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Items: 1 to 50 of 181

1.

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles.

Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ.

Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]

PMID:
31515132
2.

Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid.

Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S.

ACS Nano. 2019 Aug 27;13(8):9620-9628. doi: 10.1021/acsnano.9b04783. Epub 2019 Aug 16.

3.

Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination.

Boopathy AV, Mandal A, Kulp DW, Menis S, Bennett NR, Watkins HC, Wang W, Martin JT, Thai NT, He Y, Schief WR, Hammond PT, Irvine DJ.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16473-16478. doi: 10.1073/pnas.1902179116. Epub 2019 Jul 29.

PMID:
31358641
4.

Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor.

Ma L, Dichwalkar T, Chang JYH, Cossette B, Garafola D, Zhang AQ, Fichter M, Wang C, Liang S, Silva M, Kumari S, Mehta NK, Abraham W, Thai N, Li N, Wittrup KD, Irvine DJ.

Science. 2019 Jul 12;365(6449):162-168. doi: 10.1126/science.aav8692.

PMID:
31296767
5.

Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.

Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaaw2614. doi: 10.1126/scitranslmed.aaw2614.

PMID:
31243150
6.

Heat: An Overlooked Tool in the Practicing Hydrogeologist's Toolbox.

Kurylyk BL, Irvine DJ.

Ground Water. 2019 Jul;57(4):517-524. doi: 10.1111/gwat.12910. Epub 2019 Jun 20. No abstract available.

PMID:
31148145
7.

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC.

Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z. Epub 2019 May 29.

PMID:
31142836
8.

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S.

Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. Epub 2019 May 9.

PMID:
31080066
9.

Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models.

Rothschilds A, Tzeng A, Mehta NK, Moynihan KD, Irvine DJ, Wittrup KD.

Oncoimmunology. 2019 Feb 19;8(5):e1558678. doi: 10.1080/2162402X.2018.1558678. eCollection 2019.

PMID:
31069130
10.

In vitro evolution of enhanced RNA replicons for immunotherapy.

Li Y, Teague B, Zhang Y, Su Z, Porter E, Dobosh B, Wagner T, Irvine DJ, Weiss R.

Sci Rep. 2019 May 6;9(1):6932. doi: 10.1038/s41598-019-43422-0.

11.

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells.

Xie YQ, Arik H, Wei L, Zheng Y, Suh H, Irvine DJ, Tang L.

Biomater Sci. 2019 Mar 26;7(4):1345-1357. doi: 10.1039/c8bm01556b.

PMID:
30698174
12.

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers.

Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ.

Science. 2019 Feb 8;363(6427):649-654. doi: 10.1126/science.aat9120. Epub 2018 Dec 20.

13.

Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR.

Immunity. 2019 Jan 15;50(1):241-252.e6. doi: 10.1016/j.immuni.2018.11.011. Epub 2018 Dec 11.

14.

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles.

Yang YS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, Irvine DJ.

Biomater Sci. 2018 Dec 18;7(1):113-124. doi: 10.1039/c8bm01208c.

PMID:
30444251
15.

Cell and fluid sampling microneedle patches for monitoring skin-resident immunity.

Mandal A, Boopathy AV, Lam LKW, Moynihan KD, Welch ME, Bennett NR, Turvey ME, Thai N, Van JH, Love JC, Hammond PT, Irvine DJ.

Sci Transl Med. 2018 Nov 14;10(467). pii: eaar2227. doi: 10.1126/scitranslmed.aar2227.

PMID:
30429353
16.

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation.

Mottas I, Bekdemir A, Cereghetti A, Spagnuolo L, Yang YS, Müller M, Irvine DJ, Stellacci F, Bourquin C.

Biomaterials. 2019 Jan;190-191:111-120. doi: 10.1016/j.biomaterials.2018.10.031. Epub 2018 Oct 25.

PMID:
30415018
17.

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes.

Tokatlian T, Kulp DW, Mutafyan AA, Jones CA, Menis S, Georgeson E, Kubitz M, Zhang MH, Melo MB, Silva M, Yun DS, Schief WR, Irvine DJ.

Sci Rep. 2018 Nov 8;8(1):16527. doi: 10.1038/s41598-018-34853-2.

18.

Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination.

He Y, Hong C, Li J, Howard MT, Li Y, Turvey ME, Uppu DSSM, Martin JR, Zhang K, Irvine DJ, Hammond PT.

ACS Nano. 2018 Oct 23;12(10):10272-10280. doi: 10.1021/acsnano.8b05373. Epub 2018 Oct 4.

19.

Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy.

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Penaloza-MacMaster P, Abbink P, Blass E, Tregoning JS, Irvine DJ, Barouch DH.

J Immunol. 2018 Nov 1;201(9):2744-2752. doi: 10.4049/jimmunol.1800885. Epub 2018 Sep 24.

20.

Polymers at the Interface with Biology.

Deming TJ, Klok HA, Armes SP, Becker ML, Champion JA, Chen EY, Heilshorn SC, van Hest JCM, Irvine DJ, Johnson JA, Kiessling LL, Maynard HD, de la Cruz MO, Sullivan MO, Tirrell MV, Anseth KS, Lecommandoux S, Percec S, Zhong Z, Albertsson AC.

Biomacromolecules. 2018 Aug 13;19(8):3151-3162. doi: 10.1021/acs.biomac.8b01029. No abstract available.

PMID:
30099879
21.

Extrusion 3D Printing of Paracetamol Tablets from a Single Formulation with Tunable Release Profiles Through Control of Tablet Geometry.

Khaled SA, Alexander MR, Irvine DJ, Wildman RD, Wallace MJ, Sharpe S, Yoo J, Roberts CJ.

AAPS PharmSciTech. 2018 Nov;19(8):3403-3413. doi: 10.1208/s12249-018-1107-z. Epub 2018 Aug 10.

PMID:
30097806
22.

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery.

Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ.

Nat Biotechnol. 2018 Sep;36(8):707-716. doi: 10.1038/nbt.4181. Epub 2018 Jul 9.

23.

Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability.

Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Gall SL, Pentelute BL, Irvine DJ.

Cancer Immunol Res. 2018 Sep;6(9):1025-1038. doi: 10.1158/2326-6066.CIR-17-0607. Epub 2018 Jun 18.

24.

Inferring watershed hydraulics and cold-water habitat persistence using multi-year air and stream temperature signals.

Briggs MA, Johnson ZC, Snyder CD, Hitt NP, Kurylyk BL, Lautz L, Irvine DJ, Hurley ST, Lane JW.

Sci Total Environ. 2018 Sep 15;636:1117-1127. doi: 10.1016/j.scitotenv.2018.04.344. Epub 2018 May 3.

PMID:
29913574
25.

Confusion About "Convection"!

Ataie-Ashtiani B, Simmons CT, Irvine DJ.

Ground Water. 2018 Sep;56(5):683-687. doi: 10.1111/gwat.12790. Epub 2018 Jun 12. No abstract available.

PMID:
29691846
26.

Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes.

Atukorale PU, Guven ZP, Bekdemir A, Carney RP, Van Lehn RC, Yun DS, Jacob Silva PH, Demurtas D, Yang YS, Alexander-Katz A, Stellacci F, Irvine DJ.

Bioconjug Chem. 2018 Apr 18;29(4):1131-1140. doi: 10.1021/acs.bioconjchem.7b00777. Epub 2018 Feb 27.

27.

Identification of Novel "Inks" for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery.

Louzao I, Koch B, Taresco V, Ruiz-Cantu L, Irvine DJ, Roberts CJ, Tuck C, Alexander C, Hague R, Wildman R, Alexander MR.

ACS Appl Mater Interfaces. 2018 Feb 28;10(8):6841-6848. doi: 10.1021/acsami.7b15677. Epub 2018 Feb 15.

PMID:
29322768
28.

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.

Zhang Y, Li N, Suh H, Irvine DJ.

Nat Commun. 2018 Jan 2;9(1):6. doi: 10.1038/s41467-017-02251-3.

29.

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.

Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J, Freeman GJ, Wucherpfennig KW, Irvine DJ, Goldberg MS.

Nat Commun. 2017 Nov 23;8(1):1747. doi: 10.1038/s41467-017-01830-8.

30.

Bridging the Gap Between Research and Practice.

Irvine DJ.

Ground Water. 2018 Jan;56(1):1. doi: 10.1111/gwat.12616. Epub 2017 Nov 16. No abstract available.

PMID:
29145700
31.

Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy.

Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, Moon JJ.

Nano Lett. 2017 Dec 13;17(12):7387-7393. doi: 10.1021/acs.nanolett.7b03218. Epub 2017 Nov 22.

32.

Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.

Appelbe OK, Moynihan KD, Flor A, Rymut N, Irvine DJ, Kron SJ.

J Control Release. 2017 Nov 28;266:248-255. doi: 10.1016/j.jconrel.2017.09.043. Epub 2017 Oct 5.

33.

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.

Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS.

JCI Insight. 2017 Oct 5;2(19). pii: 94298. doi: 10.1172/jci.insight.94298.

34.

Roles for Innate Immunity in Combination Immunotherapies.

Moynihan KD, Irvine DJ.

Cancer Res. 2017 Oct 1;77(19):5215-5221. doi: 10.1158/0008-5472.CAN-17-1340. Epub 2017 Sep 19. Review.

35.

DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins.

Fotoran WL, Santangelo R, de Miranda BNM, Irvine DJ, Wunderlich G.

Mol Ther Methods Clin Dev. 2017 Aug 23;7:1-10. doi: 10.1016/j.omtm.2017.08.004. eCollection 2017 Dec 15.

36.

Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry.

Yang YS, Atukorale PU, D Moynihan K, Bekdemir A, Rakhra K, Tang L, Stellacci F, Irvine DJ.

Nat Commun. 2017 Aug 14;8:15343. doi: 10.1038/ncomms15343.

37.

Selective molecular annealing: in situ small angle X-ray scattering study of microwave-assisted annealing of block copolymers.

Toolan DTW, Adlington K, Isakova A, Kalamiotis A, Mokarian-Tabari P, Dimitrakis G, Dodds C, Arnold T, Terrill NJ, Bras W, Hermida Merino D, Topham PD, Irvine DJ, Howse JR.

Phys Chem Chem Phys. 2017 Aug 9;19(31):20412-20419. doi: 10.1039/c7cp03578k.

38.

3D printing of tablets using inkjet with UV photoinitiation.

Clark EA, Alexander MR, Irvine DJ, Roberts CJ, Wallace MJ, Sharpe S, Yoo J, Hague RJM, Tuck CJ, Wildman RD.

Int J Pharm. 2017 Aug 30;529(1-2):523-530. doi: 10.1016/j.ijpharm.2017.06.085. Epub 2017 Jun 30.

PMID:
28673860
39.

Heat as a groundwater tracer in shallow and deep heterogeneous media: Analytical solution, spreadsheet tool, and field applications.

Kurylyk BL, Irvine DJ, Carey SK, Briggs MA, Werkema DD, Bonham M.

Hydrol Process. 2017 Jul 1;31(14):2648-2661. doi: 10.1002/hyp.11216.

40.

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, McCoy LE, Oom AL, Ozorowski G, Post KW, Sharma SK, Steichen JM, de Taeye SW, Tokatlian T, Torrents de la Peña A, Butera ST, LaBranche CC, Montefiori DC, Silvestri G, Wilson IA, Irvine DJ, Sanders RW, Schief WR, Ward AB, Wyatt RT, Barouch DH, Crotty S, Burton DR.

Immunity. 2017 Jun 20;46(6):1073-1088.e6. doi: 10.1016/j.immuni.2017.05.007.

41.

Delivering safer immunotherapies for cancer.

Milling L, Zhang Y, Irvine DJ.

Adv Drug Deliv Rev. 2017 May 15;114:79-101. doi: 10.1016/j.addr.2017.05.011. Epub 2017 May 22. Review.

42.

Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors.

Zheng Y, Tang L, Mabardi L, Kumari S, Irvine DJ.

ACS Nano. 2017 Mar 28;11(3):3089-3100. doi: 10.1021/acsnano.7b00078. Epub 2017 Mar 1.

43.

Nanoscience and Nanotechnology Cross Borders.

Khademhosseini A, Chan WW, Chhowalla M, Glotzer SC, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney PA, Nel AE, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee AT, Brinker J, Chen X, Chi L, Crommie M, Dekker C, Farokhzad O, Gerber C, Ginger DS, Irvine DJ, Kiessling LL, Kostarelos K, Landes C, Lee T, Leggett GJ, Liang XJ, Liz-Marzán L, Millstone J, Odom TW, Ozcan A, Prato M, Rao CN, Sailor MJ, Weiss E, Weiss PS.

ACS Nano. 2017 Feb 28;11(2):1123-1126. doi: 10.1021/acsnano.7b00953. Epub 2017 Feb 15. No abstract available.

PMID:
28199099
44.

Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery.

Li J, Wang W, He Y, Li Y, Yan EZ, Zhang K, Irvine DJ, Hammond PT.

ACS Nano. 2017 Mar 28;11(3):2531-2544. doi: 10.1021/acsnano.6b08447. Epub 2017 Feb 14.

45.

Smart Radiation Therapy Biomaterials.

Ngwa W, Boateng F, Kumar R, Irvine DJ, Formenti S, Ngoma T, Herskind C, Veldwijk MR, Hildenbrand GL, Hausmann M, Wenz F, Hesser J.

Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):624-637. doi: 10.1016/j.ijrobp.2016.10.034. Epub 2016 Nov 1. Review.

46.

High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry.

Yang YS, Atukorale PU, Moynihan KD, Bekdemir A, Rakhra K, Tang L, Stellacci F, Irvine DJ.

Nat Commun. 2017 Jan 17;8:14069. doi: 10.1038/ncomms14069. Erratum in: Nat Commun. 2017 Aug 14;8:15343.

47.

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.

Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J, Khader SA.

Nat Commun. 2016 Dec 22;7:13894. doi: 10.1038/ncomms13894.

48.

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.

Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ.

Biomaterials. 2017 Feb;117:44-53. doi: 10.1016/j.biomaterials.2016.11.048. Epub 2016 Nov 25.

49.

Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy.

Tzeng A, Kauke MJ, Zhu EF, Moynihan KD, Opel CF, Yang NJ, Mehta N, Kelly RL, Szeto GL, Overwijk WW, Irvine DJ, Wittrup KD.

Cell Rep. 2016 Dec 6;17(10):2503-2511. doi: 10.1016/j.celrep.2016.11.020.

50.

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.

Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, Kumari S, Kelly RL, Kwan BH, Abraham W, Hu K, Mehta NK, Kauke MJ, Suh H, Cochran JR, Lauffenburger DA, Wittrup KD, Irvine DJ.

Nat Med. 2016 Dec;22(12):1402-1410. doi: 10.1038/nm.4200. Epub 2016 Oct 24.

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