Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 137

1.

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.

Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA.

Nat Commun. 2019 Jan 11;10(1):163. doi: 10.1038/s41467-018-08046-4.

2.

LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival.

Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA.

Nat Commun. 2018 Oct 10;9(1):4055. doi: 10.1038/s41467-018-06137-w.

3.

Vision Outcomes Following Anti-Vascular Endothelial Growth Factor Treatment of Diabetic Macular Edema in Clinical Practice.

Holekamp NM, Campbell J, Almony A, Ingraham H, Marks S, Chandwani H, Cole AL, Kiss S.

Am J Ophthalmol. 2018 Jul;191:83-91. doi: 10.1016/j.ajo.2018.04.010. Epub 2018 Apr 21. Erratum in: Am J Ophthalmol. 2018 Oct;194:192.

4.

LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA.

JCI Insight. 2018 Mar 8;3(5). pii: 96151. doi: 10.1172/jci.insight.96151.

5.

Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior.

Krause WC, Ingraham HA.

Adv Exp Med Biol. 2017;1043:199-213. doi: 10.1007/978-3-319-70178-3_10. Review.

6.

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

Xing Y, Morohashi KI, Ingraham HA, Hammer GD.

Development. 2017 Oct 15;144(20):3798-3807. doi: 10.1242/dev.150516. Epub 2017 Sep 11.

7.

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D.

Cell. 2017 Jun 29;170(1):185-198.e16. doi: 10.1016/j.cell.2017.05.034. Epub 2017 Jun 22.

8.

Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α.

Conde K, Fabelo C, Krause WC, Propst R, Goethel J, Fischer D, Hur J, Meza C, Ingraham HA, Wagner EJ.

Neuroendocrinology. 2017;105(4):341-356. doi: 10.1159/000453370. Epub 2016 Nov 21.

9.

Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2).

de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM.

PLoS One. 2016 Jul 28;11(7):e0159316. doi: 10.1371/journal.pone.0159316. eCollection 2016.

10.

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.

Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA.

Elife. 2015 Dec 11;4. pii: e09003. doi: 10.7554/eLife.09003.

11.

Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output.

Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA.

Mol Metab. 2015 Sep 11;4(11):857-66. doi: 10.1016/j.molmet.2015.09.001. eCollection 2015 Nov.

12.

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.

Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ.

J Struct Biol. 2015 Dec;192(3):342-348. doi: 10.1016/j.jsb.2015.09.012. Epub 2015 Sep 28.

13.

An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.

Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA.

Cell Rep. 2015 Jan 6;10(1):62-74. doi: 10.1016/j.celrep.2014.12.011. Epub 2014 Dec 24.

14.

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.

Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15054-9. doi: 10.1073/pnas.1416740111. Epub 2014 Oct 6.

16.

Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

Blind RD, Suzawa M, Ingraham HA.

Sci Signal. 2012 Jun 19;5(229):ra44. doi: 10.1126/scisignal.2003111.

17.

An affective disorder in zebrafish with mutation of the glucocorticoid receptor.

Ziv L, Muto A, Schoonheim PJ, Meijsing SH, Strasser D, Ingraham HA, Schaaf MJ, Yamamoto KR, Baier H.

Mol Psychiatry. 2013 Jun;18(6):681-91. doi: 10.1038/mp.2012.64. Epub 2012 May 29.

18.

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA.

Dev Cell. 2011 Aug 16;21(2):315-27. doi: 10.1016/j.devcel.2011.06.028. Epub 2011 Aug 4.

19.

Metabolism: A lipid for fat disorders.

Ingraham HA.

Nature. 2011 Jun 22;474(7352):455-6. doi: 10.1038/474455a. No abstract available.

PMID:
21697939
20.

Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes.

Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, McCoy KA, Muñoz-de-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa M, Tavera-Mendoza LE, Trudeau VL, Victor-Costa AB, Willingham E.

J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):64-73. doi: 10.1016/j.jsbmb.2011.03.015. Epub 2011 Mar 23. Review.

21.

Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).

Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA.

J Med Chem. 2011 Apr 14;54(7):2266-81. doi: 10.1021/jm1014296. Epub 2011 Mar 10.

22.

Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation.

Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T.

J Neurosci. 2010 Nov 10;30(45):14925-30. doi: 10.1523/JNEUROSCI.4499-10.2010. Review.

23.

Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.

Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K.

Cell Metab. 2010 Oct 6;12(4):398-410. doi: 10.1016/j.cmet.2010.08.013.

24.

Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.

Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA.

Cancer Res. 2009 Jul 1;69(13):5415-23. doi: 10.1158/0008-5472.CAN-08-1622. Epub 2009 Jun 23.

25.

Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.

Kurrasch DM, Nevin LM, Wong JS, Baier H, Ingraham HA.

Neural Dev. 2009 Jun 23;4:22. doi: 10.1186/1749-8104-4-22.

26.

The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.

Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. doi: 10.1073/pnas.0808936105. Epub 2008 Nov 17.

27.

Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.

Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA.

Mol Endocrinol. 2009 Jan;23(1):25-34. doi: 10.1210/me.2007-0508. Epub 2008 Nov 6.

28.

Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1).

Campbell LA, Faivre EJ, Show MD, Ingraham JG, Flinders J, Gross JD, Ingraham HA.

Mol Cell Biol. 2008 Dec;28(24):7476-86. doi: 10.1128/MCB.00103-08. Epub 2008 Oct 6.

29.
30.

The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.

Kurrasch DM, Cheung CC, Lee FY, Tran PV, Hata K, Ingraham HA.

J Neurosci. 2007 Dec 12;27(50):13624-34.

31.

International Union of Pharmacology. LXVI. Orphan nuclear receptors.

Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V.

Pharmacol Rev. 2006 Dec;58(4):798-836. Review.

PMID:
17132856
32.

Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.

Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA.

J Comp Neurol. 2006 Oct 10;498(5):637-48.

PMID:
16917842
33.

Orphan nuclear receptors adopted by crystallography.

Ingraham HA, Redinbo MR.

Curr Opin Struct Biol. 2005 Dec;15(6):708-15. Epub 2005 Nov 2. Review.

PMID:
16263271
34.

The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.

Lee MB, Lebedeva LA, Suzawa M, Wadekar SA, Desclozeaux M, Ingraham HA.

Mol Cell Biol. 2005 Mar;25(5):1879-90.

35.

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA.

Cell. 2005 Feb 11;120(3):343-55.

36.

Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function.

Bland ML, Fowkes RC, Ingraham HA.

Mol Endocrinol. 2004 Apr;18(4):941-52. Epub 2004 Jan 15.

PMID:
14726490
37.

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy.

Jordan BK, Shen JH, Olaso R, Ingraham HA, Vilain E.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10866-71. Epub 2003 Aug 29.

38.
39.

Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.

Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA.

Mol Cell. 2003 Jun;11(6):1575-85.

40.

Tissue growth and remodeling of the embryonic and adult adrenal gland.

Bland ML, Desclozeaux M, Ingraham HA.

Ann N Y Acad Sci. 2003 May;995:59-72. Review.

PMID:
12814939
41.

Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons.

Tran PV, Lee MB, Marín O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA.

Mol Cell Neurosci. 2003 Apr;22(4):441-53.

42.

Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.

Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ.

Mol Endocrinol. 2003 Jan;17(1):107-16.

PMID:
12511610
43.

Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.

Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA.

Mol Cell Biol. 2002 Oct;22(20):7193-203.

44.

Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development.

Roberts LM, Visser JA, Ingraham HA.

Development. 2002 Mar;129(6):1487-96.

45.

Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins.

Shen JH, Ingraham HA.

Mol Endocrinol. 2002 Mar;16(3):529-40.

PMID:
11875113
46.

Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary.

Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, Uilenbroek JT, Grootegoed JA, Themmen AP.

Endocrinology. 2002 Mar;143(3):1076-84.

PMID:
11861535
47.

The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling.

Visser JA, Olaso R, Verhoef-Post M, Kramer P, Themmen AP, Ingraham HA.

Mol Endocrinol. 2001 Jun;15(6):936-45.

PMID:
11376112
48.

Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress.

Bland ML, Jamieson C, Akana S, Dallman M, Ingraham HA.

Endocr Res. 2000 Nov;26(4):515-6. No abstract available.

PMID:
11196422
49.

Müllerian inhibitory substance induces growth of rat preantral ovarian follicles.

McGee EA, Smith R, Spears N, Nachtigal MW, Ingraham H, Hsueh AJ.

Biol Reprod. 2001 Jan;64(1):293-8.

PMID:
11133686
50.

Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response.

Bland ML, Jamieson CA, Akana SF, Bornstein SR, Eisenhofer G, Dallman MF, Ingraham HA.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14488-93.

Supplemental Content

Loading ...
Support Center