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Items: 1 to 50 of 56

1.

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma'ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G.

J Clin Invest. 2017 Jun 1;127(6):2081-2090. doi: 10.1172/JCI89548. Epub 2017 May 15.

2.

Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.

Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, Sturley SL.

J Biol Chem. 2017 Mar 17;292(11):4395-4410. doi: 10.1074/jbc.M116.770578. Epub 2016 Dec 28.

3.

PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport.

Tamari F, Chen FW, Li C, Chaudhari J, Ioannou YA.

PLoS One. 2013 Aug 15;8(8):e74169. doi: 10.1371/journal.pone.0074169. eCollection 2013.

4.

MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site.

Liapis A, Chen FW, Davies JP, Wang R, Ioannou YA.

PLoS One. 2012;7(4):e34424. doi: 10.1371/journal.pone.0034424. Epub 2012 Apr 13.

5.

An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.

Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL.

J Biol Chem. 2011 Jul 8;286(27):23842-51. doi: 10.1074/jbc.M111.227645. Epub 2011 Apr 13.

6.

In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver.

Seested T, Appa RS, Christensen EI, Ioannou YA, Krogh TN, Karpf DM, Nielsen HM.

Thromb Res. 2011 Apr;127(4):356-62. doi: 10.1016/j.thromres.2010.12.016. Epub 2011 Jan 22.

PMID:
21262526
7.

Cyclodextrin induces calcium-dependent lysosomal exocytosis.

Chen FW, Li C, Ioannou YA.

PLoS One. 2010 Nov 29;5(11):e15054. doi: 10.1371/journal.pone.0015054.

8.

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.

Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L.

J Lipid Res. 2009 May;50(5):915-23. doi: 10.1194/jlr.M800631-JLR200. Epub 2009 Jan 13.

9.

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.

Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L.

J Lipid Res. 2009 Feb;50(2):293-300. doi: 10.1194/jlr.M800439-JLR200. Epub 2008 Sep 15.

10.

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

Labonté ED, Camarota LM, Rojas JC, Jandacek RJ, Gilham DE, Davies JP, Ioannou YA, Tso P, Hui DY, Howles PN.

Am J Physiol Gastrointest Liver Physiol. 2008 Oct;295(4):G776-83. doi: 10.1152/ajpgi.90275.2008. Epub 2008 Aug 21.

11.

Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.

Walter M, Chen FW, Tamari F, Wang R, Ioannou YA.

Biol Cell. 2009 Mar;101(3):141-52. doi: 10.1042/BC20070171.

PMID:
18681838
12.

Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice.

Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L.

Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):448-54. doi: 10.1161/ATVBAHA.107.160465. Epub 2008 Jan 10.

PMID:
18187667
13.

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.

Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H.

Biochim Biophys Acta. 2007 Sep;1771(9):1140-7. Epub 2007 Jun 23.

PMID:
17689140
14.

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.

Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L.

J Clin Invest. 2007 Jul;117(7):1968-78.

15.

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.

Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY.

Biochim Biophys Acta. 2007 Sep;1771(9):1132-9. Epub 2007 Mar 16.

16.
17.
18.

Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.

Ohsaki Y, Sugimoto Y, Suzuki M, Hosokawa H, Yoshimori T, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H.

J Cell Sci. 2006 Jul 1;119(Pt 13):2643-53. Epub 2006 Jun 6.

19.
20.

Guilty until proven innocent: the case of NPC1 and cholesterol.

Ioannou YA.

Trends Biochem Sci. 2005 Sep;30(9):498-505.

PMID:
16054367
22.

Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA.

J Biol Chem. 2005 Apr 1;280(13):12710-20. Epub 2005 Jan 25.

23.

The NPC1 protein: structure implies function.

Scott C, Ioannou YA.

Biochim Biophys Acta. 2004 Oct 11;1685(1-3):8-13. Review.

PMID:
15465421
24.

Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain.

Scott C, Higgins ME, Davies JP, Ioannou YA.

J Biol Chem. 2004 Nov 12;279(46):48214-23. Epub 2004 Sep 3.

25.

Reduced sensitivity of Niemann-Pick C1-deficient cells to theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles.

Ohsaki Y, Sugimoto Y, Suzuki M, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Davies JP, Ioannou YA, Ohno K, Ninomiya H.

Histochem Cell Biol. 2004 Apr;121(4):263-72. Epub 2004 Apr 7.

PMID:
15069562
26.

Gene therapy for lysosomal storage disorders.

Ioannou YA, Enriquez A, Benjamin C.

Expert Opin Biol Ther. 2003 Aug;3(5):789-801. Review.

PMID:
12880379
27.
28.

Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice.

Oishi K, Hofmann S, Diaz GA, Brown T, Manwani D, Ng L, Young R, Vlassara H, Ioannou YA, Forrest D, Gelb BD.

Hum Mol Genet. 2002 Nov 1;11(23):2951-60.

PMID:
12393806
29.

Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease.

Ziegler RJ, Li C, Cherry M, Zhu Y, Hempel D, van Rooijen N, Ioannou YA, Desnick RJ, Goldberg MA, Yew NS, Cheng SH.

Hum Gene Ther. 2002 May 20;13(8):935-45.

PMID:
12031126
30.

Polarity of alpha-galactosidase A uptake by renal tubule cells.

Stern AS, Klotman ME, Ioannou YA, Burrow CR, Wilson PD, Klotman PE, Lipkowitz MS.

Kidney Int. 2002 Jan;61(1 Suppl):S52-5.

31.
32.

Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells.

Sugimoto Y, Ninomiya H, Ohsaki Y, Higaki K, Davies JP, Ioannou YA, Ohno K.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12391-6.

33.

Multidrug permeases and subcellular cholesterol transport.

Ioannou YA.

Nat Rev Mol Cell Biol. 2001 Sep;2(9):657-68. Review.

PMID:
11533723
34.

Transmembrane molecular pump activity of Niemann-Pick C1 protein.

Davies JP, Chen FW, Ioannou YA.

Science. 2000 Dec 22;290(5500):2295-8.

35.

Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice.

Ioannou YA, Zeidner KM, Gordon RE, Desnick RJ.

Am J Hum Genet. 2001 Jan;68(1):14-25. Epub 2000 Dec 13.

36.

The structure and function of the Niemann-Pick C1 protein.

Ioannou YA.

Mol Genet Metab. 2000 Sep-Oct;71(1-2):175-81. Review.

PMID:
11001808
37.

Gene therapy for lysosomal storage disorders with neuropathology.

Ioannou YA.

J Am Soc Nephrol. 2000 Aug;11(8):1542-7. Review. No abstract available.

39.

Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

Davies JP, Levy B, Ioannou YA.

Genomics. 2000 Apr 15;65(2):137-45.

PMID:
10783261
40.

Human alpha-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides.

Ohta M, Ohnishi T, Ioannou YA, Hodgson ME, Matsuura F, Desnick RJ.

Glycobiology. 2000 Mar;10(3):251-61.

PMID:
10704524
41.

Ribosomal proteins in cell proliferation and apoptosis.

Chen FW, Ioannou YA.

Int Rev Immunol. 1999;18(5-6):429-48. Review.

PMID:
10672495
42.

Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network.

Higgins ME, Davies JP, Chen FW, Ioannou YA.

Mol Genet Metab. 1999 Sep;68(1):1-13.

PMID:
10479477
43.

Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer.

Ziegler RJ, Yew NS, Li C, Cherry M, Berthelette P, Romanczuk H, Ioannou YA, Zeidner KM, Desnick RJ, Cheng SH.

Hum Gene Ther. 1999 Jul 1;10(10):1667-82.

PMID:
10428212
44.
45.
47.
48.

Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility.

Ioannou YA, Zeidner KM, Grace ME, Desnick RJ.

Biochem J. 1998 Jun 15;332 ( Pt 3):789-97.

50.

Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)Gal.

Osman N, McKenzie IF, Ostenried K, Ioannou YA, Desnick RJ, Sandrin MS.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14677-82.

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