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Items: 1 to 50 of 181

1.

Inhibition of natriuretic peptide receptor 1 reduces itch in mice.

Solinski HJ, Dranchak P, Oliphant E, Gu X, Earnest TW, Braisted J, Inglese J, Hoon MA.

Sci Transl Med. 2019 Jul 10;11(500). pii: eaav5464. doi: 10.1126/scitranslmed.aav5464.

PMID:
31292265
2.

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.

Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J.

PLoS One. 2019 Jul 5;14(7):e0218897. doi: 10.1371/journal.pone.0218897. eCollection 2019.

3.

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.

Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ.

J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15.

4.

A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.

Getz RA, Kwak G, Cornell S, Mbugua S, Eberhard J, Huang SX, Abbasi Z, de Medeiros AS, Thomas R, Bukowski B, Dranchak PK, Inglese J, Hoffman CS.

Cell Signal. 2019 Aug;60:114-121. doi: 10.1016/j.cellsig.2019.04.010. Epub 2019 Apr 24.

PMID:
31026495
5.

Detecting Secretory Proteins by Acoustic Droplet Ejection in Multiplexed High-Throughput Applications.

Iannotti MJ, MacArthur R, Jones R, Tao D, Singeç I, Michael S, Inglese J.

ACS Chem Biol. 2019 May 17;14(5):1063. doi: 10.1021/acschembio.9b00274. Epub 2019 Apr 23. No abstract available.

PMID:
31012573
6.

Detecting Secretory Proteins by Acoustic Droplet Ejection in Multiplexed High-Throughput Applications.

Iannotti MJ, MacArthur R, Jones R, Tao D, Singeç I, Michael S, Inglese J.

ACS Chem Biol. 2019 Mar 15;14(3):497-505. doi: 10.1021/acschembio.9b00001. Epub 2019 Feb 14. Erratum in: ACS Chem Biol. 2019 May 17;14(5):1063.

PMID:
30699290
7.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.

8.

Interferences with Luciferase Reporter Enzymes.

Auld DS, Inglese J.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2016 Jul 1 [updated 2018 Jul 1].

9.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP.

Clin Transl Sci. 2018 Sep;11(5):461-470. doi: 10.1111/cts.12570. Epub 2018 Jul 24. Review.

10.

Genome-Edited Cell Lines for High-Throughput Screening.

Dranchak P, Moran JJ, MacArthur R, Lopez-Anido C, Inglese J, Svaren J.

Methods Mol Biol. 2018;1755:1-17. doi: 10.1007/978-1-4939-7724-6_1.

11.

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.

Baird TD, Cheng KC, Chen YC, Buehler E, Martin SE, Inglese J, Hogg JR.

Elife. 2018 Mar 12;7. pii: e33178. doi: 10.7554/eLife.33178.

12.

Assay Interference by Aggregation.

Auld DS, Inglese J, Dahlin JL.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. No abstract available.
2017 Jul 26.

13.

Quantitative High-Throughput Screening Using a Coincidence Reporter Biocircuit.

Schuck BW, MacArthur R, Inglese J.

Curr Protoc Neurosci. 2017 Apr 10;79:5.32.1-5.32.27. doi: 10.1002/cpns.27.

14.

Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.

Yu H, Dranchak P, Li Z, MacArthur R, Munson MS, Mehzabeen N, Baird NJ, Battalie KP, Ross D, Lovell S, Carlow CK, Suga H, Inglese J.

Nat Commun. 2017 Apr 3;8:14932. doi: 10.1038/ncomms14932.

15.

Early Drug Discovery and Development Guidelines: For Academic Researchers, Collaborators, and Start-up Companies.

Strovel J, Sittampalam S, Coussens NP, Hughes M, Inglese J, Kurtz A, Andalibi A, Patton L, Austin C, Baltezor M, Beckloff M, Weingarten M, Weir S.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2016 Jul 1].

16.

Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes.

Baird NJ, Inglese J, Ferré-D'Amaré AR.

Nat Commun. 2015 Dec 7;6:8898. doi: 10.1038/ncomms9898.

18.

Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.

Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese J.

J Nat Prod. 2015 Oct 23;78(10):2411-22. doi: 10.1021/acs.jnatprod.5b00489. Epub 2015 Oct 14.

19.

Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.

Fuller JA, Berlinicke CA, Inglese J, Zack DJ.

Adv Exp Med Biol. 2016;854:597-603. doi: 10.1007/978-3-319-17121-0_79.

20.

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ.

Sci Rep. 2015 Sep 25;5:13891. doi: 10.1038/srep13891.

21.

Mitigating risk in academic preclinical drug discovery.

Dahlin JL, Inglese J, Walters MA.

Nat Rev Drug Discov. 2015 Apr;14(4):279-94. doi: 10.1038/nrd4578. Review.

22.

Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion.

Gallardo VE, Varshney GK, Lee M, Bupp S, Xu L, Shinn P, Crawford NP, Inglese J, Burgess SM.

Dis Model Mech. 2015 Jun;8(6):565-76. doi: 10.1242/dmm.018689. Epub 2015 Mar 25.

23.

Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter.

Hasson SA, Fogel AI, Wang C, MacArthur R, Guha R, Heman-Ackah S, Martin S, Youle RJ, Inglese J.

ACS Chem Biol. 2015 May 15;10(5):1188-97. doi: 10.1021/cb5010417. Epub 2015 Feb 26.

PMID:
25689131
24.

Designing innovative therapies for neuropathic pain: pros and cons of target-based drug discovery.

Inglese J.

J Peripher Nerv Syst. 2014 Oct;19 Suppl 2:S6-9. doi: 10.1111/jns.12079_3. No abstract available.

PMID:
25269741
25.

Engineering bacterial transcription regulation to create a synthetic in vitro two-hybrid system for protein interaction assays.

Zhou Y, Asahara H, Schneider N, Dranchak P, Inglese J, Chong S.

J Am Chem Soc. 2014 Oct 8;136(40):14031-8. doi: 10.1021/ja502512g. Epub 2014 Sep 26.

26.

Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease.

Inglese J, Dranchak P, Moran JJ, Jang SW, Srinivasan R, Santiago Y, Zhang L, Guha R, Martinez N, MacArthur R, Cost GJ, Svaren J.

ACS Chem Biol. 2014 Nov 21;9(11):2594-602. doi: 10.1021/cb5005492. Epub 2014 Sep 16.

27.

Identification of small molecule modulators of gene transcription with anticancer activity.

Tran TA, Wichterman-Kouznetsova J, Varghese D, Huang R, Huang W, Becker M, Austin CP, Inglese J, Johnson RL, Martinez ED.

ACS Chem Biol. 2014 Nov 21;9(11):2603-11. doi: 10.1021/cb500532x. Epub 2014 Sep 16.

28.

The increasing urgency for standards in basic biologic research.

Freedman LP, Inglese J.

Cancer Res. 2014 Aug 1;74(15):4024-9. doi: 10.1158/0008-5472.CAN-14-0925. Epub 2014 Jul 17.

29.

A high throughput screening assay system for the identification of small molecule inhibitors of gsp.

Bhattacharyya N, Hu X, Chen CZ, Mathews Griner LA, Zheng W, Inglese J, Austin CP, Marugan JJ, Southall N, Neumann S, Northup JK, Ferrer M, Collins MT.

PLoS One. 2014 Mar 25;9(3):e90766. doi: 10.1371/journal.pone.0090766. eCollection 2014.

30.

A high content screening approach to identify molecules neuroprotective for photoreceptor cells.

Fuller JA, Shaw GC, Bonnet-Wersinger D, Hansen BS, Berlinicke CA, Inglese J, Zack DJ.

Adv Exp Med Biol. 2014;801:773-81. doi: 10.1007/978-1-4614-3209-8_97.

31.

Chemical genomics for studying parasite gene function and interaction.

Li J, Yuan J, Cheng KC, Inglese J, Su XZ.

Trends Parasitol. 2013 Dec;29(12):603-11. doi: 10.1016/j.pt.2013.10.005. Epub 2013 Nov 9. Review.

32.

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

Huh JR, Englund EE, Wang H, Huang R, Huang P, Rastinejad F, Inglese J, Austin CP, Johnson RL, Huang W, Littman DR.

ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.

33.

Innovation in academic chemical screening: filling the gaps in chemical biology.

Hasson SA, Inglese J.

Curr Opin Chem Biol. 2013 Jun;17(3):329-38. doi: 10.1016/j.cbpa.2013.04.018. Epub 2013 May 14. Review.

34.

Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays.

Dranchak P, MacArthur R, Guha R, Zuercher WJ, Drewry DH, Auld DS, Inglese J.

PLoS One. 2013;8(3):e57888. doi: 10.1371/journal.pone.0057888. Epub 2013 Mar 7.

35.

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.

Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4045-50. doi: 10.1073/pnas.1211284110. Epub 2013 Feb 19.

36.

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ.

Medchemcomm. 2012 Dec;3(12):1505-1511.

37.

Effect of voxel size on the accuracy of 3D reconstructions with cone beam CT.

Maret D, Telmon N, Peters OA, Lepage B, Treil J, Inglèse JM, Peyre A, Kahn JL, Sixou M.

Dentomaxillofac Radiol. 2012 Dec;41(8):649-55. doi: 10.1259/dmf/81804525.

38.

A coincidence reporter-gene system for high-throughput screening.

Cheng KC, Inglese J.

Nat Methods. 2012 Oct;9(10):937. doi: 10.1038/nmeth.2170. No abstract available.

39.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG.

Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

40.

Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.

Thorne N, Shen M, Lea WA, Simeonov A, Lovell S, Auld DS, Inglese J.

Chem Biol. 2012 Aug 24;19(8):1060-72. doi: 10.1016/j.chembiol.2012.07.015.

41.

Identification of drug modulators targeting gene-dosage disease CMT1A.

Jang SW, Lopez-Anido C, MacArthur R, Svaren J, Inglese J.

ACS Chem Biol. 2012 Jul 20;7(7):1205-13. doi: 10.1021/cb300048d. Epub 2012 May 2.

42.

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.

Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas CJ, Inglese J, Austin CP, Gershengorn MC, Huang W.

Medchemcomm. 2011 Oct;2(10):1016-1020.

43.

Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.

Cruz PG, Auld DS, Schultz PJ, Lovell S, Battaile KP, MacArthur R, Shen M, Tamayo-Castillo G, Inglese J, Sherman DH.

Chem Biol. 2011 Nov 23;18(11):1442-52. doi: 10.1016/j.chembiol.2011.08.011.

44.

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.

Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z.

Chem Biol. 2011 Nov 23;18(11):1390-400. doi: 10.1016/j.chembiol.2011.08.014.

45.

Biology-driven library design for probe discovery.

Inglese J, Hasson SA.

Chem Biol. 2011 Oct 28;18(10):1204-5. doi: 10.1016/j.chembiol.2011.10.004.

46.

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.

Huang W, Huang R, Attene-Ramos MS, Sakamuru S, Englund EE, Inglese J, Austin CP, Xia M.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5239-43. doi: 10.1016/j.bmcl.2011.07.043. Epub 2011 Jul 21.

47.

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.

Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin CP, Su XZ.

Science. 2011 Aug 5;333(6043):724-9. doi: 10.1126/science.1205216.

48.

Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists.

Titus S, Huang W, Marugan J, Southall N, Inglese J, Austin C, Zheng W, Englund E, Neumann S, Gershengorn M.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Sep 1 [updated 2011 Mar 25].

49.

Discovery of new antimalarial chemotypes through chemical methodology and library development.

Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA Jr.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6775-80. doi: 10.1073/pnas.1017666108. Epub 2011 Apr 15.

50.

A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2.

Johnson RL, Hwang JY, Arnold LA, Huang R, Wichterman J, Augustinaite I, Austin CP, Inglese J, Guy RK, Huang W.

J Biomol Screen. 2011 Jul;16(6):618-27. doi: 10.1177/1087057111402199. Epub 2011 Apr 11.

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