Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 888


Multivariate Genome-Wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.

Nath AP, Ritchie SC, Grinberg NF, Tang HH, Huang QQ, Teo SM, Ahola-Olli AV, Würtz P, Havulinna AS, Santalahti K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salmi M, Wallace C, Raitakari OT, Salomaa V, Abraham G, Kettunen J, Inouye M.

Am J Hum Genet. 2019 Oct 30. pii: S0002-9297(19)30389-1. doi: 10.1016/j.ajhg.2019.10.001. [Epub ahead of print]


Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality.

Ritchie SC, Kettunen J, Brozynska M, Nath AP, Havulinna AS, Männistö S, Perola M, Salomaa V, Ala-Korpela M, Abraham G, Würtz P, Inouye M.

PLoS One. 2019 Oct 23;14(10):e0223692. doi: 10.1371/journal.pone.0223692. eCollection 2019.


Systems biology and big data in asthma and allergy - recent discoveries and emerging challenges.

Tang HHF, Sly PD, Holt PG, Holt KE, Inouye M.

Eur Respir J. 2019 Oct 16. pii: 1900844. doi: 10.1183/13993003.00844-2019. [Epub ahead of print]


Protein Structure Prediction Assisted with Sparse NMR Data in CASP13.

Sala D, Huang YJ, Cole CA, Snyder D, Liu G, Ishida Y, Swapna GVT, Brock KP, Sander C, Fidelis K, Kryshtafovych A, Inouye M, Tejero R, Valafar H, Rosato A, Montelione GT.

Proteins. 2019 Oct 11. doi: 10.1002/prot.25837. [Epub ahead of print]


A CUGGU/UUGGU-specific MazF homologue from Methanohalobium evestigatum.

Ishida Y, Inouye K, Ming O, Inouye M.

Biochem Biophys Res Commun. 2019 Oct 20;518(3):533-540. doi: 10.1016/j.bbrc.2019.08.076. Epub 2019 Aug 21.


Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus.

Kato F, Yoshizumi S, Yamaguchi Y, Inouye M.

Appl Environ Microbiol. 2019 Oct 1;85(20). pii: e00915-19. doi: 10.1128/AEM.00915-19. Print 2019 Oct 15.


Enantioselective Solid-Liquid Extraction of Native Saccharides with Chiral BINOL-Based Pyridine-Phenol Type Macrocycles.

Ohishi Y, Murase M, Abe H, Inouye M.

Org Lett. 2019 Aug 16;21(16):6202-6207. doi: 10.1021/acs.orglett.9b01980. Epub 2019 Aug 1.


Towards clinical utility of polygenic risk scores.

Lambert SA, Abraham G, Inouye M.

Hum Mol Genet. 2019 Jul 31. pii: ddz187. doi: 10.1093/hmg/ddz187. [Epub ahead of print]


Gene Regulatory Networks to Explain Coronary Artery Disease Heritability.

Inouye M, Lannelongue L.

J Am Coll Cardiol. 2019 Jun 18;73(23):2958-2960. doi: 10.1016/j.jacc.2019.03.511. No abstract available.


Additive-Free Enzymatic Phosphorylation and Ligation of Artificial Oligonucleotides with C-Nucleosides at the Reaction Points.

Oda Y, Chiba J, Kurosaki F, Yamade Y, Inouye M.

Chembiochem. 2019 Aug 1;20(15):1945-1952. doi: 10.1002/cbic.201900217. Epub 2019 Jun 28.


Identification of MazF Homologue in Legionella pneumophila Which Cleaves RNA at the AACU Sequence.

Shaku M, Park JH, Inouye M, Yamaguchi Y.

J Mol Microbiol Biotechnol. 2018;28(6):269-280. doi: 10.1159/000497146. Epub 2019 Mar 20.


Acute effects of active breaks during prolonged sitting on subcutaneous adipose tissue gene expression: an ancillary analysis of a randomised controlled trial.

Grace MS, Formosa MF, Bozaoglu K, Bergouignan A, Brozynska M, Carey AL, Veiga CB, Sethi P, Dillon F, Bertovic DA, Inouye M, Owen N, Dunstan DW, Kingwell BA.

Sci Rep. 2019 Mar 7;9(1):3847. doi: 10.1038/s41598-019-40490-0.


Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells.

Nath AP, Braun A, Ritchie SC, Carbone FR, Mackay LK, Gebhardt T, Inouye M.

PLoS One. 2019 Feb 11;14(2):e0210495. doi: 10.1371/journal.pone.0210495. eCollection 2019.


Combining Evolutionary Covariance and NMR Data for Protein Structure Determination.

Huang YJ, Brock KP, Ishida Y, Swapna GVT, Inouye M, Marks DS, Sander C, Montelione GT.

Methods Enzymol. 2019;614:363-392. doi: 10.1016/bs.mie.2018.11.004. Epub 2018 Dec 23.


Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.

Kettunen J, Ritchie SC, Anufrieva O, Lyytikäinen LP, Hernesniemi J, Karhunen PJ, Kuukasjärvi P, Laurikka J, Kähönen M, Lehtimäki T, Havulinna AS, Salomaa V, Männistö S, Ala-Korpela M, Perola M, Inouye M, Würtz P.

Circ Genom Precis Med. 2018 Nov;11(11):e002234. doi: 10.1161/CIRCGEN.118.002234.


Trajectories of childhood immune development and respiratory health relevant to asthma and allergy.

Tang HH, Teo SM, Belgrave DC, Evans MD, Jackson DJ, Brozynska M, Kusel MM, Johnston SL, Gern JE, Lemanske RF, Simpson A, Custovic A, Sly PD, Holt PG, Holt KE, Inouye M.

Elife. 2018 Oct 15;7. pii: e35856. doi: 10.7554/eLife.35856.


Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.

Inouye M, Abraham G, Nelson CP, Wood AM, Sweeting MJ, Dudbridge F, Lai FY, Kaptoge S, Brozynska M, Wang T, Ye S, Webb TR, Rutter MK, Tzoulaki I, Patel RS, Loos RJF, Keavney B, Hemingway H, Thompson J, Watkins H, Deloukas P, Di Angelantonio E, Butterworth AS, Danesh J, Samani NJ; UK Biobank CardioMetabolic Consortium CHD Working Group.

J Am Coll Cardiol. 2018 Oct 16;72(16):1883-1893. doi: 10.1016/j.jacc.2018.07.079.


Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.

Teo SM, Tang HHF, Mok D, Judd LM, Watts SC, Pham K, Holt BJ, Kusel M, Serralha M, Troy N, Bochkov YA, Grindle K, Lemanske RF Jr, Johnston SL, Gern JE, Sly PD, Holt PG, Holt KE, Inouye M.

Cell Host Microbe. 2018 Sep 12;24(3):341-352.e5. doi: 10.1016/j.chom.2018.08.005.


Power, false discovery rate and Winner's Curse in eQTL studies.

Huang QQ, Ritchie SC, Brozynska M, Inouye M.

Nucleic Acids Res. 2018 Dec 14;46(22):e133. doi: 10.1093/nar/gky780.


FastSpar: rapid and scalable correlation estimation for compositional data.

Watts SC, Ritchie SC, Inouye M, Holt KE.

Bioinformatics. 2019 Mar 15;35(6):1064-1066. doi: 10.1093/bioinformatics/bty734.


Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue.

Bhalala OG, Nath AP; UK Brain Expression Consortium, Inouye M, Sibley CR.

PLoS Genet. 2018 Aug 24;14(8):e1007607. doi: 10.1371/journal.pgen.1007607. eCollection 2018 Aug.


Observation of Circularly Polarized Luminescence of the Excimer from Two Perylene Cores in the Form of [4]Rotaxane.

Hayashi K, Miyaoka Y, Ohishi Y, Uchida TA, Iwamura M, Nozaki K, Inouye M.

Chemistry. 2018 Oct 1;24(55):14613-14616. doi: 10.1002/chem.201803215. Epub 2018 Sep 4.


Genome-Wide Association Studies and Risk Scores for Coronary Artery Disease: Sex Biases.

Byars SG, Inouye M.

Adv Exp Med Biol. 2018;1065:627-642. doi: 10.1007/978-3-319-77932-4_38. Review.


Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B12) Transport across the Inner Blood-Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin.

Kinoshita Y, Nogami K, Jomura R, Akanuma SI, Abe H, Inouye M, Kubo Y, Hosoya KI.

Mol Pharm. 2018 Aug 6;15(8):3583-3594. doi: 10.1021/acs.molpharmaceut.8b00617. Epub 2018 Jul 17.


Spontaneous Helix Formation of " meta"-Ethynylphenol Oligomers by Sequential Intramolecular Hydrogen Bonding inside the Cavities.

Hayashi T, Ohishi Y, Hee-Soo S, Abe H, Matsumoto S, Inouye M.

J Org Chem. 2018 Aug 3;83(15):8724-8730. doi: 10.1021/acs.joc.8b00996. Epub 2018 Jun 8.


Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.

Holt KE, McAdam P, Thai PVK, Thuong NTT, Ha DTM, Lan NN, Lan NH, Nhu NTQ, Hai HT, Ha VTN, Thwaites G, Edwards DJ, Nath AP, Pham K, Ascher DB, Farrar J, Khor CC, Teo YY, Inouye M, Caws M, Dunstan SJ.

Nat Genet. 2018 Jun;50(6):849-856. doi: 10.1038/s41588-018-0117-9. Epub 2018 May 21.


Nonplanar Macrocycle Consisting of Four Pyridine and Phenol Units Connected with Acetylene Bonds Displaying Preferential Binding to Maltoside over Monosaccharides.

Ohishi Y, Yamamoto N, Abe H, Inouye M.

J Org Chem. 2018 May 18;83(10):5766-5770. doi: 10.1021/acs.joc.8b00062. Epub 2018 May 8.


Hexaphenolic Rigid Cages Prepared by Self-Organization of C3 v Tridentates.

Abe H, Hashikawa D, Minami T, Ohtani K, Masuda K, Matsumoto S, Inouye M.

J Org Chem. 2018 Mar 16;83(6):3132-3141. doi: 10.1021/acs.joc.7b03111. Epub 2018 Mar 7.


Validation and implementation of Planova™ BioEX virus filters in the manufacture of a new liquid intravenous immunoglobulin in China.

Ma S, Pang GL, Shao YJ, Hongo-Hirasaki T, Shang MX, Inouye M, Jian CY, Zhu MZ, Yang HH, Gao JF, Xi ZY, Song DW.

Biologicals. 2018 Mar;52:37-43. doi: 10.1016/j.biologicals.2018.01.004. Epub 2018 Feb 9.


Widespread transcriptional pausing and elongation control at enhancers.

Henriques T, Scruggs BS, Inouye MO, Muse GW, Williams LH, Burkholder AB, Lavender CA, Fargo DC, Adelman K.

Genes Dev. 2018 Jan 1;32(1):26-41. doi: 10.1101/gad.309351.117. Epub 2018 Jan 29.


Bcl-XL-binding helical peptides possessing d-Ala residues at their C-termini with the advantage of long-lasting intracellular stabilities.

Nogami K, Tokumaru H, Isokawa G, Oyoshi T, Fujimoto K, Inouye M.

Chem Commun (Camb). 2017 Nov 7;53(89):12104-12107. doi: 10.1039/c7cc06904a.


Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry.

Gray LA, D'Antoine HA, Tong SYC, McKinnon M, Bessarab D, Brown N, Reményi B, Steer A, Syn G, Blackwell JM, Inouye M, Carapetis JR.

J Infect Dis. 2017 Dec 12;216(11):1460-1470. doi: 10.1093/infdis/jix497.


Corrigendum: In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages.

Ingle DJ, Valcanis M, Kuzevski A, Tauschek M, Inouye M, Stinear T, Levine MM, Robins-Browne RM, Holt KE.

Microb Genom. 2017 Aug 1;3(7):e000109. doi: 10.1099/mgen.0.000109. eCollection 2017 Jul.


An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.

Nath AP, Ritchie SC, Byars SG, Fearnley LG, Havulinna AS, Joensuu A, Kangas AJ, Soininen P, Wennerström A, Milani L, Metspalu A, Männistö S, Würtz P, Kettunen J, Raitoharju E, Kähönen M, Juonala M, Palotie A, Ala-Korpela M, Ripatti S, Lehtimäki T, Abraham G, Raitakari O, Salomaa V, Perola M, Inouye M.

Genome Biol. 2017 Aug 1;18(1):146. doi: 10.1186/s13059-017-1279-y.


An exposome perspective: Early-life events and immune development in a changing world.

Renz H, Holt PG, Inouye M, Logan AC, Prescott SL, Sly PD.

J Allergy Clin Immunol. 2017 Jul;140(1):24-40. doi: 10.1016/j.jaci.2017.05.015. Review.


Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.

Byars SG, Huang QQ, Gray LA, Bakshi A, Ripatti S, Abraham G, Stearns SC, Inouye M.

PLoS Genet. 2017 Jun 22;13(6):e1006328. doi: 10.1371/journal.pgen.1006328. eCollection 2017 Jun.


Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure.

Marques FZ, Prestes PR, Byars SG, Ritchie SC, Würtz P, Patel SK, Booth SA, Rana I, Minoda Y, Berzins SP, Curl CL, Bell JR, Wai B, Srivastava PM, Kangas AJ, Soininen P, Ruohonen S, Kähönen M, Lehtimäki T, Raitoharju E, Havulinna A, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, McGlynn M, Kelly J, Wlodek ME, Lewandowski PA, Delbridge LM, Burrell LM, Inouye M, Harrap SB, Charchar FJ.

J Am Heart Assoc. 2017 Jun 14;6(6). pii: e005971. doi: 10.1161/JAHA.117.005971.


Translation-dependent mRNA cleavage by YhaV in Escherichia coli.

Choi W, Yamaguchi Y, Lee JW, Jang KM, Inouye M, Kim SG, Yoon MH, Park JH.

FEBS Lett. 2017 Jul;591(13):1853-1861. doi: 10.1002/1873-3468.12705. Epub 2017 Jun 26.


FlashPCA2: principal component analysis of Biobank-scale genotype datasets.

Abraham G, Qiu Y, Inouye M.

Bioinformatics. 2017 Sep 1;33(17):2776-2778. doi: 10.1093/bioinformatics/btx299.


Characterization of YjjJ toxin of Escherichia coli.

Maeda Y, Lin CY, Ishida Y, Inouye M, Yamaguchi Y, Phadtare S.

FEMS Microbiol Lett. 2017 Jun 15;364(11). doi: 10.1093/femsle/fnx086.


Toxins of Prokaryotic Toxin-Antitoxin Systems with Sequence-Specific Endoribonuclease Activity.

Masuda H, Inouye M.

Toxins (Basel). 2017 Apr 14;9(4). pii: E140. doi: 10.3390/toxins9040140. Review.


In silico serotyping of E. coli from short read data identifies limited novel O-loci but extensive diversity of O:H serotype combinations within and between pathogenic lineages.

Ingle DJ, Valcanis M, Kuzevski A, Tauschek M, Inouye M, Stinear T, Levine MM, Robins-Browne RM, Holt KE.

Microb Genom. 2016 Jul 11;2(7):e000064. doi: 10.1099/mgen.0.000064. eCollection 2016 Jul. Erratum in: Microb Genom. 2017 Aug 01;3(7):e000109.


Deletion of mazF increases Staphylococcus aureus biofilm formation in an ica-dependent manner.

Kato F, Yabuno Y, Yamaguchi Y, Sugai M, Inouye M.

Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx026.


Interactions within the MHC contribute to the genetic architecture of celiac disease.

Goudey B, Abraham G, Kikianty E, Wang Q, Rawlinson D, Shi F, Haviv I, Stern L, Kowalczyk A, Inouye M.

PLoS One. 2017 Mar 10;12(3):e0172826. doi: 10.1371/journal.pone.0172826. eCollection 2017.


Designing of a single gene encoding four functional proteins.

Inouye M, Ishida Y, Inouye K.

J Theor Biol. 2017 Apr 21;419:266-268. doi: 10.1016/j.jtbi.2017.01.042. Epub 2017 Feb 3.


The role of the loop 1 region in MazFbs mRNA interferase from Bacillus subtilis in recognition of the 3' end of the RNA substrate.

Ishida Y, Inouye K, Inouye M.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):403-408. doi: 10.1016/j.bbrc.2016.12.130. Epub 2016 Dec 23.


Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems.

Shu L, Zhao Y, Kurt Z, Byars SG, Tukiainen T, Kettunen J, Orozco LD, Pellegrini M, Lusis AJ, Ripatti S, Zhang B, Inouye M, Mäkinen VP, Yang X.

BMC Genomics. 2016 Nov 4;17(1):874.


The first demonstration of the existence of reverse transcriptases in bacteria.

Inouye M.

Gene. 2017 Jan 15;597:76-77. doi: 10.1016/j.gene.2016.10.031. Epub 2016 Oct 21. Review.


The first discovery of RNA interference by RNA restriction enzymes to inhibit protein synthesis.

Inouye M.

Gene. 2017 Jan 15;597:78-79. doi: 10.1016/j.gene.2016.10.025. Epub 2016 Oct 21. Review.


D3h -Symmetrical Shape-Persistent Macrocycles Consisting of Pyridine-Acetylene-Phenol Conjugates as an Efficient Host Architecture for Saccharide Recognition.

Abe H, Yoneda T, Ohishi Y, Inouye M.

Chemistry. 2016 Dec 23;22(52):18944-18952. doi: 10.1002/chem.201603987. Epub 2016 Nov 22.


Supplemental Content

Loading ...
Support Center