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Items: 42

1.

Peptidic Scaffolds To Reduce the Interaction of Cu(II) Ions with β-Amyloid Protein.

Caballero AB, Iranzo O, Hautier A, Sabaté R, Gamez P.

Inorg Chem. 2020 Jan 6;59(1):837-846. doi: 10.1021/acs.inorgchem.9b03099. Epub 2019 Dec 19.

PMID:
31855423
2.

Rational De Novo Design of a Cu Metalloenzyme for Superoxide Dismutation.

Mathieu E, Tolbert AE, Koebke KJ, Tard C, Iranzo O, Penner-Hahn JE, Policar C, Pecoraro V.

Chemistry. 2020 Jan 2;26(1):249-258. doi: 10.1002/chem.201903808. Epub 2019 Dec 3.

PMID:
31710732
3.

Ruminococcin C, a promising antibiotic produced by a human gut symbiont.

Chiumento S, Roblin C, Kieffer-Jaquinod S, Tachon S, Leprètre C, Basset C, Aditiyarini D, Olleik H, Nicoletti C, Bornet O, Iranzo O, Maresca M, Hardré R, Fons M, Giardina T, Devillard E, Guerlesquin F, Couté Y, Atta M, Perrier J, Lafond M, Duarte V.

Sci Adv. 2019 Sep 25;5(9):eaaw9969. doi: 10.1126/sciadv.aaw9969. eCollection 2019 Sep.

4.

β-Hairpins as peptidomimetics of human phosphoprotein-binding domains.

Batalha IL, Lychko I, Branco RJF, Iranzo O, Roque ACA.

Org Biomol Chem. 2019 Apr 17;17(16):3996-4004. doi: 10.1039/c9ob00564a.

PMID:
30945720
5.

Studying the reactivity of "old" Cu(II) complexes for "novel" anticancer purposes.

Peña Q, Lorenzo J, Sciortino G, Rodríguez-Calado S, Maréchal JD, Bayón P, Simaan AJ, Iranzo O, Capdevila M, Palacios Ò.

J Inorg Biochem. 2019 Jun;195:51-60. doi: 10.1016/j.jinorgbio.2019.03.011. Epub 2019 Mar 18.

PMID:
30925401
6.

The role of methylation in the copper(ii) coordination properties of a His-containing decapeptide.

Hautier A, Carvalho T, Valensin D, Simaan AJ, Faure B, Mateus P, Delgado R, Iranzo O.

Dalton Trans. 2019 Feb 7;48(5):1859-1870. doi: 10.1039/c8dt05037f. Epub 2019 Jan 16.

PMID:
30648708
7.

A computational and experimental study to develop E-selectin targeted peptides for molecular imaging applications.

Fernandes AC, Liu M, Sorbo T, Appold LC, Ilbert M, Ferracci G, Kiessling F, F Branco RJ, Lammers T, Iranzo O.

Future Med Chem. 2018 Dec 6. doi: 10.4155/fmc-2018-0244. [Epub ahead of print]

PMID:
30520324
8.

Electrochemical Water Oxidation and Stereoselective Oxygen Atom Transfer Mediated by a Copper Complex.

Kafentzi MC, Papadakis R, Gennarini F, Kochem A, Iranzo O, Le Mest Y, Le Poul N, Tron T, Faure B, Simaan AJ, Réglier M.

Chemistry. 2018 Apr 6;24(20):5213-5224. doi: 10.1002/chem.201704613. Epub 2018 Feb 6.

PMID:
29406617
9.

Characterization of plasma labile heme in hemolytic conditions.

Gouveia Z, Carlos AR, Yuan X, Aires-da-Silva F, Stocker R, Maghzal GJ, Leal SS, Gomes CM, Todorovic S, Iranzo O, Ramos S, Santos AC, Hamza I, Gonçalves J, Soares MP.

FEBS J. 2017 Oct;284(19):3278-3301. doi: 10.1111/febs.14192. Epub 2017 Sep 11.

10.

Recognition of phosphopeptides by a dinuclear copper(ii) macrocyclic complex in a water : methanol 50 : 50 v/v solution.

Mesquita LM, Mateus P, Fernandes RDV, Iranzo O, André V, Tiago de Oliveira F, Platas-Iglesias C, Delgado R.

Dalton Trans. 2017 Jul 25;46(29):9549-9564. doi: 10.1039/c7dt01724c.

PMID:
28702582
11.

PBCA-based polymeric microbubbles for molecular imaging and drug delivery.

Koczera P, Appold L, Shi Y, Liu M, Dasgupta A, Pathak V, Ojha T, Fokong S, Wu Z, van Zandvoort M, Iranzo O, Kuehne AJC, Pich A, Kiessling F, Lammers T.

J Control Release. 2017 Aug 10;259:128-135. doi: 10.1016/j.jconrel.2017.03.006. Epub 2017 Mar 6.

12.

Copper(II) Complexes of Phenanthroline and Histidine Containing Ligands: Synthesis, Characterization and Evaluation of their DNA Cleavage and Cytotoxic Activity.

Leite SM, Lima LM, Gama S, Mendes F, Orio M, Bento I, Paulo A, Delgado R, Iranzo O.

Inorg Chem. 2016 Nov 21;55(22):11801-11814. Epub 2016 Nov 7.

PMID:
27934321
13.

Integration of Molecular Dynamics Based Predictions into the Optimization of De Novo Protein Designs: Limitations and Benefits.

Carvalho HF, Barbosa AJ, Roque AC, Iranzo O, Branco RJ.

Methods Mol Biol. 2017;1529:181-201.

PMID:
27914051
14.

Engineering Short Preorganized Peptide Sequences for Metal Ion Coordination: Copper(II) a Case Study.

Lima LM, Iranzo O.

Methods Enzymol. 2016;580:333-64. doi: 10.1016/bs.mie.2016.04.007. Epub 2016 Jun 16.

PMID:
27586340
15.

Constant-pH MD Simulations Portray the Protonation and Structural Behavior of Four Decapeptides Designed to Coordinate Cu(2+).

Campos SR, Iranzo O, Baptista AM.

J Phys Chem B. 2016 Feb 18;120(6):1080-91. doi: 10.1021/acs.jpcb.5b12052. Epub 2016 Feb 9.

PMID:
26813109
16.

Repairing oxidized proteins in the bacterial envelope using respiratory chain electrons.

Gennaris A, Ezraty B, Henry C, Agrebi R, Vergnes A, Oheix E, Bos J, Leverrier P, Espinosa L, Szewczyk J, Vertommen D, Iranzo O, Collet JF, Barras F.

Nature. 2015 Dec 17;528(7582):409-412. doi: 10.1038/nature15764. Epub 2015 Dec 7.

17.

Comparison of the Internal Dynamics of Metalloproteases Provides New Insights on Their Function and Evolution.

Carvalho HF, Roque AC, Iranzo O, Branco RJ.

PLoS One. 2015 Sep 23;10(9):e0138118. doi: 10.1371/journal.pone.0138118. eCollection 2015.

18.

Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles.

Spivak I, Rix A, Schmitz G, Fokong S, Iranzo O, Lederle W, Kiessling F.

Mol Imaging Biol. 2016 Apr;18(2):180-90. doi: 10.1007/s11307-015-0894-9.

PMID:
26391990
19.

Effect of the Peptidic Scaffold in Copper(II) Coordination and the Redox Properties of Short Histidine-Containing Peptides.

Fragoso A, Carvalho T, Rousselot-Pailley P, Correia Dos Santos MM, Delgado R, Iranzo O.

Chemistry. 2015 Sep 7;21(37):13100-11. doi: 10.1002/chem.201501715. Epub 2015 Jul 28.

PMID:
26227175
20.

Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease.

Vila-Real H, Coelho H, Rocha J, Fernandes A, Ventura MR, Maycock CD, Iranzo O, Simplício AL.

J Med Chem. 2015 Jul 23;58(14):5408-18. doi: 10.1021/acs.jmedchem.5b00658. Epub 2015 Jul 1.

PMID:
26061085
21.

Ultrasound molecular imaging of E-selectin in tumor vessels using poly n-butyl cyanoacrylate microbubbles covalently coupled to a short targeting peptide.

Fokong S, Fragoso A, Rix A, Curaj A, Wu Z, Lederle W, Iranzo O, Gätjens J, Kiessling F, Palmowski M.

Invest Radiol. 2013 Dec;48(12):843-50. doi: 10.1097/RLI.0b013e31829d03ec.

PMID:
23857137
22.

Computational protein design with electrostatic focusing: experimental characterization of a conditionally folded helical domain with a reduced amino acid alphabet.

Suárez-Diez M, Pujol AM, Matzapetakis M, Jaramillo A, Iranzo O.

Biotechnol J. 2013 Jul;8(7):855-64. doi: 10.1002/biot.201200380. Epub 2013 Jun 21.

PMID:
23788466
23.

Copper(II) coordination properties of decapeptides containing three His residues: the impact of cyclization and Asp residue coordination.

Fragoso A, Delgado R, Iranzo O.

Dalton Trans. 2013 May 7;42(17):6182-92. doi: 10.1039/c3dt32384f. Epub 2013 Mar 25.

PMID:
23529654
24.

Harnessing the flexibility of peptidic scaffolds to control their copper(II)-coordination properties: a potentiometric and spectroscopic study.

Fragoso A, Lamosa P, Delgado R, Iranzo O.

Chemistry. 2013 Feb 4;19(6):2076-88. doi: 10.1002/chem.201203545. Epub 2013 Jan 4.

PMID:
23293061
25.

Design of a peptidic turn with high affinity for Hg(II).

Pires S, Habjanič J, Sezer M, Soares CM, Hemmingsen L, Iranzo O.

Inorg Chem. 2012 Nov 5;51(21):11339-48. doi: 10.1021/ic3008014. Epub 2012 Oct 17.

PMID:
23074970
26.

Experimental and theoretical evaluation of multisite cadmium(II) exchange in designed three-stranded coiled-coil peptides.

Chakraborty S, Iranzo O, Zuiderweg ER, Pecoraro VL.

J Am Chem Soc. 2012 Apr 11;134(14):6191-203. doi: 10.1021/ja210510g. Epub 2012 Mar 28.

27.

Manganese complexes displaying superoxide dismutase activity: a balance between different factors.

Iranzo O.

Bioorg Chem. 2011 Apr;39(2):73-87. doi: 10.1016/j.bioorg.2011.02.001. Epub 2011 Feb 18. Review.

PMID:
21397291
28.

Controlling and fine tuning the physical properties of two identical metal coordination sites in de novo designed three stranded coiled coil peptides.

Iranzo O, Chakraborty S, Hemmingsen L, Pecoraro VL.

J Am Chem Soc. 2011 Jan 19;133(2):239-51. doi: 10.1021/ja104433n. Epub 2010 Dec 16.

29.

Harnessing natures ability to control metal ion coordination geometry using de novo designed peptides.

Peacock AF, Iranzo O, Pecoraro VL.

Dalton Trans. 2009 Apr 7;(13):2271-80. doi: 10.1039/b818306f. Epub 2009 Jan 16.

30.
31.

Altered transition state for the reaction of an RNA model catalyzed by a dinuclear zinc(II) catalyst.

Humphry T, Iyer S, Iranzo O, Morrow JR, Richard JP, Paneth P, Hengge AC.

J Am Chem Soc. 2008 Dec 31;130(52):17858-66. doi: 10.1021/ja8059864.

33.

Heterochromia in designed metallopeptides: geometry-selective binding of CdII in a de novo peptide.

Iranzo O, Cabello C, Pecoraro VL.

Angew Chem Int Ed Engl. 2007;46(35):6688-91. No abstract available.

34.

Assessing the integrity of designed homomeric parallel three-stranded coiled coils in the presence of metal ions.

Iranzo O, Ghosh D, Pecoraro VL.

Inorg Chem. 2006 Dec 11;45(25):9959-73.

PMID:
17140192
35.

Solvent deuterium isotope effects on phosphodiester cleavage catalyzed by an extraordinarily active Zn(II) complex.

Yang MY, Iranzo O, Richard JP, Morrow JR.

J Am Chem Soc. 2005 Feb 2;127(4):1064-5.

PMID:
15669821
36.

Recruitment of divalent metal ions by incorporation of 4-thio-2'-deoxythymidine or 4-thio-2'-deoxyuridine into DNA.

Iranzo O, Khalili H, Epstein DM, Morrow JR.

J Biol Inorg Chem. 2004 Jun;9(4):462-70. Epub 2004 Apr 30.

PMID:
15118878
37.

Synthetic metallonucleases for RNA cleavage.

Morrow JR, Iranzo O.

Curr Opin Chem Biol. 2004 Apr;8(2):192-200. Review.

PMID:
15062781
38.
39.

Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn(II) catalysts.

Iranzo O, Elmer T, Richard JP, Morrow JR.

Inorg Chem. 2003 Dec 1;42(24):7737-46.

PMID:
14632489
41.

Physical and kinetic analysis of the cooperative role of metal ions in catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex.

Iranzo O, Kovalevsky AY, Morrow JR, Richard JP.

J Am Chem Soc. 2003 Feb 19;125(7):1988-93.

PMID:
12580627
42.

Oligonucleotide conjugates of Eu(III) tetraazamacrocycles with pendent alcohol and amide groups promote sequence-specific RNA cleavage.

Huang L, Chappell LL, Iranzo O, Baker BF, Morrow JR.

J Biol Inorg Chem. 2000 Feb;5(1):85-92.

PMID:
10766440

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