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Items: 1 to 50 of 56

1.

MYC-driven small cell lung cancer is metabolically distinct and vulnerable to arginine depletion.

Chalishazar MD, Wait SJ, Huang F, Ireland AS, Mukhopadhyay A, Lee Y, Schuman S, Guthrie MR, Berrett K, Vahrenkamp J, Hu Z, Kudla M, Modzelewska K, Wang G, Ingolia NT, Gertz J, Lum DH, Cosulich SC, Bomalaski JS, DeBerardinis RJ, Oliver TG.

Clin Cancer Res. 2019 Jun 4. pii: clincanres.4140.2018. doi: 10.1158/1078-0432.CCR-18-4140. [Epub ahead of print]

PMID:
31164374
2.

An Accessible Continuous-Culture Turbidostat for Pooled Analysis of Complex Libraries.

McGeachy AM, Meacham ZA, Ingolia NT.

ACS Synth Biol. 2019 Apr 19;8(4):844-856. doi: 10.1021/acssynbio.8b00529. Epub 2019 Apr 2.

PMID:
30908907
3.

A methodology for discovering novel brain-relevant peptides: Combination of ribosome profiling and peptidomics.

Tharakan R, Kreimer S, Ubaida-Mohien C, Lavoie J, Olexiouk V, Menschaert G, Ingolia NT, Cole RN, Ishizuka K, Sawa A, Nucifora LG.

Neurosci Res. 2019 Mar 9. pii: S0168-0102(18)30722-3. doi: 10.1016/j.neures.2019.02.006. [Epub ahead of print]

PMID:
30862443
4.

Ribosomal protein RPL26 is the principal target of UFMylation.

Walczak CP, Leto DE, Zhang L, Riepe C, Muller RY, DaRosa PA, Ingolia NT, Elias JE, Kopito RR.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1299-1308. doi: 10.1073/pnas.1816202116. Epub 2019 Jan 9.

PMID:
30626644
5.

The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.

Iwasaki S, Iwasaki W, Takahashi M, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T, Ingolia NT.

Mol Cell. 2019 Feb 21;73(4):738-748.e9. doi: 10.1016/j.molcel.2018.11.026. Epub 2018 Dec 27.

PMID:
30595437
6.

Ribosome Profiling: Global Views of Translation.

Ingolia NT, Hussmann JA, Weissman JS.

Cold Spring Harb Perspect Biol. 2019 May 1;11(5). pii: a032698. doi: 10.1101/cshperspect.a032698. Review.

PMID:
30037969
7.

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T.

Nat Commun. 2017 Jul 31;8(1):159. doi: 10.1038/s41467-017-00188-1.

8.

Tracking the Missing Footprints of Idle Ribosomes.

Ingolia NT.

Cell Syst. 2017 Jun 28;4(6):583-584. doi: 10.1016/j.cels.2017.06.008.

9.

Transcriptome-wide measurement of translation by ribosome profiling.

McGlincy NJ, Ingolia NT.

Methods. 2017 Aug 15;126:112-129. doi: 10.1016/j.ymeth.2017.05.028. Epub 2017 Jun 1.

10.

The Growing Toolbox for Protein Synthesis Studies.

Iwasaki S, Ingolia NT.

Trends Biochem Sci. 2017 Aug;42(8):612-624. doi: 10.1016/j.tibs.2017.05.004. Epub 2017 May 28. Review.

11.
12.

Slowed decay of mRNAs enhances platelet specific translation.

Mills EW, Green R, Ingolia NT.

Blood. 2017 Apr 27;129(17):e38-e48. doi: 10.1182/blood-2016-08-736108. Epub 2017 Feb 17.

13.

Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes.

Ishikawa K, Makanae K, Iwasaki S, Ingolia NT, Moriya H.

PLoS Genet. 2017 Jan 25;13(1):e1006554. doi: 10.1371/journal.pgen.1006554. eCollection 2017 Jan.

14.

Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets.

Mills EW, Wangen J, Green R, Ingolia NT.

Cell Rep. 2016 Sep 27;17(1):1-10. doi: 10.1016/j.celrep.2016.08.088.

15.

eIF4B stimulates translation of long mRNAs with structured 5' UTRs and low closed-loop potential but weak dependence on eIF4G.

Sen ND, Zhou F, Harris MS, Ingolia NT, Hinnebusch AG.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10464-72. doi: 10.1073/pnas.1612398113. Epub 2016 Sep 6.

16.

PROTEIN TRANSLATION. Seeing translation.

Iwasaki S, Ingolia NT.

Science. 2016 Jun 17;352(6292):1391-2. doi: 10.1126/science.aag1039. No abstract available.

PMID:
27313023
17.

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.

Iwasaki S, Floor SN, Ingolia NT.

Nature. 2016 Jun 23;534(7608):558-61. doi: 10.1038/nature17978. Epub 2016 Jun 15.

18.

Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.

Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M.

Cell Syst. 2015 Sep 23;1(3):224-37. doi: 10.1016/j.cels.2015.08.012. Epub 2015 Sep 17.

19.

Ribosome Footprint Profiling of Translation throughout the Genome.

Ingolia NT.

Cell. 2016 Mar 24;165(1):22-33. doi: 10.1016/j.cell.2016.02.066.

20.

Ribosome Profiling as a Tool to Decipher Viral Complexity.

Stern-Ginossar N, Ingolia NT.

Annu Rev Virol. 2015 Nov;2(1):335-49. doi: 10.1146/annurev-virology-100114-054854. Epub 2015 Jul 30. Review.

PMID:
26958919
21.

Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9.

Newman ZR, Young JM, Ingolia NT, Barton GM.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1362-71. doi: 10.1073/pnas.1518976113. Epub 2016 Feb 22.

22.

Starting too soon: upstream reading frames repress downstream translation.

McGeachy AM, Ingolia NT.

EMBO J. 2016 Apr 1;35(7):699-700. doi: 10.15252/embj.201693946. Epub 2016 Feb 19.

23.

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.

Fields AP, Rodriguez EH, Jovanovic M, Stern-Ginossar N, Haas BJ, Mertins P, Raychowdhury R, Hacohen N, Carr SA, Ingolia NT, Regev A, Weissman JS.

Mol Cell. 2015 Dec 3;60(5):816-827. doi: 10.1016/j.molcel.2015.11.013.

24.

Cell-fate determination by ubiquitin-dependent regulation of translation.

Werner A, Iwasaki S, McGourty CA, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia NT, Rape M.

Nature. 2015 Sep 24;525(7570):523-7. doi: 10.1038/nature14978.

25.

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.

Sen ND, Zhou F, Ingolia NT, Hinnebusch AG.

Genome Res. 2015 Aug;25(8):1196-205. doi: 10.1101/gr.191601.115. Epub 2015 Jun 29.

26.

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

Sidrauski C, McGeachy AM, Ingolia NT, Walter P.

Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.

27.

Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation.

Pop C, Rouskin S, Ingolia NT, Han L, Phizicky EM, Weissman JS, Koller D.

Mol Syst Biol. 2014 Dec 23;10:770. doi: 10.15252/msb.20145524.

28.

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity.

Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M.

Nat Commun. 2014 Nov 4;5:5248. doi: 10.1038/ncomms6248.

29.

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei.

Jensen BC, Ramasamy G, Vasconcelos EJ, Ingolia NT, Myler PJ, Parsons M.

BMC Genomics. 2014 Oct 20;15:911. doi: 10.1186/1471-2164-15-911.

30.

Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.

Ingolia NT, Brar GA, Stern-Ginossar N, Harris MS, Talhouarne GJ, Jackson SE, Wills MR, Weissman JS.

Cell Rep. 2014 Sep 11;8(5):1365-79. doi: 10.1016/j.celrep.2014.07.045. Epub 2014 Aug 21.

31.

Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice.

Castañeda J, Genzor P, van der Heijden GW, Sarkeshik A, Yates JR 3rd, Ingolia NT, Bortvin A.

EMBO J. 2014 Sep 17;33(18):1999-2019. doi: 10.15252/embj.201386855. Epub 2014 Jul 25.

32.

A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity.

Brubaker SW, Gauthier AE, Mills EW, Ingolia NT, Kagan JC.

Cell. 2014 Feb 13;156(4):800-11. doi: 10.1016/j.cell.2014.01.021.

33.

Ribosome profiling: new views of translation, from single codons to genome scale.

Ingolia NT.

Nat Rev Genet. 2014 Mar;15(3):205-13. doi: 10.1038/nrg3645. Epub 2014 Jan 28. Review.

PMID:
24468696
34.

Identification of long-lived proteins reveals exceptional stability of essential cellular structures.

Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR 3rd, Hetzer MW.

Cell. 2013 Aug 29;154(5):971-982. doi: 10.1016/j.cell.2013.07.037.

35.

Genome-wide annotation and quantitation of translation by ribosome profiling.

Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS.

Curr Protoc Mol Biol. 2013 Jul;Chapter 4:Unit 4.18. doi: 10.1002/0471142727.mb0418s103.

36.

Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins.

Guttman M, Russell P, Ingolia NT, Weissman JS, Lander ES.

Cell. 2013 Jul 3;154(1):240-51. doi: 10.1016/j.cell.2013.06.009. Epub 2013 Jun 27.

37.

Aneuploid yeast strains exhibit defects in cell growth and passage through START.

Thorburn RR, Gonzalez C, Brar GA, Christen S, Carlile TM, Ingolia NT, Sauer U, Weissman JS, Amon A.

Mol Biol Cell. 2013 May;24(9):1274-89. doi: 10.1091/mbc.E12-07-0520. Epub 2013 Mar 6.

38.

PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity.

Nakatsu F, Baskin JM, Chung J, Tanner LB, Shui G, Lee SY, Pirruccello M, Hao M, Ingolia NT, Wenk MR, De Camilli P.

J Cell Biol. 2012 Dec 10;199(6):1003-16. doi: 10.1083/jcb.201206095.

39.

Decoding human cytomegalovirus.

Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS.

Science. 2012 Nov 23;338(6110):1088-93. doi: 10.1126/science.1227919.

40.

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments.

Ingolia NT, Brar GA, Rouskin S, McGeachy AM, Weissman JS.

Nat Protoc. 2012 Jul 26;7(8):1534-50. doi: 10.1038/nprot.2012.086.

41.

Observation of dually decoded regions of the human genome using ribosome profiling data.

Michel AM, Choudhury KR, Firth AE, Ingolia NT, Atkins JF, Baranov PV.

Genome Res. 2012 Nov;22(11):2219-29. doi: 10.1101/gr.133249.111. Epub 2012 May 16.

42.

The translational landscape of mTOR signalling steers cancer initiation and metastasis.

Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D.

Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912.

43.

High-resolution view of the yeast meiotic program revealed by ribosome profiling.

Brar GA, Yassour M, Friedman N, Regev A, Ingolia NT, Weissman JS.

Science. 2012 Feb 3;335(6068):552-7. doi: 10.1126/science.1215110. Epub 2011 Dec 22.

44.

Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.

Ingolia NT, Lareau LF, Weissman JS.

Cell. 2011 Nov 11;147(4):789-802. doi: 10.1016/j.cell.2011.10.002. Epub 2011 Nov 3.

45.

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats.

Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, Julius D.

Nature. 2011 Aug 3;476(7358):88-91. doi: 10.1038/nature10245.

46.

Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.

Takacs JE, Neary TB, Ingolia NT, Saini AK, Martin-Marcos P, Pelletier J, Hinnebusch AG, Lorsch JR.

RNA. 2011 Mar;17(3):439-52. doi: 10.1261/rna.2475211. Epub 2011 Jan 10.

47.

Genome-wide translational profiling by ribosome footprinting.

Ingolia NT.

Methods Enzymol. 2010;470:119-42. doi: 10.1016/S0076-6879(10)70006-9. Epub 2010 Mar 1.

PMID:
20946809
48.

Mammalian microRNAs predominantly act to decrease target mRNA levels.

Guo H, Ingolia NT, Weissman JS, Bartel DP.

Nature. 2010 Aug 12;466(7308):835-40. doi: 10.1038/nature09267.

49.

Molecular basis of infrared detection by snakes.

Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D.

Nature. 2010 Apr 15;464(7291):1006-11. doi: 10.1038/nature08943. Epub 2010 Mar 14.

50.

Rapid creation and quantitative monitoring of high coverage shRNA libraries.

Bassik MC, Lebbink RJ, Churchman LS, Ingolia NT, Patena W, LeProust EM, Schuldiner M, Weissman JS, McManus MT.

Nat Methods. 2009 Jun;6(6):443-5. doi: 10.1038/nmeth.1330. Epub 2009 May 17.

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