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Items: 31


Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes.

Leontovich AA, Intine RV, Sarras MP Jr.

J Diabetes Res. 2016;2016:2860780. doi: 10.1155/2016/2860780. Epub 2016 Feb 14.


Use of zebrafish as a model to investigate the role of epigenetics in propagating the secondary complications observed in diabetes mellitus.

Sarras MP Jr, Leontovich AA, Intine RV.

Comp Biochem Physiol C Toxicol Pharmacol. 2015 Dec;178:3-7. doi: 10.1016/j.cbpc.2015.07.001. Epub 2015 Jul 10. Review.


Inhibition of poly-ADP ribose polymerase enzyme activity prevents hyperglycemia-induced impairment of angiogenesis during wound healing.

Sarras MP Jr, Mason S, McAllister G, Intine RV.

Wound Repair Regen. 2014 Sep-Oct;22(5):666-70. doi: 10.1111/wrr.12216.


An assay for lateral line regeneration in adult zebrafish.

Pisano GC, Mason SM, Dhliwayo N, Intine RV, Sarras MP Jr.

J Vis Exp. 2014 Apr 8;(86). doi: 10.3791/51343.


Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation.

Dhliwayo N, Sarras MP Jr, Luczkowski E, Mason SM, Intine RV.

Diabetes. 2014 Sep;63(9):3069-76. doi: 10.2337/db13-1916. Epub 2014 Apr 10.


A zebrafish model of diabetes mellitus and metabolic memory.

Intine RV, Olsen AS, Sarras MP Jr.

J Vis Exp. 2013 Feb 28;(72):e50232. doi: 10.3791/50232.


Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish.

Sarras MP Jr, Leontovich AA, Olsen AS, Intine RV.

Wound Repair Regen. 2013 Mar-Apr;21(2):320-8. doi: 10.1111/wrr.12027. Epub 2013 Feb 25.


Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms.

Intine RV, Sarras MP Jr.

Curr Diab Rep. 2012 Oct;12(5):551-9. doi: 10.1007/s11892-012-0302-7. Review.


Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression.

Olsen AS, Sarras MP Jr, Leontovich A, Intine RV.

Diabetes. 2012 Feb;61(2):485-91. doi: 10.2337/db11-0588. Epub 2012 Jan 6.


Limb regeneration is impaired in an adult zebrafish model of diabetes mellitus.

Olsen AS, Sarras MP Jr, Intine RV.

Wound Repair Regen. 2010 Sep-Oct;18(5):532-42. doi: 10.1111/j.1524-475X.2010.00613.x.


De novo formation of a subnuclear body.

Kaiser TE, Intine RV, Dundr M.

Science. 2008 Dec 12;322(5908):1713-7. doi: 10.1126/science.1165216. Epub 2008 Oct 23.


Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation.

Bayfield MA, Kaiser TE, Intine RV, Maraia RJ.

Mol Cell Biol. 2007 May;27(9):3303-12. Epub 2007 Feb 16.


Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation.

Huang Y, Bayfield MA, Intine RV, Maraia RJ.

Nat Struct Mol Biol. 2006 Jul;13(7):611-8. Epub 2006 Jun 25.


The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells.

Park JM, Kohn MJ, Bruinsma MW, Vech C, Intine RV, Fuhrmann S, Grinberg A, Mukherjee I, Love PE, Ko MS, DePamphilis ML, Maraia RJ.

Mol Cell Biol. 2006 Feb;26(4):1445-51.


Human La is found at RNA polymerase III-transcribed genes in vivo.

Fairley JA, Kantidakis T, Kenneth NS, Intine RV, Maraia RJ, White RJ.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18350-5. Epub 2005 Dec 12.


Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis.

Intine RV, Dundr M, Vassilev A, Schwartz E, Zhao Y, Zhao Y, Depamphilis ML, Maraia RJ.

Mol Cell Biol. 2004 Dec;24(24):10894-904.


Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs.

Intine RV, Tenenbaum SA, Sakulich AL, Keene JD, Maraia RJ.

Mol Cell. 2003 Nov;12(5):1301-7.


BCR/ABL activates mdm2 mRNA translation via the La antigen.

Trotta R, Vignudelli T, Candini O, Intine RV, Pecorari L, Guerzoni C, Santilli G, Byrom MW, Goldoni S, Ford LP, Caligiuri MA, Maraia RJ, Perrotti D, Calabretta B.

Cancer Cell. 2003 Feb;3(2):145-60.


Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs.

Intine RV, Dundr M, Misteli T, Maraia RJ.

Mol Cell. 2002 May;9(5):1113-23.


La protein and its associated small nuclear and nucleolar precursor RNAs.

Maraia RJ, Intine RV.

Gene Expr. 2002;10(1-2):41-57. Review.


Polymerase chain reaction-mediated mutagenesis in sequences resistant to homogeneous amplification.

Nazar RN, Abeyrathne PD, Intine RV.

Methods Mol Biol. 2002;182:117-26. No abstract available.


Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.

Maraia RJ, Intine RV.

Mol Cell Biol. 2001 Jan;21(2):367-79. Review. No abstract available.


Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366.

Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, Goodier JL, Phan L, Maraia RJ.

Mol Cell. 2000 Aug;6(2):339-48.


Essential structural features in the Schizosaccharomyces pombe pre-rRNA 5' external transcribed spacer.

Intine RV, Good L, Nazar RN.

J Mol Biol. 1999 Feb 26;286(3):695-708.


PCR-mediated mutagenesis in sequences recalcitrant to homogeneous amplification.

Intine RV, Nazar RN.

Biotechniques. 1998 Sep;25(3):364-6. No abstract available.


Interdependence in the processing of ribosomal RNAs in Schizosaccharomyces pombe.

Good L, Intine RV, Nazar RN.

J Mol Biol. 1997 Nov 7;273(4):782-8.


The ribosomal-RNA-processing pathway in Schizosaccharomyces pombe.

Good L, Intine RV, Nazar RN.

Eur J Biochem. 1997 Jul 1;247(1):314-21.

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