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Items: 1 to 50 of 121

1.

SUMO2 regulates vascular endothelial function and oxidative stress in mice.

Kim YR, Jacobs JS, Li Q, Gaddam RR, Vikram A, Liu J, Kassan M, Irani K, Kumar S.

Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1292-H1300. doi: 10.1152/ajpheart.00530.2019. Epub 2019 Oct 4.

PMID:
31584834
2.

A retrospective study of tunnelled haemodialysis central line-associated bloodstream infections.

Krishnan A, Irani K, Swaminathan R, Boan P.

J Chemother. 2019 May;31(3):132-136. doi: 10.1080/1120009X.2019.1595894. Epub 2019 Apr 1.

PMID:
30935344
3.

MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure.

Gabani M, Liu J, Ait-Aissa K, Koval O, Kim YR, Castañeda D, Vikram A, Jacobs JS, Grumbach I, Trebak M, Irani K, Kassan M.

Cell Calcium. 2019 Jun;80:18-24. doi: 10.1016/j.ceca.2019.03.006. Epub 2019 Mar 23.

PMID:
30925290
4.

Management of a rare presentation of Kindler disease with digital constriction bands-Case report.

Ting JWC, Kaur S, Ogboli M, Irani K, Jester A.

Pediatr Dermatol. 2018 Nov;35(6):864-865. doi: 10.1111/pde.13674. Epub 2018 Sep 6.

PMID:
30187964
5.

Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress.

Choi SJ, Piao S, Nagar H, Jung SB, Kim S, Lee I, Kim SM, Song HJ, Shin N, Kim DW, Irani K, Jeon BH, Park JW, Kim CS.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1805-1811. doi: 10.1016/j.bbrc.2018.07.117. Epub 2018 Jul 30.

PMID:
30072100
6.

CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.

Piao S, Lee JW, Nagar H, Jung SB, Choi S, Kim S, Lee I, Kim SM, Shin N, Lee YR, Lee SD, Park JB, Irani K, Won M, Hur GM, Jeon BH, Kim DW, Kim CS.

PLoS One. 2018 Feb 23;13(2):e0192693. doi: 10.1371/journal.pone.0192693. eCollection 2018.

7.

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.

Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, Taylor AL, Yancy CW, Feldman AM, McNamara DM, Irani K, Spitz DR, Breheny P, Margulies KB, London B, Boudreau RL.

J Clin Invest. 2018 Mar 1;128(3):1154-1163. doi: 10.1172/JCI95710. Epub 2018 Feb 19.

8.

Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity.

Murthy S, Koval OM, Ramiro Diaz JM, Kumar S, Nuno D, Scott JA, Allamargot C, Zhu LJ, Broadhurst K, Santhana V, Kutschke WJ, Irani K, Lamping KG, Grumbach IM.

PLoS One. 2017 Oct 23;12(10):e0186311. doi: 10.1371/journal.pone.0186311. eCollection 2017.

9.

MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1.

Kassan M, Vikram A, Li Q, Kim YR, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K.

Sci Rep. 2017 Aug 24;7(1):9308. doi: 10.1038/s41598-017-06721-y.

10.

Reversible lysine acetylation: Another layer of post-translational regulation of the cardiac sodium channel.

Yoon JY, Vikram A, London B, Irani K.

Channels (Austin). 2017 Sep 3;11(5):360-361. doi: 10.1080/19336950.2017.1340015. Epub 2017 Jun 9. No abstract available.

11.

Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K.

Sci Rep. 2017 Apr 10;7:46123. doi: 10.1038/srep46123. No abstract available.

12.

Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.

Vikram A, Lewarchik CM, Yoon JY, Naqvi A, Kumar S, Morgan GM, Jacobs JS, Li Q, Kim YR, Kassan M, Liu J, Gabani M, Kumar A, Mehdi H, Zhu X, Guan X, Kutschke W, Zhang X, Boudreau RL, Dai S, Matasic DS, Jung SB, Margulies KB, Kumar V, Bachschmid MM, London B, Irani K.

Nat Med. 2017 Mar;23(3):361-367. doi: 10.1038/nm.4284. Epub 2017 Feb 13.

13.

Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress.

Kassan M, Vikram A, Kim YR, Li Q, Kassan A, Patel HH, Kumar S, Gabani M, Liu J, Jacobs JS, Irani K.

Sci Rep. 2017 Feb 9;7:42265. doi: 10.1038/srep42265. Erratum in: Sci Rep. 2017 Apr 10;7:46123.

14.

Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.

Kumar S, Kim YR, Vikram A, Naqvi A, Li Q, Kassan M, Kumar V, Bachschmid MM, Jacobs JS, Kumar A, Irani K.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1714-1719. doi: 10.1073/pnas.1614112114. Epub 2017 Jan 30.

15.

CR6-Interacting Factor 1 Deficiency Impairs Vascular Function by Inhibiting the Sirt1-Endothelial Nitric Oxide Synthase Pathway.

Nagar H, Jung SB, Ryu MJ, Choi SJ, Piao S, Song HJ, Kang SK, Shin N, Kim DW, Jin SA, Jeong JO, Irani K, Jeon BH, Shong M, Kweon GR, Kim CS.

Antioxid Redox Signal. 2017 Aug 1;27(4):234-249. doi: 10.1089/ars.2016.6719. Epub 2017 May 24.

PMID:
28117598
16.

Abnormal CD161+ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension.

Singh MV, Cicha MZ, Kumar S, Meyerholz DK, Irani K, Chapleau MW, Abboud FM.

J Allergy Clin Immunol. 2017 Sep;140(3):809-821.e3. doi: 10.1016/j.jaci.2016.11.039. Epub 2017 Jan 16.

17.

Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.

Shafique E, Torina A, Reichert K, Colantuono B, Nur N, Zeeshan K, Ravichandran V, Liu Y, Feng J, Zeeshan K, Benjamin LE, Irani K, Harrington EO, Sellke FW, Abid MR.

Cardiovasc Res. 2017 Feb;113(2):234-246. doi: 10.1093/cvr/cvw249. Epub 2017 Jan 14.

18.

P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.

Li Q, Kim YR, Vikram A, Kumar S, Kassan M, Gabani M, Lee SK, Jacobs JS, Irani K.

Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2394-2403. Epub 2016 Oct 27.

19.

Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1.

Vikram A, Kim YR, Kumar S, Li Q, Kassan M, Jacobs JS, Irani K.

Nat Commun. 2016 Sep 2;7:12565. doi: 10.1038/ncomms12565.

20.

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.

Kassan M, Ait-Aissa K, Radwan E, Mali V, Haddox S, Gabani M, Zhang W, Belmadani S, Irani K, Trebak M, Matrougui K.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1900-9. doi: 10.1161/ATVBAHA.116.307869. Epub 2016 Jul 28.

21.

IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function.

Park JB, Nagar H, Choi S, Jung SB, Kim HW, Kang SK, Lee JW, Lee JH, Park JW, Irani K, Jeon BH, Song HJ, Kim CS.

Free Radic Biol Med. 2016 May;94:36-46. doi: 10.1016/j.freeradbiomed.2016.02.017. Epub 2016 Feb 17.

PMID:
26898144
22.

Disorder in Milk Proteins: Formation, Structure, Function, Isolation and Applications of Casein Phosphopeptides.

Naqvi MA, Irani KA, Katanishooshtari M, Rousseau D.

Curr Protein Pept Sci. 2016;17(4):368-79. Review.

PMID:
26630980
23.

APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.

Shin JH, Choi S, Lee YR, Park MS, Na YG, Irani K, Lee SD, Park JB, Kim JM, Lim JS, Jeon BH.

Cancer Res Treat. 2015 Oct;47(4):823-33. doi: 10.4143/crt.2014.074. Epub 2015 Jan 2.

24.

Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.

Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ Jr, Kim CS, Irani K.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2301-9. doi: 10.1161/ATVBAHA.114.304338. Epub 2014 Aug 21.

25.

CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.

Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS.

PLoS One. 2014 Jun 6;9(6):e98670. doi: 10.1371/journal.pone.0098670. eCollection 2014.

26.

P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia.

Kumar S, Vikram A, Kim YR, S Jacobs J, Irani K.

Biochem Biophys Res Commun. 2014 Jul 11;449(4):496-501. doi: 10.1016/j.bbrc.2014.05.029. Epub 2014 May 15.

PMID:
24845561
27.

MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):99-109. doi: 10.1161/ATVBAHA.113.302104. Epub 2013 Oct 31.

28.

Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells.

Jung SB, Kwon SK, Kwon M, Nagar H, Jeon BH, Irani K, Yoon SH, Kim CS.

Biochem Biophys Res Commun. 2013 Jul 19;437(1):114-9. doi: 10.1016/j.bbrc.2013.06.049. Epub 2013 Jun 24.

PMID:
23806688
29.

GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension.

Tan R, Li J, Peng X, Zhu L, Cai L, Wang T, Su Y, Irani K, Hu Q.

Cardiovasc Res. 2013 Oct 1;100(1):19-27. doi: 10.1093/cvr/cvt165. Epub 2013 Jun 25.

PMID:
23801767
30.

Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.

Jung SB, Kim CS, Kim YR, Naqvi A, Yamamori T, Kumar S, Kumar A, Irani K.

PLoS One. 2013 Jun 3;8(6):e65415. doi: 10.1371/journal.pone.0065415. Print 2013.

31.

Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol.

Kumar A, Kumar S, Vikram A, Hoffman TA, Naqvi A, Lewarchik CM, Kim YR, Irani K.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1936-42. doi: 10.1161/ATVBAHA.113.301765. Epub 2013 May 30.

PMID:
23723375
32.

Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1.

Choi S, Lee YR, Park MS, Joo HK, Cho EJ, Kim HS, Kim CS, Park JB, Irani K, Jeon BH.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):403-7. doi: 10.1016/j.bbrc.2013.04.101. Epub 2013 May 9.

PMID:
23665318
33.

Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.

Mattagajasingh SN, Yang XP, Irani K, Mattagajasingh I, Becker LC.

Biochim Biophys Acta. 2012 May;1823(5):997-1006.

34.

Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction.

Kim YR, Kim CS, Naqvi A, Kumar A, Kumar S, Hoffman TA, Irani K.

Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H189-96. doi: 10.1152/ajpheart.01218.2011. Epub 2012 Jun 1.

35.

Clinical presentation, response to therapy, and outcome of gastroparesis in children.

Rodriguez L, Irani K, Jiang H, Goldstein AM.

J Pediatr Gastroenterol Nutr. 2012 Aug;55(2):185-90. doi: 10.1097/MPG.0b013e318248ed3f.

PMID:
22228004
36.

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc.

Kim CS, Kim YR, Naqvi A, Kumar S, Hoffman TA, Jung SB, Kumar A, Jeon BH, McNamara DM, Irani K.

Cardiovasc Res. 2011 Dec 1;92(3):466-75. doi: 10.1093/cvr/cvr250. Epub 2011 Sep 20.

37.

Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths.

Yende S, D'Angelo G, Mayr F, Kellum JA, Weissfeld L, Kaynar AM, Young T, Irani K, Angus DC; GenIMS Investigators.

PLoS One. 2011;6(8):e22847. doi: 10.1371/journal.pone.0022847. Epub 2011 Aug 10.

38.

Crippling of Krüppel (-like factor 2) by bad flow portends a miRky day for endothelial function.

Irani K.

Circulation. 2011 Aug 2;124(5):541-3. doi: 10.1161/CIRCULATIONAHA.111.043299. No abstract available.

PMID:
21810672
39.

Percutaneous treatment of thoracic duct injuries.

Marcon F, Irani K, Aquino T, Saunders JK, Gouge TH, Melis M.

Surg Endosc. 2011 Sep;25(9):2844-8. doi: 10.1007/s00464-011-1629-x. Epub 2011 May 17. Review.

PMID:
21584855
40.

Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.

Lee SK, Chung JI, Park MS, Joo HK, Lee EJ, Cho EJ, Park JB, Ryoo S, Irani K, Jeon BH.

Cardiovasc Res. 2011 Aug 1;91(3):502-9. doi: 10.1093/cvr/cvr095. Epub 2011 Apr 4.

41.

Midterm results for gastric banding as salvage procedure for patients with weight loss failure after Roux-en-Y gastric bypass.

Irani K, Youn HA, Ren-Fielding CJ, Fielding GA, Kurian M.

Surg Obes Relat Dis. 2011 Mar-Apr;7(2):219-24. doi: 10.1016/j.soard.2010.09.024. Epub 2010 Oct 11.

PMID:
21130044
42.

Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity.

Yamamori T, Mizobata A, Saito Y, Urano Y, Inanami O, Irani K, Noguchi N.

Free Radic Res. 2011 Mar;45(3):342-50. doi: 10.3109/10715762.2010.532496. Epub 2010 Nov 3.

PMID:
21047172
43.

p53 impairs endothelial function by transcriptionally repressing Kruppel-Like Factor 2.

Kumar A, Kim CS, Hoffman TA, Naqvi A, Dericco J, Jung SB, Lin Z, Jain MK, Irani K.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):133-41. doi: 10.1161/ATVBAHA.110.215061. Epub 2010 Oct 14.

44.

Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.

Jung SB, Kim CS, Naqvi A, Yamamori T, Mattagajasingh I, Hoffman TA, Cole MP, Kumar A, Dericco JS, Jeon BH, Irani K.

Circ Res. 2010 Oct 1;107(7):877-87. doi: 10.1161/CIRCRESAHA.110.222968. Epub 2010 Aug 12.

45.

A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression.

Naqvi A, Hoffman TA, DeRicco J, Kumar A, Kim CS, Jung SB, Yamamori T, Kim YR, Mehdi F, Kumar S, Rankinen T, Ravussin E, Irani K.

Hum Mol Genet. 2010 Nov 1;19(21):4123-33. doi: 10.1093/hmg/ddq331. Epub 2010 Aug 6.

46.

p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism.

Haga S, Morita N, Irani K, Fujiyoshi M, Ogino T, Ozawa T, Ozaki M.

Lab Invest. 2010 Dec;90(12):1718-26. doi: 10.1038/labinvest.2010.119. Epub 2010 Jun 21.

47.

Mechanical dissociation of swine liver to produce organoid units for tissue engineering and in vitro disease modeling.

Irani K, Pomerantseva I, Hart AR, Sundback CA, Neville CM, Vacanti JP.

Artif Organs. 2010 Jan;34(1):75-8.

PMID:
20432518
48.

SIRT1 deacetylates APE1 and regulates cellular base excision repair.

Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, Kasuno K, Jung SB, Kim CS, Irani K.

Nucleic Acids Res. 2010 Jan;38(3):832-45. doi: 10.1093/nar/gkp1039. Epub 2009 Nov 24.

49.

Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.

Kumar A, Hoffman TA, Dericco J, Naqvi A, Jain MK, Irani K.

FASEB J. 2009 Dec;23(12):4344-52. doi: 10.1096/fj.09-138743. Epub 2009 Aug 20.

50.

Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway.

Lee HM, Jeon BH, Won KJ, Lee CK, Park TK, Choi WS, Bae YM, Kim HS, Lee SK, Park SH, Irani K, Kim B.

Circ Res. 2009 Jan 30;104(2):219-27, 5p following 227. doi: 10.1161/CIRCRESAHA.108.178699. Epub 2008 Nov 26.

PMID:
19038866

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