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Items: 1 to 50 of 175

1.

Decreased ATP production and myocardial contractile reserve in metabolic heart disease.

Luptak I, Sverdlov AL, Panagia M, Qin F, Pimentel DR, Croteau D, Siwik DA, Ingwall JS, Bachschmid MM, Balschi JA, Colucci WS.

J Mol Cell Cardiol. 2018 Mar;116:106-114. doi: 10.1016/j.yjmcc.2018.01.017. Epub 2018 Feb 1.

2.

The energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathy.

Ingwall JS.

Cardiovasc Res. 2014 Jul 15;103(2):192-3. doi: 10.1093/cvr/cvu145. Epub 2014 Jun 15. Review. No abstract available.

PMID:
24935429
3.

Creatine--a dispensable metabolite?

Taegtmeyer H, Ingwall JS.

Circ Res. 2013 Mar 15;112(6):878-80. doi: 10.1161/CIRCRESAHA.113.300974. No abstract available.

4.

Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heart.

Grossman AN, Opie LH, Beshansky JR, Ingwall JS, Rackley CE, Selker HP.

Circulation. 2013 Mar 5;127(9):1040-8. doi: 10.1161/CIRCULATIONAHA.112.130625. Review. No abstract available.

PMID:
23459576
5.

Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific.

He H, Hoyer K, Tao H, Rice R, Jimenez J, Tardiff JC, Ingwall JS.

J Physiol. 2012 Nov 1;590(21):5371-88. doi: 10.1113/jphysiol.2012.234252. Epub 2012 Aug 20.

6.

Study design for the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care (IMMEDIATE) Trial: A double-blind randomized controlled trial of intravenous glucose, insulin, and potassium for acute coronary syndromes in emergency medical services.

Selker HP, Beshansky JR, Griffith JL, D'Agostino RB, Massaro JM, Udelson JE, Rashba EJ, Ruthazer R, Sheehan PR, Desvigne-Nickens P, Rosenberg YD, Atkins JM, Sayah AJ, Aufderheide TP, Rackley CE, Opie LH, Lambrew CT, Cobb LA, Macleod BA, Ingwall JS, Zalenski RJ, Apstein CS.

Am Heart J. 2012 Mar;163(3):315-22. doi: 10.1016/j.ahj.2012.02.002.

7.

Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency.

Dzeja PP, Hoyer K, Tian R, Zhang S, Nemutlu E, Spindler M, Ingwall JS.

J Physiol. 2011 Nov 1;589(Pt 21):5193-211. doi: 10.1113/jphysiol.2011.212829. Epub 2011 Aug 30.

8.

An improved isolation procedure for adult mouse cardiomyocytes.

Pinz I, Zhu M, Mende U, Ingwall JS.

Cell Biochem Biophys. 2011 Sep;61(1):93-101. doi: 10.1007/s12013-011-9165-9.

9.

Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.

Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC.

J Pharmacol Exp Ther. 2011 May;337(2):513-23. doi: 10.1124/jpet.110.176776. Epub 2011 Feb 16.

PMID:
21325441
10.

Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a.

Pinz I, Tian R, Belke D, Swanson E, Dillmann W, Ingwall JS.

J Biol Chem. 2011 Mar 25;286(12):10163-8. doi: 10.1074/jbc.M110.210757. Epub 2011 Jan 29.

11.

On energy circuits in the failing myocardium.

Ingwall JS, Shen W.

Eur J Heart Fail. 2010 Dec;12(12):1268-70. doi: 10.1093/eurjhf/hfq193. No abstract available.

12.

Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts.

Rice R, Guinto P, Dowell-Martino C, He H, Hoyer K, Krenz M, Robbins J, Ingwall JS, Tardiff JC.

J Mol Cell Cardiol. 2010 May;48(5):979-88. doi: 10.1016/j.yjmcc.2009.11.018. Epub 2009 Dec 31.

13.

Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.

Shen W, Vatner DE, Vatner SF, Ingwall JS.

J Mol Cell Cardiol. 2010 Apr;48(4):591-9. doi: 10.1016/j.yjmcc.2009.10.029. Epub 2009 Nov 11.

14.

On the control of metabolic remodeling in mitochondria of the failing heart.

Ingwall JS.

Circ Heart Fail. 2009 Jul;2(4):275-7. doi: 10.1161/CIRCHEARTFAILURE.109.885301. No abstract available.

PMID:
19808349
15.

Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction.

Gnecchi M, He H, Melo LG, Noiseaux N, Morello F, de Boer RA, Zhang L, Pratt RE, Dzau VJ, Ingwall JS.

Stem Cells. 2009 Apr;27(4):971-9. doi: 10.1002/stem.12.

16.

Energy metabolism in heart failure and remodelling.

Ingwall JS.

Cardiovasc Res. 2009 Feb 15;81(3):412-9. doi: 10.1093/cvr/cvn301. Epub 2008 Nov 5. Review.

17.

Creatine kinase inhibitor iodoacetamide antagonizes calcium-stimulated inotropy in cardiomyocytes.

Ren J, Davidoff AJ, Ingwall JS.

Clin Exp Pharmacol Physiol. 2009 Feb;36(2):141-5. doi: 10.1111/j.1440-1681.2008.05034.x. Epub 2008 Aug 29.

PMID:
18761665
18.

Low over-expression of TNFalpha in the mouse heart increases contractile performance via TNFR1.

Pinz I, Wax SD, Anderson P, Ingwall JS.

J Cell Biochem. 2008 Sep 1;105(1):99-107. doi: 10.1002/jcb.21798.

PMID:
18452158
19.

How does folic acid cure heart attacks?

Tian R, Ingwall JS.

Circulation. 2008 Apr 8;117(14):1772-4. doi: 10.1161/CIRCULATIONAHA.108.766105. No abstract available.

PMID:
18391119
20.

Calcineurin-induced energy wasting in a transgenic mouse model of heart failure.

Pinz I, Ostroy SE, Hoyer K, Osinska H, Robbins J, Molkentin JD, Ingwall JS.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1459-66. doi: 10.1152/ajpheart.00911.2007. Epub 2008 Jan 11.

21.

On substrate selection for ATP synthesis in the failing human myocardium.

Ingwall JS.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3225-6. Epub 2007 Oct 5. No abstract available.

22.

Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts.

Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS.

FASEB J. 2008 Jan;22(1):84-92. Epub 2007 Sep 10.

PMID:
17846079
23.

R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts.

He H, Javadpour MM, Latif F, Tardiff JC, Ingwall JS.

Biophys J. 2007 Sep 1;93(5):1834-44. Epub 2007 May 25.

24.

Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.

Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, Tian R.

J Clin Invest. 2007 May;117(5):1432-9. Epub 2007 Apr 12.

25.
26.

Energetics of the failing heart: new insights using genetic modification in the mouse.

Ingwall JS.

Arch Mal Coeur Vaiss. 2006 Sep;99(9):839-47. Review.

PMID:
17067106
27.

Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency.

Hoyer K, Krenz M, Robbins J, Ingwall JS.

J Mol Cell Cardiol. 2007 Jan;42(1):214-21. Epub 2006 Oct 19.

28.

Energetics of the Na(+) pump in the heart.

Ingwall JS, Balschi JA.

J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S127-S133. Review.

PMID:
16686667
29.

Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement.

Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ.

FASEB J. 2006 Apr;20(6):661-9.

PMID:
16581974
30.

Histidine button engineered into cardiac troponin I protects the ischemic and failing heart.

Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM.

Nat Med. 2006 Feb;12(2):181-9. Epub 2006 Jan 22.

PMID:
16429145
31.

Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice.

Ertz-Berger BR, He H, Dowell C, Factor SM, Haim TE, Nunez S, Schwartz SD, Ingwall JS, Tardiff JC.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18219-24. Epub 2005 Dec 2.

32.

Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.

Ahmad F, Arad M, Musi N, He H, Wolf C, Branco D, Perez-Atayde AR, Stapleton D, Bali D, Xing Y, Tian R, Goodyear LJ, Berul CI, Ingwall JS, Seidman CE, Seidman JG.

Circulation. 2005 Nov 15;112(20):3140-8. Epub 2005 Nov 7.

PMID:
16275868
33.

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM.

Cell Metab. 2005 Apr;1(4):259-71.

34.

N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity.

Zou L, Shen M, Arad M, He H, Løfgren B, Ingwall JS, Seidman CE, Seidman JG, Tian R.

Circ Res. 2005 Aug 19;97(4):323-8. Epub 2005 Jul 28.

PMID:
16051890
35.

The fall in creatine levels and creatine kinase isozyme changes in the failing heart are reversible: complex post-transcriptional regulation of the components of the CK system.

Shen W, Spindler M, Higgins MA, Jin N, Gill RM, Bloem LJ, Ryan TP, Ingwall JS.

J Mol Cell Cardiol. 2005 Sep;39(3):537-44.

PMID:
15978613
36.

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.

Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, Noiseux N, Zhang L, Pratt RE, Ingwall JS, Dzau VJ.

Nat Med. 2005 Apr;11(4):367-8. No abstract available.

PMID:
15812508
37.

Mechanisms for increased glycolysis in the hypertrophied rat heart.

Nascimben L, Ingwall JS, Lorell BH, Pinz I, Schultz V, Tornheim K, Tian R.

Hypertension. 2004 Nov;44(5):662-7. Epub 2004 Oct 4.

PMID:
15466668
38.

Transgenesis and cardiac energetics: new insights into cardiac metabolism.

Ingwall JS.

J Mol Cell Cardiol. 2004 Sep;37(3):613-23. Review.

PMID:
15350834
39.

Is the failing heart energy starved? On using chemical energy to support cardiac function.

Ingwall JS, Weiss RG.

Circ Res. 2004 Jul 23;95(2):135-45. Review.

PMID:
15271865
40.

Do the FHC-associated R403 mutations in myosin heavy chain lead to a greater energetic cost of contraction?

Ingwall JS.

J Mol Cell Cardiol. 2004 Mar;36(3):327-30. No abstract available.

PMID:
15010270
41.

Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T.

Javadpour MM, Tardiff JC, Pinz I, Ingwall JS.

J Clin Invest. 2003 Sep;112(5):768-75.

42.

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.

Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ.

Nat Med. 2003 Sep;9(9):1195-201. Epub 2003 Aug 10.

43.
44.

Is creatine kinase a target for AMP-activated protein kinase in the heart?

Ingwall JS.

J Mol Cell Cardiol. 2002 Sep;34(9):1111-20.

PMID:
12392883
45.
46.

Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.

Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, Dzau VJ, Lee ME, Perrella MA.

Circ Res. 2001 Jul 20;89(2):168-73.

PMID:
11463724
47.

Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts.

Shen W, Tian R, Saupe KW, Spindler M, Ingwall JS.

Am J Physiol Heart Circ Physiol. 2001 Aug;281(2):H838-46.

48.

Metabolic support as an adjunct to inotropic support in the hypoperfused heart.

Saupe KW, Eberli FR, Ingwall JS, Apstein CS.

J Mol Cell Cardiol. 2001 Feb;33(2):261-9.

PMID:
11162131
49.

Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.

Pachucki J, Hopkins J, Peeters R, Tu H, Carvalho SD, Kaulbach H, Abel ED, Wondisford FE, Ingwall JS, Larsen PR.

Endocrinology. 2001 Jan;142(1):13-20.

PMID:
11145561
50.

Phenotypical features of long Q-T syndrome in transgenic mice expressing human Na-K-ATPase alpha(3)-isoform in hearts.

O'Brien SE, Apkon M, Berul CI, Patel HT, Saupe K, Spindler M, Ingwall JS, Zahler R.

Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2133-42.

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