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Items: 1 to 50 of 350

1.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

Santofimia-Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, Neira JL, González A, Urrutia R, Soubeyran P, Iovanna J.

Sci Rep. 2018 Nov 19;8(1):16999. doi: 10.1038/s41598-018-35020-3.

2.

Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors.

Garrigue P, Tang J, Ding L, Bouhlel A, Tintaru A, Laurini E, Huang Y, Lyu Z, Zhang M, Fernandez S, Balasse L, Lan W, Mas E, Marson D, Weng Y, Liu X, Giorgio S, Iovanna J, Pricl S, Guillet B, Peng L.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11454-11459. doi: 10.1073/pnas.1812938115. Epub 2018 Oct 22.

3.

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R.

Sci Rep. 2018 Oct 10;8(1):15077. doi: 10.1038/s41598-018-33475-y.

4.

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

Waldschmitt N, Kitamoto S, Secher T, Zacharioudaki V, Boulard O, Floquet E, Delacre M, Lamas B, Pham HP, Six A, Richard ML, Dagorn JC, Eberl G, Langella P, Chatel JM, Ryffel B, Iovanna JL, Poulin LF, Sokol H, Kamada N, Chamaillard M.

Gut. 2018 Oct 2. pii: gutjnl-2018-316757. doi: 10.1136/gutjnl-2018-316757. [Epub ahead of print]

PMID:
30279238
5.

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features.

Puleo F, Nicolle R, Blum Y, Cros J, Marisa L, Demetter P, Quertinmont E, Svrcek M, Elarouci N, Iovanna J, Franchimont D, Verset L, Galdon MG, Devière J, de Reyniès A, Laurent-Puig P, Van Laethem JL, Bachet JB, Maréchal R.

Gastroenterology. 2018 Aug 27. pii: S0016-5085(18)34919-9. doi: 10.1053/j.gastro.2018.08.033. [Epub ahead of print]

PMID:
30165049
6.

Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma.

Molejon MI, Swayden M, Fanale D, Bintz J, Gayet O, Soubeyran P, Iovanna J.

Oncotarget. 2018 Jul 20;9(56):30837-30846. doi: 10.18632/oncotarget.25745. eCollection 2018 Jul 20.

7.

Epigenetics of gastrointestinal diseases: notes from a workshop.

Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME.

Epigenetics. 2018;13(4):449-457. doi: 10.1080/15592294.2018.1464351. Epub 2018 Jul 30.

8.

α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study.

Casciato P, Ambrosi N, Caro F, Vazquez M, Müllen E, Gadano A, de Santibañes E, de Santibañes M, Zandomeni M, Chahdi M, Lazarte JC, Biagiola DA, Iaquinandi JC, Santofimia-Castaño P, Iovanna J, Incardona C, Chuluyan E.

Transpl Int. 2018 Dec;31(12):1357-1368. doi: 10.1111/tri.13314. Epub 2018 Jul 20.

PMID:
29974521
9.

The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue.

Neira JL, López MB, Sevilla P, Rizzuti B, Cámara-Artigas A, Vidal M, Iovanna JL.

Biochem J. 2018 Jul 26;475(14):2271-2291. doi: 10.1042/BCJ20180365.

PMID:
29925531
10.

[Multi-omic approaches reveal new therapeutic targets for the treatment of pancreatic cancer].

Nicolle R, Blum Y, Marisa L, Dusetti N, Iovanna J.

Med Sci (Paris). 2018 May;34(5):379-382. doi: 10.1051/medsci/20183405003. Epub 2018 Jun 13. French. No abstract available.

PMID:
29900832
11.

Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment.

Foucher ED, Ghigo C, Chouaib S, Galon J, Iovanna J, Olive D.

Front Immunol. 2018 May 14;9:1044. doi: 10.3389/fimmu.2018.01044. eCollection 2018. Review.

12.

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments.

Lan W, Bian B, Xia Y, Dou S, Gayet O, Bigonnet M, Santofimia-Castaño P, Cong M, Peng L, Dusetti N, Iovanna J.

Sci Rep. 2018 May 29;8(1):8330. doi: 10.1038/s41598-018-26613-z.

13.

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reyniès A, Dusetti N, Iovanna J, Urrutia R.

Nat Commun. 2018 May 17;9(1):1978. doi: 10.1038/s41467-018-04383-6.

14.

Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation.

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Quesniaux V, Sokol H, Ryffel B.

Mucosal Immunol. 2018 Jul;11(4):1181-1190. doi: 10.1038/s41385-018-0005-8. Epub 2018 May 4.

PMID:
29728643
15.

Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors.

Mild JG, Fernandez LR, Gayet O, Iovanna J, Dusetti N, Edreira MM.

Mol Biotechnol. 2018 May;60(5):369-379. doi: 10.1007/s12033-018-0078-3.

PMID:
29600316
16.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL, Neira JL.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1283-1295. doi: 10.1016/j.bbagen.2018.03.009. Epub 2018 Mar 10.

PMID:
29530795
17.

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

Badalamenti G, Fanale D, Incorvaia L, Barraco N, Listì A, Maragliano R, Vincenzi B, Calò V, Iovanna JL, Bazan V, Russo A.

Cell Immunol. 2018 Jan 30. pii: S0008-8749(18)30014-5. doi: 10.1016/j.cellimm.2018.01.013. [Epub ahead of print] Review.

PMID:
29395859
18.

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC).

Benyamine A, Loncle C, Foucher E, Blazquez JL, Castanier C, Chrétien AS, Modesti M, Secq V, Chouaib S, Gironella M, Vila-Navarro E, Montalto G, Dagorn JC, Dusetti N, Iovanna J, Olive D.

Oncoimmunology. 2017 Sep 21;7(1):e1372080. doi: 10.1080/2162402X.2017.1372080. eCollection 2017.

19.

LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker.

Bressy C, Lac S, Nigri J, Leca J, Roques J, Lavaut MN, Secq V, Guillaumond F, Bui TT, Pietrasz D, Granjeaud S, Bachet JB, Ouaissi M, Iovanna J, Vasseur S, Tomasini R.

Cancer Res. 2018 Feb 15;78(4):909-921. doi: 10.1158/0008-5472.CAN-15-2790. Epub 2017 Dec 21.

PMID:
29269518
20.

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts.

Nicolle R, Blum Y, Marisa L, Loncle C, Gayet O, Moutardier V, Turrini O, Giovannini M, Bian B, Bigonnet M, Rubis M, Elarouci N, Armenoult L, Ayadi M, Duconseil P, Gasmi M, Ouaissi M, Maignan A, Lomberk G, Boher JM, Ewald J, Bories E, Garnier J, Goncalves A, Poizat F, Raoul JL, Secq V, Garcia S, Grandval P, Barraud-Blanc M, Norguet E, Gilabert M, Delpero JR, Roques J, Calvo E, Guillaumond F, Vasseur S, Urrutia R, de Reyniès A, Dusetti N, Iovanna J.

Cell Rep. 2017 Nov 28;21(9):2458-2470. doi: 10.1016/j.celrep.2017.11.003.

21.

Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma.

Siret C, Dobric A, Martirosyan A, Terciolo C, Germain S, Bonier R, Dirami T, Dusetti N, Tomasini R, Rubis M, Garcia S, Iovanna J, Lombardo D, Rigot V, André F.

Br J Cancer. 2018 Feb 20;118(4):546-557. doi: 10.1038/bjc.2017.411. Epub 2017 Nov 21.

PMID:
29161242
22.

Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Lupinacci RM, Goloudina A, Buhard O, Bachet JB, Maréchal R, Demetter P, Cros J, Bardier-Dupas A, Collura A, Cervera P, Scriva A, Dumont S, Hammel P, Sauvanet A, Louvet C, Delpéro JR, Paye F, Vaillant JC, André T, Closset J, Emile JF, Van Laethem JL, Jonchère V, Abd Alsamad I, Antoine M, Rodenas A, Fléjou JF, Dusetti N, Iovanna J, Duval A, Svrcek M.

Gastroenterology. 2018 Mar;154(4):1061-1065. doi: 10.1053/j.gastro.2017.11.009. Epub 2017 Nov 20.

PMID:
29158190
23.

Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression.

Iovanna JL, Closa D.

Oncoimmunology. 2017 Aug 8;6(11):e1358840. doi: 10.1080/2162402X.2017.1358840. eCollection 2017. Review.

24.

A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation.

Radulovic K, Normand S, Rehman A, Delanoye-Crespin A, Chatagnon J, Delacre M, Waldschmitt N, Poulin LF, Iovanna J, Ryffel B, Rosenstiel P, Chamaillard M.

Mucosal Immunol. 2018 May;11(3):811-819. doi: 10.1038/mi.2017.87. Epub 2017 Nov 15.

PMID:
29139477
25.

Speeding towards individualized treatment for pancreatic cancer by taking an alternative road.

Iovanna J, Dusetti N.

Cancer Lett. 2017 Dec 1;410:63-67. doi: 10.1016/j.canlet.2017.09.016. Epub 2017 Sep 22. Review.

PMID:
28947138
26.

Resectable pancreatic head adenocarcinoma: Is R0 resection an illusion? Genetic evaluation of venous resection margin affirmed unrecognized disease.

Turrini O, Gilabert M, Ewald J, Moutardier V, Delpero JR, Iovanna JL.

J Visc Surg. 2017 Oct;154(5):329-333. doi: 10.1016/j.jviscsurg.2017.05.009. Epub 2017 Aug 23.

PMID:
28844705
27.

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

Santofimia-Castaño P, Rizzuti B, Pey ÁL, Soubeyran P, Vidal M, Urrutia R, Iovanna JL, Neira JL.

Proc Natl Acad Sci U S A. 2017 Jul 18. pii: 201619932. doi: 10.1073/pnas.1619932114. [Epub ahead of print]

28.

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions.

Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F, Vander Heiden MG, Vasseur S.

Nat Commun. 2017 Jul 7;8:16031. doi: 10.1038/ncomms16031.

29.

PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker.

Nigri J, Gironella M, Bressy C, Vila-Navarro E, Roques J, Lac S, Bontemps C, Kozaczyk C, Cros J, Pietrasz D, Maréchal R, Van Laethem JL, Iovanna J, Bachet JB, Folch-Puy E, Tomasini R.

Cell Mol Life Sci. 2017 Nov;74(22):4231-4243. doi: 10.1007/s00018-017-2579-9. Epub 2017 Jun 27.

PMID:
28656348
30.

REG3β modifies cell tumor function by impairing extracellular vesicle uptake.

Bonjoch L, Gironella M, Iovanna JL, Closa D.

Sci Rep. 2017 Jun 9;7(1):3143. doi: 10.1038/s41598-017-03244-4.

31.

Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe.

Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G.

Mol Cancer Res. 2017 Aug;15(8):984-997. doi: 10.1158/1541-7786.MCR-17-0063. Epub 2017 Apr 25.

32.

[Autophagy contributes to the initiation of pancreatic cancer].

Iovanna JL.

Med Sci (Paris). 2017 Mar;33(3):335-339. doi: 10.1051/medsci/20173303022. Epub 2017 Apr 3. Review. French.

33.

Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.

Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J.

EMBO Mol Med. 2017 Apr;9(4):482-497. doi: 10.15252/emmm.201606975.

34.

Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination.

Bonacci T, Audebert S, Camoin L, Baudelet E, Iovanna JL, Soubeyran P.

PLoS One. 2017 Jan 18;12(1):e0169988. doi: 10.1371/journal.pone.0169988. eCollection 2017.

35.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Neira JL, Bintz J, Arruebo M, Rizzuti B, Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL, Abián O.

Sci Rep. 2017 Jan 5;7:39732. doi: 10.1038/srep39732.

36.

Autophagy Induced during Pancreatitis Promotes KRAS-Dependent Transformation in the Pancreas.

Iovanna JL.

Front Oncol. 2016 Oct 26;6:226. eCollection 2016. Review.

37.

Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.

Leca J, Martinez S, Lac S, Nigri J, Secq V, Rubis M, Bressy C, Sergé A, Lavaut MN, Dusetti N, Loncle C, Roques J, Pietrasz D, Bousquet C, Garcia S, Granjeaud S, Ouaissi M, Bachet JB, Brun C, Iovanna JL, Zimmermann P, Vasseur S, Tomasini R.

J Clin Invest. 2016 Nov 1;126(11):4140-4156. doi: 10.1172/JCI87734. Epub 2016 Oct 4.

38.

Stratification and therapeutic potential of PML in metastatic breast cancer.

Martín-Martín N, Piva M, Urosevic J, Aldaz P, Sutherland JD, Fernández-Ruiz S, Arreal L, Torrano V, Cortazar AR, Planet E, Guiu M, Radosevic-Robin N, Garcia S, Macías I, Salvador F, Domenici G, Rueda OM, Zabala-Letona A, Arruabarrena-Aristorena A, Zúñiga-García P, Caro-Maldonado A, Valcárcel-Jiménez L, Sánchez-Mosquera P, Varela-Rey M, Martínez-Chantar ML, Anguita J, Ibrahim YH, Scaltriti M, Lawrie CH, Aransay AM, Iovanna JL, Baselga J, Caldas C, Barrio R, Serra V, Vivanco Md, Matheu A, Gomis RR, Carracedo A.

Nat Commun. 2016 Aug 24;7:12595. doi: 10.1038/ncomms12595.

39.

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.

Maida A, Zota A, Sjøberg KA, Schumacher J, Sijmonsma TP, Pfenninger A, Christensen MM, Gantert T, Fuhrmeister J, Rothermel U, Schmoll D, Heikenwälder M, Iovanna JL, Stemmer K, Kiens B, Herzig S, Rose AJ.

J Clin Invest. 2016 Sep 1;126(9):3263-78. doi: 10.1172/JCI85946. Epub 2016 Aug 22.

40.

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.

Aden K, Rehman A, Falk-Paulsen M, Secher T, Kuiper J, Tran F, Pfeuffer S, Sheibani-Tezerji R, Breuer A, Luzius A, Jentzsch M, Häsler R, Billmann-Born S, Will O, Lipinski S, Bharti R, Adolph T, Iovanna JL, Kempster SL, Blumberg RS, Schreiber S, Becher B, Chamaillard M, Kaser A, Rosenstiel P.

Cell Rep. 2016 Aug 23;16(8):2208-2218. doi: 10.1016/j.celrep.2016.07.054. Epub 2016 Aug 11.

41.

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT.

Barraud M, Garnier J, Loncle C, Gayet O, Lequeue C, Vasseur S, Bian B, Duconseil P, Gilabert M, Bigonnet M, Maignan A, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Guibert N, Iovanna J, Dusetti N.

Oncotarget. 2016 Aug 16;7(33):53783-53796. doi: 10.18632/oncotarget.10776.

42.

Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo.

Galichon P, Bataille A, Vandermeersch S, Wetzstein M, Xu-Dubois YC, Legouis D, Hertig A, Buob D, Placier S, Bigé N, Lefevre G, Jouanneau C, Martin C, Iovanna JL, Rondeau E.

J Am Soc Nephrol. 2017 Feb;28(2):545-556. doi: 10.1681/ASN.2015080936. Epub 2016 Jul 22.

43.

The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation.

Loncle C, Molejon MI, Lac S, Tellechea JI, Lomberk G, Gramatica L, Fernandez Zapico MF, Dusetti N, Urrutia R, Iovanna JL.

Cell Death Dis. 2016 Jul 14;7:e2295. doi: 10.1038/cddis.2016.202.

44.

The promise of epigenomic therapeutics in pancreatic cancer.

Lomberk GA, Iovanna J, Urrutia R.

Epigenomics. 2016 Jun;8(6):831-42. doi: 10.2217/epi-2015-0016. Epub 2016 Jun 23. Review.

45.

NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance.

Emma MR, Iovanna JL, Bachvarov D, Puleio R, Loria GR, Augello G, Candido S, Libra M, Gulino A, Cancila V, McCubrey JA, Montalto G, Cervello M.

Cell Death Dis. 2016 Jun 23;7(6):e2269. doi: 10.1038/cddis.2016.175.

46.

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

Martinelli P, Carrillo-de Santa Pau E, Cox T, Sainz B Jr, Dusetti N, Greenhalf W, Rinaldi L, Costello E, Ghaneh P, Malats N, Büchler M, Pajic M, Biankin AV, Iovanna J, Neoptolemos J, Real FX.

Gut. 2017 Sep;66(9):1665-1676. doi: 10.1136/gutjnl-2015-311256. Epub 2016 Jun 20.

47.

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.

Salazar M, Lorente M, García-Taboada E, Gómez EP, Dávila D, Zúñiga-García P, Flores JM, Rodríguez A, Hegedus Z, Mosén-Ansorena D, Aransay AM, Hernández-Tiedra S, López-Valero I, Quintanilla M, Sánchez C, Iovanna JL, Dusetti N, Guzmán M, Francis SE, Carracedo A, Kiss-Toth E, Velasco G.

Mol Cell Oncol. 2015 Apr 18;2(3):e980134. doi: 10.4161/23723556.2014.980134. eCollection 2015 Jul-Sep.

48.

Heterogeneity of metastatic pancreatic adenocarcinoma: Lung metastasis show better prognosis than liver metastasis-a case control study.

Decoster C, Gilabert M, Autret A, Turrini O, Oziel-Taieb S, Poizat F, Giovannini M, Viens P, Iovanna J, Raoul JL.

Oncotarget. 2016 Jul 19;7(29):45649-45655. doi: 10.18632/oncotarget.9861.

49.

IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice.

Moyat M, Bouzourene H, Ouyang W, Iovanna J, Renauld JC, Velin D.

Mucosal Immunol. 2017 Jan;10(1):271-281. doi: 10.1038/mi.2016.38. Epub 2016 May 4.

PMID:
27143303
50.

Determinants of the pKa values of ionizable residues in an intrinsically disordered protein.

Neira JL, Rizzuti B, Iovanna JL.

Arch Biochem Biophys. 2016 May 15;598:18-27. doi: 10.1016/j.abb.2016.03.034. Epub 2016 Apr 1.

PMID:
27046343

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