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Items: 12

1.

Development of Novel Intramolecular FRET-Based ABC Transporter Biosensors to Identify New Substrates and Modulators.

Osa-Andrews B, Tan KW, Sampson A, Iram SH.

Pharmaceutics. 2018 Oct 13;10(4). pii: E186. doi: 10.3390/pharmaceutics10040186.

2.

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells.

Tan KW, Sampson A, Osa-Andrews B, Iram SH.

Drug Metab Dispos. 2018 Sep 19. pii: dmd.118.081612. doi: 10.1124/dmd.118.081612. [Epub ahead of print]

PMID:
30232176
3.

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.

Molinski SV, Bozóky Z, Iram SH, Ahmadi S.

Int J Med Chem. 2017;2017:1529402. doi: 10.1155/2017/1529402. Epub 2017 Mar 19. Review.

4.

High-content screening of clinically tested anticancer drugs identifies novel inhibitors of human MRP1 (ABCC1).

Peterson BG, Tan KW, Osa-Andrews B, Iram SH.

Pharmacol Res. 2017 May;119:313-326. doi: 10.1016/j.phrs.2017.02.024. Epub 2017 Feb 28.

5.

ATP-Binding Cassette Transporter Structure Changes Detected by Intramolecular Fluorescence Energy Transfer for High-Throughput Screening.

Iram SH, Gruber SJ, Raguimova ON, Thomas DD, Robia SL.

Mol Pharmacol. 2015 Jul;88(1):84-94. doi: 10.1124/mol.114.096792. Epub 2015 Apr 29.

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Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2.

Iram SH, Cole SP.

J Biol Chem. 2011 Mar 4;286(9):7202-13. doi: 10.1074/jbc.M110.166959. Epub 2010 Dec 20.

9.

Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase.

Momcilovic M, Iram SH, Liu Y, Carlson M.

J Biol Chem. 2008 Jul 11;283(28):19521-9. doi: 10.1074/jbc.M803624200. Epub 2008 May 12.

10.

Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.

Rudolph MJ, Amodeo GA, Iram SH, Hong SP, Pirino G, Carlson M, Tong L.

Structure. 2007 Jan;15(1):65-74.

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Unexpected functional diversity among FadR fatty acid transcriptional regulatory proteins.

Iram SH, Cronan JE.

J Biol Chem. 2005 Sep 16;280(37):32148-56. Epub 2005 Jul 15.

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