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Items: 24


p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.

Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA.

J Clin Invest. 2019 Oct 7. pii: 128626. doi: 10.1172/JCI128626. [Epub ahead of print]


Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.

Ajayi TA, Innes CL, Grimm SA, Rai P, Finethy R, Coers J, Wang X, Bell DA, McGrath JA, Schurman SH, Fessler MB.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G95-G105. doi: 10.1152/ajpgi.00196.2018. Epub 2018 Oct 18.


Toll-like Receptor 4 Pathway Polymorphisms Interact with Pollution to Influence Asthma Diagnosis and Severity.

Schurman SH, Bravo MA, Innes CL, Jackson WB 2nd, McGrath JA, Miranda ML, Garantziotis S.

Sci Rep. 2018 Aug 23;8(1):12713. doi: 10.1038/s41598-018-30865-0.


A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.

Morales AJ, Carrero JA, Hung PJ, Tubbs AT, Andrews JM, Edelson BT, Calderon B, Innes CL, Paules RS, Payton JE, Sleckman BP.

Elife. 2017 Mar 31;6. pii: e24655. doi: 10.7554/eLife.24655.


Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.

Cui Y, Palii SS, Innes CL, Paules RS.

Cell Cycle. 2014;13(22):3541-50. doi: 10.4161/15384101.2014.960729.


Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.

Zhang L, Simpson DA, Innes CL, Chou J, Bushel PR, Paules RS, Kaufmann WK, Zhou T.

Physiol Genomics. 2013 Oct 1;45(19):907-16. doi: 10.1152/physiolgenomics.00064.2013. Epub 2013 Aug 13.


Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells.

Hesse JE, Liu L, Innes CL, Cui Y, Palii SS, Paules RS.

PLoS One. 2013 May 31;8(5):e64779. doi: 10.1371/journal.pone.0064779. Print 2013.


DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs.

Innes CL, Hesse JE, Palii SS, Helmink BA, Holub AJ, Sleckman BP, Paules RS.

BMC Genomics. 2013 Mar 12;14:163. doi: 10.1186/1471-2164-14-163.


Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit.

Palii SS, Cui Y, Innes CL, Paules RS.

Cell Cycle. 2013 Apr 1;12(7):1105-18. doi: 10.4161/cc.24127. Epub 2013 Mar 5.


DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes.

Bredemeyer AL, Helmink BA, Innes CL, Calderon B, McGinnis LM, Mahowald GK, Gapud EJ, Walker LM, Collins JB, Weaver BK, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP.

Nature. 2008 Dec 11;456(7223):819-23. doi: 10.1038/nature07392. Epub 2008 Oct 12.


DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.

Arlander SJ, Greene BT, Innes CL, Paules RS.

Cancer Res. 2008 Jan 1;68(1):89-97. doi: 10.1158/0008-5472.CAN-07-0675.


ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts.

Innes CL, Heinloth AN, Flores KG, Sieber SO, Deming PB, Bushel PR, Kaufmann WK, Paules RS.

Mol Cancer Res. 2006 Mar;4(3):197-207.


ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.

Heinloth AN, Shackelford RE, Innes CL, Bennett L, Li L, Amin RP, Sieber SO, Flores KG, Bushel PR, Paules RS.

Radiat Res. 2003 Sep;160(3):273-90.


Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation.

Heinloth AN, Shackelford RE, Innes CL, Bennett L, Li L, Amin RP, Sieber SO, Flores KG, Bushel PR, Paules RS.

Mol Carcinog. 2003 Jun;37(2):65-82.


The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts.

Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS.

J Biol Chem. 2001 Jun 15;276(24):21951-9. Epub 2001 Apr 4.


Serum starved v-mos-transformed cells are unable to appropriately downregulate cyclins and CDKs.

Rhodes N, Innes CL, Propst F, Paules RS.

Oncogene. 1997 Jun 26;14(25):3017-27.


Defective G2 checkpoint function in cells from individuals with familial cancer syndromes.

Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK.

Cancer Res. 1995 Apr 15;55(8):1763-73.


v-mos-transformed cells fail to enter quiescence but growth arrest in G1 following serum withdrawal.

Rhodes N, Hicks R, Kasenally AB, Innes CL, Paules RS, Propst F.

Exp Cell Res. 1994 Jul;213(1):210-7.


Analysis of Fv-1 restriction in two murine embryonal carcinoma cell lines and a series of differentiated derivatives.

Heitman CK, Innes CL, Jetten AM, Boone LR.

J Gen Virol. 1991 Mar;72 ( Pt 3):609-16.


Cationic liposomes (Lipofectin) mediate retroviral infection in the absence of specific receptors.

Innes CL, Smith PB, Langenbach R, Tindall KR, Boone LR.

J Virol. 1990 Feb;64(2):957-61.


Fv-1 N- and B-tropism-specific sequences in murine leukemia virus and related endogenous proviral genomes.

Boone LR, Glover PL, Innes CL, Niver LA, Bondurant MC, Yang WK.

J Virol. 1988 Aug;62(8):2644-50.


Hematopoietic neoplasias of the RFM/Un mouse contain somatic re-integration of the restriction endogenous ecotropic provirus.

Boone LR, Boone GS, Innes CL, Yang WK, Tennant RW.

Carcinogenesis. 1986 Apr;7(4):529-34.


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