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Are presepsin and resistin better markers for bacterial infection in patients with decompensated liver cirrhosis?

Fischer P, Grigoras C, Bugariu A, Nicoara-Farcau O, Stefanescu H, Benea A, Hadade A, Margarit S, Sparchez Z, Tantau M, Ionescu D, Procopet B.

Dig Liver Dis. 2019 Jun 17. pii: S1590-8658(19)30626-7. doi: 10.1016/j.dld.2019.05.025. [Epub ahead of print]


How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence.

Forget P, Aguirre JA, Bencic I, Borgeat A, Cama A, Condron C, Eintrei C, Eroles P, Gupta A, Hales TG, Ionescu D, Johnson M, Kabata P, Kirac I, Ma D, Mokini Z, Guerrero Orriach JL, Retsky M, Sandrucci S, Siekmann W, Štefančić L, Votta-Vellis G, Connolly C, Buggy D.

Cancers (Basel). 2019 Apr 28;11(5). pii: E592. doi: 10.3390/cancers11050592. Review.


Antiproliferative effects of propofol and lidocaine on the colon adenocarcinoma microenvironment.

Tat T, Jurj A, Selicean C, Pasca S, Ionescu D.

J BUON. 2019 Jan-Feb;24(1):106-115.


SOX10 expression in mammary invasive ductal carcinomas and benign breast tissue.

Chiu K, Ionescu DN, Hayes M.

Virchows Arch. 2019 Jun;474(6):667-672. doi: 10.1007/s00428-019-02557-1. Epub 2019 Mar 23.


Resistin-Can it be a new early marker for prognosis in patients who survive after a cardiac arrest? A pilot study.

Tat RM, Golea A, Vesa ŞC, Ionescu D.

PLoS One. 2019 Jan 16;14(1):e0210666. doi: 10.1371/journal.pone.0210666. eCollection 2019.


Correction: Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD).

Fava M, Freeman MP, Flynn M, Judge H, Hoeppner BB, Cusin C, Ionescu DF, Mathew SJ, Chang LC, Iosifescu DV, Murrough J, Debattista C, Schatzberg AF, Trivedi MH, Jha MK, Sanacora G, Wilkinson ST, Papakostas GI.

Mol Psychiatry. 2019 Jan 7. doi: 10.1038/s41380-018-0311-2. [Epub ahead of print]


Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression.

Salloum NC, Fava M, Freeman MP, Flynn M, Hoeppner B, Hock RS, Cusin C, Iosifescu DV, Trivedi MH, Sanacora G, Mathew SJ, Debattista C, Ionescu DF, Papakostas GI.

Depress Anxiety. 2019 Mar;36(3):235-243. doi: 10.1002/da.22875. Epub 2018 Dec 30.


MUC4 Staining in Sarcomatoid Carcinomas.

Berg KB, Ionescu D, Churg AM.

Mod Pathol. 2019 Jan;32(1):157. doi: 10.1038/s41379-018-0022-x. Epub 2018 Dec 19. No abstract available.


Clinical outcomes after whole-genome sequencing in patients with metastatic non-small-cell lung cancer.

Tsang ES, Shen Y, Chooback N, Ho C, Jones M, Renouf DJ, Lim H, Sun S, Yip S, Pleasance E, Ionescu DN, Mungall K, Kasaian K, Ma Y, Zhao Y, Mungall A, Moore R, Jones SJM, Marra M, Laskin J.

Cold Spring Harb Mol Case Stud. 2019 Feb 1;5(1). pii: a002659. doi: 10.1101/mcs.a002659. Print 2019 Feb.


Canadian perspectives: update on inhibition of ALK-positive tumours in advanced non-small-cell lung cancer.

Melosky B, Cheema P, Agulnik J, Albadine R, Bebb DG, Blais N, Burkes R, Butts C, Card PB, Chan AMY, Hirsh V, Ionescu DN, Juergens R, Morzycki W, Poonja Z, Sangha R, Tehfe M, Tsao MS, Vincent M, Xu Z, Liu G.

Curr Oncol. 2018 Oct;25(5):317-328. doi: 10.3747/co.25.4379. Epub 2018 Oct 31. Review.


Organic Particles: Heterogeneous Hubs for Microbial Interactions in Aquatic Ecosystems.

Bižić-Ionescu M, Ionescu D, Grossart HP.

Front Microbiol. 2018 Oct 26;9:2569. doi: 10.3389/fmicb.2018.02569. eCollection 2018.


Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial.

Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C.

J Affect Disord. 2019 Jan 15;243:516-524. doi: 10.1016/j.jad.2018.09.037. Epub 2018 Sep 17.


Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD).

Fava M, Freeman MP, Flynn M, Judge H, Hoeppner BB, Cusin C, Ionescu DF, Mathew SJ, Chang LC, Iosifescu DV, Murrough J, Debattista C, Schatzberg AF, Trivedi MH, Jha MK, Sanacora G, Wilkinson ST, Papakostas GI.

Mol Psychiatry. 2018 Oct 3. doi: 10.1038/s41380-018-0256-5. [Epub ahead of print] Erratum in: Mol Psychiatry. 2019 Jan 7;:.


Pain distress: the negative emotion associated with procedures in ICU patients.

Puntillo KA, Max A, Timsit JF, Ruckly S, Chanques G, Robleda G, Roche-Campo F, Mancebo J, Divatia JV, Soares M, Ionescu DC, Grintescu IM, Maggiore SM, Rusinova K, Owczuk R, Egerod I, Papathanassoglou EDE, Kyranou M, Joynt GM, Burghi G, Freebairn RC, Ho KM, Kaarlola A, Gerritsen RT, Kesecioglu J, Sulaj MMS, Norrenberg M, Benoit DD, Seha MSG, Hennein A, Pereira FJ, Benbenishty JS, Abroug F, Aquilina A, Monte JRC, An Y, Azoulay E.

Intensive Care Med. 2018 Sep;44(9):1493-1501. doi: 10.1007/s00134-018-5344-0. Epub 2018 Aug 21.


Harmonization of PD-L1 testing in oncology: a Canadian pathology perspective.

Ionescu DN, Downes MR, Christofides A, Tsao MS.

Curr Oncol. 2018 Jun;25(3):e209-e216. doi: 10.3747/co.25.4031. Epub 2018 Jun 28. Review.


Breaking the biomarker code: PD-L1 expression and checkpoint inhibition in advanced NSCLC.

Melosky B, Chu Q, Juergens RA, Leighl N, Ionescu D, Tsao MS, McLeod D, Hirsh V.

Cancer Treat Rev. 2018 Apr;65:65-77. doi: 10.1016/j.ctrv.2018.02.005. Epub 2018 Feb 22. Review.


Recovering Genomics Clusters of Secondary Metabolites from Lakes Using Genome-Resolved Metagenomics.

Cuadrat RRC, Ionescu D, Dávila AMR, Grossart HP.

Front Microbiol. 2018 Feb 20;9:251. doi: 10.3389/fmicb.2018.00251. eCollection 2018.


Standardizing biomarker testing for Canadian patients with advanced lung cancer.

Melosky B, Blais N, Cheema P, Couture C, Juergens R, Kamel-Reid S, Tsao MS, Wheatley-Price P, Xu Z, Ionescu DN.

Curr Oncol. 2018 Feb;25(1):73-82. doi: 10.3747/co.25.3867. Epub 2018 Feb 28.


Ketamine-Associated Brain Changes: A Review of the Neuroimaging Literature.

Ionescu DF, Felicione JM, Gosai A, Cusin C, Shin P, Shapero BG, Deckersbach T.

Harv Rev Psychiatry. 2018 Nov/Dec;26(6):320-339. doi: 10.1097/HRP.0000000000000179. Review.


Practical Updates on Gastrointestinal Pathology From the CAMP 2017 Conference.

Ionescu DN.

Arch Pathol Lab Med. 2018 Jan;142(1):16. doi: 10.5858/arpa.2017-0393-ED. No abstract available.


Metastatic non-small cell lung carcinoma a mimic of primary breast carcinoma-case series and literature review.

Ali RH, Taraboanta C, Mohammad T, Hayes MM, Ionescu DN.

Virchows Arch. 2018 May;472(5):771-777. doi: 10.1007/s00428-017-2262-4. Epub 2017 Nov 5. Review.


Corrigendum to "Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants" [J. Affect. Disord. 208 (2017, Jan. 15) 6-14, doi: 10.1016/j.jad.2016.08.029, Epub 2016 Oct. 1].

Mischoulon D, Hylek L, Yeung AS, Clain AJ, Baer L, Cusin C, Ionescu DF, Alpert JE, Soskin DP, Fava M.

J Affect Disord. 2018 Feb;227:198. doi: 10.1016/j.jad.2017.10.040. Epub 2017 Nov 5. No abstract available.


Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study.

Tammemagi MC, Schmidt H, Martel S, McWilliams A, Goffin JR, Johnston MR, Nicholas G, Tremblay A, Bhatia R, Liu G, Soghrati K, Yasufuku K, Hwang DM, Laberge F, Gingras M, Pasian S, Couture C, Mayo JR, Nasute Fauerbach PV, Atkar-Khattra S, Peacock SJ, Cressman S, Ionescu D, English JC, Finley RJ, Yee J, Puksa S, Stewart L, Tsai S, Haider E, Boylan C, Cutz JC, Manos D, Xu Z, Goss GD, Seely JM, Amjadi K, Sekhon HS, Burrowes P, MacEachern P, Urbanski S, Sin DD, Tan WC, Leighl NB, Shepherd FA, Evans WK, Tsao MS, Lam S; PanCan Study Team.

Lancet Oncol. 2017 Nov;18(11):1523-1531. doi: 10.1016/S1470-2045(17)30597-1. Epub 2017 Oct 18.


The antidepressant efficacy of subanesthetic-dose ketamine does not correlate with baseline subcortical volumes in a replication sample with major depressive disorder.

Niciu MJ, Iadarola ND, Banerjee D, Luckenbaugh DA, Park M, Lener M, Park L, Ionescu DF, Ballard ED, Brutsche NE, Akula N, McMahon FJ, Machado-Vieira R, Nugent AC, Zarate CA Jr.

J Psychopharmacol. 2017 Dec;31(12):1570-1577. doi: 10.1177/0269881117732514. Epub 2017 Oct 17.


Re-evaluation of peri-operative cardiac risk (the MET REPAIR study): Study protocol of a prospective, multicentre cohort study sponsored by the European Society of Anaesthesiology.

Mauermann E, De Hert S, Dell-Kuster S, Filipovic M, Howell S, Ionescu D, Seeberger MD, Szczeklik W, Lurati Buse GAL.

Eur J Anaesthesiol. 2017 Nov;34(11):709-712. doi: 10.1097/EJA.0000000000000697. No abstract available.


Phyto-mediated metallic nano-architectures via Melissa officinalis L.: synthesis, characterization and biological properties.

Fierascu I, Georgiev MI, Ortan A, Fierascu RC, Avramescu SM, Ionescu D, Sutan A, Brinzan A, Ditu LM.

Sci Rep. 2017 Sep 29;7(1):12428. doi: 10.1038/s41598-017-12804-7.


Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer.

Jones MR, Lim H, Shen Y, Pleasance E, Ch'ng C, Reisle C, Leelakumari S, Zhao C, Yip S, Ho J, Zhong E, Ng T, Ionescu D, Schaeffer DF, Mungall AJ, Mungall KL, Zhao Y, Moore RA, Ma Y, Chia S, Ho C, Renouf DJ, Gelmon K, Jones SJM, Marra MA, Laskin J.

Ann Oncol. 2017 Dec 1;28(12):3092-3097. doi: 10.1093/annonc/mdx523.


Community-like genome in single cells of the sulfur bacterium Achromatium oxaliferum.

Ionescu D, Bizic-Ionescu M, De Maio N, Cypionka H, Grossart HP.

Nat Commun. 2017 Sep 6;8(1):455. doi: 10.1038/s41467-017-00342-9.


Supply-side and demand-side policies for biosimilars: an overview in 10 European member states.

Rémuzat C, Kapuśniak A, Caban A, Ionescu D, Radière G, Mendoza C, Toumi M.

J Mark Access Health Policy. 2017 Apr 28;5(1):1307315. doi: 10.1080/20016689.2017.1307315. eCollection 2017.


Frutexites-like structures formed by iron oxidizing biofilms in the continental subsurface (Äspö Hard Rock Laboratory, Sweden).

Heim C, Quéric NV, Ionescu D, Schäfer N, Reitner J.

PLoS One. 2017 May 19;12(5):e0177542. doi: 10.1371/journal.pone.0177542. eCollection 2017.


The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency.

Cressman S, Peacock SJ, Tammemägi MC, Evans WK, Leighl NB, Goffin JR, Tremblay A, Liu G, Manos D, MacEachern P, Bhatia R, Puksa S, Nicholas G, McWilliams A, Mayo JR, Yee J, English JC, Pataky R, McPherson E, Atkar-Khattra S, Johnston MR, Schmidt H, Shepherd FA, Soghrati K, Amjadi K, Burrowes P, Couture C, Sekhon HS, Yasufuku K, Goss G, Ionescu DN, Hwang DM, Martel S, Sin DD, Tan WC, Urbanski S, Xu Z, Tsao MS, Lam S.

J Thorac Oncol. 2017 Aug;12(8):1210-1222. doi: 10.1016/j.jtho.2017.04.021. Epub 2017 May 10.


Management of EGFR-mutated non-small-cell lung cancer: practical implications from a clinical and pathology perspective.

Cabanero M, Sangha R, Sheffield BS, Sukhai M, Pakkal M, Kamel-Reid S, Karsan A, Ionescu D, Juergens RA, Butts C, Tsao MS.

Curr Oncol. 2017 Apr;24(2):111-119. doi: 10.3747/co.24.3524. Epub 2017 Apr 27. Review.


Classics in Chemical Neuroscience: Ketamine.

Tyler MW, Yourish HB, Ionescu DF, Haggarty SJ.

ACS Chem Neurosci. 2017 Jun 21;8(6):1122-1134. doi: 10.1021/acschemneuro.7b00074. Epub 2017 Apr 21. Review.


Basic Features and Clinical Applicability of 'Preliminary Universal Surgical Invasiveness Score' (pUSIS): A Multi-Centre Pilot Study.

Biro P, Sermeus L, Jankovic R, Savić N, Onuţu AH, Ionescu D, Godoroja D, Gurman G.

Turk J Anaesthesiol Reanim. 2017 Feb;45(1):9-15. doi: 10.5152/TJAR.2017.77785. Epub 2017 Feb 1.


Antiproliferative and Apoptotic Effects of Lidocaine on Human Hepatocarcinoma Cells. A preliminary study.

Jurj A, Tomuleasa C, Tat TT, Berindan-Neagoe I, Vesa SV, Ionescu DC.

J Gastrointestin Liver Dis. 2017 Mar;26(1):45-50. doi: 10.15403/jgld.2014.1121.261.juj.


Experimental medication treatment approaches for depression.

Ionescu DF, Papakostas GI.

Transl Psychiatry. 2017 Mar 21;7(3):e1068. doi: 10.1038/tp.2017.33. Review.


Key drivers for market penetration of biosimilars in Europe.

Rémuzat C, Dorey J, Cristeau O, Ionescu D, Radière G, Toumi M.

J Mark Access Health Policy. 2017 Jan 30;5(1):1272308. doi: 10.1080/20016689.2016.1272308. eCollection 2017.


Anaesthesia and Intensive Care Residents' Perception of Simulation Training in Four Romanian Centres.

Vasian HN, Mărgărit SC, Grigoraş I, Azamfirei L, Corneci D, Ionescu D.

J Crit Care Med (Targu Mures). 2017 Feb 18;3(1):18-23. doi: 10.1515/jccm-2017-0005. eCollection 2017 Feb.


Drs Ionescu and Cusin Reply.

Ionescu DF, Cusin C.

J Clin Psychiatry. 2017 Jan;78(1):e72. doi: 10.4088/JCP.16lr11210a. No abstract available.


Pethidine efficacy in achieving the ultrasound-guided oblique subcostal transversus abdominis plane block in laparoscopic cholecystectomy: A prospective study.

Breazu CM, Ciobanu L, Bartos A, Bodea R, Mircea PA, Ionescu D.

Bosn J Basic Med Sci. 2017 Feb 21;17(1):67-73. doi: 10.17305/bjbms.2016.1647.


Loss of BRCA1-associated protein 1 (BAP1) expression is rare in non-small cell lung cancer.

Owen D, Sheffield BS, Ionescu D, Churg A.

Hum Pathol. 2017 Feb;60:82-85. doi: 10.1016/j.humpath.2016.10.005. Epub 2016 Oct 28.


Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants.

Mischoulon D, Hylek L, Yeung AS, Clain AJ, Baer L, Cusin C, Ionescu DF, Alpert JE, Soskin DP, Fava M.

J Affect Disord. 2017 Jan 15;208:6-14. doi: 10.1016/j.jad.2016.08.029. Epub 2016 Oct 1. Erratum in: J Affect Disord. 2017 Oct 27;227:198.


cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.

Fujita M, Richards EM, Niciu MJ, Ionescu DF, Zoghbi SS, Hong J, Telu S, Hines CS, Pike VW, Zarate CA, Innis RB.

Mol Psychiatry. 2017 May;22(5):754-759. doi: 10.1038/mp.2016.171. Epub 2016 Oct 11.


A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia.

Lam S, Mandrekar SJ, Gesthalter Y, Allen Ziegler KL, Seisler DK, Midthun DE, Mao JT, Aubry MC, McWilliams A, Sin DD, Shaipanich T, Liu G, Johnson E, Bild A, Lenburg ME, Ionescu DN, Mayo J, Yi JE, Tazelaar H, Harmsen WS, Smith J, Spira AE, Beane J, Limburg PJ, Szabo E; Cancer Prevention Network.

Cancer Prev Res (Phila). 2016 Dec;9(12):906-914. Epub 2016 Sep 22.


Connectivity to the surface determines diversity patterns in subsurface aquifers of the Fennoscandian shield.

Hubalek V, Wu X, Eiler A, Buck M, Heim C, Dopson M, Bertilsson S, Ionescu D.

ISME J. 2016 Oct;10(10):2556. doi: 10.1038/ismej.2016.94. No abstract available.


Recognition of emotional facial expressions in anxious and nonanxious depression.

Berg HE, Ballard ED, Luckenbaugh DA, Nugent AC, Ionescu DF, Zarate CA Jr.

Compr Psychiatry. 2016 Oct;70:1-8. doi: 10.1016/j.comppsych.2016.06.007. Epub 2016 Jun 14.


Investigation of PD-L1 Biomarker Testing Methods for PD-1 Axis Inhibition in Non-squamous Non-small Cell Lung Cancer.

Sheffield BS, Fulton R, Kalloger SE, Milne K, Geller G, Jones M, Jacquemont C, Zachara S, Zhao E, Pleasance E, Laskin J, Jones SJ, Marra MA, Yip S, Nelson BH, Gown AM, Ho C, Ionescu DN.

J Histochem Cytochem. 2016 Oct;64(10):587-600. doi: 10.1369/0022155416665338. Epub 2016 Sep 2.


Current Trends in Identifying Rapidly Acting Treatments for Depression.

Ionescu DF, Papakostas GI.

Curr Behav Neurosci Rep. 2016 Jun;3(2):185-191. Epub 2016 Apr 15.


Have Severity Scores a Place in Predicting Septic Complications in ICU Multiple Trauma Patients?

Ionescu D.

J Crit Care Med (Targu Mures). 2016 Aug 10;2(3):107-108. doi: 10.1515/jccm-2016-0023. eCollection 2016 Jul. No abstract available.


Insights on the "Why, When, and How" of Integrating Molecular Testing in Anatomic Pathology Practice: Dedicated to the Memory of Gregory J. Naus, MD (1951-2015).

Ionescu DN.

Arch Pathol Lab Med. 2016 Aug;140(8):746-7. doi: 10.5858/arpa.2016-0192-ED. No abstract available.


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