0042988. Epub 2012 Aug 10.


Propagation of Dachsous-Fat planar cell polarity.

Ambegaonkar AA, Pan G, Mani M, Feng Y, Irvine KD.

Curr Biol. 2012 Jul 24;22(14):1302-8. doi: 10.1016/j.cub.2012.05.049. Epub 2012 Jun 21.


Integration of intercellular signaling through the Hippo pathway.

Irvine KD.

Semin Cell Dev Biol. 2012 Sep;23(7):812-7. doi: 10.1016/j.semcdb.2012.04.006. Epub 2012 Apr 24. Review.


Hippo signaling in Drosophila: recent advances and insights.

Staley BK, Irvine KD.

Dev Dyn. 2012 Jan;241(1):3-15. doi: 10.1002/dvdy.22723. Epub 2011 Aug 25. Review.


Drosophila as a model for understanding development and disease.

Singh A, Irvine KD.

Dev Dyn. 2012 Jan;241(1):1-2. doi: 10.1002/dvdy.23712. No abstract available.


Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling.

Reddy BV, Irvine KD.

Development. 2011 Dec;138(23):5201-12. doi: 10.1242/dev.069385.


Zyxin links fat signaling to the hippo pathway.

Rauskolb C, Pan G, Reddy BV, Oh H, Irvine KD.

PLoS Biol. 2011 Jun;9(6):e1000624. doi: 10.1371/journal.pbio.1000624. Epub 2011 Jun 7.


Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.

Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD.

Development. 2011 Mar;138(5):947-57. doi: 10.1242/dev.057166.


Cooperative regulation of growth by Yorkie and Mad through bantam.

Oh H, Irvine KD.

Dev Cell. 2011 Jan 18;20(1):109-22. doi: 10.1016/j.devcel.2010.12.002.


Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.

Sun G, Irvine KD.

Dev Biol. 2011 Feb 1;350(1):139-51. doi: 10.1016/j.ydbio.2010.11.036. Epub 2010 Dec 9.


Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation.

Staley BK, Irvine KD.

Curr Biol. 2010 Sep 14;20(17):1580-7. doi: 10.1016/j.cub.2010.07.041. Epub 2010 Aug 19.


Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia.

Reddy BV, Rauskolb C, Irvine KD.

Development. 2010 Jul;137(14):2397-408. doi: 10.1242/dev.050013.


Yorkie: the final destination of Hippo signaling.

Oh H, Irvine KD.

Trends Cell Biol. 2010 Jul;20(7):410-7. doi: 10.1016/j.tcb.2010.04.005. Epub 2010 May 7. Review.


Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed.

Simon MA, Xu A, Ishikawa HO, Irvine KD.

Curr Biol. 2010 May 11;20(9):811-7. doi: 10.1016/j.cub.2010.04.016. Epub 2010 Apr 29.

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