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Items: 1 to 50 of 101

1.

Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

Dragset MS, Ioerger TR, Zhang YJ, Mærk M, Ginbot Z, Sacchettini JC, Flo TH, Rubin EJ, Steigedal M.

Sci Rep. 2019 Aug 6;9(1):11394. doi: 10.1038/s41598-019-47905-y.

2.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT.

Nature. 2019 Jul;571(7763):72-78. doi: 10.1038/s41586-019-1315-z. Epub 2019 Jun 19.

PMID:
31217586
3.

3-O-Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.

Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00136-19. doi: 10.1128/AAC.00136-19. Print 2019 Sep.

PMID:
31209015
4.

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM.

PLoS Pathog. 2019 Jun 4;15(6):e1007846. doi: 10.1371/journal.ppat.1007846. eCollection 2019 Jun.

5.

Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase.

Wu KJ, Boutte CC, Ioerger TR, Rubin EJ.

Cell Rep. 2019 May 21;27(8):2468-2479.e3. doi: 10.1016/j.celrep.2018.12.063.

6.

Correlations between secondary structure- and protein-protein interface-mimicry: the interface mimicry hypothesis.

Taechalertpaisarn J, Lyu RL, Arancillo M, Lin CM, Perez LM, Ioerger TR, Burgess K.

Org Biomol Chem. 2019 Mar 20;17(12):3267-3274. doi: 10.1039/c9ob00204a.

PMID:
30847453
7.

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.

Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, Scarry SM, Aubé J, Yang G, Ouerfelli O, Schnappinger D, Ioerger TR, Engelhart CA, McConnell JA, McAulay K, Fay A, Roubert C, Sacchettini J, Nathan C.

Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959. Erratum in: Science. 2019 Jun 21;364(6446):.

8.

Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium.

Kannan N, Lai YP, Haug M, Lilleness MK, Bakke SS, Marstad A, Hov H, Naustdal T, Afset JE, Ioerger TR, Flo TH, Steigedal M.

Infect Immun. 2019 Mar 25;87(4). pii: e00323-18. doi: 10.1128/IAI.00323-18. Print 2019 Apr.

9.

Design criteria for minimalist mimics of protein-protein interface segments.

Taechalertpaisarn J, Lyu RL, Arancillo M, Lin CM, Jiang Z, Perez LM, Ioerger TR, Burgess K.

Org Biomol Chem. 2019 Jan 23;17(4):908-915. doi: 10.1039/c8ob02901f.

PMID:
30629068
10.

A statistical method to identify recombination in bacterial genomes based on SNP incompatibility.

Lai YP, Ioerger TR.

BMC Bioinformatics. 2018 Nov 22;19(1):450. doi: 10.1186/s12859-018-2456-z.

11.

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.

Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M.

Life Sci Alliance. 2018 Jun 1;1(3):e201800025. doi: 10.26508/lsa.201800025. eCollection 2018 Jun.

12.

A proteomics approach for the identification of species-specific immunogenic proteins in the Mycobacterium abscessus complex.

Steindor M, Nkwouano V, Stefanski A, Stuehler K, Ioerger TR, Bogumil D, Jacobsen M, Mackenzie CR, Kalscheuer R.

Microbes Infect. 2018 Nov 13. pii: S1286-4579(18)30168-0. doi: 10.1016/j.micinf.2018.10.006. [Epub ahead of print]

PMID:
30445130
13.

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape.

Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney JD, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH.

Elife. 2018 Oct 16;7. pii: e37516. doi: 10.7554/eLife.37516.

14.

Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

Ellenbarger JF, Krieger IV, Huang HL, Gómez-Coca S, Ioerger TR, Sacchettini JC, Wheeler SE, Dunbar KR.

J Chem Inf Model. 2018 Oct 22;58(10):2085-2091. doi: 10.1021/acs.jcim.8b00417. Epub 2018 Sep 12.

PMID:
30137983
15.

Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.

Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T.

BMC Res Notes. 2018 Jun 28;11(1):416. doi: 10.1186/s13104-018-3526-z.

16.

Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.

Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER.

Chembiochem. 2018 Aug 6;19(15):1590-1594. doi: 10.1002/cbic.201800124. Epub 2018 Jun 10.

PMID:
29700993
17.

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D.

Campodónico VL, Rifat D, Chuang YM, Ioerger TR, Karakousis PC.

Front Microbiol. 2018 Mar 19;9:494. doi: 10.3389/fmicb.2018.00494. eCollection 2018.

18.

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.

Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T.

Tuberculosis (Edinb). 2018 Jan;108:96-98. doi: 10.1016/j.tube.2017.11.003. Epub 2017 Nov 7.

19.

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares de Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, Riley J, Shishikura Y, Ferguson L, Osuna-Cabello M, Read KD, Green SR, Lamprecht DA, Finin PM, Steyn AJC, Ioerger TR, Sacchettini J, Rhee KY, Arora K, Barry CE 3rd, Wyatt PG, Boshoff HIM.

ACS Infect Dis. 2018 Jun 8;4(6):954-969. doi: 10.1021/acsinfecdis.7b00275. Epub 2018 Mar 26.

20.

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM.

PLoS Pathog. 2018 Mar 5;14(3):e1006939. doi: 10.1371/journal.ppat.1006939. eCollection 2018 Mar. Erratum in: PLoS Pathog. 2019 Jun 4;15(6):e1007846.

21.

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis.

Rehberg N, Akone HS, Ioerger TR, Erlenkamp G, Daletos G, Gohlke H, Proksch P, Kalscheuer R.

ACS Infect Dis. 2018 Feb 9;4(2):123-134. doi: 10.1021/acsinfecdis.7b00055. Epub 2017 Nov 16.

PMID:
29108416
22.

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.

Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T.

ACS Infect Dis. 2017 Dec 8;3(12):898-916. doi: 10.1021/acsinfecdis.7b00112. Epub 2017 Oct 31.

23.

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS.

Nat Commun. 2017 Sep 19;8(1):588. doi: 10.1038/s41467-017-00721-2.

24.

Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.

Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01334-17. doi: 10.1128/AAC.01334-17. Print 2017 Dec.

25.

Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.

Moosa A, Lamprecht DA, Arora K, Barry CE 3rd, Boshoff HIM, Ioerger TR, Steyn AJC, Mizrahi V, Warner DF.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01338-17. doi: 10.1128/AAC.01338-17. Print 2017 Oct.

26.

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.

Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e01205-17. doi: 10.1128/AAC.01205-17. Print 2017 Sep.

27.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

28.

Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection".

Perkowski EF, Zulauf KE, Weerakoon D, Hayden JD, Ioerger TR, Oreper D, Gomez SM, Sacchettini JC, Braunstein M.

MBio. 2017 Jun 20;8(3). pii: e00872-17. doi: 10.1128/mBio.00872-17. No abstract available.

29.

The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection.

Perkowski EF, Zulauf KE, Weerakoon D, Hayden JD, Ioerger TR, Oreper D, Gomez SM, Sacchettini JC, Braunstein M.

MBio. 2017 Apr 25;8(2). pii: e00333-17. doi: 10.1128/mBio.00333-17. Erratum in: MBio. 2017 Jun 20;8(3):.

30.

Statistical analysis of genetic interactions in Tn-Seq data.

DeJesus MA, Nambi S, Smith CM, Baker RE, Sassetti CM, Ioerger TR.

Nucleic Acids Res. 2017 Jun 20;45(11):e93. doi: 10.1093/nar/gkx128.

31.

Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.

Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2225-E2232. doi: 10.1073/pnas.1617655114. Epub 2017 Mar 6.

32.

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT.

Elife. 2017 Feb 21;6. pii: e20420. doi: 10.7554/eLife.20420.

33.

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR.

MBio. 2017 Jan 17;8(1). pii: e02133-16. doi: 10.1128/mBio.02133-16.

34.

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.

Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R.

PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec.

35.

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

Park Y, Pacitto A, Bayliss T, Cleghorn LA, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M, Donini S, Blundell TL, Ascher DB, Rhee K, Breda A, Zhou N, Dartois V, Jonnala SR, Via LE, Mizrahi V, Epemolu O, Stojanovski L, Simeons F, Osuna-Cabello M, Ellis L, MacKenzie CJ, Smith AR, Davis SH, Murugesan D, Buchanan KI, Turner PA, Huggett M, Zuccotto F, Rebollo-Lopez MJ, Lafuente-Monasterio MJ, Sanz O, Diaz GS, Lelièvre J, Ballell L, Selenski C, Axtman M, Ghidelli-Disse S, Pflaumer H, Bösche M, Drewes G, Freiberg GM, Kurnick MD, Srikumaran M, Kempf DJ, Green SR, Ray PC, Read K, Wyatt P, Barry CE 3rd, Boshoff HI.

ACS Infect Dis. 2017 Jan 13;3(1):18-33. doi: 10.1021/acsinfecdis.6b00103. Epub 2016 Oct 17.

36.

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis.

Koliwer-Brandl H, Syson K, van de Weerd R, Chandra G, Appelmelk B, Alber M, Ioerger TR, Jacobs WR Jr, Geurtsen J, Bornemann S, Kalscheuer R.

PLoS Pathog. 2016 Aug 11;12(8):e1005768. doi: 10.1371/journal.ppat.1005768. eCollection 2016 Aug.

37.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6271-80. doi: 10.1128/AAC.01339-16. Print 2016 Oct.

38.

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.

Lanzas F, Ioerger TR, Shah H, Acosta W, Karakousis PC.

J Clin Microbiol. 2016 Oct;54(10):2498-502. doi: 10.1128/JCM.01196-16. Epub 2016 Jul 20.

39.

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, Martinez-Hoyos M, Burns-Huang K, Roberts J, Ling Y, Rhee KY, Mendoza-Losana A, Luo M, Nathan CF.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4523-30. doi: 10.1073/pnas.1606590113. Epub 2016 Jul 18.

40.

A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis.

Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ.

Elife. 2016 Jun 15;5. pii: e14590. doi: 10.7554/eLife.14590.

41.

Normalization of transposon-mutant library sequencing datasets to improve identification of conditionally essential genes.

DeJesus MA, Ioerger TR.

J Bioinform Comput Biol. 2016 Jun;14(3):1642004. doi: 10.1142/S021972001642004X. Epub 2016 Jan 14.

42.

Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.

Swanson S, Ioerger TR, Rigel NW, Miller BK, Braunstein M, Sacchettini JC.

J Bacteriol. 2015 Dec 14;198(4):720-30. doi: 10.1128/JB.00696-15.

43.

Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape.

Shell SS, Wang J, Lapierre P, Mir M, Chase MR, Pyle MM, Gawande R, Ahmad R, Sarracino DA, Ioerger TR, Fortune SM, Derbyshire KM, Wade JT, Gray TA.

PLoS Genet. 2015 Nov 4;11(11):e1005641. doi: 10.1371/journal.pgen.1005641. eCollection 2015 Nov.

44.

TRANSIT--A Software Tool for Himar1 TnSeq Analysis.

DeJesus MA, Ambadipudi C, Baker R, Sassetti C, Ioerger TR.

PLoS Comput Biol. 2015 Oct 8;11(10):e1004401. doi: 10.1371/journal.pcbi.1004401. eCollection 2015 Oct.

45.

Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility.

Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13087-92. doi: 10.1073/pnas.1514135112. Epub 2015 Oct 5.

46.

Capturing Uncertainty by Modeling Local Transposon Insertion Frequencies Improves Discrimination of Essential Genes.

DeJesus MA, Ioerger TR.

IEEE/ACM Trans Comput Biol Bioinform. 2015 Jan-Feb;12(1):92-102. doi: 10.1109/TCBB.2014.2326857.

PMID:
26357081
47.

RNA sequencing for transcript 5'-end mapping in mycobacteria.

Shell SS, Chase MR, Ioerger TR, Fortune SM.

Methods Mol Biol. 2015;1285:31-45. doi: 10.1007/978-1-4939-2450-9_3.

PMID:
25779309
48.

A novel antimycobacterial compound acts as an intracellular iron chelator.

Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ.

Antimicrob Agents Chemother. 2015 Apr;59(4):2256-64. doi: 10.1128/AAC.05114-14. Epub 2015 Feb 2.

49.

A multifaceted secondary structure mimic based on piperidine-piperidinones.

Xin D, Perez LM, Ioerger TR, Burgess K.

Angew Chem Int Ed Engl. 2014 Apr 1;53(14):3594-8. doi: 10.1002/anie.201400927. Epub 2014 Mar 3.

50.

The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence.

Shi X, Festa RA, Ioerger TR, Butler-Wu S, Sacchettini JC, Darwin KH, Samanovic MI.

MBio. 2014 Feb 18;5(1). pii: e00876-13. doi: 10.1128/mBio.00876-13.

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