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Items: 1 to 50 of 153

1.

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC.

Am J Pathol. 2019 Feb;189(2):258-271. doi: 10.1016/j.ajpath.2018.10.007. Epub 2018 Nov 16.

2.

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.

3.

An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias.

Lynch RW, Hawley CA, Pellicoro A, Bain CC, Iredale JP, Jenkins SJ.

J Leukoc Biol. 2018 Sep;104(3):579-586. doi: 10.1002/JLB.1TA0517-169R. Epub 2018 Apr 1.

4.

The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzalez S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP.

J Immunol. 2018 Feb 1;200(3):1169-1187. doi: 10.4049/jimmunol.1701247. Epub 2017 Dec 20.

5.

11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z.

Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22.

6.

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.

Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC.

Nat Commun. 2017 Oct 24;8(1):1118. doi: 10.1038/s41467-017-01097-z.

7.

Erratum to: Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells.

Lucendo-Villarin B, Filis P, Swortwood MJ, Huestis MA, Meseguer-Ripolles J, Cameron K, Iredale JP, O'Shaughnessy PJ, Fowler PA, Hay DC.

Arch Toxicol. 2017 Nov;91(11):3645. doi: 10.1007/s00204-017-2075-x.

PMID:
28980015
8.

Detecting drug-target binding in cells using fluorescence-activated cell sorting coupled with mass spectrometry analysis.

Wilson K, Webster SP, Iredale JP, Zheng X, Homer NZ, Pham NT, Auer M, Mole DJ.

Methods Appl Fluoresc. 2017 Dec 15;6(1):015002. doi: 10.1088/2050-6120/aa8c60.

PMID:
28901950
9.

In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis.

McBride A, Hoy AM, Bamford MJ, Mossakowska DE, Ruediger MP, Griggs J, Desai S, Simpson K, Caballero-Hernandez I, Iredale JP, Pell T, Aucott RL, Holmes DS, Webster SP, Fallowfield JA.

Sci Rep. 2017 Sep 7;7(1):10806. doi: 10.1038/s41598-017-10521-9.

10.

Erratum to: Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells.

Lucendo-Villarin B, Filis P, Swortwood MJ, Huestis MA, Meseguer-Ripolles J, Cameron K, Iredale JP, O'Shaughnessy PJ, Fowler PA, Hay DC.

Arch Toxicol. 2017 Jul 21. doi: 10.1007/s00204-017-2030-x. [Epub ahead of print] No abstract available.

PMID:
28733887
11.

Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells.

Lucendo-Villarin B, Filis P, Swortwood MJ, Huestis MA, Meseguer-Ripolles J, Cameron K, Iredale JP, O'Shaughnessy PJ, Fowler PA, Hay DC.

Arch Toxicol. 2017 Nov;91(11):3633-3643. doi: 10.1007/s00204-017-1983-0. Epub 2017 May 16. Erratum in: Arch Toxicol. 2017 Jul 21;:. Arch Toxicol. 2017 Oct 3;:.

12.

Liver Fibrosis: Understanding the Dynamics of Bidirectional Wound Repair to Inform the Design of Markers and Therapies.

Iredale JP, Pellicoro A, Fallowfield JA.

Dig Dis. 2017;35(4):310-313. doi: 10.1159/000456581. Epub 2017 May 3. Review.

13.

MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation.

Ho GT, Aird RE, Liu B, Boyapati RK, Kennedy NA, Dorward DA, Noble CL, Shimizu T, Carter RN, Chew ETS, Morton NM, Rossi AG, Sartor RB, Iredale JP, Satsangi J.

Mucosal Immunol. 2018 Jan;11(1):120-130. doi: 10.1038/mi.2017.31. Epub 2017 Apr 12.

14.

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial.

Snowdon VK, Lachlan NJ, Hoy AM, Hadoke PW, Semple SI, Patel D, Mungall W, Kendall TJ, Thomson A, Lennen RJ, Jansen MA, Moran CM, Pellicoro A, Ramachandran P, Shaw I, Aucott RL, Severin T, Saini R, Pak J, Yates D, Dongre N, Duffield JS, Webb DJ, Iredale JP, Hayes PC, Fallowfield JA.

PLoS Med. 2017 Feb 28;14(2):e1002248. doi: 10.1371/journal.pmed.1002248. eCollection 2017 Feb.

15.

Regression of Liver Fibrosis.

Campana L, Iredale JP.

Semin Liver Dis. 2017 Feb;37(1):1-10. doi: 10.1055/s-0036-1597816. Epub 2017 Feb 15. Review.

PMID:
28201843
16.

BREXIT and science, where do we go from here.

Iredale JP.

QJM. 2016 Oct;109(10):643-644. Epub 2016 Aug 10. No abstract available.

PMID:
27512105
17.

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.

Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L, Hayes AJ, Tsoumanis A, Lyster D, Parks RW, Garden OJ, Iredale JP, Uings IJ, Liddle J, Wright WL, Dukes G, Webster SP, Mole DJ.

Sci Rep. 2016 Sep 27;6:33951. doi: 10.1038/srep33951.

18.

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback.

Wilson K, Auer M, Binnie M, Zheng X, Pham NT, Iredale JP, Webster SP, Mole DJ.

Cell Death Dis. 2016 Apr 14;7:e2197. doi: 10.1038/cddis.2016.87.

19.

Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.

20.

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.

Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.

21.

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).

Villarin BL, Cameron K, Szkolnicka D, Rashidi H, Bates N, Kimber SJ, Flint O, Forbes SJ, Iredale JP, Bradley M, Hay DC.

Adv Healthc Mater. 2015 Aug 26;4(12):1819. doi: 10.1002/adhm.201570072.

PMID:
26308957
22.

Liver fibrosis: Therapeutic armory 40 years on.

Iredale JP, Sci FM, Pellicoro A.

Clin Liver Dis (Hoboken). 2015 Jul 28;6(1):1-4. doi: 10.1002/cld.476. eCollection 2015 Jul. No abstract available.

23.

Hepatic progenitor cells of biliary origin with liver repopulation capacity.

Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ.

Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20.

24.

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.

Villarin BL, Cameron K, Szkolnicka D, Rashidi H, Bates N, Kimber SJ, Flint O, Forbes SJ, Iredale JP, Bradley M, Hay DC.

Adv Healthc Mater. 2015 Aug 26;4(12):1820-5. doi: 10.1002/adhm.201500391. Epub 2015 Jun 24.

25.

Resolution of liver fibrosis: basic mechanisms and clinical relevance.

Ramachandran P, Iredale JP, Fallowfield JA.

Semin Liver Dis. 2015 May;35(2):119-31. doi: 10.1055/s-0035-1550057. Epub 2015 May 14. Review.

PMID:
25974898
26.

Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner.

Filis P, Nagrath N, Fraser M, Hay DC, Iredale JP, O'Shaughnessy P, Fowler PA.

J Clin Endocrinol Metab. 2015 Jun;100(6):E861-70. doi: 10.1210/jc.2014-3941. Epub 2015 Mar 24.

27.

Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM).

Warner P, Weir CJ, Hansen CH, Douglas A, Madhra M, Hillier SG, Saunders PT, Iredale JP, Semple S, Walker BR, Critchley HO.

BMJ Open. 2015 Jan 14;5(1):e006837. doi: 10.1136/bmjopen-2014-006837.

28.

A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.

Wilson K, Mole DJ, Homer NZ, Iredale JP, Auer M, Webster SP.

J Biomol Screen. 2015 Feb;20(2):292-8. doi: 10.1177/1087057114554171. Epub 2014 Oct 8.

PMID:
25296660
29.

Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver.

Macfarlane DP, Raubenheimer PJ, Preston T, Gray CD, Bastin ME, Marshall I, Iredale JP, Andrew R, Walker BR.

Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1;307(7):G760-8. doi: 10.1152/ajpgi.00030.2014. Epub 2014 Aug 7.

30.

Galectin-3 regulates hepatic progenitor cell expansion during liver injury.

Hsieh WC, Mackinnon AC, Lu WY, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG, Medine CN, Hay DC, Sethi T, Iredale JP, Forbes SJ.

Gut. 2015 Feb;64(2):312-21. doi: 10.1136/gutjnl-2013-306290. Epub 2014 May 16.

PMID:
24837171
31.

Identifying molecular factors that contribute to resolution of liver fibrosis.

Iredale JP, Bataller R.

Gastroenterology. 2014 May;146(5):1160-4. doi: 10.1053/j.gastro.2014.03.019. Epub 2014 Mar 26. No abstract available.

PMID:
24680971
32.

Liver fibrosis and repair: immune regulation of wound healing in a solid organ.

Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA.

Nat Rev Immunol. 2014 Mar;14(3):181-94. doi: 10.1038/nri3623. Review.

PMID:
24566915
33.

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ.

PLoS One. 2014 Jan 27;9(1):e86241. doi: 10.1371/journal.pone.0086241. eCollection 2014.

34.

Accurate prediction of drug-induced liver injury using stem cell-derived populations.

Szkolnicka D, Farnworth SL, Lucendo-Villarin B, Storck C, Zhou W, Iredale JP, Flint O, Hay DC.

Stem Cells Transl Med. 2014 Feb;3(2):141-8. doi: 10.5966/sctm.2013-0146. Epub 2013 Dec 27.

35.

Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.

Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP.

Protein Expr Purif. 2014 Mar;95:96-103. doi: 10.1016/j.pep.2013.11.015. Epub 2013 Dec 4.

36.

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D.

Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10.

37.

ECAT-V: where clinical and research training meet.

Argyle DJ, Iredale JP, Jackson AP, Walker BR.

Vet Rec. 2013 Oct 19;173(15):364-5. doi: 10.1136/vr.f6185. No abstract available.

PMID:
24141161
38.

Origins of fibrosis: pericytes take centre stage.

Greenhalgh SN, Iredale JP, Henderson NC.

F1000Prime Rep. 2013 Sep 2;5:37. doi: 10.12703/P5-37. Review.

39.

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.

Fallowfield JA, Hayden AL, Snowdon VK, Aucott RL, Stutchfield BM, Mole DJ, Pellicoro A, Gordon-Walker TT, Henke A, Schrader J, Trivedi PJ, Princivalle M, Forbes SJ, Collins JE, Iredale JP.

Hepatology. 2014 Apr;59(4):1492-504. doi: 10.1002/hep.26627. Epub 2014 Mar 3.

PMID:
23873655
40.

Developing high-fidelity hepatotoxicity models from pluripotent stem cells.

Medine CN, Lucendo-Villarin B, Storck C, Wang F, Szkolnicka D, Khan F, Pernagallo S, Black JR, Marriage HM, Ross JA, Bradley M, Iredale JP, Flint O, Hay DC.

Stem Cells Transl Med. 2013 Jul;2(7):505-9. doi: 10.5966/sctm.2012-0138. Epub 2013 Jun 11.

41.

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling.

Bird TG, Lu WY, Boulter L, Gordon-Keylock S, Ridgway RA, Williams MJ, Taube J, Thomas JA, Wojtacha D, Gambardella A, Sansom OJ, Iredale JP, Forbes SJ.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6542-7. doi: 10.1073/pnas.1302168110. Epub 2013 Apr 1.

42.

Reply to Elastin-based molecular MRI of liver fibrosis.

Pellicoro A, Iredale JP.

Hepatology. 2013 Oct;58(4):1518-9. doi: 10.1002/hep.26332. Epub 2013 Sep 4. No abstract available.

PMID:
23424101
43.

Reversibility of liver fibrosis.

Pellicoro A, Ramachandran P, Iredale JP.

Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S26. doi: 10.1186/1755-1536-5-S1-S26. eCollection 2012.

44.

Novel biopolymers to enhance endothelialisation of intra-vascular devices.

Pernagallo S, Tura O, Wu M, Samuel K, Diaz-Mochon JJ, Hansen A, Zhang R, Jackson M, Padfield GJ, Hadoke PW, Mills NL, Turner ML, Iredale JP, Hay DC, Bradley M.

Adv Healthc Mater. 2012 Sep;1(5):646-56. doi: 10.1002/adhm.201200130. Epub 2012 Aug 9.

PMID:
23184801
45.

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation.

Iredale JP, Thompson A, Henderson NC.

Biochim Biophys Acta. 2013 Jul;1832(7):876-83. doi: 10.1016/j.bbadis.2012.11.002. Epub 2012 Nov 10. Review.

46.

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.

Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Manning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3186-95. doi: 10.1073/pnas.1119964109. Epub 2012 Oct 24.

47.

Standing down the guard: stellate cells leave quietly.

Henderson NC, Iredale JP.

Gastroenterology. 2012 Oct;143(4):890-2. doi: 10.1053/j.gastro.2012.08.014. Epub 2012 Aug 20. No abstract available.

PMID:
22917861
48.

Liver fibrosis: a bidirectional model of fibrogenesis and resolution.

Ramachandran P, Iredale JP.

QJM. 2012 Sep;105(9):813-7. doi: 10.1093/qjmed/hcs069. Epub 2012 May 29. Review.

49.

SUMOylation of HNF4α regulates protein stability and hepatocyte function.

Zhou W, Hannoun Z, Jaffray E, Medine CN, Black JR, Greenhough S, Zhu L, Ross JA, Forbes S, Wilmut I, Iredale JP, Hay RT, Hay DC.

J Cell Sci. 2012 Aug 1;125(Pt 15):3630-5. Epub 2012 Apr 14.

50.

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, Ridgway RA, Seo SS, Spee B, Van Rooijen N, Sansom OJ, Iredale JP, Lowell S, Roskams T, Forbes SJ.

Nat Med. 2012 Mar 4;18(4):572-9. doi: 10.1038/nm.2667.

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