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Generation of ints14 Knockout Zebrafish using CRISPR/Cas9 for the Study of Development and Disease Mechanisms.
Jung JH, Jeon S, Kim H, Jung SH. Jung JH, et al. Dev Reprod. 2023 Dec;27(4):205-211. doi: 10.12717/DR.2023.27.4.205. Epub 2023 Dec 31. Dev Reprod. 2023. PMID: 38292235 Free PMC article.
To address this gap, we aimed to investigate the expression patterns of INTS14 during zebrafish embryonic development. We generated ints14 mutant strains using the CRISPR/Cas9 system. ...For the first time, we used the CRISPR/Cas9 system to create a model in which s …
To address this gap, we aimed to investigate the expression patterns of INTS14 during zebrafish embryonic development. We generated …
INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
Sabath K, Stäubli ML, Marti S, Leitner A, Moes M, Jonas S. Sabath K, et al. Nat Commun. 2020 Jul 9;11(1):3422. doi: 10.1038/s41467-020-17232-2. Nat Commun. 2020. PMID: 32647223 Free PMC article.
The molecular basis for Integrator's functions remains obscure. Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional Integrator module. The structure of INTS13-INTS14 reveals a strongly entwined complex with a unique chain interlink. ... …
The molecular basis for Integrator's functions remains obscure. Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable …
Structural basis of Integrator-dependent RNA polymerase II termination.
Fianu I, Ochmann M, Walshe JL, Dybkov O, Cruz JN, Urlaub H, Cramer P. Fianu I, et al. Nature. 2024 Apr 3. doi: 10.1038/s41586-024-07269-4. Online ahead of print. Nature. 2024. PMID: 38570683
The structure of the pre-termination complex reveals a previously unresolved, scorpion-tail-shaped INTS10-INTS13-INTS14-INTS15 module that may use its 'sting' to open the DSIF DNA clamp and facilitate termination. ...
The structure of the pre-termination complex reveals a previously unresolved, scorpion-tail-shaped INTS10-INTS13-INTS14-INTS15 module …
Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings.
Tanaka Y, Kambayashi H, Yamamoto A, Onishi I, Sugita K, Matsumura M, Ishibashi S, Ikeda M, Yamamoto K, Kitagawa M, Kurata M. Tanaka Y, et al. Int J Mol Sci. 2022 Jul 13;23(14):7723. doi: 10.3390/ijms23147723. Int J Mol Sci. 2022. PMID: 35887071 Free PMC article.
For the efficient identification of candidate genes, a database was used, for which mRNA expression was correlated with MYC using datasets featuring "Similar" and "Not exactly similar" contexts. INTS14 and ERI2 were identified using datasets featuring the "Similar" context …
For the efficient identification of candidate genes, a database was used, for which mRNA expression was correlated with MYC using datasets f …
Genome-Wide Association Studies Reveal Candidate Genes Associated with Pigmentation Patterns of Single Feathers of Tianfu Nonghua Ducks.
Twumasi G, Wang H, Xi Y, Qi J, Li L, Bai L, Liu H. Twumasi G, et al. Animals (Basel). 2023 Dec 26;14(1):85. doi: 10.3390/ani14010085. Animals (Basel). 2023. PMID: 38200816 Free PMC article.
This study also revealed that five candidate genes, including DPP8, HACD3, INTS14, SLC24A1, and DENND4A, were associated with the color pigment on the dorsal feathers of the ducks. ...
This study also revealed that five candidate genes, including DPP8, HACD3, INTS14, SLC24A1, and DENND4A, were associated with the col …