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Items: 1 to 50 of 135

1.

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

Das NK, Schwartz AJ, Barthel G, Inohara N, Liu Q, Sankar A, Hill DR, Ma X, Lamberg O, Schnizlein MK, Arqués JL, Spence JR, Nunez G, Patterson AD, Sun D, Young VB, Shah YM.

Cell Metab. 2019 Nov 1. pii: S1550-4131(19)30560-1. doi: 10.1016/j.cmet.2019.10.005. [Epub ahead of print]

PMID:
31708445
2.

Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.

Kitamoto S, Alteri CJ, Rodrigues M, Nagao-Kitamoto H, Sugihara K, Himpsl SD, Bazzi M, Miyoshi M, Nishioka T, Hayashi A, Morhardt TL, Kuffa P, Grasberger H, El-Zaatari M, Bishu S, Ishii C, Hirayama A, Eaton KA, Dogan B, Simpson KW, Inohara N, Mobley HLT, Kao JY, Fukuda S, Barnich N, Kamada N.

Nat Microbiol. 2019 Nov 4. doi: 10.1038/s41564-019-0591-6. [Epub ahead of print]

PMID:
31686025
3.

Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice.

Caruso R, Ono M, Bunker ME, Núñez G, Inohara N.

Cell Rep. 2019 Jun 11;27(11):3401-3412.e3. doi: 10.1016/j.celrep.2019.05.042.

4.

A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice.

Caruso R, Mathes T, Martens EC, Kamada N, Nusrat A, Inohara N, Núñez G.

Sci Immunol. 2019 Apr 19;4(34). pii: eaaw4341. doi: 10.1126/sciimmunol.aaw4341.

PMID:
31004013
5.

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk.

Caballero-Flores G, Sakamoto K, Zeng MY, Wang Y, Hakim J, Matus-Acuña V, Inohara N, Núñez G.

Cell Host Microbe. 2019 Feb 13;25(2):313-323.e4. doi: 10.1016/j.chom.2018.12.015. Epub 2019 Jan 24.

PMID:
30686564
6.

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Triner D, Devenport SN, Ramakrishnan SK, Ma X, Frieler RA, Greenson JK, Inohara N, Nunez G, Colacino JA, Mortensen RM, Shah YM.

Gastroenterology. 2019 Apr;156(5):1467-1482. doi: 10.1053/j.gastro.2018.12.003. Epub 2018 Dec 11.

PMID:
30550822
7.

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.

Hara H, Seregin SS, Yang D, Fukase K, Chamaillard M, Alnemri ES, Inohara N, Chen GY, Núñez G.

Cell. 2018 Nov 29;175(6):1651-1664.e14. doi: 10.1016/j.cell.2018.09.047. Epub 2018 Nov 1.

8.

An experimental murine model to study periodontitis.

Marchesan J, Girnary MS, Jing L, Miao MZ, Zhang S, Sun L, Morelli T, Schoenfisch MH, Inohara N, Offenbacher S, Jiao Y.

Nat Protoc. 2018 Oct;13(10):2247-2267. doi: 10.1038/s41596-018-0035-4.

9.

Route Connection: Mouth to Intestine in Colitis.

Inohara N.

Cell Host Microbe. 2017 Dec 13;22(6):730-731. doi: 10.1016/j.chom.2017.11.012.

10.

Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation.

Nakagawa S, Matsumoto M, Katayama Y, Oguma R, Wakabayashi S, Nygaard T, Saijo S, Inohara N, Otto M, Matsue H, Núñez G, Nakamura Y.

Cell Host Microbe. 2017 Nov 8;22(5):667-677.e5. doi: 10.1016/j.chom.2017.10.008.

11.

Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes.

Kim D, Seo SU, Zeng MY, Kim WU, Kamada N, Inohara N, Núñez G.

J Immunol. 2017 Aug 15;199(4):1362-1371. doi: 10.4049/jimmunol.1601527. Epub 2017 Jul 3.

12.

Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.

Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG 3rd, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G.

Science. 2017 Apr 21;356(6335):315-319. doi: 10.1126/science.aag2029.

13.

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.

Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Núñez G.

Sci Immunol. 2017 Feb;2(8). pii: eaai8371. doi: 10.1126/sciimmunol.aai8371. Epub 2017 Feb 3.

14.

Mechanisms of inflammation-driven bacterial dysbiosis in the gut.

Zeng MY, Inohara N, Nuñez G.

Mucosal Immunol. 2017 Jan;10(1):18-26. doi: 10.1038/mi.2016.75. Epub 2016 Aug 24. Review.

15.

Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.

Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Philpott DJ, Rosenstiel P, Inohara N, Núñez G.

Nat Med. 2016 Aug 4;22(8):961. doi: 10.1038/nm0816-961. No abstract available.

PMID:
27490437
16.

The Genomic Sequence of the Oral Pathobiont Strain NI1060 Reveals Unique Strategies for Bacterial Competition and Pathogenicity.

Darzi Y, Jiao Y, Hasegawa M, Moon H, Núñez G, Inohara N, Raes J.

PLoS One. 2016 Jul 13;11(7):e0158866. doi: 10.1371/journal.pone.0158866. eCollection 2016.

17.

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.

Kim D, Kim YG, Seo SU, Kim DJ, Kamada N, Prescott D, Chamaillard M, Philpott DJ, Rosenstiel P, Inohara N, Núñez G.

Nat Med. 2016 May;22(5):524-30. doi: 10.1038/nm.4075. Epub 2016 Apr 11. Erratum in: Nat Med. 2016 Aug 4;22(8):961.

18.

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.

Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G.

Immunity. 2016 Mar 15;44(3):647-658. doi: 10.1016/j.immuni.2016.02.006. Epub 2016 Mar 2.

19.

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses.

Wang Q, Matsuo Y, Pradipta AR, Inohara N, Fujimoto Y, Fukase K.

Org Biomol Chem. 2016 Jan 21;14(3):1013-23. doi: 10.1039/c5ob02145f. Epub 2015 Dec 3.

PMID:
26631868
20.

Epigenetic Modifications of Histones in Periodontal Disease.

Martins MD, Jiao Y, Larsson L, Almeida LO, Garaicoa-Pazmino C, Le JM, Squarize CH, Inohara N, Giannobile WV, Castilho RM.

J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.

PMID:
26496800
21.

TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens.

Marchesan J, Jiao Y, Schaff RA, Hao J, Morelli T, Kinney JS, Gerow E, Sheridan R, Rodrigues V, Paster BJ, Inohara N, Giannobile WV.

Mol Oral Microbiol. 2016 Jun;31(3):243-258. doi: 10.1111/omi.12116. Epub 2015 Sep 10.

22.

Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G.

Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.

23.

NOD1 and NOD2: signaling, host defense, and inflammatory disease.

Caruso R, Warner N, Inohara N, Núñez G.

Immunity. 2014 Dec 18;41(6):898-908. doi: 10.1016/j.immuni.2014.12.010. Epub 2014 Dec 6. Review.

24.

Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.

Hasegawa M, Yada S, Liu MZ, Kamada N, Muñoz-Planillo R, Do N, Núñez G, Inohara N.

Immunity. 2014 Oct 16;41(4):620-32. doi: 10.1016/j.immuni.2014.09.010.

25.

Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling.

Burberry A, Zeng MY, Ding L, Wicks I, Inohara N, Morrison SJ, Núñez G.

Cell Host Microbe. 2014 Jun 11;15(6):779-91. doi: 10.1016/j.chom.2014.05.004. Epub 2014 May 29.

26.

Regulation of the gut microbiota by the mucosal immune system in mice.

Hasegawa M, Inohara N.

Int Immunol. 2014 Sep;26(9):481-7. doi: 10.1093/intimm/dxu049. Epub 2014 May 2. Review.

27.

The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development.

Jiao Y, Hasegawa M, Inohara N.

J Dent Res. 2014 Jun;93(6):539-46. doi: 10.1177/0022034514528212. Epub 2014 Mar 19. Review.

28.

Emerging roles of immunostimulatory oral bacteria in periodontitis development.

Jiao Y, Hasegawa M, Inohara N.

Trends Microbiol. 2014 Mar;22(3):157-63. doi: 10.1016/j.tim.2013.12.005. Epub 2014 Jan 13. Review.

29.

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.

Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G.

Nature. 2013 Nov 21;503(7476):397-401. doi: 10.1038/nature12655. Epub 2013 Oct 30.

30.

Control of pathogens and pathobionts by the gut microbiota.

Kamada N, Chen GY, Inohara N, Núñez G.

Nat Immunol. 2013 Jul;14(7):685-90. doi: 10.1038/ni.2608. Review.

31.

Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity.

Jiao Y, Darzi Y, Tawaratsumida K, Marchesan JT, Hasegawa M, Moon H, Chen GY, Núñez G, Giannobile WV, Raes J, Inohara N.

Cell Host Microbe. 2013 May 15;13(5):595-601. doi: 10.1016/j.chom.2013.04.005.

32.

Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library.

Wang N, Huang CY, Hasegawa M, Inohara N, Fujimoto Y, Fukase K.

Chembiochem. 2013 Mar 4;14(4):482-8. doi: 10.1002/cbic.201200655. Epub 2013 Jan 29.

33.

Divergence of the systemic immune response following oral infection with distinct strains of Porphyromonas gingivalis.

Marchesan JT, Morelli T, Lundy SK, Jiao Y, Lim S, Inohara N, Nunez G, Fox DA, Giannobile WV.

Mol Oral Microbiol. 2012 Dec;27(6):483-95. doi: 10.1111/omi.12001. Epub 2012 Sep 18.

34.

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.

Hasegawa M, Kamada N, Jiao Y, Liu MZ, Núñez G, Inohara N.

J Immunol. 2012 Sep 15;189(6):3085-91. doi: 10.4049/jimmunol.1200821. Epub 2012 Aug 10.

35.

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation.

Fujimoto Y, Pradipta AR, Inohara N, Fukase K.

Nat Prod Rep. 2012 May 1;29(5):568-79. doi: 10.1039/c2np00091a. Epub 2012 Feb 28. Review.

PMID:
22370813
36.

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.

Hasegawa M, Yamazaki T, Kamada N, Tawaratsumida K, Kim YG, Núñez G, Inohara N.

J Immunol. 2011 Apr 15;186(8):4872-80. doi: 10.4049/jimmunol.1003761. Epub 2011 Mar 16.

37.

Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.

Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H.

J Biol Chem. 2011 May 20;286(20):17879-88. doi: 10.1074/jbc.M111.221853. Epub 2011 Mar 10.

38.

Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment.

Pradipta AR, Fujimoto Y, Hasegawa M, Inohara N, Fukase K.

J Biol Chem. 2010 Jul 30;285(31):23607-13. doi: 10.1074/jbc.M110.137893. Epub 2010 Jun 2.

39.

[Structures and functions of NLRs, intracellular pattern recognition receptors].

Inohara N.

Seikagaku. 2010 Jan;82(1):12-20. Review. Japanese. No abstract available.

PMID:
20169992
40.

Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.

Hasegawa M, Osaka T, Tawaratsumida K, Yamazaki T, Tada H, Chen GY, Tsuneda S, Núñez G, Inohara N.

Infect Immun. 2010 Feb;78(2):639-50. doi: 10.1128/IAI.01043-09. Epub 2009 Nov 23.

41.

A putative role for human BFK in DNA damage-induced apoptosis.

Ozören N, Inohara N, Núñez G.

Biotechnol J. 2009 Jul;4(7):1046-54. doi: 10.1002/biot.200900091.

42.

Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions.

Kawasaki A, Karasudani Y, Otsuka Y, Hasegawa M, Inohara N, Fujimoto Y, Fukase K.

Chemistry. 2008;14(33):10318-30. doi: 10.1002/chem.200801121.

43.

Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample.

Huang W, Payne TJ, Ma JZ, Beuten J, Dupont RT, Inohara N, Li MD.

Neuropsychopharmacology. 2009 Jan;34(2):319-30. doi: 10.1038/npp.2008.37. Epub 2008 Mar 19.

44.

The NLR gene family: a standard nomenclature.

Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA.

Immunity. 2008 Mar;28(3):285-7. doi: 10.1016/j.immuni.2008.02.005. No abstract available.

45.

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.

Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Núñez G.

Immunity. 2008 Feb;28(2):246-57. doi: 10.1016/j.immuni.2007.12.012. Epub 2008 Feb 7.

46.

Monomer/dimer transition of the caspase-recruitment domain of human Nod1.

Srimathi T, Robbins SL, Dubas RL, Hasegawa M, Inohara N, Park YC.

Biochemistry. 2008 Feb 5;47(5):1319-25. doi: 10.1021/bi7016602. Epub 2008 Jan 11.

PMID:
18186648
47.

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N.

EMBO J. 2008 Jan 23;27(2):373-83. Epub 2007 Dec 13.

48.

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.

Suzuki T, Franchi L, Toma C, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Inohara N, Sasakawa C, Nuñez G.

PLoS Pathog. 2007 Aug 10;3(8):e111.

49.

Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.

Park JH, Kim YG, Shaw M, Kanneganti TD, Fujimoto Y, Fukase K, Inohara N, Núñez G.

J Immunol. 2007 Jul 1;179(1):514-21.

50.

[The molecular mechanism of autoinflammatory disease--lessons from the function of NOD protein families].

Masumoto J, Hasegawa M, Inohara N.

Nihon Rinsho Meneki Gakkai Kaishi. 2007 Apr;30(2):68-77. Review. Japanese.

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