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Items: 1 to 50 of 115

1.

SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.

Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W.

Nat Commun. 2018 Sep 3;9(1):3569. doi: 10.1038/s41467-018-06038-y.

2.

Reply.

Sawada A, Inuzuka H, Yamamoto T.

Am J Ophthalmol. 2018 Jul;191:167-168. doi: 10.1016/j.ajo.2018.04.029. Epub 2018 May 24. No abstract available.

PMID:
29801657
3.

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Clement E, Inuzuka H, Nihira NT, Wei W, Toker A.

Sci Signal. 2018 Mar 13;11(521). pii: eaao3810. doi: 10.1126/scisignal.aao3810.

4.

SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation.

Ci Y, Li X, Chen M, Zhong J, North BJ, Inuzuka H, He X, Li Y, Guo J, Dai X.

Protein Cell. 2018 Mar 1. doi: 10.1007/s13238-018-0510-2. [Epub ahead of print]

PMID:
29497989
5.

Physiological functions of FBW7 in cancer and metabolism.

Shimizu K, Nihira NT, Inuzuka H, Wei W.

Cell Signal. 2018 Jun;46:15-22. doi: 10.1016/j.cellsig.2018.02.009. Epub 2018 Feb 21. Review.

PMID:
29474981
6.

Comparison of Changes in Macular Ganglion Cell-Inner Plexiform Layer Thickness Between Medically and Surgically Treated Eyes With Advanced Glaucoma.

Inuzuka H, Sawada A, Yamamoto T.

Am J Ophthalmol. 2018 Mar;187:43-50. doi: 10.1016/j.ajo.2017.12.012. Epub 2017 Dec 26.

PMID:
29288029
7.

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.

Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H.

Mol Cell. 2017 Nov 16;68(4):645-658.e5. doi: 10.1016/j.molcel.2017.10.018.

PMID:
29149593
8.

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W.

Nat Med. 2017 Sep;23(9):1063-1071. doi: 10.1038/nm.4378. Epub 2017 Aug 14.

9.

FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A.

Takada M, Zhang W, Suzuki A, Kuroda TS, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry CJ, Bloom K, Li G, Karpen GH, Wei W, Zhang Q.

Cancer Res. 2017 Sep 15;77(18):4881-4893. doi: 10.1158/0008-5472.CAN-17-1240. Epub 2017 Jul 31.

10.

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W.

Sci Signal. 2017 Feb 14;10(466). pii: eaai8026. doi: 10.1126/scisignal.aai8026.

11.

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.

Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P.

Nat Cell Biol. 2017 Mar;19(3):177-188. doi: 10.1038/ncb3474. Epub 2017 Feb 13.

12.

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W.

Cancer Discov. 2017 Apr;7(4):424-441. doi: 10.1158/2159-8290.CD-16-0647. Epub 2017 Feb 7.

13.

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.

Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.

14.

Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression.

Nagashima K, Fukushima H, Shimizu K, Yamada A, Hidaka M, Hasumi H, Ikebe T, Fukumoto S, Okabe K, Inuzuka H.

Oncotarget. 2017 Feb 7;8(6):9947-9960. doi: 10.18632/oncotarget.14221.

15.

EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor.

Takada M, Zhuang M, Inuzuka H, Zhang J, Zurlo G, Zhang J, Zhang Q.

Oncotarget. 2017 Jan 24;8(4):6787-6795. doi: 10.18632/oncotarget.14290.

16.

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.

Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR.

Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. Epub 2016 Aug 26.

17.

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.

Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG Jr, Wei W.

Science. 2016 Aug 26;353(6302):929-32. doi: 10.1126/science.aad5755.

18.

Smurf1 regulation of DAB2IP controls cell proliferation and migration.

Li X, Dai X, Wan L, Inuzuka H, Sun L, North BJ.

Oncotarget. 2016 May 3;7(18):26057-69. doi: 10.18632/oncotarget.8424.

19.

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation.

Wang Z, Dai X, Zhong J, Inuzuka H, Wan L, Li X, Wang L, Ye X, Sun L, Gao D, Zou L, Wei W.

Nat Commun. 2015 Dec 15;6:10185. doi: 10.1038/ncomms10185.

20.

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W.

Mol Cell. 2015 Sep 17;59(6):917-30. doi: 10.1016/j.molcel.2015.07.026. Epub 2015 Sep 3.

21.

Development of Glaucomatous Visual Field Defects in Preperimetric Glaucoma Patients Within 3 Years of Diagnosis.

Inuzuka H, Kawase K, Sawada A, Kokuzawa S, Ishida K, Yamamoto T.

J Glaucoma. 2016 Jun;25(6):e591-5. doi: 10.1097/IJG.0000000000000260.

PMID:
25943739
22.

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.

Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, Paladino S, Inuzuka H, Guggino G, Monaco R, Colecchia D, Monaco G, Cerrato A, Chiariello M, Denning K, Claudio PP, Staibano S, Celetti A.

Oncotarget. 2015 May 20;6(14):12697-709.

23.

Inhibitory effects of antimicrobial agents against Fusarium species.

Kawakami H, Inuzuka H, Hori N, Takahashi N, Ishida K, Mochizuki K, Ohkusu K, Muraosa Y, Watanabe A, Kamei K.

Med Mycol. 2015 Aug;53(6):603-11. doi: 10.1093/mmy/myv016. Epub 2015 Apr 3.

PMID:
25841054
24.

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.

Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A.

Mol Cell. 2014 Nov 20;56(4):595-607. doi: 10.1016/j.molcel.2014.09.023. Epub 2014 Oct 30.

25.

Cyclin C is a haploinsufficient tumour suppressor.

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P.

Nat Cell Biol. 2014 Nov;16(11):1080-91. doi: 10.1038/ncb3046. Epub 2014 Oct 26.

26.

Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis.

Dai X, Liu P, Lau AW, Liu Y, Inuzuka H.

Cancer Med. 2014 Oct;3(5):1211-24. doi: 10.1002/cam4.298. Epub 2014 Aug 13.

27.

Contralateral Adrenal Metastasis of Renal Cell Carcinoma Arising From a Horseshoe Kidney: An Initial Case Report.

Zakoji H, Miyamoto T, Inuzuka H, Sawada N, Takeda M.

Urol Case Rep. 2014 May 17;2(4):131-3. doi: 10.1016/j.eucr.2014.04.003. eCollection 2014 Jul.

28.

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination.

Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W.

Oncotarget. 2014 Jun 30;5(12):4211-21.

29.

SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.

Lau AW, Liu P, Inuzuka H, Gao D.

Am J Cancer Res. 2014 May 26;4(3):245-55. eCollection 2014.

30.

Negative regulation of DAB2IP by Akt and SCFFbw7 pathways.

Dai X, North BJ, Inuzuka H.

Oncotarget. 2014 May 30;5(10):3307-15.

31.

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W.

Dev Cell. 2014 May 27;29(4):377-91. doi: 10.1016/j.devcel.2014.04.022.

32.

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.

Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9.

33.

Roles of F-box proteins in cancer.

Wang Z, Liu P, Inuzuka H, Wei W.

Nat Rev Cancer. 2014 Apr;14(4):233-47. doi: 10.1038/nrc3700. Review.

34.

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.

Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W.

Oncotarget. 2014 Feb 28;5(4):1026-37.

35.

Case of keratitis caused by Streptomyces thermocarboxydus.

Kawakami H, Inuzuka H, Mochizuki K, Muto T, Ohkusu K, Yaguchi T, Yamagishi Y, Mikamo H.

J Infect Chemother. 2014 Jan;20(1):57-60. doi: 10.1016/j.jiac.2013.11.001. Epub 2013 Dec 11.

PMID:
24462427
36.

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration.

Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W.

Oncotarget. 2013 Dec;4(12):2339-53.

37.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.

Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27.

38.

Contribution of fetal ANXA5 gene promoter polymorphisms to the onset of pre-eclampsia.

Ota S, Miyamura H, Nishizawa H, Inagaki H, Inagaki A, Inuzuka H, Suzuki M, Miyazaki J, Sekiya T, Udagawa Y, Kurahashi H.

Placenta. 2013 Dec;34(12):1202-10. doi: 10.1016/j.placenta.2013.09.010. Epub 2013 Oct 7.

PMID:
24140079
39.

Macular ganglion cell complex thickness in glaucoma with superior or inferior visual hemifield defects.

Inuzuka H, Kawase K, Yamada H, Oie S, Kokuzawa S, Yamamoto T.

J Glaucoma. 2014 Mar;23(3):145-9. doi: 10.1097/IJG.0b013e31826a7e20.

PMID:
24042125
40.

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W.

Cell Rep. 2013 Aug 29;4(4):803-16. doi: 10.1016/j.celrep.2013.07.031. Epub 2013 Aug 22.

41.

Late-onset bleb-related endophthalmitis caused by Streptococcus pseudopneumoniae.

Kawakami H, Nakane Y, Inuzuka H, Fukagawa T, Muto T, Mochizuki K, Ohkusu K, Suematsu H, Yamagishi Y, Mikamo H.

Int Ophthalmol. 2014 Jun;34(3):643-6. doi: 10.1007/s10792-013-9835-2. Epub 2013 Jul 25.

PMID:
23884602
42.

Decreased expression of apelin in placentas from severe pre-eclampsia patients.

Inuzuka H, Nishizawa H, Inagaki A, Suzuki M, Ota S, Miyamura H, Miyazaki J, Sekiya T, Kurahashi H, Udagawa Y.

Hypertens Pregnancy. 2013 Nov;32(4):410-21. doi: 10.3109/10641955.2013.813535. Epub 2013 Jul 11.

PMID:
23844873
43.

Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7.

Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W.

Cell Res. 2013 Jul;23(7):947-61. doi: 10.1038/cr.2013.67. Epub 2013 May 14.

44.

Degradation of the transcription factor Twist, an oncoprotein that promotes cancer metastasis.

Zhong J, Ogura K, Wang Z, Inuzuka H.

Discov Med. 2013 Jan;15(80):7-15.

45.

DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.

Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y.

Mol Cell Biol. 2013 Mar;33(6):1139-48. doi: 10.1128/MCB.01191-12. Epub 2013 Jan 7.

46.

Female pseudohermaphroditism associated with maternal steroid cell tumor, not otherwise specified of the ovary: a case report and literature review.

Hasegawa K, Minami Y, Inuzuka H, Oe S, Kato R, Tsukada K, Udagawa Y, Kuroda M.

Clin Exp Obstet Gynecol. 2013;40(4):591-5. Review.

PMID:
24597265
47.

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2.

Wang Z, Inuzuka H, Zhong J, Liu P, Sarkar FH, Sun Y, Wei W.

Oncotarget. 2012 Nov;3(11):1294-300.

48.

Cdc20: a potential novel therapeutic target for cancer treatment.

Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W.

Curr Pharm Des. 2013;19(18):3210-4. Review.

49.

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction.

Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W.

Oncotarget. 2012 Sep;3(9):1026-35.

50.

Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia.

Inagaki A, Nishizawa H, Ota S, Suzuki M, Inuzuka H, Miyamura H, Sekiya T, Kurahashi H, Udagawa Y.

Placenta. 2012 Nov;33(11):919-26. doi: 10.1016/j.placenta.2012.08.003. Epub 2012 Sep 8.

PMID:
22964307

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