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Items: 1 to 50 of 159

1.

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery.

Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ.

Nat Biotechnol. 2018 Jul 9. doi: 10.1038/nbt.4181. [Epub ahead of print]

PMID:
29985479
2.

Enhancement of peptide vaccine immunogenicity by increasing lymphatic drainage and boosting serum stability.

Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Le Gall S, Pentelute B, Irvine DJ.

Cancer Immunol Res. 2018 Jun 18. pii: canimm.0607.2017. doi: 10.1158/2326-6066.CIR-17-0607. [Epub ahead of print]

PMID:
29915023
3.

Inferring watershed hydraulics and cold-water habitat persistence using multi-year air and stream temperature signals.

Briggs MA, Johnson ZC, Snyder CD, Hitt NP, Kurylyk BL, Lautz L, Irvine DJ, Hurley ST, Lane JW.

Sci Total Environ. 2018 Sep 15;636:1117-1127. doi: 10.1016/j.scitotenv.2018.04.344. Epub 2018 May 3.

PMID:
29913574
4.

Confusion About "Convection"!

Ataie-Ashtiani B, Simmons CT, Irvine DJ.

Ground Water. 2018 Apr 25. doi: 10.1111/gwat.12790. [Epub ahead of print] No abstract available.

PMID:
29691846
5.

Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes.

Atukorale PU, Guven ZP, Bekdemir A, Carney RP, Van Lehn RC, Yun DS, Jacob Silva PH, Demurtas D, Yang YS, Alexander-Katz A, Stellacci F, Irvine DJ.

Bioconjug Chem. 2018 Apr 18;29(4):1131-1140. doi: 10.1021/acs.bioconjchem.7b00777. Epub 2018 Feb 27.

PMID:
29465986
6.

Identification of Novel "Inks" for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery.

Louzao I, Koch B, Taresco V, Ruiz-Cantu L, Irvine DJ, Roberts CJ, Tuck C, Alexander C, Hague R, Wildman R, Alexander MR.

ACS Appl Mater Interfaces. 2018 Feb 28;10(8):6841-6848. doi: 10.1021/acsami.7b15677. Epub 2018 Feb 15.

PMID:
29322768
7.

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.

Zhang Y, Li N, Suh H, Irvine DJ.

Nat Commun. 2018 Jan 2;9(1):6. doi: 10.1038/s41467-017-02251-3.

8.

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.

Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J, Freeman GJ, Wucherpfennig KW, Irvine DJ, Goldberg MS.

Nat Commun. 2017 Nov 23;8(1):1747. doi: 10.1038/s41467-017-01830-8.

9.

Bridging the Gap Between Research and Practice.

Irvine DJ.

Ground Water. 2018 Jan;56(1):1. doi: 10.1111/gwat.12616. Epub 2017 Nov 16. No abstract available.

PMID:
29145700
10.

Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy.

Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, Moon JJ.

Nano Lett. 2017 Dec 13;17(12):7387-7393. doi: 10.1021/acs.nanolett.7b03218. Epub 2017 Nov 22.

11.

Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.

Appelbe OK, Moynihan KD, Flor A, Rymut N, Irvine DJ, Kron SJ.

J Control Release. 2017 Nov 28;266:248-255. doi: 10.1016/j.jconrel.2017.09.043. Epub 2017 Oct 5.

PMID:
28987882
12.

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.

Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS.

JCI Insight. 2017 Oct 5;2(19). pii: 94298. doi: 10.1172/jci.insight.94298. [Epub ahead of print]

13.

Roles for Innate Immunity in Combination Immunotherapies.

Moynihan KD, Irvine DJ.

Cancer Res. 2017 Oct 1;77(19):5215-5221. doi: 10.1158/0008-5472.CAN-17-1340. Epub 2017 Sep 19. Review.

14.

DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins.

Fotoran WL, Santangelo R, de Miranda BNM, Irvine DJ, Wunderlich G.

Mol Ther Methods Clin Dev. 2017 Aug 23;7:1-10. doi: 10.1016/j.omtm.2017.08.004. eCollection 2017 Dec 15.

15.

Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry.

Yang YS, Atukorale PU, D Moynihan K, Bekdemir A, Rakhra K, Tang L, Stellacci F, Irvine DJ.

Nat Commun. 2017 Aug 14;8:15343. doi: 10.1038/ncomms15343.

16.

Selective molecular annealing: in situ small angle X-ray scattering study of microwave-assisted annealing of block copolymers.

Toolan DTW, Adlington K, Isakova A, Kalamiotis A, Mokarian-Tabari P, Dimitrakis G, Dodds C, Arnold T, Terrill NJ, Bras W, Hermida Merino D, Topham PD, Irvine DJ, Howse JR.

Phys Chem Chem Phys. 2017 Aug 9;19(31):20412-20419. doi: 10.1039/c7cp03578k.

PMID:
28731101
17.

3D printing of tablets using inkjet with UV photoinitiation.

Clark EA, Alexander MR, Irvine DJ, Roberts CJ, Wallace MJ, Sharpe S, Yoo J, Hague RJM, Tuck CJ, Wildman RD.

Int J Pharm. 2017 Aug 30;529(1-2):523-530. doi: 10.1016/j.ijpharm.2017.06.085. Epub 2017 Jun 30.

PMID:
28673860
18.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR.

Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007.

19.

Delivering safer immunotherapies for cancer.

Milling L, Zhang Y, Irvine DJ.

Adv Drug Deliv Rev. 2017 May 15;114:79-101. doi: 10.1016/j.addr.2017.05.011. Epub 2017 May 22. Review.

20.

Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors.

Zheng Y, Tang L, Mabardi L, Kumari S, Irvine DJ.

ACS Nano. 2017 Mar 28;11(3):3089-3100. doi: 10.1021/acsnano.7b00078. Epub 2017 Mar 1.

21.

Nanoscience and Nanotechnology Cross Borders.

Khademhosseini A, Chan WW, Chhowalla M, Glotzer SC, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney PA, Nel AE, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee AT, Brinker J, Chen X, Chi L, Crommie M, Dekker C, Farokhzad O, Gerber C, Ginger DS, Irvine DJ, Kiessling LL, Kostarelos K, Landes C, Lee T, Leggett GJ, Liang XJ, Liz-Marzán L, Millstone J, Odom TW, Ozcan A, Prato M, Rao CN, Sailor MJ, Weiss E, Weiss PS.

ACS Nano. 2017 Feb 28;11(2):1123-1126. doi: 10.1021/acsnano.7b00953. Epub 2017 Feb 15. No abstract available.

PMID:
28199099
22.

Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery.

Li J, Wang W, He Y, Li Y, Yan EZ, Zhang K, Irvine DJ, Hammond PT.

ACS Nano. 2017 Mar 28;11(3):2531-2544. doi: 10.1021/acsnano.6b08447. Epub 2017 Feb 14.

23.

Smart Radiation Therapy Biomaterials.

Ngwa W, Boateng F, Kumar R, Irvine DJ, Formenti S, Ngoma T, Herskind C, Veldwijk MR, Hildenbrand GL, Hausmann M, Wenz F, Hesser J.

Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):624-637. doi: 10.1016/j.ijrobp.2016.10.034. Epub 2016 Nov 1. Review.

24.

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry.

Yang YS, Atukorale PU, Moynihan KD, Bekdemir A, Rakhra K, Tang L, Stellacci F, Irvine DJ.

Nat Commun. 2017 Jan 17;8:14069. doi: 10.1038/ncomms14069. Erratum in: Nat Commun. 2017 Aug 14;8:15343.

25.

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.

Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J, Khader SA.

Nat Commun. 2016 Dec 22;7:13894. doi: 10.1038/ncomms13894.

26.

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.

Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ.

Biomaterials. 2017 Feb;117:44-53. doi: 10.1016/j.biomaterials.2016.11.048. Epub 2016 Nov 25.

27.

Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy.

Tzeng A, Kauke MJ, Zhu EF, Moynihan KD, Opel CF, Yang NJ, Mehta N, Kelly RL, Szeto GL, Overwijk WW, Irvine DJ, Wittrup KD.

Cell Rep. 2016 Dec 6;17(10):2503-2511. doi: 10.1016/j.celrep.2016.11.020.

28.

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.

Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, Mehta NK, Kauke MJ, Suh H, Cochran JR, Lauffenburger DA, Wittrup KD, Irvine DJ.

Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24.

29.

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.

Tam HH, Melo MB, Kang M, Pelet JM, Ruda VM, Foley MH, Hu JK, Kumari S, Crampton J, Baldeon AD, Sanders RW, Moore JP, Crotty S, Langer R, Anderson DG, Chakraborty AK, Irvine DJ.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6639-E6648. Epub 2016 Oct 4.

30.

Synthesis of Lymph Node-Targeting Adjuvants.

Hanson MC, Irvine DJ.

Methods Mol Biol. 2017;1494:145-152.

PMID:
27718191
31.

Using Diurnal Temperature Signals to Infer Vertical Groundwater-Surface Water Exchange.

Irvine DJ, Briggs MA, Lautz LK, Gordon RP, McKenzie JM, Cartwright I.

Ground Water. 2017 Jan;55(1):10-26. doi: 10.1111/gwat.12459. Epub 2016 Oct 3. Review.

PMID:
27696430
32.

Groundwater flow estimation using temperature-depth profiles in a complex environment and a changing climate.

Irvine DJ, Kurylyk BL, Cartwright I, Bonham M, Post VEA, Banks EW, Simmons CT.

Sci Total Environ. 2017 Jan 1;574:272-281. doi: 10.1016/j.scitotenv.2016.08.212. Epub 2016 Oct 14.

PMID:
27639024
33.

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR.

Immunity. 2016 Sep 20;45(3):483-496. doi: 10.1016/j.immuni.2016.08.016. Epub 2016 Sep 8.

34.

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS.

J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6.

35.

Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers.

Adlington K, Nguyen NT, Eaves E, Yang J, Chang CY, Li J, Gower AL, Stimpson A, Anderson DG, Langer R, Davies MC, Hook AL, Williams P, Alexander MR, Irvine DJ.

Biomacromolecules. 2016 Sep 12;17(9):2830-8. doi: 10.1021/acs.biomac.6b00615. Epub 2016 Aug 26.

PMID:
27461341
36.

Improved Vertical Streambed Flux Estimation Using Multiple Diurnal Temperature Methods in Series.

Irvine DJ, Briggs MA, Cartwright I, Scruggs CR, Lautz LK.

Ground Water. 2017 Jan;55(1):73-80. doi: 10.1111/gwat.12436. Epub 2016 Jun 22.

PMID:
27331372
37.

Facile Determination of Molecular Structure Trends in Amphiphilic Core Corona Star Polymer Synthesis via Dielectric Property Measurement.

Hild F, Nguyen NT, Deng E, Katrib J, Dimitrakis G, Lau PL, Irvine DJ.

Macromol Rapid Commun. 2016 Aug;37(15):1295-9. doi: 10.1002/marc.201600149. Epub 2016 Jun 17.

PMID:
27315130
38.

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.

Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD.

PLoS Pathog. 2016 Apr 15;12(4):e1005545. doi: 10.1371/journal.ppat.1005545. eCollection 2016 Apr.

39.

Beyond antigens and adjuvants: formulating future vaccines.

Moyer TJ, Zmolek AC, Irvine DJ.

J Clin Invest. 2016 Mar 1;126(3):799-808. doi: 10.1172/JCI81083. Epub 2016 Mar 1. Review.

40.

A Receptor for All Occasions.

Irvine DJ.

Cell. 2016 Feb 11;164(4):599-600. doi: 10.1016/j.cell.2016.01.030.

41.

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties.

Chen M, Parsons AJ, Felfel RM, Rudd CD, Irvine DJ, Ahmed I.

J Mech Behav Biomed Mater. 2016 Jun;59:78-89. doi: 10.1016/j.jmbbm.2015.12.019. Epub 2015 Dec 23.

PMID:
26748261
42.

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

Kimmerling RJ, Lee Szeto G, Li JW, Genshaft AS, Kazer SW, Payer KR, de Riba Borrajo J, Blainey PC, Irvine DJ, Shalek AK, Manalis SR.

Nat Commun. 2016 Jan 6;7:10220. doi: 10.1038/ncomms10220.

43.

Molecular Design of Squalene/Squalane Countertypes via the Controlled Oligomerization of Isoprene and Evaluation of Vaccine Adjuvant Applications.

Adlington K, El Harfi J, Li J, Carmichael K, Guderian JA, Fox CB, Irvine DJ.

Biomacromolecules. 2016 Jan 11;17(1):165-72. doi: 10.1021/acs.biomac.5b01285. Epub 2015 Dec 29.

PMID:
26652915
44.

Molecular Differentiated Initiator Reactivity in the Synthesis of Poly(caprolactone)-Based Hydrophobic Homopolymer and Amphiphilic Core Corona Star Polymers.

Deng E, Nguyen NT, Hild F, Hamilton IE, Dimitrakis G, Kingman SW, Lau PL, Irvine DJ.

Molecules. 2015 Nov 9;20(11):20131-45. doi: 10.3390/molecules201119681.

45.

Big thinking for adjuvants.

Dane EL, Irvine DJ.

Nat Biotechnol. 2015 Nov;33(11):1146-8. doi: 10.1038/nbt.3398. No abstract available.

PMID:
26544144
46.

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals.

Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA.

Sci Signal. 2015 Oct 20;8(399):ra104. doi: 10.1126/scisignal.aab0808.

47.

Biomaterial Strategies for Immunomodulation.

Hotaling NA, Tang L, Irvine DJ, Babensee JE.

Annu Rev Biomed Eng. 2015;17:317-49. doi: 10.1146/annurev-bioeng-071813-104814. Epub 2015 Sep 29. Review.

48.

Engineering New Approaches to Cancer Vaccines.

Mehta NK, Moynihan KD, Irvine DJ.

Cancer Immunol Res. 2015 Aug;3(8):836-43. doi: 10.1158/2326-6066.CIR-15-0112. Epub 2015 Jul 8. Review.

49.

Synthetic Nanoparticles for Vaccines and Immunotherapy.

Irvine DJ, Hanson MC, Rakhra K, Tokatlian T.

Chem Rev. 2015 Oct 14;115(19):11109-46. doi: 10.1021/acs.chemrev.5b00109. Epub 2015 Jul 8. Review. No abstract available.

50.

Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes.

Atukorale PU, Yang YS, Bekdemir A, Carney RP, Silva PJ, Watson N, Stellacci F, Irvine DJ.

Nanoscale. 2015 Jul 14;7(26):11420-32. doi: 10.1039/c5nr01355k.

PMID:
26077112

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