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Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts.

Jones RM, Melton PE, Pinese M, Rea AJ, Ingley E, Ballinger ML; International Sarcoma Kindred Study, Wood DJ, Thomas DM, Moses EK.

BMC Med Genet. 2019 May 3;20(1):69. doi: 10.1186/s12881-019-0808-9.


Author Correction: Identification of a novel cAMP dependent protein kinase A phosphorylation site on the human cardiac calcium channel.

Szappanos HC, Muralidharan P, Ingley E, Petereit J, Millar AH, Hool LC.

Sci Rep. 2018 May 3;8(1):7207. doi: 10.1038/s41598-018-24792-3.


The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma.

Calvert N, Wu J, Sneddon S, Woodhouse J, Carey-Smith R, Wood D, Ingley E.

Clin Sarcoma Res. 2018 Mar 8;8:4. doi: 10.1186/s13569-018-0090-1. eCollection 2018.


Identification of a novel cAMP dependent protein kinase A phosphorylation site on the human cardiac calcium channel.

Cserne Szappanos H, Muralidharan P, Ingley E, Petereit J, Millar AH, Hool LC.

Sci Rep. 2017 Nov 9;7(1):15118. doi: 10.1038/s41598-017-15087-0. Erratum in: Sci Rep. 2018 May 3;8(1):7207.


Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCĪ“.

Samuels AL, Louw A, Zareie R, Ingley E.

World J Biol Chem. 2017 Aug 26;8(3):163-174. doi: 10.4331/wjbc.v8.i3.163.


The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor.

Ward BK, Rea SL, Magno AL, Pedersen B, Brown SJ, Mullin S, Arulpragasam A, Ingley E, Conigrave AD, Ratajczak T.

J Cell Physiol. 2018 Jan;233(1):38-56. doi: 10.1002/jcp.25957. Epub 2017 Jun 5.


The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress-the role of cysteine residues in the alpha interacting domain.

Muralidharan P, Cserne Szappanos H, Ingley E, Hool LC.

Clin Exp Pharmacol Physiol. 2017 Dec;44 Suppl 1:46-54. doi: 10.1111/1440-1681.12750. Epub 2017 Sep 20. Review.


Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity.

Plani-Lam JH, Slavova-Azmanova NS, Kucera N, Louw A, Satiaputra J, Singer P, Lam KP, Hibbs ML, Ingley E.

Exp Hematol. 2017 Feb;46:70-82.e10. doi: 10.1016/j.exphem.2016.10.001. Epub 2016 Oct 15.


High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity.

Plani-Lam JH, Chow TC, Fan YH, Garcia-Bloj B, Cheng L, Jin DY, Hancock W, Fanayan S, Ingley E, Song YQ.

Blood Cancer J. 2016 Jan 15;6:e388. doi: 10.1038/bcj.2015.107. No abstract available.


Evidence for redox sensing by a human cardiac calcium channel.

Muralidharan P, Cserne Szappanos H, Ingley E, Hool L.

Sci Rep. 2016 Jan 11;6:19067. doi: 10.1038/srep19067.


Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.

Tie SR, McCarthy DJ, Kendrick TS, Louw A, Le C, Satiaputra J, Kucera N, Phillips M, Ingley E.

Oncogene. 2016 Apr 21;35(16):2098-111. doi: 10.1038/onc.2015.272. Epub 2015 Jul 27.


PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling.

Plani-Lam JH, Chow TC, Siu KL, Chau WH, Ng MH, Bao S, Ng CT, Sham P, Shum DK, Ingley E, Jin DY, Song YQ.

Int J Biochem Cell Biol. 2015 Apr;61:53-62. doi: 10.1016/j.biocel.2015.02.003. Epub 2015 Feb 11.


Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival.

Slavova-Azmanova NS, Kucera N, Louw A, Satiaputra J, Handoko A, Singer P, Stone L, McCarthy DJ, Klinken SP, Hibbs ML, Ingley E.

Biochem J. 2014 May 1;459(3):455-66. doi: 10.1042/BJ20130903.


Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling.

Slavova-Azmanova NS, Kucera N, Satiaputra J, Stone L, Magno A, Maxwell MJ, Quilici C, Erber W, Klinken SP, Hibbs ML, Ingley E.

Blood. 2013 Jul 11;122(2):262-71. doi: 10.1182/blood-2012-10-463158. Epub 2013 May 21.


Functions of the Lyn tyrosine kinase in health and disease.

Ingley E.

Cell Commun Signal. 2012 Jul 17;10(1):21. doi: 10.1186/1478-811X-10-21.


Integrating novel signaling pathways involved in erythropoiesis.

Ingley E.

IUBMB Life. 2012 May;64(5):402-10. doi: 10.1002/iub.1024. Epub 2012 Mar 20. Review.


Targeting Lyn tyrosine kinase through protein fusions encompassing motifs of Cbp (Csk-binding protein) and the SOCS box of SOCS1.

Whiting RJ, Payne CJ, Satiaputra J, Kucera N, Qiu TW, Irtegun S, Gunn NJ, Slavova-Azmanova NS, Mulhern TD, Ingley E.

Biochem J. 2012 Mar 15;442(3):611-20. doi: 10.1042/BJ20111485. Erratum in: Biochem J. 2012 Apr 15;443(2):585. Lavova-Azmanova, Neli S [corrected to Slavova-Azmanova, Neli S].


A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture.

Wang JZ, Deogan MS, Lewis JR, Chew S, Mullin BH, McNab TJ, Wilson SG, Ingley E, Prince RL.

BMC Med Genet. 2011 Dec 20;12:165. doi: 10.1186/1471-2350-12-165.


The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling.

Arulpragasam A, Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK.

Biochem J. 2012 Feb 1;441(3):995-1006. doi: 10.1042/BJ20111277.


Significant association between common polymorphisms in the aromatase gene CYP19A1 and bone mineral density in postmenopausal women.

Mullin BH, Carter KW, Lewis JR, Ingley E, Wilson SG, Prince RL.

Calcif Tissue Int. 2011 Dec;89(6):464-71. doi: 10.1007/s00223-011-9535-8. Epub 2011 Sep 28.


Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling.

Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):584-9. doi: 10.1016/j.bbrc.2011.07.132. Epub 2011 Aug 6.


Evidence of altered guinea pig ventricular cardiomyocyte protein expression and growth in response to a 5 min in vitro exposure to H(2)O(2).

Seenarain V, Viola HM, Ravenscroft G, Casey TM, Lipscombe RJ, Ingley E, Laing NG, Bringans SD, Hool LC.

J Proteome Res. 2010 Apr 5;9(4):1985-94. doi: 10.1021/pr9011393.


In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors.

Payne EJ, Ingley E, Dick IM, Wilson SG, Bond CS, Prince RL.

J Clin Endocrinol Metab. 2009 Aug;94(8):2998-3002. doi: 10.1210/jc.2008-2309. Epub 2009 May 26.


Csk-binding protein can regulate Lyn signals controlling cell morphology.

Ingley E.

Int J Biochem Cell Biol. 2009 Jun;41(6):1332-43. doi: 10.1016/j.biocel.2008.12.001. Epub 2008 Dec 11.


Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.

Samuels AL, Klinken SP, Ingley E.

Blood. 2009 Apr 16;113(16):3845-56. doi: 10.1182/blood-2008-04-153452. Epub 2008 Dec 8.


Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.

Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J.

J Biol Chem. 2009 Jan 2;284(1):284-91. doi: 10.1074/jbc.M807850200. Epub 2008 Nov 4.


Erythroid defects in TRalpha-/- mice.

Kendrick TS, Payne CJ, Epis MR, Schneider JR, Leedman PJ, Klinken SP, Ingley E.

Blood. 2008 Mar 15;111(6):3245-8. doi: 10.1182/blood-2007-07-101105. Epub 2008 Jan 18.


Src family kinases: regulation of their activities, levels and identification of new pathways.

Ingley E.

Biochim Biophys Acta. 2008 Jan;1784(1):56-65. Epub 2007 Aug 22. Review.


Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule.

Winteringham LN, Endersby R, Kobelke S, McCulloch RK, Williams JH, Stillitano J, Cornwall SM, Ingley E, Klinken SP.

J Biol Chem. 2006 Dec 15;281(50):38791-800. Epub 2006 Sep 28.


Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.

Ingley E, Schneider JR, Payne CJ, McCarthy DJ, Harder KW, Hibbs ML, Klinken SP.

J Biol Chem. 2006 Oct 20;281(42):31920-9. Epub 2006 Aug 18.


Cross-regulation of JAK and Src kinases.

Ingley E, Klinken SP.

Growth Factors. 2006 Mar;24(1):89-95. Review.


NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

Hunter M, Angelicheva D, Tournev I, Ingley E, Chan DC, Watts GF, Kremensky I, Kalaydjieva L.

Biochem Biophys Res Commun. 2005 Jul 15;332(4):982-92.


Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.

Court NW, Ingley E, Klinken SP, Bogoyevitch MA.

Biochim Biophys Acta. 2005 May 15;1744(1):68-75. Epub 2004 Dec 31.


Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.

Ingley E, McCarthy DJ, Pore JR, Sarna MK, Adenan AS, Wright MJ, Erber W, Tilbrook PA, Klinken SP.

Oncogene. 2005 Jan 13;24(3):336-43.


New insights into the regulation of erythroid cells.

Ingley E, Tilbrook PA, Klinken SP.

IUBMB Life. 2004 Apr;56(4):177-84. Review.


Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation.

Winteringham LN, Kobelke S, Williams JH, Ingley E, Klinken SP.

Oncogene. 2004 Jun 24;23(29):5105-9.


HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.

Lalonde JP, Lim R, Ingley E, Tilbrook PA, Thompson MJ, McCulloch R, Beaumont JG, Wicking C, Eyre HJ, Sutherland GR, Howe K, Solomon E, Williams JH, Klinken SP.

J Biol Chem. 2004 Feb 27;279(9):8181-9. Epub 2003 Dec 8.


Differential regulation of SOCS genes in normal and transformed erythroid cells.

Sarna MK, Ingley E, Busfield SJ, Cull VS, Lepere W, McCarthy DJ, Wright MJ, Palmer GA, Chappell D, Sayer MS, Alexander WS, Hilton DJ, Starr R, Watowich SS, Bittorf T, Klinken SP, Tilbrook PA.

Oncogene. 2003 May 22;22(21):3221-30.


MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.

Lim R, Winteringham LN, Williams JH, McCulloch RK, Ingley E, Tiao JY, Lalonde JP, Tsai S, Tilbrook PA, Sun Y, Wu X, Morris SW, Klinken SP.

J Biol Chem. 2002 Oct 25;277(43):40997-1008. Epub 2002 Aug 9.


Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.

Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA.

Science. 2001 Oct 12;294(5541):374-80.


Thyroid hormone receptor-interacting protein 1 modulates cytokine and nuclear hormone signaling in erythroid cells.

Ingley E, Chappell D, Poon SY, Sarna MK, Beaumont JG, Williams JH, Stillitano JP, Tsai S, Leedman PJ, Tilbrook PA, Klinken SP.

J Biol Chem. 2001 Nov 16;276(46):43428-34. Epub 2001 Sep 5.


Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn.

Tilbrook PA, Palmer GA, Bittorf T, McCarthy DJ, Wright MJ, Sarna MK, Linnekin D, Cull VS, Williams JH, Ingley E, Schneider-Mergener J, Krystal G, Klinken SP.

Cancer Res. 2001 Mar 15;61(6):2453-8.


Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells.

Sayer MS, Tilbrook PA, Spadaccini A, Ingley E, Sarna MK, Williams JH, Andrews NC, Klinken SP.

J Biol Chem. 2000 Aug 18;275(33):25292-8.


HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells.

Ingley E, Sarna MK, Beaumont JG, Tilbrook PA, Tsai S, Takemoto Y, Williams JH, Klinken SP.

J Biol Chem. 2000 Mar 17;275(11):7887-93.


Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo.

Cull V, Tilbrook PA, Adenan AS, Chappell D, Ingley E, Sarna MK, Palmer TN, Watowich SS, Klinken SP.

Oncogene. 2000 Feb 17;19(7):953-60.


HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1.

Williams JH, Daly LN, Ingley E, Beaumont JG, Tilbrook PA, Lalonde JP, Stillitano JP, Klinken SP.

EMBO J. 1999 Oct 15;18(20):5559-66.


A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit.

Ingley E, Williams JH, Walker CE, Tsai S, Colley S, Sayer MS, Tilbrook PA, Sarna M, Beaumont JG, Klinken SP.

FEBS Lett. 1999 Oct 1;459(1):69-74.


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