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Items: 13

1.

TP0463518, a Novel Prolyl Hydroxylase Inhibitor, Specifically Induces Erythropoietin Production in the Liver.

Kato S, Ochiai N, Takano H, Io F, Takayama N, Koretsune H, Kunioka EI, Uchida S, Yamamoto K.

J Pharmacol Exp Ther. 2019 Dec;371(3):675-683. doi: 10.1124/jpet.119.258731. Epub 2019 Oct 4.

PMID:
31585986
2.

SGL5213, a novel and potent intestinal SGLT1 inhibitor, suppresses intestinal glucose absorption and enhances plasma GLP-1 and GLP-2 secretion in rats.

Io F, Gunji E, Koretsune H, Kato K, Sugisaki-Kitano M, Okumura-Kitajima L, Kimura K, Uchida S, Yamamoto K.

Eur J Pharmacol. 2019 Jun 15;853:136-144. doi: 10.1016/j.ejphar.2019.03.023. Epub 2019 Mar 13.

PMID:
30878385
3.

Discovery of potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor SGL5213 for type 2 diabetes treatment.

Kuroda S, Kobashi Y, Oi T, Kawabe K, Shiozawa F, Okumura-Kitajima L, Sugisaki-Kitano M, Io F, Yamamoto K, Kakinuma H.

Bioorg Med Chem. 2019 Jan 15;27(2):394-409. doi: 10.1016/j.bmc.2018.12.015. Epub 2018 Dec 11.

PMID:
30579799
4.

Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes.

Kuroda S, Kobashi Y, Oi T, Amada H, Okumura-Kitajima L, Io F, Yamamto K, Kakinuma H.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3534-3539. doi: 10.1016/j.bmcl.2018.09.035. Epub 2018 Sep 29.

PMID:
30297284
5.

Identification of 2-[2-(4-tert-Butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide as an Orally Active MGAT2 Inhibitor.

Busujima T, Tanaka H, Iwakiri K, Shirasaki Y, Munetomo E, Saito M, Masuko A, Kitano K, Io F, Kato K, Kamigaso S, Nozoe A, Sato N.

Chem Pharm Bull (Tokyo). 2016;64(3):228-38. doi: 10.1248/cpb.c15-00803.

6.

Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits.

Ohno T, Hata K, Baba T, Io F, Kobayashi M, Horio F, Nishimura M.

Mamm Genome. 2012 Dec;23(11-12):764-9. doi: 10.1007/s00335-012-9435-x. Epub 2012 Oct 10.

PMID:
23052825
7.

Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.

Chonan T, Wakasugi D, Yamamoto D, Yashiro M, Oi T, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A.

Bioorg Med Chem. 2011 Mar 1;19(5):1580-93. doi: 10.1016/j.bmc.2011.01.041. Epub 2011 Jan 27.

PMID:
21324704
8.

Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.

Chonan T, Tanaka H, Yamamoto D, Yashiro M, Oi T, Wakasugi D, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3965-8. doi: 10.1016/j.bmcl.2010.04.134. Epub 2010 May 4.

PMID:
20537533
9.

(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.

Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K.

J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x.

PMID:
20302302
10.

(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.

Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8. doi: 10.1016/j.bmcl.2009.10.012. Epub 2009 Oct 8.

PMID:
19853443
11.

Searching for genetic factors of fatty liver in SMXA-5 mice by quantitative trait loci analysis under a high-fat diet.

Kumazawa M, Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F.

J Lipid Res. 2007 Sep;48(9):2039-46. Epub 2007 Jun 26.

12.

Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.

Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F.

Diabetologia. 2006 Mar;49(3):486-95. Epub 2006 Jan 31.

PMID:
16447060
13.

SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet.

Kobayashi M, Io F, Kawai T, Nishimura M, Ohno T, Horio F.

Biosci Biotechnol Biochem. 2004 Jan;68(1):226-30.

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