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Items: 1 to 50 of 53

1.

Regulated Production of CXCL13 within the Central Nervous System.

Irani DN.

J Clin Cell Immunol. 2016 Oct;7(5). pii: 460. doi: 10.4172/2155-9899.1000460. Epub 2016 Oct 5.

2.

Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination.

Irani DN.

Ann Clin Transl Neurol. 2016 Dec 20;4(2):145-150. doi: 10.1002/acn3.379. eCollection 2017 Feb.

3.

An emerging role for eotaxins in neurodegenerative disease.

Huber AK, Giles DA, Segal BM, Irani DN.

Clin Immunol. 2018 Apr;189:29-33. doi: 10.1016/j.clim.2016.09.010. Epub 2016 Sep 21. Review.

PMID:
27664933
4.

Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice.

Blakely PK, Huber AK, Irani DN.

J Neuroinflammation. 2016 Aug 25;13(1):196. doi: 10.1186/s12974-016-0683-7.

5.

Targeting CXCL13 During Neuroinflammation.

Huber AK, Irani DN.

Adv Neuroimmune Biol. 2015;6(1):1-8. Epub 2015 Nov 13.

6.

Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.

Wang B, Merillat SA, Vincent M, Huber AK, Basrur V, Mangelberger D, Zeng L, Elenitoba-Johnson K, Miller RA, Irani DN, Dlugosz AA, Schnell S, Scaglione KM, Paulson HL.

J Biol Chem. 2016 Feb 5;291(6):3030-42. doi: 10.1074/jbc.M115.676601. Epub 2015 Nov 24.

7.
8.

Is the concept of central nervous system immune privilege irrelevant in the setting of acute infection?

Huber AK, Irani DN.

Front Oncol. 2015 Apr 28;5:99. doi: 10.3389/fonc.2015.00099. eCollection 2015. Review. No abstract available.

9.

The conundrum of interferon-β non-responsiveness in relapsing-remitting multiple sclerosis.

Huber AK, Duncker PC, Irani DN.

Cytokine. 2015 Aug;74(2):228-36. doi: 10.1016/j.cyto.2015.01.004. Epub 2015 Feb 15.

PMID:
25691330
10.

Immune responses to non-tumor antigens in the central nervous system.

Huber AK, Duncker PC, Irani DN.

Front Oncol. 2014 Nov 13;4:328. doi: 10.3389/fonc.2014.00328. eCollection 2014. Review.

11.

Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development.

Blakely PK, Delekta PC, Miller DJ, Irani DN.

J Neurovirol. 2015 Feb;21(1):43-55. doi: 10.1007/s13365-014-0297-8. Epub 2014 Nov 1.

12.

Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS.

Huber AK, Wang L, Han P, Zhang X, Ekholm S, Srinivasan A, Irani DN, Segal BM.

Neurology. 2014 Oct 21;83(17):1500-7. doi: 10.1212/WNL.0000000000000908. Epub 2014 Sep 24.

13.

Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.

Delekta PC, Dobry CJ, Sindac JA, Barraza SJ, Blakely PK, Xiang J, Kirchhoff PD, Keep RF, Irani DN, Larsen SD, Miller DJ.

J Virol. 2014 Oct;88(19):11199-214. doi: 10.1128/JVI.01671-14. Epub 2014 Jul 16.

14.

Type-I interferons suppress microglial production of the lymphoid chemokine, CXCL13.

Esen N, Rainey-Barger EK, Huber AK, Blakely PK, Irani DN.

Glia. 2014 Sep;62(9):1452-62. doi: 10.1002/glia.22692. Epub 2014 May 14.

15.

Discovery of potent broad spectrum antivirals derived from marine actinobacteria.

Raveh A, Delekta PC, Dobry CJ, Peng W, Schultz PJ, Blakely PK, Tai AW, Matainaho T, Irani DN, Sherman DH, Miller DJ.

PLoS One. 2013 Dec 5;8(12):e82318. doi: 10.1371/journal.pone.0082318. eCollection 2013.

16.

Optimization of novel indole-2-carboxamide inhibitors of neurotropic alphavirus replication.

Sindac JA, Barraza SJ, Dobry CJ, Xiang J, Blakely PK, Irani DN, Keep RF, Miller DJ, Larsen SD.

J Med Chem. 2013 Nov 27;56(22):9222-41. doi: 10.1021/jm401330r. Epub 2013 Nov 12.

17.

Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations.

Rainey-Barger EK, Blakely PK, Huber AK, Segal BM, Irani DN.

J Neuroimmunol. 2013 Jun 15;259(1-2):47-54. doi: 10.1016/j.jneuroim.2013.03.011. Epub 2013 Apr 18.

18.

Complexity of the microglial activation pathways that drive innate host responses during lethal alphavirus encephalitis in mice.

Esen N, Blakely PK, Rainey-Barger EK, Irani DN.

ASN Neuro. 2012 May 3;4(4):207-21. doi: 10.1042/AN20120016.

19.

Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.

Sindac JA, Yestrepsky BD, Barraza SJ, Bolduc KL, Blakely PK, Keep RF, Irani DN, Miller DJ, Larsen SD.

J Med Chem. 2012 Apr 12;55(7):3535-45. doi: 10.1021/jm300214e. Epub 2012 Apr 3.

20.

The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous system.

Rainey-Barger EK, Rumble JM, Lalor SJ, Esen N, Segal BM, Irani DN.

Brain Behav Immun. 2011 Jul;25(5):922-31. doi: 10.1016/j.bbi.2010.10.002. Epub 2010 Oct 8.

21.

Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection.

Blakely PK, Kleinschmidt-DeMasters BK, Tyler KL, Irani DN.

J Neuropathol Exp Neurol. 2009 Oct;68(10):1061-72. doi: 10.1097/NEN.0b013e3181b8ba14.

22.

Aseptic meningitis and viral myelitis.

Irani DN.

Neurol Clin. 2008 Aug;26(3):635-55, vii-viii. doi: 10.1016/j.ncl.2008.03.003. Review.

23.

The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis.

Prow NA, Irani DN.

J Neurochem. 2008 May;105(4):1276-86. doi: 10.1111/j.1471-4159.2008.05230.x. Epub 2008 Jan 14. Erratum in: J Neurochem. 2008 Oct;107(2): 588.

24.

Characteristics and reversibility of dementia in Normal Pressure Hydrocephalus.

Chaudhry P, Kharkar S, Heidler-Gary J, Hillis AE, Newhart M, Kleinman JT, Davis C, Rigamonti D, Wang P, Irani DN, Williams MA.

Behav Neurol. 2007;18(3):149-58.

25.
26.
27.

Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients.

Venkataramana A, Pardo CA, McArthur JC, Kerr DA, Irani DN, Griffin JW, Burger P, Reich DS, Calabresi PA, Nath A.

Neurology. 2006 Aug 8;67(3):383-8.

PMID:
16894096
28.

Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis.

Irani DN, Anderson C, Gundry R, Cotter R, Moore S, Kerr DA, McArthur JC, Sacktor N, Pardo CA, Jones M, Calabresi PA, Nath A.

Ann Neurol. 2006 Feb;59(2):237-47.

PMID:
16437581
29.

14-3-3 protein in CSF: an early predictor of SIV CNS disease.

Helke KL, Queen SE, Tarwater PM, Turchan-Cholewo J, Nath A, Zink MC, Irani DN, Mankowski JL.

J Neuropathol Exp Neurol. 2005 Mar;64(3):202-8.

PMID:
15804051
30.

Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.

Darman J, Backovic S, Dike S, Maragakis NJ, Krishnan C, Rothstein JD, Irani DN, Kerr DA.

J Neurosci. 2004 Aug 25;24(34):7566-75.

31.

Glutamate receptor antagonists protect from virus-induced neural degeneration.

Nargi-Aizenman JL, Havert MB, Zhang M, Irani DN, Rothstein JD, Griffin DE.

Ann Neurol. 2004 Apr;55(4):541-9.

PMID:
15048893
32.

Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.

Kerr DA, Lladó J, Shamblott MJ, Maragakis NJ, Irani DN, Crawford TO, Krishnan C, Dike S, Gearhart JD, Rothstein JD.

J Neurosci. 2003 Jun 15;23(12):5131-40.

33.

The classic and variant forms of Creutzfeldt-Jakob disease.

Irani DN.

Semin Clin Neuropsychiatry. 2003 Jan;8(1):71-9. Review.

PMID:
12567334
34.

Diagnosis and prevention of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease.

Irani DN, Johnson RT.

Annu Rev Med. 2003;54:305-19. Epub 2001 Dec 3. Review.

PMID:
12525677
35.

West Nile virus encephalitis in the United States.

Johnson RT, Irani DN.

Curr Neurol Neurosci Rep. 2002 Nov;2(6):496-500. Review.

PMID:
12359102
36.

BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysis.

Kerr DA, Larsen T, Cook SH, Fannjiang YR, Choi E, Griffin DE, Hardwick JM, Irani DN.

J Virol. 2002 Oct;76(20):10393-400.

37.

How much control does the brain exert over the immune system?

Irani DN.

Curr Opin Neurol. 2002 Jun;15(3):323-6. No abstract available.

PMID:
12045732
38.

Regulation of T cell responses during central nervous system viral infection.

Irani DN, Griffin DE.

Adv Virus Res. 2001;56:175-97. Review. No abstract available.

PMID:
11450299
39.

Central nervous system inflammation: can't live with it, can't live without it.

Irani DN.

Curr Opin Neurol. 2001 Jun;14(3):347-8. No abstract available.

PMID:
11371758
40.

14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis.

Irani DN, Kerr DA.

Lancet. 2000 Mar 11;355(9207):901.

PMID:
10752712
41.
42.

Interferon beta in multiple sclerosis: is IL-12 suppression the key?

Karp CL, Biron CA, Irani DN.

Immunol Today. 2000 Jan;21(1):24-8. Review. No abstract available.

PMID:
10637555
43.

Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia.

Conant K, McArthur JC, Griffin DE, Sjulson L, Wahl LM, Irani DN.

Ann Neurol. 1999 Sep;46(3):391-8.

PMID:
10482270
45.

Brain-derived gangliosides induce cell cycle arrest in a murine T cell line.

Irani DN.

J Neuroimmunol. 1998 Jul 1;87(1-2):11-6.

PMID:
9670840
46.

Regulation of brain-derived T cells during acute central nervous system inflammation.

Irani DN, Lin KI, Griffin DE.

J Immunol. 1997 Mar 1;158(5):2318-26.

PMID:
9036980
47.

Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells.

Irani DN, Lin KI, Griffin DE.

J Immunol. 1996 Nov 15;157(10):4333-40.

PMID:
8906807
48.
49.

Relapse in Guillain-Barré syndrome after treatment with human immune globulin.

Irani DN, Cornblath DR, Chaudhry V, Borel C, Hanley DF.

Neurology. 1993 May;43(5):872-5.

PMID:
8492939
50.

The immune response in viral encephalitis.

Griffin DE, Levine B, Tyor WR, Irani DN.

Semin Immunol. 1992 Apr;4(2):111-9. Review.

PMID:
1319767

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