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Items: 26

1.

Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.

Flett FJ, Ruksenaite E, Armstrong LA, Bharati S, Carloni R, Morris ER, Mackay CL, Interthal H, Richardson JM.

Nat Commun. 2018 Jan 2;9(1):24. doi: 10.1038/s41467-017-02530-z.

2.

Differential Enzymatic 16O/18O Labeling for the Detection of Cross-Linked Nucleic Acid-Protein Heteroconjugates.

Flett FJ, Sachsenberg T, Kohlbacher O, Mackay CL, Interthal H.

Anal Chem. 2017 Nov 7;89(21):11208-11213. doi: 10.1021/acs.analchem.7b01625. Epub 2017 Oct 13.

3.

Click chemistry generated model DNA-peptide heteroconjugates as tools for mass spectrometry.

Flett FJ, Walton JG, Mackay CL, Interthal H.

Anal Chem. 2015 Oct 6;87(19):9595-9. doi: 10.1021/acs.analchem.5b02047.

PMID:
26335278
4.

Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.

Dean RA, Fam HK, An J, Choi K, Shimizu Y, Jones SJ, Boerkoel CF, Interthal H, Pfeifer TA.

J Biomol Screen. 2014 Dec;19(10):1372-82. doi: 10.1177/1087057114546551. Epub 2014 Aug 12.

PMID:
25117203
5.

Separation of DNA oligonucleotides using denaturing urea PAGE.

Flett F, Interthal H.

Methods Mol Biol. 2013;1054:173-85. doi: 10.1007/978-1-62703-565-1_11.

PMID:
23913292
6.

Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.

Interthal H, Champoux JJ.

Biochem J. 2011 Jun 15;436(3):559-66. doi: 10.1042/BJ20101841.

7.

Spinocerebellar ataxia with axonal neuropathy.

Walton C, Interthal H, Hirano R, Salih MA, Takashima H, Boerkoel CF.

Adv Exp Med Biol. 2010;685:75-83. Review.

PMID:
20687496
8.

4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.

Dexheimer TS, Gediya LK, Stephen AG, Weidlich I, Antony S, Marchand C, Interthal H, Nicklaus M, Fisher RJ, Njar VC, Pommier Y.

J Med Chem. 2009 Nov 26;52(22):7122-31. doi: 10.1021/jm901061s.

9.

Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei.

Amaro RE, Schnaufer A, Interthal H, Hol W, Stuart KD, McCammon JA.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17278-83. doi: 10.1073/pnas.0805820105. Epub 2008 Nov 3.

10.

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, Bhattacharjee MB, Arimura K, Umehara F, Izumo S, Northrop JL, Salih MA, Inoue K, Armstrong DL, Champoux JJ, Takashima H, Boerkoel CF.

EMBO J. 2007 Nov 14;26(22):4732-43. Epub 2007 Oct 18.

11.

The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA.

Davies DR, Mushtaq A, Interthal H, Champoux JJ, Hol WG.

J Mol Biol. 2006 Apr 7;357(4):1202-10. Epub 2006 Jan 26.

PMID:
16487540
12.

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

Interthal H, Chen HJ, Champoux JJ.

J Biol Chem. 2005 Oct 28;280(43):36518-28. Epub 2005 Aug 31.

13.

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.

Interthal H, Chen HJ, Kehl-Fie TE, Zotzmann J, Leppard JB, Champoux JJ.

EMBO J. 2005 Jun 15;24(12):2224-33. Epub 2005 May 26.

14.

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.

Barthelmes HU, Habermeyer M, Christensen MO, Mielke C, Interthal H, Pouliot JJ, Boege F, Marko D.

J Biol Chem. 2004 Dec 31;279(53):55618-25. Epub 2004 Oct 19.

15.

Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.

Davies DR, Interthal H, Champoux JJ, Hol WG.

J Med Chem. 2004 Feb 12;47(4):829-37.

PMID:
14761185
16.

The role of lysine 532 in the catalytic mechanism of human topoisomerase I.

Interthal H, Quigley PM, Hol WG, Champoux JJ.

J Biol Chem. 2004 Jan 23;279(4):2984-92. Epub 2003 Oct 31.

17.

Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide.

Davies DR, Interthal H, Champoux JJ, Hol WG.

Chem Biol. 2003 Feb;10(2):139-47.

PMID:
12618186
18.
19.

The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1.

Davies DR, Interthal H, Champoux JJ, Hol WG.

Structure. 2002 Feb;10(2):237-48.

20.

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily.

Interthal H, Pouliot JJ, Champoux JJ.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12009-14. Epub 2001 Sep 25.

21.

Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.

Boddy MN, Lopez-Girona A, Shanahan P, Interthal H, Heyer WD, Russell P.

Mol Cell Biol. 2000 Dec;20(23):8758-66.

23.

Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins.

Clever B, Interthal H, Schmuckli-Maurer J, King J, Sigrist M, Heyer WD.

EMBO J. 1997 May 1;16(9):2535-44.

24.

A role of Sep1 (= Kem1, Xrn1) as a microtubule-associated protein in Saccharomyces cerevisiae.

Interthal H, Bellocq C, Bähler J, Bashkirov VI, Edelstein S, Heyer WD.

EMBO J. 1995 Mar 15;14(6):1057-66.

25.

Structure of the bovine lactoferrin-encoding gene and its promoter.

Seyfert HM, Tuckoricz A, Interthal H, Koczan D, Hobom G.

Gene. 1994 Jun 10;143(2):265-9.

PMID:
8206385
26.

Definition, distribution, and use of a conserved Bovidae retroposon element sequence motif.

Seyfert HM, Interthal H, Hahnen J, Koczan D.

Mamm Genome. 1993;4(3):153-8.

PMID:
8439727

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