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Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets.

Insel PA, Sriram K, Salmerón C, Wiley SZ.

Future Med Chem. 2020 Mar;12(6):523-532. doi: 10.4155/fmc-2019-0357. Epub 2020 Mar 2.


GPCRs in pancreatic adenocarcinoma: Contributors to tumor biology and novel therapeutic targets.

Sriram K, Salmeron CS, Wiley SZ, Insel PA.

Br J Pharmacol. 2020 Feb 14. doi: 10.1111/bph.15028. [Epub ahead of print] Review.


Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses.

Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E.

Elife. 2020 Feb 4;9. pii: e49416. doi: 10.7554/eLife.49416.


Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxia.

Gorr MW, Sriram K, Chinn AM, Muthusamy A, Insel PA.

Physiol Rep. 2020 Jan;8(2):e14344. doi: 10.14814/phy2.14344.


The BJP expects authors to share data.

George CH, Alexander SPH, Cirino G, Docherty JR, Hoyer D, Insel PA, Izzo AA, Ji Y, Panettieri RA, Sobey CG, Stanford SC, Stefanska B, Stephens G, Teixeira M, Ahluwalia A.

Br J Pharmacol. 2019 Dec;176(24):4595-4598. doi: 10.1111/bph.14907. No abstract available.


Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future".

Dolphin AC, Insel PA, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:1-6. doi: 10.1146/annurev-pharmtox-082719-110050.


GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors.

Sriram K, Moyung K, Corriden R, Carter H, Insel PA.

PLoS Biol. 2019 Nov 25;17(11):e3000434. doi: 10.1371/journal.pbio.3000434. eCollection 2019 Nov.


Detection and Quantification of GPCR mRNA: An Assessment and Implications of Data from High-Content Methods.

Sriram K, Wiley SZ, Moyung K, Gorr MW, Salmerón C, Marucut J, French RP, Lowy AM, Insel PA.

ACS Omega. 2019 Sep 30;4(16):17048-17059. doi: 10.1021/acsomega.9b02811. eCollection 2019 Oct 15.


GPCRomics: An Approach to Discover GPCR Drug Targets.

Insel PA, Sriram K, Gorr MW, Wiley SZ, Michkov A, Salmerón C, Chinn AM.

Trends Pharmacol Sci. 2019 Jun;40(6):378-387. doi: 10.1016/ Epub 2019 May 8. Review.


Prostaglandin E2 inhibits profibrotic function of human pulmonary fibroblasts by disrupting Ca2+ signaling.

Mukherjee S, Sheng W, Michkov A, Sriarm K, Sun R, Dvorkin-Gheva A, Insel PA, Janssen LJ.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L810-L821. doi: 10.1152/ajplung.00403.2018. Epub 2019 Feb 13.


GPR68: An Emerging Drug Target in Cancer.

Wiley SZ, Sriram K, Salmerón C, Insel PA.

Int J Mol Sci. 2019 Jan 28;20(3). pii: E559. doi: 10.3390/ijms20030559. Review.


Introduction to the Theme "New Therapeutic Targets".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:15-20. doi: 10.1146/annurev-pharmtox-101018-112717.


GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets.

Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F.

Front Pharmacol. 2018 May 22;9:431. doi: 10.3389/fphar.2018.00431. eCollection 2018.


Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2018 Apr;175(7):987-993. doi: 10.1111/bph.14153.


Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology.

Alexander SPH, Roberts RE, Broughton BRS, Sobey CG, George CH, Stanford SC, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Mangum J, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2018 Feb;175(3):407-411. doi: 10.1111/bph.14112. No abstract available.


G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

Sriram K, Insel PA.

Mol Pharmacol. 2018 Apr;93(4):251-258. doi: 10.1124/mol.117.111062. Epub 2018 Jan 3. Review.


GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells.

Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA.

FASEB J. 2018 Mar;32(3):1170-1183. doi: 10.1096/fj.201700834R. Epub 2018 Jan 3.


Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:33-36. doi: 10.1146/annurev-pharmtox-092617-121952. Epub 2017 Oct 20.


Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts.

George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2017 Sep;174(17):2801-2804. doi: 10.1111/bph.13925. No abstract available.


Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology.

Busija AR, Patel HH, Insel PA.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C459-C477. doi: 10.1152/ajpcell.00355.2016. Epub 2017 Jan 25. Review.


Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:13-17. doi: 10.1146/annurev-pharmtox-091616-023708. Epub 2016 Oct 12.


The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman.

Sunahara RK, Insel PA.

Mol Pharmacol. 2016 May;89(5):585-92. doi: 10.1124/mol.116.104216. Epub 2016 Mar 16.


The Gq signalling pathway inhibits brown and beige adipose tissue.

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.

Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895.


Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.

Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D.

FASEB J. 2016 Apr;30(4):1464-79. doi: 10.1096/fj.15-280982. Epub 2015 Dec 16.


Introduction to the Theme "Cancer Pharmacology".

Insel PA, Amara SG, Blaschke TF, Meyer UA.

Annu Rev Pharmacol Toxicol. 2016;56:19-22. doi: 10.1146/annurev-pharmtox-102015-123106. Epub 2015 Nov 9. No abstract available.


Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system.

Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12681-6. doi: 10.1073/pnas.1516057112. Epub 2015 Sep 28.


Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A.

Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA.

J Biol Chem. 2015 Sep 4;290(36):22274-86. doi: 10.1074/jbc.M115.658153. Epub 2015 Jul 22.


A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.

Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL.

Ann Clin Transl Neurol. 2015 Jun;2(6):595-608. doi: 10.1002/acn3.197. Epub 2015 Apr 1.


Experimental design and analysis and their reporting: new guidance for publication in BJP.

Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SP, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LD, Wonnacott S, Weston AH, McGrath JC.

Br J Pharmacol. 2015 Jul;172(14):3461-71. doi: 10.1111/bph.12856. No abstract available. Erratum in: Br J Pharmacol. 2015 Sep;172(18):4600.


The First 50 Years of Molecular Pharmacology.

Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF.

Mol Pharmacol. 2015 Jul;88(1):139-40. doi: 10.1124/mol.115.099564. Epub 2015 May 5. Review.


Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation.

Overland AC, Insel PA.

J Biol Chem. 2015 Apr 17;290(16):9941-7. doi: 10.1074/jbc.C115.647073. Epub 2015 Mar 10.


G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets.

Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R.

Mol Pharmacol. 2015 Jul;88(1):181-7. doi: 10.1124/mol.115.098129. Epub 2015 Mar 3. Review.


Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma.

Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1529-34. doi: 10.1073/pnas.1417972112. Epub 2015 Jan 20.


Introduction to the theme "Precision medicine and prediction in pharmacology".

Insel PA, Amara SG, Blaschke TF.

Annu Rev Pharmacol Toxicol. 2015;55:11-4. doi: 10.1146/annurev-pharmtox-101714-123102. Epub 2014 Dec 17. No abstract available.


Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors.

Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel PA.

J Biol Chem. 2014 Oct 17;289(42):29148-57. doi: 10.1074/jbc.M114.569319. Epub 2014 Sep 2.


Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells.

Insel PA, Wilderman A, Zhang L, Keshwani MM, Zambon AC.

Horm Metab Res. 2014 Nov;46(12):854-62. doi: 10.1055/s-0034-1384519. Epub 2014 Jul 16. Review.


AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.

Foufelle F, Lotersztajn S, Insel PA, Chevet E.

Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C581. doi: 10.1152/ajpcell.00221.2014. Epub 2014 Jul 2. No abstract available.


Regulation of intracellular signaling and function by caveolin.

Fridolfsson HN, Roth DM, Insel PA, Patel HH.

FASEB J. 2014 Sep;28(9):3823-31. doi: 10.1096/fj.14-252320. Epub 2014 May 22. Review.


Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition.

Brown LM, Rogers KE, McCammon JA, Insel PA.

J Biol Chem. 2014 Mar 21;289(12):8217-30. doi: 10.1074/jbc.M114.548636. Epub 2014 Feb 4.


Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis.

Lu D, Insel PA.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C779-88. doi: 10.1152/ajpcell.00381.2013. Epub 2013 Dec 18. Review.


I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?".

Fuller CM, Insel PA.

Am J Physiol Cell Physiol. 2014 Jan 1;306(1):C1-2. doi: 10.1152/ajpcell.00342.2013. Epub 2013 Nov 13. No abstract available.


Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.

Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA.

Mol Pharmacol. 2013 Dec;84(6):787-93. doi: 10.1124/mol.113.087742. Epub 2013 Oct 1.


A theme series on physical biology in cancer in AJP-Cell.

McCarty OJ, King MR, Insel PA.

Am J Physiol Cell Physiol. 2014 Jan 15;306(2):C77. doi: 10.1152/ajpcell.00295.2013. Epub 2013 Sep 25. No abstract available.


Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling.

Head BP, Patel HH, Insel PA.

Biochim Biophys Acta. 2014 Feb;1838(2):532-45. doi: 10.1016/j.bbamem.2013.07.018. Epub 2013 Jul 27. Review.


AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology.

Torday JS, Insel PA.

Am J Physiol Cell Physiol. 2013 Oct 1;305(7):C681. doi: 10.1152/ajpcell.00200.2013. Epub 2013 Jul 3. No abstract available.


Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

Goldberg C, Insel PA.

Acad Med. 2013 Jun;88(6):745-7. doi: 10.1097/ACM.0b013e31828ffeeb.


Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma.

Murray F, Insel PA.

Expert Opin Ther Targets. 2013 Aug;17(8):937-49. doi: 10.1517/14728222.2013.798304. Epub 2013 May 7. Review.


AJP-Cell begins a theme series on tissue fibrosis.

Lotersztajn S, Insel PA.

Am J Physiol Cell Physiol. 2013 Feb 1;304(3):C215. doi: 10.1152/ajpcell.00405.2012. Epub 2012 Dec 19. No abstract available.


Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway.

Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA.

Biochemistry. 2012 Nov 20;51(46):9323-32. doi: 10.1021/bi301282k. Epub 2012 Nov 12.

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