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Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization.

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S.

Cell Rep. 2019 Nov 12;29(7):1756-1766.e8. doi: 10.1016/j.celrep.2019.10.008.


Making Tablets for Delivery of Poorly Soluble Drugs Using Photoinitiated 3D Inkjet Printing.

Clark EA, Alexander MR, Irvine DJ, Roberts CJ, Wallace MJ, Yoo J, Wildman RD.

Int J Pharm. 2019 Nov 9:118805. doi: 10.1016/j.ijpharm.2019.118805. [Epub ahead of print]


Adaptive radiotherapy for head and neck cancer reduces the requirement for rescans during treatment due to spinal cord dose.

Belshaw L, Agnew CE, Irvine DM, Rooney KP, McGarry CK.

Radiat Oncol. 2019 Nov 1;14(1):189. doi: 10.1186/s13014-019-1400-3.


A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy.

Fotoran WL, Müntefering T, Kleiber N, Miranda BNM, Liebau E, Irvine DJ, Wunderlich G.

Nanomedicine. 2019 Oct 21;22:102099. doi: 10.1016/j.nano.2019.102099. [Epub ahead of print]


Not All T Cell Synapses Are Built the Same Way.

Kumari S, Colin-York H, Irvine DJ, Fritzsche M.

Trends Immunol. 2019 Nov;40(11):977-980. doi: 10.1016/ Epub 2019 Oct 20.


Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation.

Dundas AA, Sanni O, Dubern JF, Dimitrakis G, Hook AL, Irvine DJ, Williams P, Alexander MR.

Adv Mater. 2019 Oct 3:e1903513. doi: 10.1002/adma.201903513. [Epub ahead of print]


Donor-Cell Engineering with GSK3 Inhibitor-Loaded Nanoparticles Enhances Engraftment Following in Utero Transplantation.

Loukogeorgakis SP, Fachin CG, Santos Dias A, Li H, Tang L, Kim AG, Vrecenak JD, Stratigis J, Ahn NJ, Nissim I, Nissim I, Moron AF, Martins JL, Peranteau WH, De Coppi P, Irvine DJ, Flake AW.

Blood. 2019 Sep 30. pii: blood.2019001037. doi: 10.1182/blood.2019001037. [Epub ahead of print]


Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles.

Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ.

Mol Ther. 2019 Aug 19. pii: S1525-0016(19)30367-3. doi: 10.1016/j.ymthe.2019.08.007. [Epub ahead of print]


Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid.

Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S.

ACS Nano. 2019 Aug 27;13(8):9620-9628. doi: 10.1021/acsnano.9b04783. Epub 2019 Aug 16.


Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination.

Boopathy AV, Mandal A, Kulp DW, Menis S, Bennett NR, Watkins HC, Wang W, Martin JT, Thai NT, He Y, Schief WR, Hammond PT, Irvine DJ.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16473-16478. doi: 10.1073/pnas.1902179116. Epub 2019 Jul 29.


Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor.

Ma L, Dichwalkar T, Chang JYH, Cossette B, Garafola D, Zhang AQ, Fichter M, Wang C, Liang S, Silva M, Kumari S, Mehta NK, Abraham W, Thai N, Li N, Wittrup KD, Irvine DJ.

Science. 2019 Jul 12;365(6449):162-168. doi: 10.1126/science.aav8692.


Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.

Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD.

Sci Transl Med. 2019 Jun 26;11(498). pii: eaaw2614. doi: 10.1126/scitranslmed.aaw2614.


Heat: An Overlooked Tool in the Practicing Hydrogeologist's Toolbox.

Kurylyk BL, Irvine DJ.

Ground Water. 2019 Jul;57(4):517-524. doi: 10.1111/gwat.12910. Epub 2019 Jun 20. No abstract available.


Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC.

Nature. 2019 Jun;570(7762):468-473. doi: 10.1038/s41586-019-1250-z. Epub 2019 May 29.


Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance.

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, Pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S.

Cell. 2019 May 16;177(5):1153-1171.e28. doi: 10.1016/j.cell.2019.04.012. Epub 2019 May 9.


Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models.

Rothschilds A, Tzeng A, Mehta NK, Moynihan KD, Irvine DJ, Wittrup KD.

Oncoimmunology. 2019 Feb 19;8(5):e1558678. doi: 10.1080/2162402X.2018.1558678. eCollection 2019.


In vitro evolution of enhanced RNA replicons for immunotherapy.

Li Y, Teague B, Zhang Y, Su Z, Porter E, Dobosh B, Wagner T, Irvine DJ, Weiss R.

Sci Rep. 2019 May 6;9(1):6932. doi: 10.1038/s41598-019-43422-0.


Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells.

Xie YQ, Arik H, Wei L, Zheng Y, Suh H, Irvine DJ, Tang L.

Biomater Sci. 2019 Mar 26;7(4):1345-1357. doi: 10.1039/c8bm01556b.


Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers.

Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ.

Science. 2019 Feb 8;363(6427):649-654. doi: 10.1126/science.aat9120. Epub 2018 Dec 20.


High-Dose Chemotherapy in Relapsed or Refractory Metastatic Germ-Cell Cancer: The Scotland Experience.

Tan YY, Al-Bubseeree B, Irvine D, MacDonald G, McQuaker G, Parker A, Waterston A, White J.

Clin Genitourin Cancer. 2019 Apr;17(2):125-131. doi: 10.1016/j.clgc.2018.11.013. Epub 2018 Nov 17.


Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.

Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Lee JH, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, Burton DR.

Immunity. 2019 Jan 15;50(1):241-252.e6. doi: 10.1016/j.immuni.2018.11.011. Epub 2018 Dec 11.


Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles.

Yang YS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, Irvine DJ.

Biomater Sci. 2018 Dec 18;7(1):113-124. doi: 10.1039/c8bm01208c.


An evaluation of techniques for dose calculation on cone beam computed tomography.

Giacometti V, King RB, Agnew CE, Irvine DM, Jain S, Hounsell AR, McGarry CK.

Br J Radiol. 2019 Apr;92(1096):20180383. doi: 10.1259/bjr.20180383. Epub 2019 Feb 26.


Cell and fluid sampling microneedle patches for monitoring skin-resident immunity.

Mandal A, Boopathy AV, Lam LKW, Moynihan KD, Welch ME, Bennett NR, Turvey ME, Thai N, Van JH, Love JC, Hammond PT, Irvine DJ.

Sci Transl Med. 2018 Nov 14;10(467). pii: eaar2227. doi: 10.1126/scitranslmed.aar2227.


Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation.

Mottas I, Bekdemir A, Cereghetti A, Spagnuolo L, Yang YS, Müller M, Irvine DJ, Stellacci F, Bourquin C.

Biomaterials. 2019 Jan;190-191:111-120. doi: 10.1016/j.biomaterials.2018.10.031. Epub 2018 Oct 25.


Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes.

Tokatlian T, Kulp DW, Mutafyan AA, Jones CA, Menis S, Georgeson E, Kubitz M, Zhang MH, Melo MB, Silva M, Yun DS, Schief WR, Irvine DJ.

Sci Rep. 2018 Nov 8;8(1):16527. doi: 10.1038/s41598-018-34853-2.


Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination.

He Y, Hong C, Li J, Howard MT, Li Y, Turvey ME, Uppu DSSM, Martin JR, Zhang K, Irvine DJ, Hammond PT.

ACS Nano. 2018 Oct 23;12(10):10272-10280. doi: 10.1021/acsnano.8b05373. Epub 2018 Oct 4.


Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy.

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Penaloza-MacMaster P, Abbink P, Blass E, Tregoning JS, Irvine DJ, Barouch DH.

J Immunol. 2018 Nov 1;201(9):2744-2752. doi: 10.4049/jimmunol.1800885. Epub 2018 Sep 24.


Polymers at the Interface with Biology.

Deming TJ, Klok HA, Armes SP, Becker ML, Champion JA, Chen EY, Heilshorn SC, van Hest JCM, Irvine DJ, Johnson JA, Kiessling LL, Maynard HD, de la Cruz MO, Sullivan MO, Tirrell MV, Anseth KS, Lecommandoux S, Percec S, Zhong Z, Albertsson AC.

Biomacromolecules. 2018 Aug 13;19(8):3151-3162. doi: 10.1021/acs.biomac.8b01029. No abstract available.


Extrusion 3D Printing of Paracetamol Tablets from a Single Formulation with Tunable Release Profiles Through Control of Tablet Geometry.

Khaled SA, Alexander MR, Irvine DJ, Wildman RD, Wallace MJ, Sharpe S, Yoo J, Roberts CJ.

AAPS PharmSciTech. 2018 Nov;19(8):3403-3413. doi: 10.1208/s12249-018-1107-z. Epub 2018 Aug 10.


Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery.

Tang L, Zheng Y, Melo MB, Mabardi L, Castaño AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, Irvine DJ.

Nat Biotechnol. 2018 Sep;36(8):707-716. doi: 10.1038/nbt.4181. Epub 2018 Jul 9.


Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability.

Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Gall SL, Pentelute BL, Irvine DJ.

Cancer Immunol Res. 2018 Sep;6(9):1025-1038. doi: 10.1158/2326-6066.CIR-17-0607. Epub 2018 Jun 18.


Inferring watershed hydraulics and cold-water habitat persistence using multi-year air and stream temperature signals.

Briggs MA, Johnson ZC, Snyder CD, Hitt NP, Kurylyk BL, Lautz L, Irvine DJ, Hurley ST, Lane JW.

Sci Total Environ. 2018 Sep 15;636:1117-1127. doi: 10.1016/j.scitotenv.2018.04.344. Epub 2018 May 3.


Material aid for vaccines.

Irvine D.

Nat Mater. 2018 Jun;17(6):472-473. doi: 10.1038/s41563-018-0089-2. No abstract available.


Confusion About "Convection"!

Ataie-Ashtiani B, Simmons CT, Irvine DJ.

Ground Water. 2018 Sep;56(5):683-687. doi: 10.1111/gwat.12790. Epub 2018 Jun 12. No abstract available.


Auditory perceptual learning and changes in the conceptualization of auditory cortex.

Irvine DRF.

Hear Res. 2018 Sep;366:3-16. doi: 10.1016/j.heares.2018.03.011. Epub 2018 Mar 12. Review.


Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes.

Atukorale PU, Guven ZP, Bekdemir A, Carney RP, Van Lehn RC, Yun DS, Jacob Silva PH, Demurtas D, Yang YS, Alexander-Katz A, Stellacci F, Irvine DJ.

Bioconjug Chem. 2018 Apr 18;29(4):1131-1140. doi: 10.1021/acs.bioconjchem.7b00777. Epub 2018 Feb 27.


Author Correction: Additive manufacture of complex 3D Au-containing nanocomposites by simultaneous two-photon polymerisation and photoreduction.

Hu Q, Sun XZ, Parmenter CDJ, Fay MW, Smith EF, Rance GA, He Y, Zhang F, Liu Y, Irvine D, Tuck C, Hague R, Wildman R.

Sci Rep. 2018 Feb 19;8(1):3512. doi: 10.1038/s41598-018-21513-8.


Improvement of off-axis SABR plan verification results by using adapted dose reconstruction algorithms for the Octavius 4D system.

Jeevanandam P, Agnew CE, Irvine DM, McGarry CK.

Med Phys. 2018 Apr;45(4):1738-1747. doi: 10.1002/mp.12805. Epub 2018 Mar 11.


Identification of Novel "Inks" for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery.

Louzao I, Koch B, Taresco V, Ruiz-Cantu L, Irvine DJ, Roberts CJ, Tuck C, Alexander C, Hague R, Wildman R, Alexander MR.

ACS Appl Mater Interfaces. 2018 Feb 28;10(8):6841-6848. doi: 10.1021/acsami.7b15677. Epub 2018 Feb 15.


Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity.

Zhang Y, Li N, Suh H, Irvine DJ.

Nat Commun. 2018 Jan 2;9(1):6. doi: 10.1038/s41467-017-02251-3.


Additive manufacture of complex 3D Au-containing nanocomposites by simultaneous two-photon polymerisation and photoreduction.

Hu Q, Sun XZ, Parmenter CDJ, Fay MW, Smith EF, Rance GA, He Y, Zhang F, Liu Y, Irvine D, Tuck C, Hague R, Wildman R.

Sci Rep. 2017 Dec 7;7(1):17150. doi: 10.1038/s41598-017-17391-1. Erratum in: Sci Rep. 2018 Feb 19;8(1):3512.


Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices.

Mikulskis P, Hook A, Dundas AA, Irvine D, Sanni O, Anderson D, Langer R, Alexander MR, Williams P, Winkler DA.

ACS Appl Mater Interfaces. 2018 Jan 10;10(1):139-149. doi: 10.1021/acsami.7b14197. Epub 2018 Jan 2.


Efficacy of a rectal spacer with prostate SABR-first UK experience.

King RB, Osman SO, Fairmichael C, Irvine DM, Lyons CA, Ravi A, O'Sullivan JM, Hounsell AR, Mitchell DM, McGarry CK, Jain S.

Br J Radiol. 2018 Feb;91(1083):20170672. doi: 10.1259/bjr.20170672. Epub 2018 Jan 23.


T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity.

Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J, Freeman GJ, Wucherpfennig KW, Irvine DJ, Goldberg MS.

Nat Commun. 2017 Nov 23;8(1):1747. doi: 10.1038/s41467-017-01830-8.


Bridging the Gap Between Research and Practice.

Irvine DJ.

Ground Water. 2018 Jan;56(1):1. doi: 10.1111/gwat.12616. Epub 2017 Nov 16. No abstract available.


Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy.

Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, Moon JJ.

Nano Lett. 2017 Dec 13;17(12):7387-7393. doi: 10.1021/acs.nanolett.7b03218. Epub 2017 Nov 22.


Plasticity in the auditory system.

Irvine DRF.

Hear Res. 2018 May;362:61-73. doi: 10.1016/j.heares.2017.10.011. Epub 2017 Oct 31. Review.


Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.

Appelbe OK, Moynihan KD, Flor A, Rymut N, Irvine DJ, Kron SJ.

J Control Release. 2017 Nov 28;266:248-255. doi: 10.1016/j.jconrel.2017.09.043. Epub 2017 Oct 5.


DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.

Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS.

JCI Insight. 2017 Oct 5;2(19). pii: 94298. doi: 10.1172/jci.insight.94298.

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