Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 103

1.

Rapid and efficient genetic engineering of both wild type and axenic strains of Dictyostelium discoideum.

Paschke P, Knecht DA, Silale A, Traynor D, Williams TD, Thomason PA, Insall RH, Chubb JR, Kay RR, Veltman DM.

PLoS One. 2018 May 30;13(5):e0196809. doi: 10.1371/journal.pone.0196809. eCollection 2018.

2.

The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes.

Visweshwaran SP, Thomason PA, Guerois R, Vacher S, Denisov EV, Tashireva LA, Lomakina ME, Lazennec-Schurdevin C, Lakisic G, Lilla S, Molinie N, Henriot V, Mechulam Y, Alexandrova AY, Cherdyntseva NV, Bièche I, Schmitt E, Insall RH, Gautreau A.

EMBO J. 2018 Jul 2;37(13). pii: e97706. doi: 10.15252/embj.201797706. Epub 2018 May 29.

PMID:
29844016
3.

A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis.

Pan M, Neilson MP, Grunfeld AM, Cruz P, Wen X, Insall RH, Jin T.

PLoS Biol. 2018 May 25;16(5):e2005754. doi: 10.1371/journal.pbio.2005754. eCollection 2018 May.

4.

WASP family proteins and formins compete in pseudopod- and bleb-based migration.

Davidson AJ, Amato C, Thomason PA, Insall RH.

J Cell Biol. 2018 Feb 5;217(2):701-714. doi: 10.1083/jcb.201705160. Epub 2017 Nov 30.

5.

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.

Susanto O, Koh YWH, Morrice N, Tumanov S, Thomason PA, Nielson M, Tweedy L, Muinonen-Martin AJ, Kamphorst JJ, Mackay GM, Insall RH.

J Cell Sci. 2017 Oct 15;130(20):3455-3466. doi: 10.1242/jcs.207514. Epub 2017 Sep 4.

6.

Mroh1, a lysosomal regulator localized by WASH-generated actin.

Thomason PA, King JS, Insall RH.

J Cell Sci. 2017 May 15;130(10):1785-1795. doi: 10.1242/jcs.197210. Epub 2017 Apr 19.

7.

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin.

Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, Insall RH, Machesky LM.

Curr Biol. 2017 Mar 6;27(5):624-637. doi: 10.1016/j.cub.2017.01.033. Epub 2017 Feb 23.

8.

A plasma membrane template for macropinocytic cups.

Veltman DM, Williams TD, Bloomfield G, Chen BC, Betzig E, Insall RH, Kay RR.

Elife. 2016 Dec 13;5. pii: e20085. doi: 10.7554/eLife.20085.

9.

Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma.

Ferguson EA, Matthiopoulos J, Insall RH, Husmeier D.

J R Soc Interface. 2016 Oct;13(123). pii: 20160695.

10.
11.

WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors.

Buckley CM, Gopaldass N, Bosmani C, Johnston SA, Soldati T, Insall RH, King JS.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5906-E5915. Epub 2016 Sep 19.

12.

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.

Tyrrell BJ, Woodham EF, Spence HJ, Strathdee D, Insall RH, Machesky LM.

Pigment Cell Melanoma Res. 2016 Sep;29(5):559-71. doi: 10.1111/pcmr.12506.

14.

Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D.

Susanto O, Muinonen-Martin AJ, Nobis M, Insall RH.

Methods Mol Biol. 2016;1407:217-28. doi: 10.1007/978-1-4939-3480-5_17.

PMID:
27271906
15.

Self-generated chemotactic gradients-cells steering themselves.

Tweedy L, Susanto O, Insall RH.

Curr Opin Cell Biol. 2016 Oct;42:46-51. doi: 10.1016/j.ceb.2016.04.003. Epub 2016 Apr 19. Review.

PMID:
27105308
16.

Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis.

Tweedy L, Knecht DA, Mackay GM, Insall RH.

PLoS Biol. 2016 Mar 16;14(3):e1002404. doi: 10.1371/journal.pbio.1002404. eCollection 2016 Mar.

17.

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.

Frej AD, Clark J, Le Roy CI, Lilla S, Thomason PA, Otto GP, Churchill G, Insall RH, Claus SP, Hawkins P, Stephens L, Williams RS.

Mol Cell Biol. 2016 May 2;36(10):1464-79. doi: 10.1128/MCB.00039-16. Print 2016 May 15.

18.

Overflow in science and its implications for trust.

Siebert S, Machesky LM, Insall RH.

Elife. 2015 Sep 14;4. doi: 10.7554/eLife.10825.

19.

Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation.

Urushihara H, Kuwayama H, Fukuhara K, Itoh T, Kagoshima H, Shin-I T, Toyoda A, Ohishi K, Taniguchi T, Noguchi H, Kuroki Y, Hata T, Uchi K, Mohri K, King JS, Insall RH, Kohara Y, Fujiyama A.

BMC Genomics. 2015 Feb 14;16:80. doi: 10.1186/s12864-015-1278-x.

20.

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.

Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, Insall RH.

PLoS Biol. 2014 Oct 14;12(10):e1001966. doi: 10.1371/journal.pbio.1001966. eCollection 2014 Oct.

21.

SCAR/WAVE: A complex issue.

Davidson AJ, Insall RH.

Commun Integr Biol. 2013 Nov 1;6(6):e27033. doi: 10.4161/cib.27033. Epub 2013 Nov 13.

22.

PIP₃-dependent macropinocytosis is incompatible with chemotaxis.

Veltman DM, Lemieux MG, Knecht DA, Insall RH.

J Cell Biol. 2014 Feb 17;204(4):497-505. doi: 10.1083/jcb.201309081.

23.

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence.

Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall RH, Stockley RA, Lord JM.

Blood. 2014 Jan 9;123(2):239-48. doi: 10.1182/blood-2013-08-519520. Epub 2013 Nov 4.

24.

Predicting cell shapes in melanomas.

Tyrrell BJ, Neilson M, Insall RH, Machesky LM.

Pigment Cell Melanoma Res. 2014 Jan;27(1):5-6. doi: 10.1111/pcmr.12176. Epub 2013 Oct 23. No abstract available.

PMID:
24118871
25.

Abi is required for modulation and stability but not localization or activation of the SCAR/WAVE complex.

Davidson AJ, Ura S, Thomason PA, Kalna G, Insall RH.

Eukaryot Cell. 2013 Nov;12(11):1509-16. doi: 10.1128/EC.00116-13. Epub 2013 Sep 13.

26.

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils.

Itakura A, Aslan JE, Kusanto BT, Phillips KG, Porter JE, Newton PK, Nan X, Insall RH, Chernoff J, McCarty OJ.

PLoS One. 2013 Sep 3;8(9):e73063. doi: 10.1371/journal.pone.0073063. eCollection 2013.

27.

WASH complex conservation: don't WASH away the family!

Insall RH.

Trends Cell Biol. 2013 Nov;23(11):519-20. doi: 10.1016/j.tcb.2013.07.009. Epub 2013 Aug 28. No abstract available.

PMID:
23993425
28.

WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion.

King JS, Gueho A, Hagedorn M, Gopaldass N, Leuba F, Soldati T, Insall RH.

Mol Biol Cell. 2013 Sep;24(17):2714-26. doi: 10.1091/mbc.E13-02-0092. Epub 2013 Jul 24.

29.

Measuring chemotaxis using direct visualization microscope chambers.

Muinonen-Martin AJ, Knecht DA, Veltman DM, Thomason PA, Kalna G, Insall RH.

Methods Mol Biol. 2013;1046:307-21. doi: 10.1007/978-1-62703-538-5_18.

PMID:
23868596
30.

The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum.

Davidson AJ, King JS, Insall RH.

Biotechniques. 2013 Jul;55(1):39-41. doi: 10.2144/000114054.

31.

Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.

Park L, Thomason PA, Zech T, King JS, Veltman DM, Carnell M, Ura S, Machesky LM, Insall RH.

Dev Cell. 2013 Jan 28;24(2):169-81. doi: 10.1016/j.devcel.2012.12.014.

32.

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM.

Curr Biol. 2013 Jan 21;23(2):107-17. doi: 10.1016/j.cub.2012.11.059. Epub 2012 Dec 27.

33.

Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium.

Choi CH, Thomason PA, Zaki M, Insall RH, Barber DL.

J Biol Chem. 2013 Jan 25;288(4):2464-74. doi: 10.1074/jbc.M112.435313. Epub 2012 Dec 5.

34.

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.

Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM, Visegrády B, Insall RH, Oien K, Blyth K, Norman JC, Machesky LM.

J Cell Biol. 2012 Oct 29;199(3):527-44. doi: 10.1083/jcb.201203025. Epub 2012 Oct 22.

35.

Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

Spence HJ, Timpson P, Tang HR, Insall RH, Machesky LM.

Biochem J. 2012 Nov 15;448(1):35-42. doi: 10.1042/BJ20112206.

36.

SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods.

Veltman DM, King JS, Machesky LM, Insall RH.

J Cell Biol. 2012 Aug 20;198(4):501-8. doi: 10.1083/jcb.201205058. Epub 2012 Aug 13.

37.

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation.

Ura S, Pollitt AY, Veltman DM, Morrice NA, Machesky LM, Insall RH.

Curr Biol. 2012 Apr 10;22(7):553-61. doi: 10.1016/j.cub.2012.02.020. Epub 2012 Mar 1.

38.

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration.

Zech T, Calaminus SD, Caswell P, Spence HJ, Carnell M, Insall RH, Norman J, Machesky LM.

J Cell Sci. 2011 Nov 15;124(Pt 22):3753-9. doi: 10.1242/jcs.080986. Epub 2011 Nov 23.

39.

The induction of autophagy by mechanical stress.

King JS, Veltman DM, Insall RH.

Autophagy. 2011 Dec;7(12):1490-9.

40.

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.

Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM.

Dev Cell. 2011 Oct 18;21(4):722-34. doi: 10.1016/j.devcel.2011.07.008. Epub 2011 Sep 15.

41.

Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes.

Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ.

J Leukoc Biol. 2011 Nov;90(5):923-7. doi: 10.1189/jlb.0411182. Epub 2011 Aug 1.

42.

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour.

Neilson MP, Veltman DM, van Haastert PJ, Webb SD, Mackenzie JA, Insall RH.

PLoS Biol. 2011 May;9(5):e1000618. doi: 10.1371/journal.pbio.1000618. Epub 2011 May 17.

43.

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis.

Carnell M, Zech T, Calaminus SD, Ura S, Hagedorn M, Johnston SA, May RC, Soldati T, Machesky LM, Insall RH.

J Cell Biol. 2011 May 30;193(5):831-9. doi: 10.1083/jcb.201009119. Epub 2011 May 23.

44.

Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis.

Veltman DM, Auciello G, Spence HJ, Machesky LM, Rappoport JZ, Insall RH.

Biochem J. 2011 May 15;436(1):45-52. doi: 10.1042/BJ20101684.

PMID:
21401524
45.

Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.

Sapey E, Stockley JA, Greenwood H, Ahmad A, Bayley D, Lord JM, Insall RH, Stockley RA.

Am J Respir Crit Care Med. 2011 May 1;183(9):1176-86. doi: 10.1164/rccm.201008-1285OC. Epub 2011 Jan 21.

PMID:
21257786
46.

Actin-based motility: WAVE regulatory complex structure reopens old SCARs.

Davidson AJ, Insall RH.

Curr Biol. 2011 Jan 25;21(2):R66-8. doi: 10.1016/j.cub.2010.12.001.

47.

An improved chamber for direct visualisation of chemotaxis.

Muinonen-Martin AJ, Veltman DM, Kalna G, Insall RH.

PLoS One. 2010 Dec 14;5(12):e15309. doi: 10.1371/journal.pone.0015309.

48.

Actin on disease--studying the pathobiology of cell motility using Dictyostelium discoideum.

Carnell MJ, Insall RH.

Semin Cell Dev Biol. 2011 Feb;22(1):82-8. doi: 10.1016/j.semcdb.2010.12.003. Epub 2010 Dec 9. Review.

PMID:
21145982
49.

Dogma bites back--the evidence for branched actin.

Insall RH.

Trends Cell Biol. 2011 Jan;21(1):2; author reply 4-5. doi: 10.1016/j.tcb.2010.11.002. Epub 2010 Dec 7. No abstract available.

PMID:
21144752
50.

Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell.

Neilson MP, Mackenzie JA, Webb SD, Insall RH.

Integr Biol (Camb). 2010 Nov;2(11-12):687-95. doi: 10.1039/c0ib00047g. Epub 2010 Oct 20.

PMID:
20959932

Supplemental Content

Loading ...
Support Center