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Neuroinflammation in frontotemporal lobar degeneration revealed by 11 C-PBR28 PET.

Kim MJ, McGwier M, Jenko KJ, Snow J, Morse C, Zoghbi SS, Pike VW, Innis RB, Kreisl WC.

Ann Clin Transl Neurol. 2019 Jul;6(7):1327-1331. doi: 10.1002/acn3.50802. Epub 2019 Jun 17.


Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors.

Lindberg A, Lu S, Nag S, Schou M, Liow JS, Zoghbi SS, Frankland MP, Gladding RL, Morse CL, Takano A, Amini N, Elmore CS, Lee YS, Innis RB, Halldin C, Pike VW.

Nucl Med Biol. 2019 Mar;70:1-13. doi: 10.1016/j.nucmedbio.2019.01.005. Epub 2019 Jan 26.


Automatic Extraction of a Reference Region for the Noninvasive Quantification of Translocator Protein in Brain Using 11C-PBR28.

Zanotti-Fregonara P, Kreisl WC, Innis RB, Lyoo CH.

J Nucl Med. 2019 Jul;60(7):978-984. doi: 10.2967/jnumed.118.222927. Epub 2019 Jan 17.


2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET-Synthesis, Triage, and Radiolabeling.

Cortes-Salva MY, Shrestha S, Singh P, Morse CL, Jenko KJ, Montero Santamaria JA, Zoghbi SS, Innis RB, Pike VW.

Molecules. 2018 Nov 2;23(11). pii: E2850. doi: 10.3390/molecules23112850.


[O-methyl-11C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([11C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey.

Liow JS, Morse CL, Lu S, Frankland M, Tye GL, Zoghbi SS, Gladding RL, Shaik AB, Innis RB, Newman AH, Pike VW.

Molecules. 2018 Oct 23;23(11). pii: E2737. doi: 10.3390/molecules23112737.


Evaluation of a PET Radioligand to Image O-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse.

Paul S, Haskali MB, Liow JS, Zoghbi SS, Barth VN, Kolodrubetz MC, Bond MR, Morse CL, Gladding RL, Frankland MP, Kant N, Slieker L, Shcherbinin S, Nuthall HN, Zanotti-Fregonara P, Hanover JA, Jesudason C, Pike VW, Innis RB.

J Nucl Med. 2019 Jan;60(1):129-134. doi: 10.2967/jnumed.118.213231. Epub 2018 Sep 13.


Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography.

Hirvonen J, Zanotti-Fregonara P, Gorelick DA, Lyoo CH, Rallis-Frutos D, Morse C, Zoghbi SS, Pike VW, Volkow ND, Huestis MA, Innis RB.

Biol Psychiatry. 2018 Nov 15;84(10):715-721. doi: 10.1016/j.biopsych.2018.07.009. Epub 2018 Jul 21.


The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.

Weidner LD, Kannan P, Mitsios N, Kang SJ, Hall MD, Theodore WH, Innis RB, Mulder J.

Epilepsia. 2018 Aug;59(8):1507-1517. doi: 10.1111/epi.14505. Epub 2018 Jul 21.


PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects.

Richards EM, Zanotti-Fregonara P, Fujita M, Newman L, Farmer C, Ballard ED, Machado-Vieira R, Yuan P, Niciu MJ, Lyoo CH, Henter ID, Salvadore G, Drevets WC, Kolb H, Innis RB, Zarate CA Jr.

EJNMMI Res. 2018 Jul 3;8(1):57. doi: 10.1186/s13550-018-0401-9.


Evaluation of Two Potent and Selective PET Radioligands to Image COX-1 and COX-2 in Rhesus Monkeys.

Kim MJ, Shrestha SS, Cortes M, Singh P, Morse C, Liow JS, Gladding RL, Brouwer C, Henry K, Gallagher E, Tye GL, Zoghbi SS, Fujita M, Pike VW, Innis RB.

J Nucl Med. 2018 Dec;59(12):1907-1912. doi: 10.2967/jnumed.118.211144. Epub 2018 Jun 29.


3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging.

Shrestha S, Singh P, Cortes-Salva MY, Jenko KJ, Ikawa M, Kim MJ, Kobayashi M, Morse CL, Gladding RL, Liow JS, Zoghbi SS, Fujita M, Innis RB, Pike VW.

ACS Chem Neurosci. 2018 Nov 21;9(11):2620-2627. doi: 10.1021/acschemneuro.8b00103. Epub 2018 Jun 13.


Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents.

Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, Park L, Liow JS, Pike V, Morse C, Vendruscolo LF, Innis RB, Koob GF, Tomasi D, Wang GJ, Volkow ND.

Neuropsychopharmacology. 2018 Aug;43(9):1832-1839. doi: 10.1038/s41386-018-0085-x. Epub 2018 May 3.


Building a database for brain 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects.

Paul S, Gallagher E, Liow JS, Mabins S, Henry K, Zoghbi SS, Gunn RN, Kreisl WC, Richards EM, Zanotti-Fregonara P, Morse CL, Hong J, Kowalski A, Pike VW, Innis RB, Fujita M.

J Cereb Blood Flow Metab. 2019 Jun;39(6):1138-1147. doi: 10.1177/0271678X18771250. Epub 2018 May 11.


3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology.

Singh P, Shrestha S, Cortes-Salva MY, Jenko KJ, Zoghbi SS, Morse CL, Innis RB, Pike VW.

ACS Chem Neurosci. 2018 Nov 21;9(11):2610-2619. doi: 10.1021/acschemneuro.8b00102. Epub 2018 Jun 13.


[11C](R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice.

Ooms M, Tsujikawa T, Lohith TG, Mabins SN, Zoghbi SS, Sumitomo A, Jaaro-Peled H, Kimura Y, Telu S, Pike VW, Tomoda T, Innis RB, Sawa A, Fujita M.

J Cereb Blood Flow Metab. 2019 Jul;39(7):1306-1313. doi: 10.1177/0271678X18758997. Epub 2018 Feb 12.


Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia.

Kreisl WC, Henter ID, Innis RB.

Adv Pharmacol. 2018;82:163-185. doi: 10.1016/bs.apha.2017.08.004. Epub 2017 Nov 10. Review.


[Carboxyl-11 C]Labelling of Four High-Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography.

Fisher MJ, McMurray L, Lu S, Morse CL, Liow JS, Zoghbi SS, Kowalski A, Tye GL, Innis RB, Aigbirhio FI, Pike VW.

ChemMedChem. 2018 Jan 22;13(2):138-146. doi: 10.1002/cmdc.201700697. Epub 2018 Jan 10.


Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.

Fujita M, Kobayashi M, Ikawa M, Gunn RN, Rabiner EA, Owen DR, Zoghbi SS, Haskali MB, Telu S, Pike VW, Innis RB.

EJNMMI Res. 2017 Oct 16;7(1):84. doi: 10.1186/s13550-017-0334-8.


11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-( R)-PK11195.

Kobayashi M, Jiang T, Telu S, Zoghbi SS, Gunn RN, Rabiner EA, Owen DR, Guo Q, Pike VW, Innis RB, Fujita M.

J Cereb Blood Flow Metab. 2018 Mar;38(3):393-403. doi: 10.1177/0271678X17699223. Epub 2017 Mar 21.


11C-PBR28 PET detects translocator protein in a patient with astrocytoma and Alzheimer disease.

Kreisl WC, Lawrence R, Page E, Teich AF, Subramaniam DS, Innis RB, Turner RS.

Neurology. 2017 Mar 7;88(10):1001-1004. doi: 10.1212/WNL.0000000000003693. Epub 2017 Feb 8. No abstract available.


Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease.

Kreisl WC, Lyoo CH, Liow JS, Snow J, Page E, Jenko KJ, Morse CL, Zoghbi SS, Pike VW, Turner RS, Innis RB.

Neurobiol Aging. 2017 Mar;51:132-140. doi: 10.1016/j.neurobiolaging.2016.12.006. Epub 2016 Dec 16.


Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia.

Schroeder FA, Gilbert TM, Feng N, Taillon BD, Volkow ND, Innis RB, Hooker JM, Lipska BK.

ACS Chem Neurosci. 2017 Mar 15;8(3):662-668. doi: 10.1021/acschemneuro.6b00372. Epub 2016 Dec 13.


11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain.

Ikawa M, Lohith TG, Shrestha S, Telu S, Zoghbi SS, Castellano S, Taliani S, Da Settimo F, Fujita M, Pike VW, Innis RB; Biomarkers Consortium Radioligand Project Team.

J Nucl Med. 2017 Feb;58(2):320-325. doi: 10.2967/jnumed.116.178996. Epub 2016 Nov 17.


cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.

Fujita M, Richards EM, Niciu MJ, Ionescu DF, Zoghbi SS, Hong J, Telu S, Hines CS, Pike VW, Zarate CA, Innis RB.

Mol Psychiatry. 2017 May;22(5):754-759. doi: 10.1038/mp.2016.171. Epub 2016 Oct 11.


Comparison of two PET radioligands, [11C]FPEB and [11C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain.

Lohith TG, Tsujikawa T, Siméon FG, Veronese M, Zoghbi SS, Lyoo CH, Kimura Y, Morse CL, Pike VW, Fujita M, Innis RB.

J Cereb Blood Flow Metab. 2017 Jul;37(7):2458-2470. doi: 10.1177/0271678X16668891. Epub 2016 Jan 1.


Translocator protein ligands based on N-methyl-(quinolin-4-yl)oxypropanamides with properties suitable for PET radioligand development.

Brouwer C, Jenko KJ, Zoghbi SS, Morse CL, Innis RB, Pike VW.

Eur J Med Chem. 2016 Nov 29;124:677-688. doi: 10.1016/j.ejmech.2016.08.046. Epub 2016 Aug 25.


The 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to α1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region.

Shrestha SS, Liow JS, Jenko K, Ikawa M, Zoghbi SS, Innis RB.

J Nucl Med. 2016 Dec;57(12):1945-1948. Epub 2016 Sep 1.


Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis.

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G.

JCI Insight. 2016 Jul 21;1(11). pii: 87336. doi: 10.1172/jci.insight.87336.


An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.

Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyás B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2062-2075. doi: 10.1177/0271678X16660984. Epub 2016 Jan 1.


(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease.

Kreisl WC, Lyoo CH, Liow JS, Wei M, Snow J, Page E, Jenko KJ, Morse CL, Zoghbi SS, Pike VW, Turner RS, Innis RB.

Neurobiol Aging. 2016 Aug;44:53-61. doi: 10.1016/j.neurobiolaging.2016.04.011. Epub 2016 Apr 27.


(18)F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier.

Liow JS, Zoghbi SS, Hu S, Hall MD, Hines CS, Shetty HU, Araneta MD, Page EM, Pike VW, Kreisl WC, Herscovitch P, Gottesman MM, Theodore WH, Innis RB.

Neuroimage. 2016 Sep;138:134-140. doi: 10.1016/j.neuroimage.2016.05.045. Epub 2016 May 19.


Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot.

Veronese M, Zanotti-Fregonara P, Rizzo G, Bertoldo A, Innis RB, Turkheimer FE.

Neuroimage. 2016 Apr 15;130:1-12. doi: 10.1016/j.neuroimage.2016.01.058. Epub 2016 Feb 2.


Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.

Weidner LD, Fung KL, Kannan P, Moen JK, Kumar JS, Mulder J, Innis RB, Gottesman MM, Hall MD.

Drug Metab Dispos. 2016 Feb;44(2):275-82. doi: 10.1124/dmd.115.067785. Epub 2015 Dec 10.


The PET Radioligand 18F-FIMX Images and Quantifies Metabotropic Glutamate Receptor 1 in Proportion to the Regional Density of Its Gene Transcript in Human Brain.

Zanotti-Fregonara P, Xu R, Zoghbi SS, Liow JS, Fujita M, Veronese M, Gladding RL, Rallis-Frutos D, Hong J, Pike VW, Innis RB.

J Nucl Med. 2016 Feb;57(2):242-7. doi: 10.2967/jnumed.115.162461. Epub 2015 Oct 29.


[carbonyl-11C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([11C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain.

Hong J, Lu S, Xu R, Liow JS, Woock AE, Jenko KJ, Gladding RL, Zoghbi SS, Innis RB, Pike VW.

Nucl Med Biol. 2015 Dec;42(12):967-74. doi: 10.1016/j.nucmedbio.2015.07.006. Epub 2015 Jul 23.


The Inhibitor Ko143 Is Not Specific for ABCG2.

Weidner LD, Zoghbi SS, Lu S, Shukla S, Ambudkar SV, Pike VW, Mulder J, Gottesman MM, Innis RB, Hall MD.

J Pharmacol Exp Ther. 2015 Sep;354(3):384-93. doi: 10.1124/jpet.115.225482. Epub 2015 Jul 6.


Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein.

Gershen LD, Zanotti-Fregonara P, Dustin IH, Liow JS, Hirvonen J, Kreisl WC, Jenko KJ, Inati SK, Fujita M, Morse CL, Brouwer C, Hong JS, Pike VW, Zoghbi SS, Innis RB, Theodore WH.

JAMA Neurol. 2015 Aug;72(8):882-8. doi: 10.1001/jamaneurol.2015.0941. Erratum in: JAMA Neurol. 2015 Aug;72(8):950.


Cerebellum Can Serve As a Pseudo-Reference Region in Alzheimer Disease to Detect Neuroinflammation Measured with PET Radioligand Binding to Translocator Protein.

Lyoo CH, Ikawa M, Liow JS, Zoghbi SS, Morse CL, Pike VW, Fujita M, Innis RB, Kreisl WC.

J Nucl Med. 2015 May;56(5):701-6. doi: 10.2967/jnumed.114.146027. Epub 2015 Mar 12.


Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.

Kreisl WC, Bhatia R, Morse CL, Woock AE, Zoghbi SS, Shetty HU, Pike VW, Innis RB.

J Nucl Med. 2015 Jan;56(1):82-7. doi: 10.2967/jnumed.114.146894. Epub 2014 Dec 11.


Application of calibrated image-derived input function to a clinical protocol.

Zanotti-Fregonara P, Lyoo CH, Bar-Hen A, Liow JS, Zoghbi SS, Fujita M, Innis RB.

Nucl Med Commun. 2014 Nov;35(11):1188-9. doi: 10.1097/MNM.0000000000000184. No abstract available.


Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971.

Zanotti-Fregonara P, Zhang Y, Jenko KJ, Gladding RL, Zoghbi SS, Fujita M, Sbardella G, Castellano S, Taliani S, Martini C, Innis RB, Da Settimo F, Pike VW.

ACS Chem Neurosci. 2014 Oct 15;5(10):963-71. doi: 10.1021/cn500138n. Epub 2014 Aug 25.


Evaluation in monkey of two candidate PET radioligands, [11 C]RX-1 and [18 F]RX-2, for imaging brain 5-HT4 receptors.

Lohith TG, Xu R, Tsujikawa T, Morse CL, Anderson KB, Gladding RL, Zoghbi SS, Fujita M, Innis RB, Pike VW.

Synapse. 2014 Dec;68(12):613-623. doi: 10.1002/syn.21773. Epub 2014 Aug 11.


Development of N-methyl-(2-arylquinolin-4-yl)oxypropanamides as leads to PET radioligands for translocator protein (18 kDa).

Brouwer C, Jenko K, Zoghbi SS, Innis RB, Pike VW.

J Med Chem. 2014 Jul 24;57(14):6240-51. doi: 10.1021/jm5007947. Epub 2014 Jul 1.


Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.

Lodge NJ, Li YW, Chin FT, Dischino DD, Zoghbi SS, Deskus JA, Mattson RJ, Imaizumi M, Pieschl R, Molski TF, Fujita M, Dulac H, Zaczek R, Bronson JJ, Macor JE, Innis RB, Pike VW.

Nucl Med Biol. 2014 Jul;41(6):524-35. doi: 10.1016/j.nucmedbio.2014.03.005. Epub 2014 Mar 29.


Image-derived input function derived from a supervised clustering algorithm: methodology and validation in a clinical protocol using [11C](R)-rolipram.

Lyoo CH, Zanotti-Fregonara P, Zoghbi SS, Liow JS, Xu R, Pike VW, Zarate CA Jr, Fujita M, Innis RB.

PLoS One. 2014 Feb 20;9(2):e89101. doi: 10.1371/journal.pone.0089101. eCollection 2014.


Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior.

Shrestha SS, Nelson EE, Liow JS, Gladding R, Lyoo CH, Noble PL, Morse C, Henter ID, Kruger J, Zhang B, Suomi SJ, Svenningsson P, Pike VW, Winslow JT, Leibenluft E, Pine DS, Innis RB.

Am J Psychiatry. 2014 Mar;171(3):323-31. doi: 10.1176/appi.ajp.2013.13020183.


(11)C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α(1) adrenoceptors in brain.

Shrestha SS, Liow JS, Lu S, Jenko K, Gladding RL, Svenningsson P, Morse CL, Zoghbi SS, Pike VW, Innis RB.

J Nucl Med. 2014 Jan;55(1):141-6. doi: 10.2967/jnumed.113.125831.


Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model.

Shrestha SS, Pine DS, Luckenbaugh DA, Varnäs K, Henter ID, Innis RB, Mathé AA, Svenningsson P.

Neurosci Lett. 2014 Jan 24;559:163-8. doi: 10.1016/j.neulet.2013.11.034. Epub 2013 Nov 25.


Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans.

Lohith TG, Zoghbi SS, Morse CL, Araneta MD, Barth VN, Goebl NA, Tauscher JT, Pike VW, Innis RB, Fujita M.

Neuroimage. 2014 Feb 15;87:89-95. doi: 10.1016/j.neuroimage.2013.10.068. Epub 2013 Nov 10.

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