Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 52


Loss of the FOXP1 Transcription Factor Leads to Deregulation of B Lymphocyte Development and Function at Multiple Stages.

Dekker JD, Baracho GV, Zhu Z, Ippolito GC, Schmitz RJ, Rickert RC, Tucker HO.

Immunohorizons. 2019 Oct 7;3(10):447-462. doi: 10.4049/immunohorizons.1800079.


Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.

Lindesmith LC, McDaniel JR, Changela A, Verardi R, Kerr SA, Costantini V, Brewer-Jensen PD, Mallory ML, Voss WN, Boutz DR, Blazeck JJ, Ippolito GC, Vinje J, Kwong PD, Georgiou G, Baric RS.

Immunity. 2019 Jun 18;50(6):1530-1541.e8. doi: 10.1016/j.immuni.2019.05.007.


Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations.

Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G.

Cell Host Microbe. 2019 Mar 13;25(3):367-376.e5. doi: 10.1016/j.chom.2019.01.010. Epub 2019 Feb 19.


Next-generation sequencing reveals new insights about gene usage and CDR-H3 composition in the horse antibody repertoire.

Manso TC, Groenner-Penna M, Minozzo JC, Antunes BC, Ippolito GC, Molina F, Felicori LF.

Mol Immunol. 2019 Jan;105:251-259. doi: 10.1016/j.molimm.2018.11.017. Epub 2018 Dec 15.


Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation.

Johnson EL, Doria-Rose NA, Gorman J, Bhiman JN, Schramm CA, Vu AQ, Law WH, Zhang B, Bekker V, Abdool Karim SS, Ippolito GC, Morris L, Moore PL, Kwong PD, Mascola JR, Georgiou G.

Nat Commun. 2018 Oct 8;9(1):4136. doi: 10.1038/s41467-018-06424-6.


Discovering human diabetes-risk gene function with genetics and physiological assays.

Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK.

Nat Commun. 2018 Sep 21;9(1):3855. doi: 10.1038/s41467-018-06249-3.


Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens.

Liu Y, McDaniel JR, Khan S, Campisi P, Propst EJ, Holler T, Grunebaum E, Georgiou G, Ippolito GC, Ehrhardt GRA.

J Immunol. 2018 Jun 15;200(12):3962-3969. doi: 10.4049/jimmunol.1701549. Epub 2018 Apr 27.


Identification of tumor-reactive B cells and systemic IgG in breast cancer based on clonal frequency in the sentinel lymph node.

McDaniel JR, Pero SC, Voss WN, Shukla GS, Sun Y, Schaetzle S, Lee CH, Horton AP, Harlow S, Gollihar J, Ellefson JW, Krag CC, Tanno Y, Sidiropoulos N, Georgiou G, Ippolito GC, Krag DN.

Cancer Immunol Immunother. 2018 May;67(5):729-738. doi: 10.1007/s00262-018-2123-2. Epub 2018 Feb 9.


Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination.

Lee BS, Lee BK, Iyer VR, Sleckman BP, Shaffer AL 3rd, Ippolito GC, Tucker HO, Dekker JD.

Mol Cell Biol. 2017 Dec 13;38(1). pii: e00362-17. doi: 10.1128/MCB.00362-17. Print 2018 Jan 1.


Retraction for Lee et al., "The BCL11A Transcription Factor Directly Activates RAG Gene Expression and V(D)J Recombination".

Lee BS, Dekker JD, Lee BK, Iyer VR, Sleckman BP, Shaffer AL 3rd, Ippolito GC, Tucker PW.

Mol Cell Biol. 2017 Oct 13;37(21). pii: e00358-17. doi: 10.1128/MCB.00358-17. Print 2017 Nov 1. No abstract available.


Mapping the secrets of the antibody pool.

McDaniel JR, Ippolito GC, Georgiou G.

Nat Biotechnol. 2017 Oct;35(10):921-922. doi: 10.1038/nbt.3972. Epub 2017 Sep 11. No abstract available.


Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation.

Lau D, Lan LY, Andrews SF, Henry C, Rojas KT, Neu KE, Huang M, Huang Y, DeKosky B, Palm AE, Ippolito GC, Georgiou G, Wilson PC.

Sci Immunol. 2017 Jan 27;2(7). pii: eaai8153. doi: 10.1126/sciimmunol.aai8153.


Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics.

Tanaka T, Zhang W, Sun Y, Shuai Z, Chida AS, Kenny TP, Yang GX, Sanz I, Ansari A, Bowlus CL, Ippolito GC, Coppel RL, Okazaki K, He XS, Leung PSC, Gershwin ME.

Hepatology. 2017 Sep;66(3):885-895. doi: 10.1002/hep.29245. Epub 2017 Jul 20.


Comparative analysis of the feline immunoglobulin repertoire.

Steiniger SC, Glanville J, Harris DW, Wilson TL, Ippolito GC, Dunham SA.

Biologicals. 2017 Mar;46:81-87. doi: 10.1016/j.biologicals.2017.01.004. Epub 2017 Jan 26.


Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire.

Wu GC, Cheung NV, Georgiou G, Marcotte EM, Ippolito GC.

Nat Commun. 2016 Dec 21;7:13838. doi: 10.1038/ncomms13838.


Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, Davis MM, Carter CE, Ross TM, Ellington AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G.

Nat Med. 2016 Dec;22(12):1456-1464. doi: 10.1038/nm.4224. Epub 2016 Nov 7.


Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.

Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA, Liao HX, Schmidt AG, Harrison SC.

Nat Med. 2016 Dec;22(12):1465-1469. doi: 10.1038/nm.4223. Epub 2016 Nov 7.


Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.

Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD.

Cell Rep. 2016 May 3;15(5):999-1012. doi: 10.1016/j.celrep.2016.03.064. Epub 2016 Apr 21.


Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.

DeKosky BJ, Lungu OI, Park D, Johnson EL, Charab W, Chrysostomou C, Kuroda D, Ellington AD, Ippolito GC, Gray JJ, Georgiou G.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2636-45. doi: 10.1073/pnas.1525510113. Epub 2016 Apr 25.


Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.

Dekker JD, Park D, Shaffer AL 3rd, Kohlhammer H, Deng W, Lee BK, Ippolito GC, Georgiou G, Iyer VR, Staudt LM, Tucker HO.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E577-86. doi: 10.1073/pnas.1524677113. Epub 2016 Jan 19.


Serology in the 21st century: the molecular-level analysis of the serum antibody repertoire.

Wine Y, Horton AP, Ippolito GC, Georgiou G.

Curr Opin Immunol. 2015 Aug;35:89-97. doi: 10.1016/j.coi.2015.06.009. Epub 2015 Jul 10. Review.


Violation of an evolutionarily conserved immunoglobulin diversity gene sequence preference promotes production of dsDNA-specific IgG antibodies.

Silva-Sanchez A, Liu CR, Vale AM, Khass M, Kapoor P, Elgavish A, Ivanov II, Ippolito GC, Schelonka RL, Schoeb TR, Burrows PD, Schroeder HW Jr.

PLoS One. 2015 Feb 23;10(2):e0118171. doi: 10.1371/journal.pone.0118171. eCollection 2015.


In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire.

DeKosky BJ, Kojima T, Rodin A, Charab W, Ippolito GC, Ellington AD, Georgiou G.

Nat Med. 2015 Jan;21(1):86-91. doi: 10.1038/nm.3743. Epub 2014 Dec 15.


Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires.

Lavinder JJ, Horton AP, Georgiou G, Ippolito GC.

Curr Opin Chem Biol. 2015 Feb;24:112-20. doi: 10.1016/j.cbpa.2014.11.007. Epub 2014 Nov 25. Review.


Differences in the composition of the human antibody repertoire by B cell subsets in the blood.

Mroczek ES, Ippolito GC, Rogosch T, Hoi KH, Hwangpo TA, Brand MG, Zhuang Y, Liu CR, Schneider DA, Zemlin M, Brown EE, Georgiou G, Schroeder HW Jr.

Front Immunol. 2014 Mar 19;5:96. doi: 10.3389/fimmu.2014.00096. eCollection 2014.


Dendritic cell fate is determined by BCL11A.

Ippolito GC, Dekker JD, Wang YH, Lee BK, Shaffer AL 3rd, Lin J, Wall JK, Lee BS, Staudt LM, Liu YJ, Iyer VR, Tucker HO.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E998-1006. doi: 10.1073/pnas.1319228111. Epub 2014 Mar 3.


Fundamental characteristics of the expressed immunoglobulin VH and VL repertoire in different canine breeds in comparison with those of humans and mice.

Steiniger SC, Dunkle WE, Bammert GF, Wilson TL, Krishnan A, Dunham SA, Ippolito GC, Bainbridge G.

Mol Immunol. 2014 May;59(1):71-8. doi: 10.1016/j.molimm.2014.01.010. Epub 2014 Feb 4.


Identification and characterization of the constituent human serum antibodies elicited by vaccination.

Lavinder JJ, Wine Y, Giesecke C, Ippolito GC, Horton AP, Lungu OI, Hoi KH, DeKosky BJ, Murrin EM, Wirth MM, Ellington AD, Dörner T, Marcotte EM, Boutz DR, Georgiou G.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2259-64. doi: 10.1073/pnas.1317793111. Epub 2014 Jan 27.


The promise and challenge of high-throughput sequencing of the antibody repertoire.

Georgiou G, Ippolito GC, Beausang J, Busse CE, Wardemann H, Quake SR.

Nat Biotechnol. 2014 Feb;32(2):158-68. doi: 10.1038/nbt.2782. Epub 2014 Jan 19. Review.


Intrinsic bias and public rearrangements in the human immunoglobulin Vλ light chain repertoire.

Hoi KH, Ippolito GC.

Genes Immun. 2013 Jun;14(4):271-6. doi: 10.1038/gene.2013.10. Epub 2013 Mar 28.


The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.

Lee BS, Dekker JD, Lee BK, Iyer VR, Sleckman BP, Shaffer AL 3rd, Ippolito GC, Tucker PW.

Mol Cell Biol. 2013 May;33(9):1768-81. doi: 10.1128/MCB.00987-12. Epub 2013 Feb 25. Retraction in: Mol Cell Biol. 2017 Oct 13;37(21):null. Erratum in: Mol Cell Biol. 2017 Dec 13;38(1):. Corrected and republished in: Mol Cell Biol. 2017 Oct 16;:null.


High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.

DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, Varadarajan N, Giesecke C, Dörner T, Andrews SF, Wilson PC, Hunicke-Smith SP, Willson CG, Ellington AD, Georgiou G.

Nat Biotechnol. 2013 Feb;31(2):166-9. doi: 10.1038/nbt.2492. Epub 2013 Jan 20.


Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts.

Rogosch T, Kerzel S, Hoi KH, Zhang Z, Maier RF, Ippolito GC, Zemlin M.

Front Immunol. 2012 Jun 28;3:176. doi: 10.3389/fimmu.2012.00176. eCollection 2012.


Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.

Ippolito GC, Hoi KH, Reddy ST, Carroll SM, Ge X, Rogosch T, Zemlin M, Shultz LD, Ellington AD, Vandenberg CL, Georgiou G.

PLoS One. 2012;7(4):e35497. doi: 10.1371/journal.pone.0035497. Epub 2012 Apr 27.


Patterns of spinal sensory-motor connectivity prescribed by a dorsoventral positional template.

Sürmeli G, Akay T, Ippolito GC, Tucker PW, Jessell TM.

Cell. 2011 Oct 28;147(3):653-65. doi: 10.1016/j.cell.2011.10.012.


Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing.

Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH.

Science. 2011 Nov 18;334(6058):993-6. doi: 10.1126/science.1211053. Epub 2011 Oct 13.


Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.

Feng X, Ippolito GC, Tian L, Wiehagen K, Oh S, Sambandam A, Willen J, Bunte RM, Maika SD, Harriss JV, Caton AJ, Bhandoola A, Tucker PW, Hu H.

Blood. 2010 Jan 21;115(3):510-8. doi: 10.1182/blood-2009-07-232694. Epub 2009 Nov 12.


Developmental and species-divergent globin switching are driven by BCL11A.

Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH.

Nature. 2009 Aug 27;460(7259):1093-7. doi: 10.1038/nature08243. Epub 2009 Aug 5.


Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.

Schmidt C, Kim D, Ippolito GC, Naqvi HR, Probst L, Mathur S, Rosas-Acosta G, Wilson VG, Oldham AL, Poenie M, Webb CF, Tucker PW.

EMBO J. 2009 Mar 18;28(6):711-24. doi: 10.1038/emboj.2009.20. Epub 2009 Feb 12.


Regulation of repertoire development through genetic control of DH reading frame preference.

Zemlin M, Schelonka RL, Ippolito GC, Zemlin C, Zhuang Y, Gartland GL, Nitschke L, Pelkonen J, Rajewsky K, Schroeder HW Jr.

J Immunol. 2008 Dec 15;181(12):8416-24.


Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.

Schelonka RL, Zemlin M, Kobayashi R, Ippolito GC, Zhuang Y, Gartland GL, Szalai A, Fujihashi K, Rajewsky K, Schroeder HW Jr.

J Immunol. 2008 Dec 15;181(12):8409-15.


FOXP1: a potential therapeutic target in cancer.

Koon HB, Ippolito GC, Banham AH, Tucker PW.

Expert Opin Ther Targets. 2007 Jul;11(7):955-65. Review.


Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer.

Lin D, Ippolito GC, Zong RT, Bryant J, Koslovsky J, Tucker P.

Mol Cancer. 2007 Mar 26;6:23.


Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production.

Ippolito GC, Schelonka RL, Zemlin M, Ivanov II, Kobayashi R, Zemlin C, Gartland GL, Nitschke L, Pelkonen J, Fujihashi K, Rajewsky K, Schroeder HW Jr.

J Exp Med. 2006 Jun 12;203(6):1567-78. Epub 2006 Jun 5.


The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells.

Pulford K, Banham AH, Lyne L, Jones M, Ippolito GC, Liu H, Tucker PW, Roncador G, Lucas E, Ashe S, Stockwin L, Walewska R, Karran L, Gascoyne RD, Mason DY, Dyer MJ.

Leukemia. 2006 Aug;20(8):1439-41. Epub 2006 May 18. No abstract available.


Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

Liu H, Ippolito GC, Wall JK, Niu T, Probst L, Lee BS, Pulford K, Banham AH, Stockwin L, Shaffer AL, Staudt LM, Das C, Dyer MJ, Tucker PW.

Mol Cancer. 2006 May 16;5:18.


A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function.

Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW Jr.

J Immunol. 2005 Nov 15;175(10):6624-32.


Towards open access.

Ippolito GC, Schmidt C, Das C, Tucker PW.

Mol Cancer. 2005 Jun 2;4(1):20. No abstract available.


Adult lupus-prone MRL/MpJ2+ mice express a primary antibody repertoire that differs in CDR-H3 length distribution and hydrophobicity from that expressed in the C3H parental strain.

Zemlin M, Ippolito GC, Zemlin C, Link J, Monestier M, Schroeder HW Jr.

Mol Immunol. 2005 May;42(7):789-98. Epub 2004 Nov 28.


Antibody repertoire in a mouse with a simplified D(H) locus: the D-limited mouse.

Ippolito GC, Pelkonen J, Nitschke L, Rajewsky K, Schroeder HW Jr.

Ann N Y Acad Sci. 2003 Apr;987:262-5. Review. No abstract available.


Supplemental Content

Loading ...
Support Center